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nsp12

Euk-Vir

Tylonycteris_bat_coronavirus_HKU4

nsp12__YP_009944320__Tylonycteris_bat_coronavirus_HKU4__694007

Identity

Accession:
YP_009944320 ↗
Protein ID:
nsp12
Kingdom:
euk

Quality

89.5 mean pLDDT

Taxonomy

Orthornavirae› Pisuviricota› Pisoniviricetes› Nidovirales› Coronaviridae› Betacoronavirus› Tylonycteris_bat_coronavirus_HKU4

TaxID: 694007

Cluster

View cluster (23 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 837-927
PDB
Domain cluster: rep: NSP12__YP_009825029__Duck_coronavirus__300188__D836-945
D2 medium residues 1-124
PDB
Domain cluster: rep: nsp12__YP_008439222__Bat_coronavirus_CDPHE15_USA_2006__1384461__D18-119
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF06478.20 best CoV_RPol_N 126.7 1.50e-36 90.3% 30.0%
D3 medium residues 125-299
PDB
Domain cluster: rep: RNA-dependent_RNA_polymerase__NP_740629__Infectious_bronchitis_virus__11120__D128-266
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF06478.20 best CoV_RPol_N 306.2 4.20e-91 100.0% 50.0%
D4 medium residues 300-362_441-483
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF06478.20 best CoV_RPol_N 115.4 4.40e-33 63.2% 18.3%
ECOD (1)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2994348 304.48.1.9 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1,CoV_RPol_N 0.96 93.0 5.24e-01 100.0% 19.8%
D5 medium residues 363-416_484-585
PDB
Domain cluster: rep: nsp12__YP_009944349__Pipistrellus_bat_coronavirus_HKU5__694008__D359-459_503-534_548-594
D6 medium residues 586-608_627-705
PDB
Domain cluster: representative
CATH (8)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3ckdA02 1.20.58.360 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Shigella T3SS effector IpaH defines 0.59 42.0 3.96e-01 77.5% 61.3%
1qhbA00 1.10.606.10 Mainly Alpha › Orthogonal Bundle › Vanadium-containing Chloroperoxidase; domain 2 › Vanadium-containing Chloroperoxidase, domain 2 0.55 41.0 2.52e-01 77.5% 54.5%
2jhjA02 1.10.340.30 Mainly Alpha › Orthogonal Bundle › Endonuclease III; domain 1 › Hypothetical protein; domain 2 0.54 39.0 3.70e-01 74.5% 75.0%
2itmB02 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.54 39.0 3.06e-01 76.5% 86.8%
3mwmA01 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.52 26.0 2.98e-01 93.1% 60.0%
1mzbA01 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.52 27.0 2.93e-01 95.1% 57.3%
2cxiA01 3.30.56.10 Alpha Beta › 2-Layer Sandwich › Phenylalanyl-tRNA Synthetase; Chain B, domain 1 › 0.51 30.0 3.43e-01 76.5% 75.9%
3m8eA00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.50 30.0 3.06e-01 82.4% 59.4%
ECOD (14)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4810251 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.74 55.0 4.03e-01 77.5% 52.9%
3479114 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.68 60.0 3.70e-01 99.0% 60.0%
3651060 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.67 47.0 3.85e-01 77.5% 39.5%
3258201 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.66 47.0 3.62e-01 77.5% 32.3%
3939572 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.65 58.0 4.51e-01 100.0% 54.7%
4289835 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.60 52.0 4.11e-01 96.1% 52.9%
3025534 304.58.1.0 ↗ a+b two layers › Alpha-beta plaits › FepE-like › FepE-like 0.59 44.0 3.52e-01 77.5% 46.9%
4959061 101.1.2.169 ↗ alpha arrays › HTH › HTH › winged helix domain › PheRS_DBD3 0.58 25.0 2.92e-01 88.2% 52.9%
3800821 5050.1.1.0 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.55 38.0 2.81e-01 71.6% 81.8%
5055279 1075.1.2.0 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › MacB transmembrane domain 0.52 36.0 2.90e-01 72.5% 86.8%
3592874 108.1.1.0 ↗ alpha arrays › EF-hand › EF-hand-related › EF-hand 0.51 37.0 3.65e-01 86.3% 70.0%
3240976 5050.1.1.6 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › OATP 0.50 35.0 2.64e-01 73.5% 81.0%
3882475 5050.1.1.6 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › OATP 0.50 36.0 2.74e-01 75.5% 59.2%
3625804 4156.1.1.0 ↗ alpha arrays › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like 0.50 37.0 3.32e-01 76.5% 56.4%
D7 medium residues 609-626_706-805
PDB
Domain cluster: rep: RNA-dependent_RNA_polymerase__NP_835352__Human_coronavirus_229E__11137__D685-789