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nsp12

Euk-Vir

Pipistrellus_bat_coronavirus_HKU5

nsp12__YP_009944349__Pipistrellus_bat_coronavirus_HKU5__694008

Identity

Accession:: YP_009944349 ↗
Protein ID:: nsp12
Kingdom:: euk

Quality

90.6 mean pLDDT

Taxonomy

Orthornavirae› Pisuviricota› Pisoniviricetes› Nidovirales› Coronaviridae› Betacoronavirus› Pipistrellus_bat_coronavirus_HKU5

TaxID: 694008

Cluster

View cluster (23 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 817-926

PDB

Domain cluster: rep: NSP12__YP_009825029__Duck_coronavirus__300188__D836-945

D2 medium residues 1-124

PDB

Domain cluster: rep: nsp12__YP_008439222__Bat_coronavirus_CDPHE15_USA_2006__1384461__D18-119

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF06478.20 best	CoV_RPol_N	123.8	1.20e-35	89.5%	29.7%

D3 medium residues 125-177

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase__NP_828849_RNA-dependent_RNA_polymerase__SARS_coronavirus_Tor2__227984__D123-185

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF06478.20 best	CoV_RPol_N	83.3	2.40e-23	100.0%	15.1%

D4 medium residues 178-290

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF06478.20 best	CoV_RPol_N	184.6	4.00e-54	100.0%	32.3%

CATH (6)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1zarA03	1.10.510.10	Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1	0.66	48.0	5.14e-01	99.1%	88.7%
2qkwB02	1.10.510.10	Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1	0.60	55.0	4.51e-01	99.1%	88.9%
2zv2A02	1.10.510.10	Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1	0.55	50.0	4.24e-01	98.2%	92.2%
5f9eB02	1.10.510.10	Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1	0.55	50.0	4.06e-01	99.1%	78.4%
1yhvA02	1.10.510.10	Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1	0.54	49.0	4.08e-01	99.1%	83.6%
3hwwA01	3.40.50.970	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains	0.51	37.0	3.09e-01	77.0%	88.2%

ECOD (6)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2994348	304.48.1.9 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1,CoV_RPol_N	0.99	97.0	5.48e-01	100.0%	12.1%
4015658	5050.1.1.0 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter	0.58	43.0	3.35e-01	76.1%	70.2%
4165023	206.1.1.12 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › SelO	0.57	50.0	3.31e-01	100.0%	23.4%
3482553	206.1.1.0 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase	0.55	50.0	3.44e-01	100.0%	33.6%
3475873	206.1.1.12 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › SelO	0.55	50.0	3.37e-01	100.0%	30.8%
3634258	206.1.1.12 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › SelO	0.55	50.0	3.17e-01	100.0%	26.7%

D5 medium residues 293-358

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF06478.20 best	CoV_RPol_N	126.9	1.40e-36	100.0%	18.9%

CATH (8)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1v62A00	2.30.42.10	Mainly Beta › Roll › Pdz3 Domain › PDZ domain	0.62	31.0	2.58e-01	93.9%	26.5%
3lhoA01	3.10.180.50	Alpha Beta › Roll › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 ›	0.58	45.0	3.18e-01	87.9%	84.1%
4lizA00	3.40.20.10	Alpha Beta › 3-Layer(aba) Sandwich › Severin › Severin	0.52	38.0	3.09e-01	80.3%	69.6%
1f2uB00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.52	38.0	3.04e-01	80.3%	84.1%
2ig6A00	2.30.110.10	Mainly Beta › Roll › Pnp Oxidase; Chain A › Electron Transport, Fmn-binding Protein; Chain A	0.52	38.0	3.06e-01	81.8%	87.4%
3ddcB00	3.10.20.90	Alpha Beta › Roll › Ubiquitin-like (UB roll) › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1	0.52	39.0	3.21e-01	84.8%	97.0%
5wzoA00	1.20.90.10	Mainly Alpha › Up-down Bundle › Phospholipase A2 › Phospholipase A2 domain	0.51	36.0	3.03e-01	75.8%	61.8%
3qktD01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.51	38.0	2.48e-01	81.8%	38.7%

ECOD (13)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2994348	304.48.1.9 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1,CoV_RPol_N	0.98	94.0	5.10e-01	100.0%	7.1%
4009409	109.4.1.2353 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HemY_N, TPR_2	0.60	41.0	2.55e-01	71.2%	30.4%
2780223	3016.1.1.0 ↗	a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases	0.59	40.0	3.24e-01	71.2%	52.9%
3875689	109.4.1.1289 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF30856	0.58	46.0	2.84e-01	90.9%	45.6%
3772654	109.4.1.1289 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF30856	0.57	46.0	2.75e-01	90.9%	39.0%
3571866	109.4.1.1289 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF30856	0.57	46.0	2.62e-01	90.9%	26.1%
3694899	5069.1.1.71 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › DUF3176	0.55	36.0	2.66e-01	75.8%	22.5%
3718526	219.3.1.0 ↗	a+b complex topology › Cysteine proteinases-like › AnkH, inserted middle domain › AnkH, inserted middle domain	0.55	45.0	3.01e-01	93.9%	57.4%
3232550	375.1.1.0 ↗	few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related	0.53	37.0	3.50e-01	75.8%	80.0%
3479024	263.1.1.0 ↗	a+b three layers › SRF-like › SRF-like › SRF-like	0.51	32.0	3.47e-01	89.4%	76.4%
4965147	5001.1.1.292 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › HisKA_7TM	0.51	41.0	2.88e-01	90.9%	69.4%
4408503	192.2.1.43 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › TraD_N	0.51	37.0	2.95e-01	77.3%	59.3%
4943839	7573.1.1.4 ↗	a/b three-layered sandwiches › PRTase-like › PRTase-like › PRTase-like › UPRTase	0.51	43.0	3.06e-01	95.5%	88.7%

D6 medium residues 359-459_503-534_548-594

PDB

Domain cluster: representative

CATH (1)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1z4hA01	1.10.238.160	Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 ›	0.51	13.0	2.27e-01	80.6%	60.3%

ECOD (1)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2994348	304.48.1.9 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1,CoV_RPol_N	0.92	89.0	5.42e-01	100.0%	25.3%

D7 medium residues 460-502_535-547_627-689

PDB

Domain cluster: representative

CATH (2)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1mukA02	3.90.1850.10	Alpha Beta › Alpha-Beta Complex › RNA-directed RNA polymerase lambda-3 › RNA-directed RNA polymerase lambda-3	0.71	64.0	4.21e-01	100.0%	58.2%
1udxA03	3.30.300.350	Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › GTP-binding protein OBG, C-terminal domain	0.53	25.0	3.02e-01	92.4%	66.2%

ECOD (6)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2994348	304.48.1.9 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1,CoV_RPol_N	0.98	96.0	5.46e-01	100.0%	24.7%
2541763	304.48.1.8 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1	0.79	73.0	5.04e-01	100.0%	64.3%
4875416	304.48.1.13 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5	0.77	71.0	4.88e-01	100.0%	57.7%
3997869	2004.1.1.87 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N	0.52	28.0	2.30e-01	80.7%	27.0%
3708776	304.48.1.0 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like	0.51	48.0	3.43e-01	100.0%	71.1%
4415569	4055.1.1.1 ↗	a+b complex topology › a+b domain in virulence-associated V antigen › a+b domain in virulence-associated V antigen › a+b domain in virulence-associated V antigen › LcrV	0.50	28.0	2.65e-01	93.3%	42.8%

D8 medium residues 595-626_690-805

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase__NP_740629__Infectious_bronchitis_virus__11120__D588-652_702-839