←Back to structures

nsp15

Euk-Vir

Human_coronavirus_OC43

nsp15__YP_009555256__Human_coronavirus_OC43__31631

Identity

Accession:: YP_009555256 ↗
Protein ID:: nsp15
Kingdom:: euk

Quality

88.6 mean pLDDT

Taxonomy

Orthornavirae› Pisuviricota› Pisoniviricetes› Nidovirales› Coronaviridae› Betacoronavirus› Human_coronavirus_OC43

TaxID: 31631

Cluster

View cluster (23 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 2-60

PDB

Domain cluster: rep: putative_coronavirus_nsp12__NP_839968__Porcine_epidemic_diarrhea_virus__28295__D1-51

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF19219.6 best	CoV_NSP15_N	81.0	7.90e-23	100.0%	96.7%

D2 high residues 69-217

PDB

Domain cluster: rep: NSP15__YP_001941188__Turkey_coronavirus__11152__D65-176

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF19216.6 best	CoV_NSP15_M	110.9	6.30e-32	75.2%	94.1%

CATH (15)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2gtiA02	3.40.50.11580	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › nsp15 middle domain	0.97	81.0	8.65e-01	85.9%	96.2%
2h85A02	3.40.50.11580	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › nsp15 middle domain	0.95	72.0	7.91e-01	77.9%	96.0%
4rs4B02	3.40.50.11580	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › nsp15 middle domain	0.90	69.0	7.52e-01	77.9%	96.0%
1eamA00	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.64	48.0	3.88e-01	77.9%	59.6%
1o54A02	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.63	46.0	4.22e-01	75.8%	89.6%
1qamA01	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.62	45.0	4.51e-01	75.2%	93.6%
3bt7A01	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.61	45.0	3.93e-01	75.8%	74.6%
2w9hA00	3.40.430.10	Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A	0.55	41.0	4.06e-01	77.2%	80.3%
2w0mA00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.54	42.0	3.70e-01	81.9%	75.0%
1dhiA00	3.40.430.10	Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A	0.53	39.0	3.88e-01	77.2%	82.4%
7cijA01	3.40.640.10	Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain)	0.53	41.0	3.22e-01	83.9%	77.0%
3d1lB01	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.52	41.0	4.06e-01	83.9%	80.1%
1wduB00	3.60.10.10	Alpha Beta › 4-Layer Sandwich › Deoxyribonuclease I; Chain A › Endonuclease/exonuclease/phosphatase	0.52	42.0	3.74e-01	87.2%	98.6%
8db3B02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.52	40.0	3.65e-01	81.9%	77.9%
1l3iA00	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.50	46.0	4.31e-01	100.0%	89.2%

ECOD (12)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1712060	2003.1.5.85 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases	0.91	69.0	6.31e-01	77.2%	62.5%
4872108	2003.1.5.85 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases	0.91	73.0	6.43e-01	81.9%	62.0%
1890251	2003.1.5.92 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › PRRSV-NSP11_N	0.77	48.0	5.73e-01	81.9%	91.3%
4253110	2003.1.5.15 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ	0.64	47.0	3.95e-01	75.8%	69.2%
3384248	2003.1.5.66 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11	0.62	45.0	4.08e-01	75.2%	71.2%
4093245	2003.1.5.53 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › tRNA_U5-meth_tr	0.61	44.0	3.36e-01	75.2%	47.0%
4928763	2003.1.5.69 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › GCD14	0.61	45.0	4.04e-01	75.8%	83.9%
3752847	2003.1.5.0 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases	0.58	43.0	3.60e-01	75.8%	82.8%
5064420	2004.1.1.146 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATPase	0.55	43.0	3.76e-01	81.9%	77.8%
None	—		0.53	40.0	3.10e-01	79.2%	46.3%
5041843	2484.1.1.43 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Endonuclease_5	0.52	38.0	3.47e-01	75.2%	75.5%
4020687	2002.1.1.0 ↗	a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels	0.52	43.0	3.20e-01	90.6%	97.4%

D3 high residues 229-372

PDB

Domain cluster: rep: coronavirus_nsp12__NP_740632__Infectious_bronchitis_virus__11120__D198-335

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF19215.6 best	CoV_NSP15_C	207.3	1.60e-61	100.0%	92.9%