←Back to structures

nsp4_-TM2-

Euk-Vir

Human_coronavirus_HKU1

nsp4_-TM2-__YP_009944272__Human_coronavirus_HKU1__290028

Identity

Accession:: YP_009944272 ↗
Protein ID:: nsp4_-TM2-
Kingdom:: euk

Quality

80.8 mean pLDDT

Taxonomy

Orthornavirae› Pisuviricota› Pisoniviricetes› Nidovirales› Coronaviridae› Betacoronavirus› Human_coronavirus_HKU1

TaxID: 290028

Cluster

View cluster (24 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 42-123

PDB

Domain cluster: rep: nsp4__YP_009924386__Rousettus_bat_coronavirus_HKU9__694006__D42-118

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF19217.6 best	CoV_NSP4_N	78.6	9.00e-22	100.0%	21.6%

D2 high residues 130-269

PDB

Domain cluster: rep: nsp4__YP_009924360__Rat_coronavirus_Parker__502102__D130-270

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF19217.6 best	CoV_NSP4_N	161.6	4.90e-47	100.0%	38.9%

D3 high residues 276-397

PDB

Domain cluster: rep: nsp4__YP_009924386__Rousettus_bat_coronavirus_HKU9__694006__D276-394

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF19217.6 best	CoV_NSP4_N	82.5	5.90e-23	84.4%	28.7%

D4 high residues 409-483

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF16348.11 best	CoV_NSP4_C	106.8	1.20e-30	100.0%	77.1%

CATH (14)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3gzfD00	1.10.150.420	Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Coronavirus nonstructural protein 4 C-terminus	0.87	81.0	7.50e-01	100.0%	81.3%
3ufeA02	1.20.58.1950	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.74	33.0	3.96e-01	93.3%	62.3%
4id0A02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.59	41.0	3.66e-01	92.0%	50.0%
3nowA02	1.25.10.10	Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant	0.58	48.0	2.99e-01	92.0%	17.3%
6tmfT00	1.10.60.20	Mainly Alpha › Orthogonal Bundle › Diphtheria Toxin Repressor; domain 2 › Ribosomal protein S17	0.54	40.0	4.31e-01	90.7%	90.6%
1gvfB00	3.20.20.70	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I	0.54	45.0	3.19e-01	100.0%	77.8%
1ithA00	1.10.490.10	Mainly Alpha › Orthogonal Bundle › Globin-like › Globins	0.53	42.0	3.43e-01	85.3%	88.7%
6s8bA01	1.10.520.30	Mainly Alpha › Orthogonal Bundle › Peroxidase; domain 1 › AF1862-like domain	0.53	46.0	3.73e-01	100.0%	76.9%
3di2A00	1.20.1250.50	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; ›	0.53	45.0	3.88e-01	93.3%	70.4%
2d2mD00	1.10.490.10	Mainly Alpha › Orthogonal Bundle › Globin-like › Globins	0.52	42.0	3.38e-01	86.7%	71.7%
1wkvA01	3.90.1530.20	Alpha Beta › Alpha-Beta Complex › Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain ›	0.52	37.0	3.70e-01	92.0%	74.0%
1fcqA00	3.20.20.70	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I	0.51	43.0	2.87e-01	93.3%	34.7%
2og9A01	3.30.390.10	Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain	0.51	43.0	3.54e-01	90.7%	81.5%
4c2uA02	1.10.10.160	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A ›	0.51	39.0	3.88e-01	90.7%	77.8%

ECOD (23)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4876930	3084.1.1.1 ↗	a+b two layers › C-terminal domain of nonstructural protein nsp4 › C-terminal domain of nonstructural protein nsp4 › C-terminal domain of nonstructural protein nsp4 › CoV_NSP4_C	0.96	91.0	8.42e-01	100.0%	82.2%
3789467	3922.1.1.0 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3	0.60	45.0	4.20e-01	81.3%	65.3%
3588662	102.1.2.14 ↗	alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › DNA-glycosylase › Transposase_20	0.56	46.0	3.79e-01	90.7%	87.9%
3589919	102.1.4.2 ↗	alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › Nop C-terminal domain › Transposase_20	0.56	46.0	3.79e-01	90.7%	87.9%
3599454	3922.1.1.132 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Enkurin	0.56	40.0	3.48e-01	80.0%	50.9%
3700115	192.8.1.310 ↗	alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain › Enkurin	0.55	39.0	3.45e-01	80.0%	50.9%
3420606	298.1.1.0 ↗	a+b two layers › FwdE/GAPDH domain-like › Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain › Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0.55	50.0	3.17e-01	100.0%	43.5%
3833570	298.1.1.24 ↗	a+b two layers › FwdE/GAPDH domain-like › Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain › Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain › GFO_IDH_MocA_C3	0.55	49.0	3.44e-01	100.0%	63.3%
3180028	2003.1.1.0 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains	0.54	49.0	3.11e-01	100.0%	46.3%
3198146	109.4.1.526 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Atx10homo_assoc	0.54	43.0	2.78e-01	89.3%	22.3%
3618719	189.1.1.2 ↗	alpha bundles › GTPase activation domain, GAP › GTPase activation domain, GAP › GTPase activation domain, GAP › RhoGAP	0.54	43.0	3.26e-01	92.0%	50.5%
4507346	102.1.1.28 ↗	alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › SAM domain-like › HHH_6	0.54	39.0	3.19e-01	78.7%	44.7%
3781008	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.53	43.0	3.34e-01	93.3%	47.0%
4433563	605.1.1.25 ↗	alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › Zds_C	0.53	38.0	4.09e-01	78.7%	89.2%
5030095	192.4.1.0 ↗	alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p)	0.52	41.0	4.14e-01	93.3%	82.7%
3713234	3187.1.1.0 ↗	alpha bundles › Microtubule-Binding Domain of Flagellar Dynein › Microtubule-Binding Domain of Flagellar Dynein › Microtubule-Binding Domain of Flagellar Dynein	0.52	45.0	3.37e-01	94.7%	52.4%
2482215	876.1.1.0 ↗	a+b complex topology › ParB/Sulfiredoxin › ParB/Sulfiredoxin › ParB/Sulfiredoxin	0.52	37.0	3.47e-01	92.0%	60.0%
3509118	2003.6.1.2 ↗	a/b three-layered sandwiches › Rossmann-like › Ribokinase-like › Ribokinase-like › Carb_kinase	0.51	43.0	2.86e-01	93.3%	91.2%
3691167	181.1.1.17 ↗	alpha bundles › Domain of the SRP/SRP receptor G proteins-like › Domain of the SRP/SRP receptor G-proteins › Domain of the SRP/SRP receptor G-proteins › MHYT	0.51	42.0	3.17e-01	88.0%	88.8%
4025989	2492.1.1.0 ↗	a+b three layers › Cytidine deaminase-like › Cytidine deaminase-like › Cytidine deaminase-like	0.51	38.0	2.75e-01	81.3%	87.2%
5026895	101.1.17.0 ↗	alpha arrays › HTH › HTH › FF domain	0.51	42.0	4.08e-01	92.0%	91.8%
3507343	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.50	37.0	3.02e-01	93.3%	37.0%
3168797	5001.1.1.190 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › NPR3	0.50	39.0	3.62e-01	85.3%	64.6%