←Back to structures

nsp6

Euk-Vir

Human_coronavirus_OC43

nsp6__YP_009555258__Human_coronavirus_OC43__31631

Identity

Accession:
YP_009555258 ↗
Protein ID:
nsp6
Kingdom:
euk

Quality

72.9 mean pLDDT

Taxonomy

Orthornavirae› Pisuviricota› Pisoniviricetes› Nidovirales› Coronaviridae› Betacoronavirus› Human_coronavirus_OC43

TaxID: 31631

Cluster

View cluster (35 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 235-286
PDB
Domain cluster: rep: nsp6__YP_009924414__Rabbit_coronavirus_HKU14__1160968__D233-286
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF19213.6 best CoV_NSP6 88.3 1.50e-24 100.0% 19.4%
D2 medium residues 1-60
PDB
Domain cluster: representative
CATH (27)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1bhaA00 1.10.287.170 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.78 53.0 5.11e-01 88.3% 62.7%
2uv8A07 6.10.140.1410 Special › Helix non-globular › Helix Hairpins › 0.76 66.0 5.87e-01 96.7% 68.2%
2vkzA02 3.40.47.10 Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase 0.76 66.0 4.26e-01 96.7% 22.1%
2rdcA00 1.10.287.800 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › protein ne1242 0.75 61.0 4.69e-01 90.0% 43.6%
6ynwH01 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.74 63.0 5.89e-01 95.0% 81.1%
2js5A00 1.10.287.660 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.74 52.0 4.87e-01 73.3% 62.0%
3hr0B01 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.72 55.0 5.05e-01 83.3% 70.9%
4nb5B02 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.72 51.0 5.02e-01 75.0% 71.9%
1rp3A01 1.10.1740.10 Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif 0.70 57.0 5.22e-01 100.0% 67.1%
2d2sA02 1.20.58.1220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Exo84p, C-terminal helical domain 0.70 55.0 4.63e-01 86.7% 54.5%
5dn6J00 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.69 55.0 5.18e-01 90.0% 87.8%
4i8oA03 1.10.8.1130 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Bacterial toxin RNase RnlA/LsoA, C-terminal Dmd-binding domain 0.68 47.0 4.56e-01 85.0% 64.2%
1is8A01 1.10.286.10 Mainly Alpha › Orthogonal Bundle › GTP Cyclohydrolase I; Chain A, domain 1 › GTP cyclohydrolase I, N-terminal domain 0.67 52.0 5.22e-01 91.7% 88.3%
3b5iA02 1.10.1200.220 Mainly Alpha › Orthogonal Bundle › Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A › 0.67 52.0 4.54e-01 88.3% 55.8%
4e6nA02 6.10.140.1010 Special › Helix non-globular › Helix Hairpins › 0.65 53.0 5.14e-01 88.3% 78.8%
1b04A03 1.10.287.610 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.63 43.0 4.32e-01 78.3% 69.4%
3r84A00 1.10.287.3490 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.63 54.0 4.90e-01 95.0% 70.4%
1gaxA05 1.10.287.380 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Valyl-tRNA synthetase, C-terminal domain 0.63 51.0 4.79e-01 88.3% 78.1%
1kf6D00 1.20.1300.10 Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit 0.62 52.0 4.22e-01 95.0% 50.4%
2yevC00 6.10.280.110 Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 45.0 4.49e-01 80.0% 74.6%
2rf4B01 6.10.250.3390 Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.62 40.0 4.18e-01 73.3% 72.7%
1z5zA02 1.20.120.850 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SWI2/SNF2 ATPases, N-terminal domain 0.61 47.0 4.36e-01 83.3% 67.1%
4hr1A00 1.20.1270.410 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.61 56.0 4.43e-01 100.0% 93.2%
3ph0C00 1.25.40.1040 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.60 34.0 3.61e-01 78.3% 64.2%
2itbB00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.59 50.0 3.52e-01 95.0% 87.9%
2bg1A01 3.90.1310.40 Alpha Beta › Alpha-Beta Complex › Penicillin-binding protein 2a (Domain 2) › 0.59 48.0 4.49e-01 90.0% 70.1%
2no4A02 1.10.150.240 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 0.56 42.0 4.02e-01 86.7% 69.3%
ECOD (31)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3486786 165.3.1.0 ↗ alpha duplicates or obligate multimers › Dimerisation interlock › Phenylalanine zipper › Phenylalanine zipper 0.81 68.0 7.05e-01 98.3% 100.0%
4295625 5043.1.1.0 ↗ extended segments › Sensor proteins transmembrane domains › Htr2 transmembrane domain-like › Htr2 transmembrane domain-like 0.79 64.0 6.41e-01 88.3% 93.3%
5078040 5069.1.3.0 ↗ alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits 0.78 61.0 5.51e-01 88.3% 65.9%
3224794 150.5.1.0 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like 0.77 54.0 5.06e-01 75.0% 66.7%
3164721 1078.1.1.0 ↗ extended segments › Bd-type quinol oxidase transmembrane helix subunit › Bd-type quinol oxidase transmembrane helix subunit › Bd-type quinol oxidase transmembrane helix subunit 0.75 62.0 5.50e-01 95.0% 74.4%
3212581 148.1.3.289 ↗ alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › PKK 0.74 65.0 6.56e-01 100.0% 98.3%
3282043 150.5.1.0 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like 0.74 61.0 5.40e-01 90.0% 64.7%
3756047 192.29.1.243 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › Fy-3 0.73 62.0 5.45e-01 95.0% 73.3%
4025522 7529.1.1.1 ↗ a/b three-layered sandwiches › Macro domain-like › Macro domain-like › Macro domain-like › Macro 0.73 65.0 4.28e-01 100.0% 43.3%
3949317 162.1.1.0 ↗ alpha bundles › PTS-regulatory domain, PRD › PTS-regulatory domain, PRD › PTS-regulatory domain, PRD 0.73 62.0 5.17e-01 95.0% 82.9%
4063563 142.1.1.5 ↗ alpha complex topology › Sigma2 domain-like › Sigma2 domain of RNA polymerase sigma factors › Sigma2 domain of RNA polymerase sigma factors › SRI 0.73 62.0 5.41e-01 100.0% 62.1%
4016091 605.1.1.0 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.72 62.0 5.59e-01 100.0% 85.9%
3935107 192.7.1.0 ↗ alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm 0.72 58.0 4.74e-01 88.3% 50.9%
3602986 5058.1.1.2 ↗ alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st 0.72 60.0 5.32e-01 100.0% 67.4%
3916831 109.4.1.1198 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Meckelin 0.71 60.0 3.90e-01 100.0% 21.4%
3838026 5058.1.1.2 ↗ alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st 0.70 60.0 5.30e-01 96.7% 66.7%
5029642 5058.1.1.0 ↗ alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region 0.70 61.0 5.21e-01 96.7% 62.1%
5012954 632.2.1.40 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Bacterial immunoglobulin/albumin-binding domains › Bacterial immunoglobulin/albumin-binding domains › DUF515 0.70 62.0 4.71e-01 100.0% 45.0%
3461627 101.1.1.0 ↗ alpha arrays › HTH › HTH › Three-helical HTH 0.69 58.0 5.49e-01 90.0% 80.0%
4950166 5076.2.1.3 ↗ alpha complex topology › Mitochondrial ADP/ATP carrier-like › Putative sulfate permease CysZ › Putative sulfate permease CysZ › DUF4013 0.68 55.0 3.80e-01 90.0% 27.6%
3909706 192.29.1.0 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.67 53.0 4.79e-01 88.3% 63.5%
3815587 3397.1.1.0 ↗ a+b complex topology › Tic22 › Tic22 › Tic22 0.67 59.0 4.49e-01 100.0% 47.6%
3270778 108.1.1.96 ↗ alpha arrays › EF-hand › EF-hand-related › EF-hand › EF-hand_1, EF-hand_6, EF-hand_7 0.67 49.0 4.26e-01 81.7% 52.0%
3935681 3664.1.1.0 ↗ alpha arrays › Small, acid-soluble spore protein C › Small, acid-soluble spore protein C › Small, acid-soluble spore protein C 0.66 50.0 5.33e-01 86.7% 100.0%
3210067 101.1.15.0 ↗ alpha arrays › HTH › HTH › HAT1, C-terminal domain 0.66 52.0 4.35e-01 88.3% 54.5%
3504922 192.29.1.0 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.66 57.0 5.24e-01 98.3% 78.8%
3214018 632.7.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain 0.66 54.0 4.78e-01 96.7% 80.0%
4959390 605.1.1.0 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.64 58.0 5.49e-01 98.3% 88.6%
5030596 3826.1.1.0 ↗ alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) 0.63 52.0 5.12e-01 95.0% 86.2%
4469296 3809.1.1.2 ↗ alpha bundles › Uncharacterized protein CV0426 › Uncharacterized protein CV0426 › Uncharacterized protein CV0426 › Caudo_TAP 0.61 54.0 5.14e-01 98.3% 98.6%
3972992 605.1.1.0 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.60 48.0 4.76e-01 91.7% 87.7%