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nsp6
Euk-VirMurine_hepatitis_virus
nsp6__YP_009915678__Murine_hepatitis_virus__11138
Identity
- Accession:
- YP_009915678 ↗
- Protein ID:
- nsp6
- Kingdom:
- euk
Quality
77.5
mean pLDDT
Taxonomy
Orthornavirae›
Pisuviricota›
Pisoniviricetes›
Nidovirales›
Coronaviridae›
Betacoronavirus›
Murine_hepatitis_virus
TaxID: 11138
Cluster
View cluster (35 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 239-286
Domain cluster:
rep: nsp6__YP_009924414__Rabbit_coronavirus_HKU14__1160968__D233-286
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF19213.6 best | CoV_NSP6 | 82.5 | 8.90e-23 | 100.0% | 18.2% |
D2
medium
residues 1-63
Domain cluster:
rep: nsp6__YP_009555258__Human_coronavirus_OC43__31631__D1-60
D3
medium
residues 64-155
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF19213.6 best | CoV_NSP6 | 42.9 | 1.00e-10 | 100.0% | 35.0% |
CATH (28)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4e6nA02 | 6.10.140.1010 | Special › Helix non-globular › Helix Hairpins › | 0.73 | 38.0 | 4.43e-01 | 75.0% | 71.2% |
| 3icxA01 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.72 | 47.0 | 5.21e-01 | 73.9% | 81.3% |
| 3vouB00 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.69 | 49.0 | 4.24e-01 | 72.8% | 59.6% |
| 4g1tA02 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.67 | 33.0 | 3.96e-01 | 88.0% | 70.5% |
| 1zhcA00 | 6.10.280.50 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.67 | 41.0 | 4.44e-01 | 75.0% | 73.7% |
| 3eslA01 | 1.20.58.2070 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.66 | 37.0 | 4.03e-01 | 83.7% | 65.3% |
| 3ilkA02 | 1.10.8.590 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.65 | 35.0 | 3.99e-01 | 83.7% | 69.1% |
| 4m70I00 | 1.20.5.4130 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.63 | 44.0 | 4.17e-01 | 75.0% | 61.1% |
| 5ha6B00 | 1.10.287.210 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.62 | 45.0 | 4.87e-01 | 75.0% | 87.3% |
| 4errB00 | 1.20.58.1190 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.62 | 37.0 | 3.94e-01 | 75.0% | 66.3% |
| 3hr0B01 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.62 | 44.0 | 4.75e-01 | 73.9% | 87.3% |
| 4id0A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.61 | 51.0 | 4.76e-01 | 88.0% | 90.2% |
| 4dciA00 | 6.10.140.1110 | Special › Helix non-globular › Helix Hairpins › | 0.61 | 44.0 | 3.73e-01 | 75.0% | 47.6% |
| 4ioeA00 | 1.10.287.850 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain | 0.61 | 44.0 | 4.53e-01 | 75.0% | 81.6% |
| 3fppA03 | 6.10.140.1990 | Special › Helix non-globular › Helix Hairpins › | 0.60 | 43.0 | 4.38e-01 | 73.9% | 80.7% |
| 3onjA00 | 1.20.58.400 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins | 0.58 | 49.0 | 4.82e-01 | 95.7% | 85.6% |
| 3u9jA00 | 1.20.120.520 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › nmb1532 protein domain like | 0.57 | 48.0 | 4.06e-01 | 94.6% | 54.8% |
| 3lqhA02 | 1.20.920.10 | Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like | 0.56 | 39.0 | 3.72e-01 | 96.7% | 62.3% |
| 4iggA01 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.56 | 38.0 | 4.22e-01 | 72.8% | 97.0% |
| 2ra1A03 | 1.20.58.770 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.56 | 35.0 | 4.08e-01 | 96.7% | 92.1% |
| 3o60A00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.55 | 41.0 | 3.35e-01 | 100.0% | 40.1% |
| 7wivA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.55 | 45.0 | 3.21e-01 | 92.4% | 41.4% |
| 6ynwH01 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.55 | 37.0 | 4.11e-01 | 70.7% | 91.9% |
| 1qsdA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.54 | 47.0 | 4.57e-01 | 93.5% | 94.1% |
| 1dxrL02 | 1.20.85.10 | Mainly Alpha › Up-down Bundle › Photosynthetic Reaction Center, subunit M; domain 1 › Photosystem II protein D1-like | 0.53 | 37.0 | 3.56e-01 | 73.9% | 77.8% |
| 3d85C00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.52 | 45.0 | 3.98e-01 | 93.5% | 87.2% |
| 8h6qD01 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.52 | 45.0 | 3.17e-01 | 98.9% | 56.0% |
| 1b48A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.51 | 40.0 | 3.80e-01 | 96.7% | 72.5% |
ECOD (17)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4385544 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.76 | 47.0 | 5.19e-01 | 75.0% | 77.3% |
| 1144728 | 604.12.1.2 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › Vta1 | 0.66 | 44.0 | 4.43e-01 | 92.4% | 67.0% |
| 3924971 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.65 | 45.0 | 3.77e-01 | 75.0% | 43.8% |
| 4061849 | 192.7.1.2 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N | 0.64 | 48.0 | 4.50e-01 | 77.2% | 64.5% |
| 3641811 | 632.7.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.64 | 43.0 | 4.41e-01 | 97.8% | 70.0% |
| 4026286 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.64 | 46.0 | 4.01e-01 | 75.0% | 51.9% |
| 4480996 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.64 | 59.0 | 4.99e-01 | 100.0% | 74.5% |
| 4440290 | 604.3.1.0 ↗ | alpha bundles › Spectrin repeat-like › BAG domain › BAG domain | 0.63 | 43.0 | 4.75e-01 | 87.0% | 88.0% |
| 3574413 | 603.2.1.0 ↗ | alpha bundles › STAT-like › STAT › STAT | 0.61 | 40.0 | 4.11e-01 | 98.9% | 68.9% |
| 4497098 | 3291.1.1.195 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › H-kinase_dim | 0.60 | 43.0 | 3.93e-01 | 75.0% | 80.8% |
| 5082516 | 5069.1.1.4 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Ferric_reduct | 0.60 | 41.0 | 3.52e-01 | 75.0% | 44.0% |
| 3962942 | 150.5.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like | 0.59 | 43.0 | 3.61e-01 | 75.0% | 46.0% |
| 3659411 | 3567.1.1.0 ↗ | a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer | 0.58 | 41.0 | 3.84e-01 | 72.8% | 60.9% |
| 3956906 | 605.1.1.4 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA_3 | 0.58 | 40.0 | 4.37e-01 | 70.7% | 97.3% |
| 5063166 | 192.7.1.2 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N | 0.58 | 41.0 | 3.95e-01 | 75.0% | 64.8% |
| 2067201 | 5086.1.1.84 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_MFP_RND | 0.58 | 41.0 | 4.48e-01 | 75.0% | 92.2% |
| 4929584 | 4992.1.1.0 ↗ | extended segments › RelB-like › RelB-like › RelB-like | 0.52 | 35.0 | 3.11e-01 | 73.9% | 48.5% |
D4
medium
residues 156-237
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF19213.6 best | CoV_NSP6 | 77.0 | 4.00e-21 | 100.0% | 28.1% |
CATH (14)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3ddhA02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.68 | 48.0 | 4.86e-01 | 80.5% | 75.3% |
| 3keyA01 | 1.10.10.1080 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Stn1, N-terminal wHTH domain | 0.61 | 46.0 | 4.59e-01 | 87.8% | 75.9% |
| 3cb2B01 | 3.40.50.1440 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Tubulin/FtsZ, GTPase domain | 0.61 | 49.0 | 3.50e-01 | 90.2% | 93.6% |
| 6mh4A03 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.58 | 43.0 | 4.39e-01 | 89.0% | 83.5% |
| 3vm9A02 | 6.10.140.2110 | Special › Helix non-globular › Helix Hairpins › | 0.57 | 37.0 | 4.20e-01 | 76.8% | 94.7% |
| 5bn3A04 | 1.10.1140.10 | Mainly Alpha › Orthogonal Bundle › Bovine Mitochondrial F1-ATPase, ATP Synthase Beta Chain; Chain D, domain3 › Bovine Mitochondrial F1-atpase; Atp Synthase Beta Chain; Chain D, domain 3 | 0.57 | 42.0 | 3.56e-01 | 78.0% | 74.1% |
| 3bhgA01 | 1.10.275.10 | Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) | 0.57 | 42.0 | 3.80e-01 | 79.3% | 65.2% |
| 3emlA01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.56 | 46.0 | 3.27e-01 | 96.3% | 49.3% |
| 3lulA01 | 3.30.470.10 | Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › Aminotransferase class 4, branched-chain amino acid transferase, N-terminal domain | 0.55 | 40.0 | 3.66e-01 | 100.0% | 57.1% |
| 3fmcC01 | 3.40.630.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Zn peptidases | 0.55 | 48.0 | 3.34e-01 | 100.0% | 77.9% |
| 3wgtA01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.53 | 43.0 | 3.26e-01 | 89.0% | 73.2% |
| 4k84A00 | 1.10.3520.10 | Mainly Alpha › Orthogonal Bundle › Glycolipid transfer protein, GLTP › Glycolipid transfer protein | 0.53 | 45.0 | 3.49e-01 | 100.0% | 82.5% |
| 1wy9A00 | 1.10.238.10 | Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › EF-hand | 0.51 | 41.0 | 3.79e-01 | 90.2% | 91.9% |
| 2qgaB01 | 1.10.275.10 | Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) | 0.51 | 39.0 | 3.51e-01 | 82.9% | 58.8% |
ECOD (25)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2394559 | 2005.1.1.0 ↗ | a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains | 0.78 | 60.0 | 4.12e-01 | 80.5% | 34.5% |
| 3764818 | 4120.1.1.68 ↗ | few secondary structure elements › Tim10/DDP › Tim10/DDP › Tim10/DDP › TMEM65 | 0.71 | 52.0 | 4.70e-01 | 79.3% | 59.1% |
| 3408346 | 633.24.1.2 ↗ | alpha bundles › Bromodomain-like › RABEX-5 helical domain › RABEX-5 helical domain › DUF5601 | 0.70 | 44.0 | 4.62e-01 | 80.5% | 69.3% |
| 3854050 | 604.12.1.43 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › Tim17 | 0.70 | 51.0 | 4.31e-01 | 76.8% | 81.5% |
| 3728444 | 101.1.1.0 ↗ | alpha arrays › HTH › HTH › Three-helical HTH | 0.69 | 45.0 | 4.16e-01 | 73.2% | 52.4% |
| 3285585 | 191.1.1.0 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain | 0.67 | 48.0 | 4.03e-01 | 74.4% | 45.2% |
| 3924078 | 1075.1.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain | 0.67 | 51.0 | 3.58e-01 | 80.5% | 65.6% |
| 4422279 | 6130.1.1.1 ↗ | alpha complex topology › Selenocysteine synthase N-terminal domain › Selenocysteine synthase N-terminal domain › Selenocysteine synthase N-terminal domain › Se-cys_synth_N | 0.65 | 50.0 | 5.19e-01 | 86.6% | 92.0% |
| 3953434 | 101.1.1.0 ↗ | alpha arrays › HTH › HTH › Three-helical HTH | 0.65 | 44.0 | 3.33e-01 | 70.7% | 33.2% |
| 4629874 | 6130.1.1.1 ↗ | alpha complex topology › Selenocysteine synthase N-terminal domain › Selenocysteine synthase N-terminal domain › Selenocysteine synthase N-terminal domain › Se-cys_synth_N | 0.64 | 52.0 | 5.26e-01 | 91.5% | 91.3% |
| 3460365 | 5054.1.1.6 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › TrkH | 0.63 | 46.0 | 4.18e-01 | 79.3% | 73.0% |
| 4948085 | 148.1.3.0 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain | 0.62 | 46.0 | 4.32e-01 | 91.5% | 64.0% |
| 3544646 | 101.1.2.352 ↗ | alpha arrays › HTH › HTH › winged helix domain › HTH_Tnp_Tc5 | 0.62 | 38.0 | 4.06e-01 | 73.2% | 71.4% |
| 3274367 | 2484.1.1.1 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › HSP70 | 0.62 | 46.0 | 3.55e-01 | 80.5% | 84.2% |
| 3957615 | 5041.1.1.0 ↗ | extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C | 0.60 | 41.0 | 3.84e-01 | 70.7% | 55.2% |
| 3610908 | 5054.1.1.6 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › TrkH | 0.60 | 46.0 | 4.31e-01 | 81.7% | 92.0% |
| 4999307 | 2003.1.2.17 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain › Amino_oxidase | 0.60 | 48.0 | 2.94e-01 | 86.6% | 92.1% |
| 3252296 | 601.55.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › anti-complement domain of BBK32 › anti-complement domain of BBK32 › NCA2 | 0.59 | 43.0 | 4.18e-01 | 78.0% | 97.9% |
| 5079165 | 3352.1.1.0 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain | 0.58 | 50.0 | 3.34e-01 | 100.0% | 99.5% |
| 3291547 | 601.1.1.84 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › DUF350 | 0.57 | 50.0 | 4.17e-01 | 98.8% | 84.1% |
| 3598977 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.56 | 38.0 | 3.84e-01 | 74.4% | 68.2% |
| 4607154 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.54 | 48.0 | 4.06e-01 | 97.6% | 77.0% |
| 3785417 | 5001.1.1.133 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Git3, GPR_Gpa2_C | 0.53 | 46.0 | 3.04e-01 | 98.8% | 37.0% |
| 3301214 | 1128.1.1.0 ↗ | alpha bundles › LYR protein › LYR protein › LYR protein | 0.52 | 42.0 | 3.62e-01 | 87.8% | 76.2% |
| 3346028 | 193.1.1.27 ↗ | alpha bundles › CH domain-like › Calponin-homology domain-like › Calponin-homology domain-like › CCDC93_N | 0.50 | 37.0 | 3.60e-01 | 79.3% | 97.9% |