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nsp6
Euk-VirSARS_coronavirus_Tor2
nsp6__YP_009944371__SARS_coronavirus_Tor2__227984
Identity
- Accession:
- YP_009944371 ↗
- Protein ID:
- nsp6
- Kingdom:
- euk
Quality
76.6
mean pLDDT
Taxonomy
Orthornavirae›
Pisuviricota›
Pisoniviricetes›
Nidovirales›
Coronaviridae›
Betacoronavirus›
SARS_coronavirus_Tor2
TaxID: 227984
Cluster
View cluster (35 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 232-289
Domain cluster:
rep: nsp6__YP_009924414__Rabbit_coronavirus_HKU14__1160968__D233-286
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF19213.6 best | CoV_NSP6 | 85.3 | 1.20e-23 | 100.0% | 22.1% |
D2
medium
residues 1-64
Domain cluster:
rep: nsp6__YP_009513008_nsp6__Betacoronavirus_Erinaceus_VMC_DEU_2012__1385427__D1-61
CATH (31)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3t98B00 | 6.10.140.1350 | Special › Helix non-globular › Helix Hairpins › | 0.76 | 57.0 | 5.07e-01 | 78.1% | 58.1% |
| 2bg1A01 | 3.90.1310.40 | Alpha Beta › Alpha-Beta Complex › Penicillin-binding protein 2a (Domain 2) › | 0.74 | 59.0 | 5.57e-01 | 92.2% | 71.4% |
| 1ku9A02 | 1.10.287.450 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.73 | 54.0 | 5.47e-01 | 85.9% | 78.1% |
| 4dylA02 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.72 | 53.0 | 4.66e-01 | 82.8% | 53.2% |
| 2w31A00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.71 | 57.0 | 4.30e-01 | 87.5% | 63.8% |
| 3if8B02 | 1.20.58.730 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.71 | 54.0 | 4.65e-01 | 85.9% | 52.0% |
| 4fwvA02 | 1.20.120.1680 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.71 | 55.0 | 4.43e-01 | 92.2% | 41.8% |
| 2x2vA00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.71 | 55.0 | 5.40e-01 | 90.6% | 79.4% |
| 4ioeA00 | 1.10.287.850 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain | 0.70 | 56.0 | 4.98e-01 | 84.4% | 66.7% |
| 1luwA01 | 1.10.287.990 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain | 0.68 | 48.0 | 4.88e-01 | 84.4% | 75.0% |
| 4ysxC00 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.68 | 57.0 | 4.39e-01 | 96.9% | 41.8% |
| 1jb0F00 | 1.10.8.110 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Photosystem I, reaction centre, subunit PsaF | 0.68 | 59.0 | 4.56e-01 | 96.9% | 44.7% |
| 3k1zA02 | 1.10.150.720 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Haloacid dehalogenase-like hydrolase | 0.68 | 48.0 | 4.47e-01 | 79.7% | 58.3% |
| 4i0xG00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.67 | 53.0 | 5.20e-01 | 84.4% | 83.8% |
| 2c2uA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.66 | 55.0 | 3.97e-01 | 90.6% | 61.2% |
| 6tkvA01 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.66 | 52.0 | 5.09e-01 | 84.4% | 83.8% |
| 4gzrB00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.65 | 49.0 | 4.66e-01 | 82.8% | 67.5% |
| 3l1nA01 | 6.10.140.790 | Special › Helix non-globular › Helix Hairpins › | 0.64 | 45.0 | 4.95e-01 | 73.4% | 90.2% |
| 4jgiA01 | 1.10.1240.10 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain | 0.64 | 44.0 | 4.09e-01 | 71.9% | 60.0% |
| 6oi7A01 | 1.10.3210.10 | Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 | 0.63 | 52.0 | 3.72e-01 | 92.2% | 48.5% |
| 4v1gA00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.63 | 53.0 | 4.83e-01 | 92.2% | 70.6% |
| 4y97D00 | 1.10.3200.20 | Mainly Alpha › Orthogonal Bundle › Hypothetical protein af0941 › DNA Polymerase alpha, zinc finger | 0.62 | 46.0 | 3.30e-01 | 78.1% | 43.3% |
| 1k32A03 | 3.30.750.44 | Alpha Beta › 2-Layer Sandwich › Transcription Regulator spoIIAA › | 0.62 | 43.0 | 4.23e-01 | 76.6% | 66.7% |
| 1w0bA01 | 1.20.58.420 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › AHSP | 0.62 | 50.0 | 4.41e-01 | 87.5% | 60.9% |
| 1gaxA05 | 1.10.287.380 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Valyl-tRNA synthetase, C-terminal domain | 0.61 | 49.0 | 4.71e-01 | 85.9% | 76.7% |
| 2qe7G01 | 1.10.287.80 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain | 0.60 | 47.0 | 4.11e-01 | 84.4% | 58.8% |
| 2ihr101 | 1.20.58.410 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Release factor | 0.60 | 43.0 | 3.70e-01 | 76.6% | 62.3% |
| 2xokP00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.58 | 48.0 | 4.60e-01 | 92.2% | 79.7% |
| 2r7rA08 | 1.20.120.1400 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.54 | 36.0 | 3.42e-01 | 71.9% | 59.3% |
| 1s35A01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.52 | 48.0 | 4.05e-01 | 100.0% | 82.2% |
| 4ar9A02 | 1.10.390.20 | Mainly Alpha › Orthogonal Bundle › Neutral Protease; domain 2 › | 0.51 | 38.0 | 3.14e-01 | 89.1% | 57.0% |
ECOD (21)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3855039 | 3050.1.1.18 ↗ | alpha bundles › Ribosomal protein L19 (L19e) C-terminal domain › Ribosomal protein L19 (L19e) C-terminal domain › Ribosomal protein L19 (L19e) C-terminal domain › SCAF11-like_C | 0.75 | 63.0 | 5.65e-01 | 95.3% | 66.7% |
| 4026843 | 5058.1.1.0 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region | 0.75 | 63.0 | 6.20e-01 | 95.3% | 91.4% |
| 3477749 | 192.1.1.0 ↗ | alpha bundles › Long alpha-hairpin › GreA transcript cleavage protein, N-terminal domain › GreA transcript cleavage protein, N-terminal domain | 0.73 | 50.0 | 4.85e-01 | 84.4% | 64.3% |
| 4978292 | 3542.1.1.1 ↗ | alpha arrays › Presenilin family intramembrane aspartate proteases › Presenilin family intramembrane aspartate proteases › Presenilin family intramembrane aspartate proteases › Presenilin | 0.72 | 64.0 | 4.15e-01 | 100.0% | 48.8% |
| 5006542 | 192.8.1.0 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain | 0.71 | 49.0 | 5.08e-01 | 87.5% | 76.7% |
| 4878845 | 5077.1.1.3 ↗ | extended segments › Chlorophyll a-b binding protein › Chlorophyll a-b binding protein › Chlorophyll a-b binding protein › PSI_PsaF | 0.69 | 61.0 | 4.92e-01 | 96.9% | 52.9% |
| 3615028 | 622.1.1.1 ↗ | alpha bundles › YvfG-like › HSC20 (HSCB), C-terminal oligomerisation domain › HSC20 (HSCB), C-terminal oligomerisation domain › HSCB_C | 0.69 | 50.0 | 4.11e-01 | 90.6% | 44.5% |
| 4955370 | 148.1.3.0 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain | 0.68 | 53.0 | 5.01e-01 | 87.5% | 75.0% |
| 3224580 | 3538.1.1.0 ↗ | extended segments › MerF › MerF › MerF | 0.68 | 44.0 | 4.62e-01 | 76.6% | 71.7% |
| 3333417 | 5041.1.1.1 ↗ | extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › ATP-synt_C | 0.67 | 54.0 | 4.78e-01 | 90.6% | 61.1% |
| 3787792 | 5041.1.1.1 ↗ | extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › ATP-synt_C | 0.67 | 53.0 | 4.76e-01 | 90.6% | 61.1% |
| 3988424 | 5041.1.1.1 ↗ | extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › ATP-synt_C | 0.66 | 53.0 | 5.31e-01 | 87.5% | 87.7% |
| 4180835 | 5041.1.1.1 ↗ | extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › ATP-synt_C | 0.66 | 56.0 | 5.43e-01 | 92.2% | 85.7% |
| 3455488 | 2006.1.4.0 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like | 0.66 | 51.0 | 5.24e-01 | 85.9% | 96.7% |
| 3973403 | 5043.1.1.0 ↗ | extended segments › Sensor proteins transmembrane domains › Htr2 transmembrane domain-like › Htr2 transmembrane domain-like | 0.65 | 56.0 | 5.78e-01 | 93.8% | 98.3% |
| 4630202 | 5041.1.1.1 ↗ | extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › ATP-synt_C | 0.64 | 54.0 | 4.84e-01 | 92.2% | 67.4% |
| 3386452 | 5050.1.1.21 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › FTR1 | 0.64 | 47.0 | 3.68e-01 | 79.7% | 35.9% |
| 3637453 | 5042.1.1.1 ↗ | extended segments › Magnesium transport protein CorA, transmembrane region › Magnesium transport protein CorA, transmembrane region › Magnesium transport protein CorA, transmembrane region › CorA | 0.62 | 49.0 | 4.85e-01 | 90.6% | 85.7% |
| 3535521 | 1073.1.1.11 ↗ | alpha arrays › Mitochondrial calcium uniporter (MCU) › Mitochondrial calcium uniporter (MCU) › Mitochondrial calcium uniporter (MCU) › WWC1 | 0.62 | 53.0 | 5.00e-01 | 90.6% | 80.0% |
| 3742044 | 192.23.1.7 ↗ | alpha bundles › Long alpha-hairpin › DUF683 › DUF683 › Cmc1 | 0.55 | 46.0 | 4.36e-01 | 96.9% | 83.7% |
| 4357473 | 314.1.1.2 ↗ | a+b three layers › Class II aaRS and biotin synthetases › Class II aaRS and biotin synthetases › Class II aaRS and biotin synthetases › tRNA-synt_2b | 0.54 | 43.0 | 2.78e-01 | 95.3% | 21.6% |
D3
medium
residues 65-231
Domain cluster:
rep: nsp6__NP_828864__SARS_coronavirus_Tor2__227984__D65-231
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF19213.6 best | CoV_NSP6 | 55.6 | 1.40e-14 | 100.0% | 62.7% |