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nsp8

Euk-Vir

Human_coronavirus_OC43

nsp8__YP_009555251__Human_coronavirus_OC43__31631

Identity

Accession:
YP_009555251 ↗
Protein ID:
nsp8
Kingdom:
euk

Quality

82.3 mean pLDDT

Taxonomy

Orthornavirae› Pisuviricota› Pisoniviricetes› Nidovirales› Coronaviridae› Betacoronavirus› Human_coronavirus_OC43

TaxID: 31631

Cluster

View cluster (35 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 10-98
PDB
Domain cluster: rep: putative_coronavirus_nsp5__NP_839962__Porcine_epidemic_diarrhea_virus__28295__D10-97
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF08717.17 best CoV_NSP8 117.3 1.00e-33 100.0% 43.7%
D2 high residues 117-187
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF08717.17 best CoV_NSP8 70.2 2.90e-19 100.0% 37.7%
CATH (38)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2ahmH02 3.30.70.3540 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Nsp8 replicase, head domain 0.90 84.0 7.53e-01 98.6% 91.4%
3ub0A02 3.30.70.3540 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Nsp8 replicase, head domain 0.85 80.0 7.19e-01 98.6% 92.4%
4a2aA02 3.30.1490.110 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › 0.67 54.0 5.06e-01 87.3% 83.9%
1r5bA02 2.40.30.10 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Translation factors 0.66 56.0 5.21e-01 100.0% 73.0%
7q6gA01 3.30.1490.110 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › 0.66 52.0 5.14e-01 87.3% 92.2%
3wdhA01 2.60.40.2320 Mainly Beta › Sandwich › Immunoglobulin-like › 0.65 49.0 4.38e-01 100.0% 58.3%
4xttA00 3.30.70.1450 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Regulator of K+ conductance, C-terminal domain 0.63 49.0 4.67e-01 90.1% 71.8%
4he6A00 2.40.30.10 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Translation factors 0.62 51.0 4.77e-01 100.0% 71.9%
2b9kA00 2.20.20.70 Mainly Beta › Single Sheet › Anthopleurin-A › 0.61 37.0 4.31e-01 85.9% 91.5%
7agvB01 3.30.70.1450 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Regulator of K+ conductance, C-terminal domain 0.61 49.0 4.76e-01 88.7% 77.8%
2ausC02 3.30.2350.10 Alpha Beta › 2-Layer Sandwich › Pseudouridine synthase › Pseudouridine synthase 0.60 45.0 3.32e-01 94.4% 29.7%
2ey4D00 2.40.10.230 Mainly Beta › Beta Barrel › Thrombin, subunit H › Probable tRNA pseudouridine synthase domain 0.60 43.0 4.23e-01 100.0% 70.7%
1twfA04 3.30.1490.180 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › RNA polymerase ii 0.60 48.0 5.01e-01 85.9% 100.0%
3htnB00 3.30.1330.80 Alpha Beta › 2-Layer Sandwich › 60s Ribosomal Protein L30; Chain: A; › Hypothetical protein, similar to alpha- acetolactate decarboxylase; domain 2 0.60 52.0 4.26e-01 100.0% 82.0%
4c2mA04 3.30.1490.180 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › RNA polymerase ii 0.60 46.0 4.53e-01 85.9% 100.0%
3qzqA02 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.58 49.0 5.00e-01 100.0% 94.2%
4g65A04 3.30.70.1450 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Regulator of K+ conductance, C-terminal domain 0.58 51.0 4.73e-01 100.0% 79.1%
4ca1B02 2.60.210.10 Mainly Beta › Sandwich › Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A › Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A 0.57 49.0 4.09e-01 100.0% 93.9%
1f46B00 3.30.1400.10 Alpha Beta › 2-Layer Sandwich › Cell Division Protein Zipa; Chain: A, › ZipA, C-terminal FtsZ-binding domain 0.57 44.0 3.64e-01 87.3% 55.0%
2ijd101 2.40.10.120 Mainly Beta › Beta Barrel › Thrombin, subunit H › 0.57 48.0 3.52e-01 100.0% 36.1%
4g54A01 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.56 45.0 3.78e-01 88.7% 61.6%
3jxoA00 3.30.70.1450 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Regulator of K+ conductance, C-terminal domain 0.54 46.0 4.38e-01 100.0% 81.0%
4g65B02 3.30.70.1450 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Regulator of K+ conductance, C-terminal domain 0.54 47.0 4.39e-01 100.0% 79.3%
3tx8A02 3.30.70.360 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.54 44.0 3.77e-01 90.1% 69.3%
3zuaA01 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.53 41.0 3.48e-01 87.3% 56.5%
3es1A02 2.60.120.10 Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls 0.53 45.0 3.81e-01 97.2% 82.5%
4necC01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.53 46.0 3.29e-01 100.0% 78.1%
1rwhA03 2.60.220.10 Mainly Beta › Sandwich › Chondroitinase Ac; Chain A, domain 3 › Polysaccharide lyase family 8-like, C-terminal 0.53 46.0 3.99e-01 100.0% 81.6%
5dm6100 2.20.28.120 Mainly Beta › Single Sheet › Rubrerythrin, domain 2 › Ribosomal protein L33 0.53 26.0 2.87e-01 93.0% 51.9%
1o7dC02 2.60.40.1180 Mainly Beta › Sandwich › Immunoglobulin-like › Golgi alpha-mannosidase II 0.52 47.0 4.37e-01 100.0% 100.0%
4b9iA00 2.60.40.3480 Mainly Beta › Sandwich › Immunoglobulin-like › 0.52 44.0 3.76e-01 100.0% 67.2%
2l3bA00 2.60.40.2410 Mainly Beta › Sandwich › Immunoglobulin-like › Uncharacterised protein PF12988, DUF3872 0.52 46.0 3.78e-01 100.0% 54.6%
2lfpA01 3.30.2000.30 Alpha Beta › 2-Layer Sandwich › STM4215-like › 0.52 43.0 3.53e-01 94.4% 94.1%
1ff3A00 3.30.1060.10 Alpha Beta › 2-Layer Sandwich › Peptide Methionine Sulfoxide Reductase; Chain A › Peptide methionine sulphoxide reductase MsrA 0.51 38.0 2.81e-01 87.3% 27.5%
4cbpB02 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.51 40.0 3.64e-01 90.1% 74.0%
1elvA01 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.51 43.0 3.97e-01 100.0% 79.6%
3v97B04 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.50 43.0 3.20e-01 100.0% 48.8%
1ykwA01 3.30.70.150 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RuBisCO large subunit, N-terminal domain 0.50 40.0 3.33e-01 88.7% 93.9%
ECOD (58)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2818339 4315.1.1.1 ↗ beta barrels › Coronavirus NSP8-like › Coronavirus NSP8-like › Coronavirus NSP8-like › CoV_NSP8 0.90 81.0 7.74e-01 95.8% 90.1%
4876705 4315.1.1.1 ↗ beta barrels › Coronavirus NSP8-like › Coronavirus NSP8-like › Coronavirus NSP8-like › CoV_NSP8 0.90 81.0 6.71e-01 95.8% 63.2%
2605331 4315.1.1.1 ↗ beta barrels › Coronavirus NSP8-like › Coronavirus NSP8-like › Coronavirus NSP8-like › CoV_NSP8 0.89 80.0 6.47e-01 95.8% 58.7%
3031755 4315.1.1.1 ↗ beta barrels › Coronavirus NSP8-like › Coronavirus NSP8-like › Coronavirus NSP8-like › CoV_NSP8 0.89 80.0 6.67e-01 95.8% 64.0%
3108982 4315.1.1.1 ↗ beta barrels › Coronavirus NSP8-like › Coronavirus NSP8-like › Coronavirus NSP8-like › CoV_NSP8 0.88 79.0 5.67e-01 95.8% 39.7%
4881031 4315.1.1.1 ↗ beta barrels › Coronavirus NSP8-like › Coronavirus NSP8-like › Coronavirus NSP8-like › CoV_NSP8 0.88 79.0 5.57e-01 95.8% 40.0%
4977196 2003.1.5.81 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25 0.73 66.0 4.47e-01 100.0% 84.3%
5009756 4972.1.1.1 ↗ beta barrels › barrel domain in CV3147-like proteins › barrel domain in CV3147-like proteins › barrel domain in CV3147-like proteins › DUF917_C 0.71 56.0 4.64e-01 85.9% 72.8%
5040750 4261.1.1.0 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like 0.68 49.0 5.39e-01 85.9% 96.4%
4956390 4261.1.1.0 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like 0.67 52.0 4.99e-01 90.1% 72.3%
3921458 7.1.1.1 ↗ beta barrels › PDZ domain › PDZ domain › PDZ domain › PDZ 0.66 54.0 4.71e-01 88.7% 81.9%
4186020 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.65 51.0 4.75e-01 90.1% 66.7%
5041150 239.1.1.15 ↗ beta barrels › Ribosomal protein L25-like › Ribosomal protein L25-like › Ribosomal protein L25-like › CPxCG_zf 0.64 51.0 5.14e-01 87.3% 85.7%
4054166 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.64 53.0 5.08e-01 90.1% 78.8%
4954616 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.63 48.0 4.73e-01 87.3% 77.3%
1556097 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.63 49.0 4.67e-01 90.1% 71.8%
4067007 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.63 49.0 4.31e-01 90.1% 57.1%
4100556 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.63 48.0 4.54e-01 88.7% 69.4%
3940477 1.1.7.50 ↗ beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › EF-G_D2 0.63 44.0 4.46e-01 73.2% 81.4%
4368410 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.62 48.0 4.56e-01 88.7% 69.4%
5067701 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.62 49.0 4.74e-01 90.1% 75.9%
3724709 1.1.7.47 ↗ beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › Aquarius_N_2nd 0.62 57.0 4.23e-01 100.0% 68.8%
3466219 219.1.1.0 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.61 53.0 3.61e-01 100.0% 42.5%
3699413 1.1.8.11 ↗ beta barrels › cradle loop barrel › RIFT-related › Aminomethyltransferase beta-barrel domain › GTP-eEF1A_C 0.60 48.0 4.26e-01 90.1% 66.1%
5022325 239.1.1.15 ↗ beta barrels › Ribosomal protein L25-like › Ribosomal protein L25-like › Ribosomal protein L25-like › CPxCG_zf 0.60 48.0 4.32e-01 87.3% 65.0%
5067699 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.60 47.0 4.53e-01 90.1% 75.0%
3556111 275.1.1.1 ↗ a+b two layers › MoeA-I/Ornithine decarboxylase-C/Reverse ferredoxin-like domain in RNA-polymerase › MoeA-I/Ornithine decarboxylase-C/Reverse ferredoxin-like domain in RNA-polymerase › MoeA-I/Ornithine decarboxylase-C/Reverse ferredoxin-like domain in RNA-polymerase › RNA_pol_Rpb1_2 0.60 48.0 4.97e-01 85.9% 96.9%
4407255 221.1.1.0 ↗ a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like 0.59 45.0 4.88e-01 83.1% 100.0%
3227067 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.59 52.0 4.59e-01 100.0% 77.1%
5025895 1.1.7.0 ↗ beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C 0.58 45.0 4.04e-01 85.9% 98.1%
4969958 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.58 50.0 4.84e-01 100.0% 84.8%
1937966 4261.1.1.2 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › BK_channel_a 0.58 47.0 3.95e-01 90.1% 64.3%
4949346 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.58 50.0 4.77e-01 100.0% 81.2%
3490918 11.1.1.1 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Cadherin 0.58 48.0 4.09e-01 91.5% 76.5%
4964001 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.57 49.0 4.79e-01 100.0% 85.0%
4962977 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.57 51.0 4.86e-01 100.0% 83.5%
3935807 10.32.1.258 ↗ beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like › GBD_IRG7_N 0.57 50.0 4.64e-01 98.6% 93.3%
4222281 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.57 50.0 4.73e-01 100.0% 81.2%
4032883 1.1.13.3 ↗ beta barrels › cradle loop barrel › RIFT-related › Phage tail proteins › Phage_H_T_join 0.57 51.0 4.44e-01 100.0% 65.7%
5041180 10.1.2.0 ↗ beta sandwiches › jelly-roll › Concanavalin A-like › GOLD domain-like (DEPRECATED) 0.57 50.0 4.12e-01 100.0% 74.6%
4585642 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.56 49.0 4.70e-01 100.0% 85.0%
3166921 219.1.1.3 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › UCH 0.56 48.0 3.17e-01 100.0% 57.3%
5082501 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.56 48.0 4.59e-01 100.0% 81.2%
5037982 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.56 48.0 4.64e-01 100.0% 86.1%
5060311 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.56 48.0 4.58e-01 100.0% 81.2%
4235006 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.56 45.0 4.35e-01 93.0% 78.8%
3686128 301.7.1.1 ↗ a+b three layers › Bacillus chorismate mutase-like › YjgF-like › YjgF-like › Ribonuc_L-PSP 0.56 48.0 3.91e-01 100.0% 94.4%
5082503 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.55 48.0 4.62e-01 100.0% 86.3%
3717790 4261.1.1.2 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › BK_channel_a 0.55 44.0 3.79e-01 90.1% 53.3%
4935452 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.55 47.0 4.53e-01 100.0% 85.0%
4935454 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.55 48.0 4.59e-01 100.0% 86.9%
4518555 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.55 47.0 4.45e-01 100.0% 84.4%
3964789 331.7.1.1 ↗ a+b two layers › TBP-like › Cell-division protein ZipA, C-terminal domain › Cell-division protein ZipA, C-terminal domain › ZipA_C 0.53 41.0 3.31e-01 87.3% 48.0%
5002413 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.53 45.0 4.32e-01 100.0% 85.7%
4981634 4261.1.1.1 ↗ a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA_C 0.53 46.0 4.39e-01 100.0% 85.9%
1173463 304.114.1.0 ↗ a+b two layers › Alpha-beta plaits › Family B DNA polymerase insertion domain › Family B DNA polymerase insertion domain 0.51 36.0 3.56e-01 85.9% 67.9%
4933921 3114.1.1.0 ↗ beta sandwiches › Mucin-binding protein domain › Mucin-binding protein domain › Mucin-binding protein domain 0.50 42.0 4.05e-01 100.0% 81.2%
3684421 10.12.1.0 ↗ beta sandwiches › jelly-roll › Double-stranded beta-helix › Double-stranded beta-helix 0.50 42.0 3.27e-01 95.8% 70.3%