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nucleoprotein
Euk-VirZaire_ebolavirus
nucleoprotein__NP_066243__Zaire_ebolavirus__186538
Identity
- Accession:
- NP_066243 ↗
- Protein ID:
- nucleoprotein
- Kingdom:
- euk
Quality
62.3
mean pLDDT
Taxonomy
Orthornavirae›
Negarnaviricota›
Monjiviricetes›
Mononegavirales›
Filoviridae›
Orthoebolavirus›
Zaire_ebolavirus
TaxID: 186538
Cluster
View cluster (9 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 240-393
Domain cluster:
rep: N__YP_009508485__Southwest_carpet_python_virus__2016402__D213-328
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF05505.18 best | Ebola_NP | 347.2 | 3.10e-103 | 100.0% | 20.4% |
D2
high
residues 648-738
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF05505.18 best | Ebola_NP | 150.2 | 1.10e-43 | 95.6% | 12.3% |
CATH (6)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2xfvA00 | 3.10.260.30 | Alpha Beta › Roll › Mlu1-box Binding Protein; DNA-binding Domain › | 0.54 | 37.0 | 3.59e-01 | 72.5% | 86.1% |
| 3pvlA02 | 3.10.20.90 | Alpha Beta › Roll › Ubiquitin-like (UB roll) › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 | 0.53 | 37.0 | 3.70e-01 | 73.6% | 95.8% |
| 2wyqA00 | 3.10.20.90 | Alpha Beta › Roll › Ubiquitin-like (UB roll) › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 | 0.51 | 37.0 | 3.92e-01 | 76.9% | 94.8% |
| 1tp6A00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.50 | 33.0 | 2.97e-01 | 94.5% | 47.6% |
| 4p6bB00 | 3.40.710.10 | Alpha Beta › 3-Layer(aba) Sandwich › Beta-lactamase › DD-peptidase/beta-lactamase superfamily | 0.50 | 43.0 | 2.93e-01 | 100.0% | 71.3% |
| 1t3aA00 | 3.90.1240.10 | Alpha Beta › Alpha-Beta Complex › Zincin-like › "Metalloproteases (""zincins""), catalytic domain like" | 0.50 | 39.0 | 2.64e-01 | 86.8% | 79.0% |
ECOD (4)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1688953 | 6154.1.1.1 ↗ | a+b complex topology › C-terminal domain of Ebola nucleoprotein › C-terminal domain of Ebola nucleoprotein › C-terminal domain of Ebola nucleoprotein › Ebola_NP | 0.96 | 93.0 | 8.80e-01 | 100.0% | 88.3% |
| 3064420 | 6154.1.2.1 ↗ | a+b complex topology › C-terminal domain of Ebola nucleoprotein › C-terminal domain of Ebola nucleoprotein › C-terminal domain of Marburg virus nucleoprotein › Ebola_NP | 0.62 | 45.0 | 5.00e-01 | 94.5% | 97.1% |
| 1210393 | 221.1.1.24 ↗ | a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like › ATG5_UblB | 0.55 | 42.0 | 4.43e-01 | 80.2% | 97.4% |
| 6140 | 221.1.1.2 ↗ | a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like › ubiquitin | 0.53 | 37.0 | 3.66e-01 | 71.4% | 73.7% |
D3
medium
residues 27-146_206-217
Domain cluster:
rep: nucleoprotein__YP_003815432__Bundibugyo_ebolavirus__565995__D39-144
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF05505.18 best | Ebola_NP | 207.2 | 6.60e-61 | 97.0% | 16.9% |
D4
medium
residues 147-205_218-239
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF05505.18 best | Ebola_NP | 151.6 | 4.40e-44 | 100.0% | 12.3% |
CATH (20)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4d3zA02 | 1.10.132.130 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › | 0.64 | 41.0 | 3.72e-01 | 98.8% | 48.2% |
| 3himA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.62 | 43.0 | 3.32e-01 | 72.8% | 51.1% |
| 3h36A00 | 1.10.10.400 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Polyribonucleotide nucleotidyltransferase, RNA-binding domain | 0.61 | 42.0 | 4.30e-01 | 72.8% | 89.7% |
| 1txuA01 | 1.10.246.120 | Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › | 0.60 | 42.0 | 4.02e-01 | 72.8% | 77.7% |
| 2yksA02 | 1.20.58.390 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain | 0.60 | 41.0 | 3.63e-01 | 70.4% | 79.5% |
| 3czhA00 | 1.10.630.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450 | 0.59 | 46.0 | 2.97e-01 | 91.4% | 67.7% |
| 1oj6A00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.57 | 43.0 | 3.60e-01 | 81.5% | 85.0% |
| 1f5oA00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.57 | 44.0 | 3.60e-01 | 81.5% | 77.9% |
| 1r9dA01 | 3.20.70.20 | Alpha Beta › Alpha-Beta Barrel › Anaerobic Ribonucleotide-triphosphate Reductase Large Chain › | 0.57 | 45.0 | 2.63e-01 | 86.4% | 48.4% |
| 2of7A02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.57 | 39.0 | 3.31e-01 | 71.6% | 56.4% |
| 3acxA00 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.55 | 37.0 | 2.61e-01 | 70.4% | 47.5% |
| 2k3oA00 | 1.10.274.60 | Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › Spidroin, repetitive domain | 0.55 | 48.0 | 4.15e-01 | 98.8% | 86.8% |
| 5u9nB00 | 1.20.920.10 | Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like | 0.55 | 40.0 | 3.60e-01 | 80.2% | 90.0% |
| 6ig5A01 | 1.10.275.10 | Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) | 0.54 | 42.0 | 3.53e-01 | 82.7% | 60.9% |
| 1qmgA02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.54 | 41.0 | 2.91e-01 | 85.2% | 85.0% |
| 3vprA02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.52 | 40.0 | 3.31e-01 | 82.7% | 74.5% |
| 2ggfA00 | 1.25.40.180 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.52 | 35.0 | 3.04e-01 | 72.8% | 42.3% |
| 1j8yF01 | 1.20.120.140 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SRP54, nucleotide-binding domain | 0.51 | 40.0 | 3.98e-01 | 84.0% | 89.5% |
| 1td6A03 | 1.10.472.40 | Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Hypothetical protein mg237 homolog; domain 3 | 0.51 | 38.0 | 3.67e-01 | 79.0% | 69.6% |
| 2hfiA00 | 1.20.120.440 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like | 0.50 | 41.0 | 3.60e-01 | 88.9% | 94.3% |
ECOD (26)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2522010 | 566.1.1.0 ↗ | alpha complex topology › P40 nucleoprotein-like › P40 nucleoprotein-related › P40 nucleoprotein-related | 0.97 | 94.0 | 5.82e-01 | 100.0% | 25.7% |
| 2476746 | 566.1.1.4 ↗ | alpha complex topology › P40 nucleoprotein-like › P40 nucleoprotein-related › P40 nucleoprotein-related › Ebola_NP | 0.96 | 92.0 | 5.68e-01 | 100.0% | 24.5% |
| 3859662 | 149.1.1.1 ↗ | alpha arrays › Cytochrome P450 › Cytochrome P450 › Cytochrome P450 › p450 | 0.69 | 48.0 | 2.96e-01 | 72.8% | 65.1% |
| 4589278 | 101.1.2.309 ↗ | alpha arrays › HTH › HTH › winged helix domain › GPAT_C | 0.69 | 61.0 | 5.64e-01 | 98.8% | 96.2% |
| 4050998 | 101.1.2.309 ↗ | alpha arrays › HTH › HTH › winged helix domain › GPAT_C | 0.69 | 62.0 | 4.60e-01 | 100.0% | 50.2% |
| 4364892 | 101.1.2.309 ↗ | alpha arrays › HTH › HTH › winged helix domain › GPAT_C | 0.68 | 60.0 | 4.11e-01 | 98.8% | 34.6% |
| 4682562 | 101.1.2.309 ↗ | alpha arrays › HTH › HTH › winged helix domain › GPAT_C | 0.67 | 59.0 | 4.54e-01 | 98.8% | 52.4% |
| 4002075 | 101.1.1.0 ↗ | alpha arrays › HTH › HTH › Three-helical HTH | 0.67 | 47.0 | 5.06e-01 | 72.8% | 92.3% |
| 5053016 | 3896.1.1.0 ↗ | alpha duplicates or obligate multimers › Intramembrane CDP-DAG synthetase-related › Intramembrane CDP-DAG synthetase-related › Intramembrane CDP-DAG synthetase | 0.65 | 45.0 | 3.16e-01 | 72.8% | 40.0% |
| 3600444 | 7064.1.1.0 ↗ | alpha bundles › Transmembrane domain of VIT1 › Transmembrane domain of VIT1 › Transmembrane domain of VIT1 | 0.62 | 43.0 | 3.60e-01 | 72.8% | 63.4% |
| 3226202 | 7558.1.1.0 ↗ | a/b three-layered sandwiches › Glycerol-3-phosphate (1)-acyltransferase › Glycerol-3-phosphate (1)-acyltransferase › Glycerol-3-phosphate (1)-acyltransferase | 0.58 | 47.0 | 4.42e-01 | 87.7% | 92.0% |
| 5017736 | 3625.1.1.0 ↗ | alpha bundles › CRISPR RNA silencing complex Cmr2 subunit second helical domain › CRISPR RNA silencing complex Cmr2 subunit second helical domain › CRISPR RNA silencing complex Cmr2 subunit second helical domain | 0.58 | 40.0 | 3.73e-01 | 72.8% | 61.9% |
| 4061485 | 4967.1.1.0 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases | 0.57 | 40.0 | 3.18e-01 | 72.8% | 37.7% |
| 3457663 | 192.29.1.178 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › PF28703 | 0.56 | 45.0 | 4.14e-01 | 86.4% | 97.1% |
| 3414050 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.56 | 41.0 | 3.79e-01 | 79.0% | 90.5% |
| 3235853 | 632.6.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Plasmid maintenance system epsilon/zeta, antidote epsilon subunit › Plasmid maintenance system epsilon/zeta, antidote epsilon subunit | 0.54 | 38.0 | 3.90e-01 | 74.1% | 90.0% |
| 4360726 | 206.1.3.0 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp | 0.53 | 42.0 | 2.90e-01 | 86.4% | 66.9% |
| 3414776 | 5054.1.1.0 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels | 0.53 | 38.0 | 3.21e-01 | 82.7% | 42.8% |
| 151182 | 191.1.1.26 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_C_24 | 0.53 | 40.0 | 3.54e-01 | 81.5% | 90.7% |
| 3702921 | 148.1.3.10 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › AAA_6 | 0.52 | 36.0 | 3.80e-01 | 76.5% | 78.7% |
| 3720014 | 650.1.1.1 ↗ | alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ | 0.52 | 36.0 | 3.89e-01 | 72.8% | 92.9% |
| 3467691 | 150.5.1.76 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › DUF1110 | 0.52 | 34.0 | 3.36e-01 | 80.2% | 62.4% |
| 3545742 | 5.1.4.1 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40 | 0.52 | 37.0 | 2.33e-01 | 98.8% | 12.7% |
| 1144440 | 191.1.1.26 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_C_24 | 0.51 | 38.0 | 3.38e-01 | 80.2% | 85.6% |
| 2946 | 4979.1.1.1 ↗ | alpha arrays › C-terminal domain of Hypothetical protein MPN330-like › C-terminal domain of Hypothetical protein MPN330 › C-terminal domain of Hypothetical protein MPN330 › DUF3196 | 0.51 | 38.0 | 3.67e-01 | 79.0% | 69.6% |
| 2325657 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.50 | 37.0 | 3.21e-01 | 81.5% | 85.4% |