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orf44
Euk-VirAlcelaphine_gammaherpesvirus_2
orf44__YP_009044426__Alcelaphine_gammaherpesvirus_2__138184
Identity
- Accession:
- YP_009044426 ↗
- Protein ID:
- orf44
- Kingdom:
- euk
Quality
85.3
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Macavirus›
Alcelaphine_gammaherpesvirus_2
TaxID: 138184
Cluster
View cluster (90 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 294-351_355-360_703-760
Domain cluster:
rep: helicase-primase_ATPase_subunit__YP_010087484__Phascolarctid_gammaherpesvirus_1__2249313__D338-366_706-759
Pfam (3)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01443.25 best | Viral_helicase1 | 27.2 | 4.60e-06 | 68.0% | 23.7% |
| PF02689.21 | Herpes_Helicase | 97.4 | 8.30e-28 | 53.3% | 7.3% |
| PF02689.21 | Herpes_Helicase | 99.3 | 2.20e-28 | 50.8% | 7.2% |
D2
medium
residues 17-107_156-233_761-783
Domain cluster:
rep: ORF35__NP_733888__Callitrichine_gammaherpesvirus_3__106331__D45-78_114-298
Pfam (3)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF13604.13 best | AAA_30 | 27.5 | 3.40e-06 | 54.7% | 44.0% |
| PF02689.21 | Herpes_Helicase | 128.7 | 2.90e-37 | 47.9% | 12.1% |
| PF02689.21 | Herpes_Helicase | 114.8 | 4.60e-33 | 43.2% | 9.8% |
D3
medium
residues 131-155_234-288
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 92.0 | 3.80e-26 | 72.5% | 7.2% |
CATH (1)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3e8oB00 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.50 | 28.0 | 2.70e-01 | 80.0% | 42.0% |
ECOD (2)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5023832 | 331.2.1.0 ↗ | a+b two layers › TBP-like › Phosphoglucomutase, C-terminal domain › Phosphoglucomutase, C-terminal domain | 0.54 | 30.0 | 3.11e-01 | 83.7% | 56.0% |
| 3797637 | 4291.1.1.0 ↗ | beta barrels › Oxysterol-binding protein › Oxysterol-binding protein › Oxysterol-binding protein | 0.51 | 39.0 | 2.60e-01 | 85.0% | 58.5% |
D4
medium
residues 366-442_674-702
Domain cluster:
rep: helicase-primase_helicase_subunit__NP_045354__Bovine_alphaherpesvirus_1__10320__D392-469_736-760
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 100.0 | 1.40e-28 | 73.6% | 9.8% |
CATH (39)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4djbA00 | 3.30.70.2870 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Mastadenovirus E4 ORF3 | 0.64 | 55.0 | 5.34e-01 | 95.3% | 94.9% |
| 1m55A00 | 3.40.1310.20 | Alpha Beta › 3-Layer(aba) Sandwich › Replication Protein E1; Chain: A, › | 0.63 | 54.0 | 4.46e-01 | 95.3% | 73.6% |
| 3ibwA00 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.62 | 43.0 | 4.90e-01 | 96.2% | 97.5% |
| 3onrJ00 | 3.30.1660.10 | Alpha Beta › 2-Layer Sandwich › Dodecin subunit-like › Flavin-binding protein dodecin | 0.60 | 37.0 | 4.50e-01 | 72.6% | 97.1% |
| 5ajiB03 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.60 | 47.0 | 4.92e-01 | 92.5% | 92.6% |
| 3qwuA03 | 3.30.70.2160 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.59 | 37.0 | 3.41e-01 | 72.6% | 48.2% |
| 6vh5C03 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.58 | 41.0 | 4.45e-01 | 96.2% | 87.6% |
| 1f3vA00 | 3.30.70.680 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › TRADD, N-terminal domain | 0.58 | 50.0 | 4.43e-01 | 96.2% | 79.1% |
| 3bn3B01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.57 | 37.0 | 4.05e-01 | 98.1% | 81.4% |
| 2gy5A04 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.57 | 40.0 | 4.19e-01 | 96.2% | 79.8% |
| 3mtjA03 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.56 | 38.0 | 4.26e-01 | 93.4% | 96.1% |
| 1qdlA00 | 3.60.120.10 | Alpha Beta › 4-Layer Sandwich › Anthranilate synthase › Anthranilate synthase | 0.56 | 45.0 | 3.02e-01 | 87.7% | 42.4% |
| 6v3pD01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.56 | 42.0 | 4.33e-01 | 98.1% | 85.9% |
| 5i2cB01 | 3.30.2130.10 | Alpha Beta › 2-Layer Sandwich › VC0802-like › VC0802-like | 0.55 | 36.0 | 3.24e-01 | 95.3% | 47.9% |
| 3tviA02 | 3.30.2130.10 | Alpha Beta › 2-Layer Sandwich › VC0802-like › VC0802-like | 0.55 | 39.0 | 3.45e-01 | 93.4% | 49.1% |
| 6yiiA01 | 3.30.70.1230 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Nucleotide cyclase, GGDEF domain | 0.55 | 47.0 | 3.74e-01 | 97.2% | 79.9% |
| 1o51A00 | 3.30.70.120 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.55 | 41.0 | 4.41e-01 | 94.3% | 93.3% |
| 3c19A01 | 3.30.70.1380 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Transcriptional regulatory protein pf0864 domain like | 0.55 | 41.0 | 4.23e-01 | 96.2% | 84.8% |
| 1dn0D02 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.55 | 39.0 | 4.14e-01 | 95.3% | 85.1% |
| 5xoyB02 | 3.30.70.360 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.54 | 47.0 | 4.70e-01 | 94.3% | 97.2% |
| 2mklC00 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.54 | 40.0 | 4.05e-01 | 98.1% | 78.1% |
| 1hxmB02 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.54 | 40.0 | 4.10e-01 | 98.1% | 79.0% |
| 3tvkA00 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.54 | 47.0 | 4.02e-01 | 97.2% | 82.6% |
| 2e7vA01 | 3.30.70.960 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › SEA domain | 0.54 | 44.0 | 4.47e-01 | 89.6% | 97.1% |
| 1tz0B00 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.54 | 41.0 | 4.30e-01 | 96.2% | 89.7% |
| 3qkbA00 | 3.30.110.70 | Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › Hypothetical protein apc22750. Chain B | 0.53 | 37.0 | 3.94e-01 | 72.6% | 83.0% |
| 2nrqA00 | 3.30.1440.10 | Alpha Beta › 2-Layer Sandwich › 50s Ribosomal Protein L5; Chain: A, › Ribosomal protein L5 | 0.53 | 46.0 | 4.25e-01 | 95.3% | 86.9% |
| 4q9bA00 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.52 | 40.0 | 4.09e-01 | 99.1% | 84.2% |
| 4bbyA05 | 3.30.300.330 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › | 0.52 | 42.0 | 4.26e-01 | 91.5% | 88.0% |
| 4er8A00 | 3.30.70.1290 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Transposase IS200-like | 0.51 | 40.0 | 3.55e-01 | 93.4% | 55.2% |
| 4cllA01 | 3.30.70.1230 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Nucleotide cyclase, GGDEF domain | 0.51 | 45.0 | 3.64e-01 | 98.1% | 88.6% |
| 5wpjA02 | 3.30.70.420 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain | 0.51 | 42.0 | 4.26e-01 | 92.5% | 94.4% |
| 4aefA02 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.51 | 34.0 | 3.59e-01 | 95.3% | 75.8% |
| 4q7aC02 | 3.30.70.360 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.51 | 42.0 | 4.26e-01 | 92.5% | 97.2% |
| 3hdiA02 | 3.30.830.10 | Alpha Beta › 2-Layer Sandwich › Cytochrome Bc1 Complex; Chain A, domain 1 › Metalloenzyme, LuxS/M16 peptidase-like | 0.51 | 43.0 | 3.58e-01 | 96.2% | 91.9% |
| 2ogkD00 | 3.30.1440.10 | Alpha Beta › 2-Layer Sandwich › 50s Ribosomal Protein L5; Chain: A, › Ribosomal protein L5 | 0.51 | 45.0 | 4.12e-01 | 99.1% | 98.6% |
| 1ybtB00 | 3.30.70.1230 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Nucleotide cyclase, GGDEF domain | 0.51 | 44.0 | 3.78e-01 | 97.2% | 79.7% |
| 3v8hC00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.50 | 35.0 | 2.55e-01 | 72.6% | 34.4% |
| 1xmbA02 | 3.30.70.360 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.50 | 40.0 | 4.08e-01 | 94.3% | 92.1% |
ECOD (38)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3965651 | 304.8.1.8 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT_4 | 0.65 | 45.0 | 5.15e-01 | 95.3% | 100.0% |
| 4516880 | 304.8.1.74 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › PF26539 | 0.62 | 44.0 | 4.91e-01 | 95.3% | 96.2% |
| 4023676 | 3156.3.1.0 ↗ | beta sandwiches › Cupredoxin-like › Surface antigen 1 (SAG1)-related-sequence (SRS) family › Surface antigen 1 (SAG1)-related-sequence (SRS) family | 0.60 | 47.0 | 4.34e-01 | 97.2% | 64.3% |
| 3385857 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.59 | 40.0 | 4.31e-01 | 98.1% | 82.2% |
| 4970335 | 304.39.1.1 ↗ | a+b two layers › Alpha-beta plaits › Mechanosensitive channel protein MscS (YggB), C-terminal domain › Mechanosensitive channel protein MscS (YggB), C-terminal domain › MS_channel_3rd | 0.59 | 46.0 | 4.90e-01 | 91.5% | 96.7% |
| 3388084 | 872.10.1.0 ↗ | a+b two layers › Dodecin subunit-like › Secreted protein HP1454 N-terminal domain › Secreted protein HP1454 N-terminal domain | 0.59 | 44.0 | 4.88e-01 | 99.1% | 98.8% |
| 5075567 | 304.25.1.0 ↗ | a+b two layers › Alpha-beta plaits › Bacterial exopeptidase dimerisation domain › Bacterial exopeptidase dimerisation domain | 0.59 | 49.0 | 4.89e-01 | 91.5% | 95.5% |
| 3605908 | 304.31.1.3 ↗ | a+b two layers › Alpha-beta plaits › HMG-CoA reductase › NAD-binding domain of HMG-CoA reductase › FAZ1_cons | 0.56 | 46.0 | 4.52e-01 | 93.4% | 100.0% |
| 3861216 | 11.1.1.3 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › ig | 0.56 | 40.0 | 4.15e-01 | 97.2% | 80.0% |
| 4174584 | 304.25.1.1 ↗ | a+b two layers › Alpha-beta plaits › Bacterial exopeptidase dimerisation domain › Bacterial exopeptidase dimerisation domain › M20_dimer | 0.56 | 48.0 | 4.63e-01 | 95.3% | 90.8% |
| 3232689 | 11.1.1.179 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Ig_3 | 0.55 | 39.0 | 4.05e-01 | 98.1% | 81.1% |
| 3633972 | 304.18.1.1 ↗ | a+b two layers › Alpha-beta plaits › Anticodon-binding domain of PheRS › Anticodon-binding domain of PheRS › FDX-ACB | 0.55 | 46.0 | 4.69e-01 | 93.4% | 100.0% |
| 4575105 | 882.1.1.0 ↗ | a+b two layers › Ribosomal protein L5 › Ribosomal protein L5 › Ribosomal protein L5 | 0.55 | 48.0 | 4.35e-01 | 98.1% | 84.0% |
| 5058470 | 304.39.1.0 ↗ | a+b two layers › Alpha-beta plaits › Mechanosensitive channel protein MscS (YggB), C-terminal domain › Mechanosensitive channel protein MscS (YggB), C-terminal domain | 0.55 | 47.0 | 4.40e-01 | 92.5% | 93.8% |
| 3760105 | 304.47.1.0 ↗ | a+b two layers › Alpha-beta plaits › SEA domain › SEA domain | 0.55 | 46.0 | 4.53e-01 | 92.5% | 94.8% |
| 4964275 | 304.57.1.1 ↗ | a+b two layers › Alpha-beta plaits › Rpp14/Pop5-like › Rpp14/Pop5-like › RNase_P_Rpp14 | 0.55 | 44.0 | 4.32e-01 | 96.2% | 80.0% |
| 3796322 | 304.109.1.0 ↗ | a+b two layers › Alpha-beta plaits › Ribosomal proteins S24e, L23 and L15e › Ribosomal proteins S24e, L23 and L15e | 0.55 | 38.0 | 3.74e-01 | 71.7% | 69.6% |
| 4943808 | 882.1.1.4 ↗ | a+b two layers › Ribosomal protein L5 › Ribosomal protein L5 › Ribosomal protein L5 › RNA_binding | 0.54 | 49.0 | 4.32e-01 | 97.2% | 96.0% |
| 3906213 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.54 | 45.0 | 4.44e-01 | 97.2% | 85.2% |
| 5005568 | 304.28.1.38 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain › CAA_C | 0.54 | 45.0 | 3.90e-01 | 93.4% | 83.5% |
| 4986560 | 304.20.1.4 ↗ | a+b two layers › Alpha-beta plaits › PAP/Archaeal CCA-adding enzyme, C-terminal domain › PAP/Archaeal CCA-adding enzyme, C-terminal domain › CAA_C | 0.54 | 45.0 | 3.86e-01 | 94.3% | 81.1% |
| 3591115 | 304.163.1.0 ↗ | a+b two layers › Alpha-beta plaits › ATP-binding protein TM_1403 insertion domain › ATP-binding protein TM_1403 insertion domain | 0.54 | 44.0 | 4.54e-01 | 93.4% | 96.0% |
| 180088 | 872.3.1.0 ↗ | a+b two layers › Dodecin subunit-like › YbjQ-like › YbjQ-like | 0.53 | 37.0 | 3.98e-01 | 72.6% | 85.7% |
| 4024239 | 304.151.1.0 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin-like domain of receptor-type protein tyrosine phosphatase › Ferredoxin-like domain of receptor-type protein tyrosine phosphatase | 0.53 | 43.0 | 4.14e-01 | 89.6% | 94.4% |
| 3857972 | 11.1.1.179 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Ig_3 | 0.53 | 40.0 | 4.10e-01 | 98.1% | 82.9% |
| 3236767 | 4955.1.1.0 ↗ | a+b two layers › permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit › permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit › permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit | 0.53 | 44.0 | 4.60e-01 | 90.6% | 100.0% |
| 3520411 | 304.47.1.0 ↗ | a+b two layers › Alpha-beta plaits › SEA domain › SEA domain | 0.53 | 45.0 | 4.53e-01 | 96.2% | 96.4% |
| 3220882 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.53 | 45.0 | 4.60e-01 | 92.5% | 98.0% |
| 3998680 | 206.1.1.0 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase | 0.53 | 40.0 | 2.45e-01 | 97.2% | 11.3% |
| 3241169 | 304.47.1.1 ↗ | a+b two layers › Alpha-beta plaits › SEA domain › SEA domain › SEA | 0.52 | 44.0 | 4.34e-01 | 94.3% | 97.4% |
| 4990439 | 304.116.1.0 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in release factor › Ferredoxin-like domain in release factor | 0.52 | 41.0 | 4.27e-01 | 93.4% | 91.0% |
| 4977616 | 882.1.1.4 ↗ | a+b two layers › Ribosomal protein L5 › Ribosomal protein L5 › Ribosomal protein L5 › RNA_binding | 0.52 | 44.0 | 4.24e-01 | 94.3% | 98.4% |
| 3528002 | 11.1.1.789 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › KIAA1549 | 0.52 | 44.0 | 4.35e-01 | 93.4% | 97.3% |
| 5045742 | 882.1.1.4 ↗ | a+b two layers › Ribosomal protein L5 › Ribosomal protein L5 › Ribosomal protein L5 › RNA_binding | 0.52 | 45.0 | 4.01e-01 | 96.2% | 95.3% |
| 5023895 | 882.1.1.4 ↗ | a+b two layers › Ribosomal protein L5 › Ribosomal protein L5 › Ribosomal protein L5 › RNA_binding | 0.52 | 45.0 | 4.05e-01 | 96.2% | 97.9% |
| 3557949 | 11.1.1.587 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › VEGFR1-3_N_Ig-like | 0.51 | 37.0 | 3.76e-01 | 97.2% | 76.4% |
| 5008586 | 304.116.1.0 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in release factor › Ferredoxin-like domain in release factor | 0.51 | 40.0 | 4.17e-01 | 93.4% | 93.7% |
| 3862603 | 11.1.1.363 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › C2-set_3 | 0.50 | 36.0 | 3.78e-01 | 95.3% | 86.3% |
D5
medium
residues 443-459_594-673
Domain cluster:
rep: helicase-primase_helicase_subunit__YP_009137079__Human_alphaherpesvirus_1__10298__D496-518_696-779
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 92.4 | 2.80e-26 | 82.5% | 10.0% |
D6
medium
residues 460-529_542-593
Domain cluster:
rep: helicase-primase_helicase_subunit__YP_004940266__Saimiriine_betaherpesvirus_4__1535247__D509-572_638-677
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 73.6 | 1.30e-20 | 59.0% | 8.0% |
| PF02689.21 | Herpes_Helicase | 32.9 | 2.70e-08 | 48.4% | 5.7% |