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p66_subunit
Euk-VirHuman_immunodeficiency_virus_1
p66_subunit__NP_705927__Human_immunodeficiency_virus_1__11676
Identity
- Accession:
- NP_705927 ↗
- Protein ID:
- p66_subunit
- Kingdom:
- euk
Quality
82.7
mean pLDDT
Taxonomy
Pararnavirae›
Artverviricota›
Revtraviricetes›
Ortervirales›
Retroviridae›
Lentivirus›
Human_immunodeficiency_virus_1
TaxID: 11676
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 97-112_156-228
Domain cluster:
rep: hypothetical_protein_2__YP_009345057__Xinzhou_nematode_virus_7__1923775__D238-258_337-401
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00078.33 best | RVT_1 | 49.2 | 8.30e-13 | 95.5% | 34.0% |
D2
high
residues 252-315
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF06817.20 best | RVT_thumb | 75.5 | 3.20e-21 | 82.8% | 81.8% |
CATH (13)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1jlcB03 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.97 | 93.0 | 7.00e-01 | 100.0% | 49.6% |
| 1c9rB03 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.91 | 85.0 | 7.87e-01 | 100.0% | 83.5% |
| 5ovnA03 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.90 | 84.0 | 7.24e-01 | 100.0% | 68.1% |
| 4xvxA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.65 | 55.0 | 4.29e-01 | 96.9% | 65.3% |
| 2e1qC04 | 3.30.465.10 | Alpha Beta › 2-Layer Sandwich › Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 › | 0.64 | 50.0 | 4.11e-01 | 90.6% | 84.6% |
| 3nb0B03 | 6.10.260.10 | Special › Helix non-globular › F1FO ATP Synthase › | 0.63 | 44.0 | 4.08e-01 | 75.0% | 83.3% |
| 1skvA00 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.61 | 42.0 | 4.25e-01 | 71.9% | 85.9% |
| 1bbnA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.57 | 41.0 | 3.33e-01 | 78.1% | 93.2% |
| 1f6kC00 | 3.20.20.70 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I | 0.56 | 50.0 | 3.23e-01 | 100.0% | 29.1% |
| 3e9lA02 | 1.20.80.40 | Mainly Alpha › Up-down Bundle › Acyl-CoA Binding Protein › Prp8 RNase H domain, fingers region | 0.56 | 49.0 | 4.35e-01 | 100.0% | 72.6% |
| 3eayA01 | 1.10.418.20 | Mainly Alpha › Orthogonal Bundle › Actin-binding Protein, T-fimbrin; domain 1 › | 0.52 | 38.0 | 3.11e-01 | 96.9% | 41.1% |
| 4wo8A03 | 1.10.135.10 | Mainly Alpha › Orthogonal Bundle › Transferase Creatine Kinase; Chain A, domain 1 › ATP:guanido phosphotransferase, N-terminal domain | 0.51 | 38.0 | 3.61e-01 | 84.4% | 76.2% |
| 6x6nA01 | 1.20.120.260 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Virulence factor YopE uncharacterised domain | 0.50 | 44.0 | 3.66e-01 | 100.0% | 77.8% |
ECOD (25)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 54740 | 4967.1.1.0 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases | 0.99 | 95.0 | 8.97e-01 | 100.0% | 86.5% |
| 4873538 | 4967.1.1.9 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › RVT_thumb | 0.96 | 92.0 | 8.16e-01 | 100.0% | 74.4% |
| 2141984 | 4967.1.1.9 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › RVT_thumb | 0.90 | 84.0 | 7.81e-01 | 100.0% | 83.1% |
| 3781213 | 4967.1.1.0 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases | 0.89 | 81.0 | 7.43e-01 | 98.4% | 81.2% |
| 2887449 | 4967.1.1.9 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › RVT_thumb | 0.88 | 81.0 | 7.23e-01 | 100.0% | 77.0% |
| 3934727 | 4967.1.1.0 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases | 0.85 | 77.0 | 7.02e-01 | 100.0% | 77.6% |
| 3931852 | 4967.1.1.0 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases | 0.81 | 73.0 | 6.79e-01 | 100.0% | 80.0% |
| 3845825 | 4967.1.1.0 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases | 0.79 | 70.0 | 6.46e-01 | 100.0% | 77.5% |
| 3926532 | 4967.1.1.0 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases | 0.79 | 69.0 | 6.59e-01 | 98.4% | 84.0% |
| 3936283 | 4967.1.1.0 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases | 0.79 | 70.0 | 6.52e-01 | 100.0% | 80.0% |
| 3934191 | 4967.1.1.0 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases | 0.77 | 66.0 | 6.18e-01 | 100.0% | 78.8% |
| 3523496 | 632.7.1.25 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain › PF27508 | 0.69 | 61.0 | 5.35e-01 | 100.0% | 96.8% |
| 3685493 | 605.2.1.4 ↗ | alpha duplicates or obligate multimers › ROP-like › Hypothetical protein D-63 › Hypothetical protein D-63 › DUF7785 | 0.68 | 47.0 | 4.24e-01 | 71.9% | 63.5% |
| 3972174 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.62 | 41.0 | 3.09e-01 | 70.3% | 87.4% |
| 3835025 | 5086.1.1.204 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › PHM7_cyt | 0.60 | 41.0 | 4.12e-01 | 71.9% | 95.4% |
| 3189639 | 4146.1.1.0 ↗ | alpha bundles › YqgQ-like › YqgQ-like › YqgQ-like | 0.59 | 47.0 | 4.72e-01 | 87.5% | 90.8% |
| 5057376 | 5054.1.1.0 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels | 0.59 | 43.0 | 3.94e-01 | 76.6% | 74.1% |
| 3642338 | 3567.1.1.0 ↗ | a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer | 0.58 | 42.0 | 3.96e-01 | 75.0% | 81.3% |
| 3473158 | 109.62.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › AFF4 C-terminal homology domain › AFF4 C-terminal homology domain | 0.58 | 47.0 | 3.05e-01 | 90.6% | 90.5% |
| 3351946 | 192.29.1.27 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › DUF1218 | 0.56 | 48.0 | 3.74e-01 | 100.0% | 75.5% |
| 3402974 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.56 | 37.0 | 2.91e-01 | 70.3% | 32.3% |
| 4940192 | 192.2.1.1 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin_2 | 0.53 | 37.0 | 3.12e-01 | 73.4% | 99.1% |
| 4931781 | 3826.1.1.97 ↗ | alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › DUF485 | 0.51 | 39.0 | 3.85e-01 | 82.8% | 94.3% |
| 3993593 | 103.1.1.0 ↗ | alpha arrays › RuvA-C › RuvA-C, UBA, CRAL/TRIO-N, HBS1 › UBA-like domain | 0.50 | 37.0 | 3.75e-01 | 93.8% | 78.5% |
| 5081054 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.50 | 37.0 | 2.80e-01 | 79.7% | 46.9% |
D3
high
residues 320-419
Domain cluster:
rep: p15NC-p14PR-p95RT_IN__NP_955619__Human_T-cell_leukemia_virus_type_I__11908__D551-648
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF06815.20 best | RVT_connect | 153.3 | 2.30e-45 | 100.0% | 98.0% |
D4
high
residues 428-559
Domain cluster:
rep: polyprotein__YP_002916057__Sweet_potato_badnavirus_B__647294__D493-623
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00075.31 best | RNase_H | 116.2 | 2.00e-33 | 92.4% | 97.2% |
D5
medium
residues 1-88_116-155
Domain cluster:
rep: pol_protein,_partial__YP_002308474__Simian_T-cell_lymphotropic_virus_6__481147__D16-81_108-143
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00078.33 best | RVT_1 | 33.8 | 4.40e-08 | 35.2% | 25.0% |