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p87

Euk-Vir

Human_coronavirus_229E

p87__NP_835357__Human_coronavirus_229E__11137

Identity

Accession:
NP_835357 ↗
Protein ID:
p87
Kingdom:
euk

Quality

90.4 mean pLDDT

Taxonomy

Orthornavirae› Pisuviricota› Pisoniviricetes› Nidovirales› Coronaviridae› Alphacoronavirus› Human_coronavirus_229E

TaxID: 11137

Cluster

View cluster (3 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 2-68
PDB
Domain cluster: rep: nsp2__YP_009924384__Rousettus_bat_coronavirus_HKU9__694006__D2-83
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF19211.6 best CoV_NSP2_N 90.6 1.30e-25 100.0% 32.8%
D2 high residues 125-265
PDB
Domain cluster: rep: nsp2__YP_008439213__Bat_coronavirus_CDPHE15_USA_2006__1384461__D83-264
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF19211.6 best CoV_NSP2_N 109.8 1.80e-31 57.5% 42.8%
D3 high residues 277-363
PDB
Domain cluster: rep: uncovered_polypeptide_Pol1__NP_598309_110-894__Porcine_epidemic_diarrhea_virus__28295__D272-345
D4 high residues 369-480
PDB
Domain cluster: rep: p87__NP_835357__Human_coronavirus_229E__11137__D681-785
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF19212.6 best CoV_NSP2_C 110.2 1.00e-31 100.0% 94.2%
D5 high residues 602-670
PDB
Domain cluster: representative
CATH (34)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2f7aA01 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.62 49.0 4.22e-01 91.3% 78.5%
5wzoA00 1.20.90.10 Mainly Alpha › Up-down Bundle › Phospholipase A2 › Phospholipase A2 domain 0.61 50.0 4.20e-01 92.8% 81.3%
3e9lA02 1.20.80.40 Mainly Alpha › Up-down Bundle › Acyl-CoA Binding Protein › Prp8 RNase H domain, fingers region 0.61 46.0 4.18e-01 95.7% 60.0%
7oode01 3.90.930.12 Alpha Beta › Alpha-Beta Complex › Outer Surface Protein A; domain 3 › Ribosomal protein L6 0.60 51.0 5.20e-01 95.7% 97.1%
2ayaA00 3.30.300.150 Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › DNA polymerase III, tau subunit, domain V 0.60 47.0 3.96e-01 91.3% 48.4%
5gaeG01 3.90.930.12 Alpha Beta › Alpha-Beta Complex › Outer Surface Protein A; domain 3 › Ribosomal protein L6 0.60 48.0 4.61e-01 95.7% 76.5%
6n8eA01 3.30.559.10 Alpha Beta › 2-Layer Sandwich › Chloramphenicol Acetyltransferase › Chloramphenicol acetyltransferase-like domain 0.59 47.0 3.66e-01 92.8% 68.6%
3thxB04 1.10.1420.10 Mainly Alpha › Orthogonal Bundle › MutS, DNA mismatch repair protein; Chain A, domain 3 › 0.59 47.0 3.98e-01 92.8% 64.1%
2fbhA00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.58 49.0 3.96e-01 95.7% 82.5%
3cjnA00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.57 47.0 3.82e-01 95.7% 76.0%
4zxhA01 3.30.559.10 Alpha Beta › 2-Layer Sandwich › Chloramphenicol Acetyltransferase › Chloramphenicol acetyltransferase-like domain 0.57 46.0 3.50e-01 89.9% 64.9%
7x0fA01 3.30.559.10 Alpha Beta › 2-Layer Sandwich › Chloramphenicol Acetyltransferase › Chloramphenicol acetyltransferase-like domain 0.57 44.0 3.54e-01 87.0% 77.0%
1ewqA04 1.10.1420.10 Mainly Alpha › Orthogonal Bundle › MutS, DNA mismatch repair protein; Chain A, domain 3 › 0.57 46.0 3.81e-01 94.2% 58.8%
2rdpA00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.57 51.0 4.04e-01 100.0% 77.9%
3u1nB01 1.10.3210.10 Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 0.55 46.0 3.07e-01 100.0% 88.1%
2h21B01 3.90.1410.10 Alpha Beta › Alpha-Beta Complex › set domain protein methyltransferase, domain 1 › set domain protein methyltransferase, domain 1 0.54 43.0 3.01e-01 89.9% 41.2%
5e1wA00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.54 48.0 3.59e-01 98.6% 66.1%
6mfxA02 3.30.559.10 Alpha Beta › 2-Layer Sandwich › Chloramphenicol Acetyltransferase › Chloramphenicol acetyltransferase-like domain 0.54 43.0 3.41e-01 91.3% 68.1%
2ckwA03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.54 42.0 3.69e-01 91.3% 56.0%
3lfkD00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.53 40.0 3.41e-01 79.7% 80.9%
2anrA02 3.30.1370.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › K Homology domain, type 1 0.53 41.0 4.02e-01 92.8% 78.7%
2zovA00 3.30.1330.60 Alpha Beta › 2-Layer Sandwich › 60s Ribosomal Protein L30; Chain: A; › OmpA-like domain 0.53 43.0 3.38e-01 95.7% 87.3%
1s7hA02 3.30.70.930 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.52 42.0 3.99e-01 95.7% 74.4%
7nmqA01 1.20.1170.10 Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › 0.52 42.0 2.82e-01 98.6% 71.1%
3pe5A00 3.40.630.190 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › LCP protein 0.52 45.0 3.02e-01 98.6% 31.4%
5i2cB01 3.30.2130.10 Alpha Beta › 2-Layer Sandwich › VC0802-like › VC0802-like 0.52 36.0 2.83e-01 78.3% 34.2%
4b3xA02 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.51 40.0 3.14e-01 89.9% 97.7%
3mfqA01 3.40.50.1980 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nitrogenase molybdenum iron protein domain 0.51 42.0 3.31e-01 88.4% 91.5%
1f02T00 4.10.820.10 Few Secondary Structures › Irregular › Translocated Intimin Receptor; Chain T › Translocated intimin receptor, central domain 0.51 40.0 4.08e-01 95.7% 90.9%
3euoA02 3.40.47.10 Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase 0.51 40.0 3.18e-01 89.9% 69.4%
2giaA00 2.30.31.40 Mainly Beta › Roll › Transcriptional Co-activator pc4; Chain A › 0.51 39.0 3.05e-01 84.1% 87.7%
2fclA00 3.30.460.40 Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › 0.51 39.0 3.12e-01 88.4% 57.1%
4i9fA03 3.30.300.290 Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › 0.50 36.0 3.49e-01 76.8% 67.5%
7yj5A02 3.40.47.10 Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase 0.50 39.0 3.14e-01 89.9% 71.0%
ECOD (17)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4250998 101.1.2.309 ↗ alpha arrays › HTH › HTH › winged helix domain › GPAT_C 0.63 37.0 3.36e-01 98.6% 43.2%
5027879 304.120.1.6 ↗ a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI › ThiI_fer 0.62 44.0 4.34e-01 87.0% 69.3%
3648955 5054.1.1.2 ↗ alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › Ion_trans 0.59 48.0 3.15e-01 91.3% 37.0%
3447245 5054.1.1.2 ↗ alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › Ion_trans 0.58 47.0 3.00e-01 89.9% 38.4%
3448409 5054.1.1.0 ↗ alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels 0.57 47.0 3.02e-01 91.3% 41.9%
3231421 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.56 44.0 4.21e-01 84.1% 78.8%
5049696 5001.1.1.0 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like 0.55 48.0 3.42e-01 100.0% 63.1%
3749051 4106.1.1.1 ↗ few secondary structure elements › Zinc hairpin stack › Zinc hairpin stack › Zinc hairpin stack › DHHC 0.55 47.0 3.22e-01 97.1% 78.8%
4932873 2498.1.1.0 ↗ mixed a+b and a/b › Zincin-like › "Metalloproteases (""zincins"") catalytic domain" › "Metalloproteases (""zincins"") catalytic domain" 0.54 43.0 3.15e-01 87.0% 45.7%
5064866 101.1.2.0 ↗ alpha arrays › HTH › HTH › winged helix domain 0.54 39.0 3.36e-01 76.8% 99.1%
3873955 7016.1.1.0 ↗ extended segments › Palmitoyltransferase DHHC C-terminal domain › Palmitoyltransferase DHHC C-terminal domain › Palmitoyltransferase DHHC C-terminal domain 0.53 44.0 3.43e-01 91.3% 91.0%
4980754 633.23.1.0 ↗ alpha bundles › Bromodomain-like › Claudin › Claudin 0.52 42.0 3.23e-01 91.3% 37.6%
4958144 101.1.2.141 ↗ alpha arrays › HTH › HTH › winged helix domain › HTH_24 0.51 39.0 3.26e-01 84.1% 83.2%
3733217 601.1.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin 0.50 42.0 3.36e-01 95.7% 64.0%
1515981 7581.1.1.6 ↗ a/b three-layered sandwiches › Thiolase-like › Thiolase-like › Thiolase-like › Chal_sti_synt_C 0.50 39.0 3.18e-01 89.9% 69.1%
3241792 5001.1.1.66 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Srg 0.50 42.0 3.08e-01 97.1% 49.3%
4930710 304.106.1.0 ↗ a+b two layers › Alpha-beta plaits › Hypothetical protein PH1602 › Hypothetical protein PH1602 0.50 43.0 2.79e-01 100.0% 83.4%
D6 high residues 681-785
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF19212.6 best CoV_NSP2_C 80.8 1.30e-22 100.0% 86.7%
ECOD (1)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2526296 4.32.1.1 ↗ beta barrels › SH3 › Replicase polyprotein 1a N-terminal beta barrel domain › Replicase polyprotein 1a N-terminal beta barrel domain › NSP2_gammaCoV 0.71 64.0 6.26e-01 100.0% 89.6%
D7 medium residues 483-588
PDB
Domain cluster: representative
CATH (9)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1x60A01 3.30.70.1070 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Sporulation related repeat 0.61 31.0 3.67e-01 71.7% 70.8%
3ca8A01 1.10.3620.10 Mainly Alpha › Orthogonal Bundle › YdcF fold › YdcF like domain 0.60 27.0 2.77e-01 72.6% 39.6%
2cveA02 3.30.70.240 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.60 27.0 3.27e-01 70.8% 63.6%
6j09A01 3.10.20.310 Alpha Beta › Roll › Ubiquitin-like (UB roll) › membrane protein fhac 0.59 37.0 4.42e-01 75.5% 98.5%
1js3A03 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.52 30.0 3.17e-01 78.3% 60.8%
3lmmA03 3.30.565.60 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › 0.52 38.0 3.25e-01 75.5% 99.4%
1lfwA03 3.30.70.360 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.51 31.0 3.39e-01 78.3% 73.9%
4e1oA03 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.50 30.0 3.08e-01 78.3% 60.2%
3hz7A00 3.30.110.40 Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › TusA-like domain 0.50 31.0 3.68e-01 76.4% 90.4%
ECOD (8)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4968322 304.126.1.0 ↗ a+b two layers › Alpha-beta plaits › ferredoxin-like domain in vacuolar ATP synthase subunit C › ferredoxin-like domain in vacuolar ATP synthase subunit C 0.60 27.0 3.42e-01 76.4% 72.7%
4881205 3121.1.1.1 ↗ a+b duplicates or obligate multimers › Polypeptide transport-associated (POTRA) domain › Polypeptide transport-associated (POTRA) domain › Polypeptide transport-associated (POTRA) domain › POTRA 0.59 37.0 4.43e-01 77.4% 95.8%
3976762 304.14.1.1 ↗ a+b two layers › Alpha-beta plaits › Sporulation related repeat (SPOR) › Sporulation related repeat (SPOR) › SPOR 0.59 31.0 3.53e-01 72.6% 68.0%
4070661 3016.1.1.0 ↗ a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases 0.58 28.0 3.40e-01 75.5% 69.2%
4031138 3016.1.1.0 ↗ a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases 0.57 28.0 3.45e-01 74.5% 78.3%
3737984 304.120.1.0 ↗ a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI 0.56 32.0 3.32e-01 72.6% 58.0%
3667031 3016.1.1.0 ↗ a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases 0.52 29.0 3.25e-01 74.5% 73.3%
5057765 4955.1.1.0 ↗ a+b two layers › permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit › permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit › permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit 0.50 30.0 3.34e-01 76.4% 77.5%