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papain-like_cysteine_peptidase

Euk-Vir

Lausannevirus

papain-like_cysteine_peptidase__YP_004347255__Lausannevirus__999883

Identity

Accession:
YP_004347255 ↗
Protein ID:
papain-like_cysteine_peptidase
Kingdom:
euk

Quality

45.3 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Megaviricetes› Pimascovirales› Marseilleviridae› Losannavirus› Lausannevirus

TaxID: 999883

Cluster

View cluster (7 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 106-174_201-242
PDB
D2 medium residues 243-364
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00112.30 best Peptidase_C1 73.9 2.90e-20 92.6% 41.8%
CATH (25)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1sp4B00 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.92 77.0 6.24e-01 100.0% 51.2%
5fpwA00 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.91 76.0 5.48e-01 99.2% 35.6%
4oelB00 2.40.50.170 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Cysteine proteinases. Chain C 0.86 41.0 5.55e-01 73.0% 84.1%
1xkgA00 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.86 74.0 5.37e-01 100.0% 36.9%
3iutA00 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.83 68.0 5.46e-01 100.0% 47.9%
5egwA00 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.83 71.0 4.88e-01 100.0% 30.0%
3oisB00 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.82 69.0 5.24e-01 100.0% 40.4%
1jqpA02 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.82 72.0 5.67e-01 99.2% 49.1%
6zq3A01 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.81 66.0 5.40e-01 98.4% 49.5%
1act000 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.81 69.0 5.54e-01 100.0% 49.5%
1deuB00 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.79 69.0 5.22e-01 99.2% 42.5%
3pnrA00 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.76 69.0 5.34e-01 100.0% 48.3%
2wbfX00 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.73 69.0 5.18e-01 100.0% 51.3%
3pw3D00 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.69 65.0 4.55e-01 100.0% 45.6%
2gfaB01 2.30.30.140 Mainly Beta › Roll › SH3 type barrels. › 0.69 37.0 4.85e-01 86.1% 100.0%
1gcbA01 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.68 63.0 4.31e-01 100.0% 39.5%
4k7cA01 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.67 63.0 4.28e-01 100.0% 40.9%
5zwzA01 2.30.30.140 Mainly Beta › Roll › SH3 type barrels. › 0.66 36.0 4.59e-01 80.3% 92.9%
1cv8A00 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.65 51.0 4.47e-01 98.4% 57.8%
4iupB01 2.40.50.40 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › 0.64 33.0 4.28e-01 93.4% 95.2%
6guuA01 2.40.50.40 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › 0.63 29.0 4.05e-01 70.5% 94.4%
1b34B00 2.30.30.100 Mainly Beta › Roll › SH3 type barrels. › 0.63 37.0 4.54e-01 89.3% 95.9%
6gbuD00 2.30.30.40 Mainly Beta › Roll › SH3 type barrels. › SH3 Domains 0.62 34.0 4.39e-01 77.0% 100.0%
4m7dA00 2.30.30.100 Mainly Beta › Roll › SH3 type barrels. › 0.60 33.0 4.32e-01 86.9% 100.0%
1a7sA01 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.50 37.0 3.86e-01 76.2% 86.6%
ECOD (89)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4377695 219.1.1.2 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1,Propeptide_C1 0.93 77.0 5.44e-01 99.2% 33.0%
3495032 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.93 77.0 6.17e-01 100.0% 48.8%
3656345 219.1.1.2 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1,Propeptide_C1 0.92 78.0 5.41e-01 100.0% 31.2%
3479869 219.1.1.0 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.92 78.0 5.46e-01 100.0% 32.7%
3250297 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.92 76.0 5.58e-01 99.2% 37.1%
2793930 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.92 75.0 5.37e-01 99.2% 33.4%
3242975 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.91 78.0 5.39e-01 100.0% 31.5%
3395889 219.1.1.2 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1,Propeptide_C1 0.91 78.0 5.47e-01 100.0% 33.4%
3510485 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.90 76.0 5.36e-01 100.0% 32.6%
4000671 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.89 75.0 5.65e-01 99.2% 40.8%
3261680 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.89 74.0 5.37e-01 99.2% 36.3%
3938586 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.87 75.0 5.67e-01 99.2% 41.9%
4047160 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.86 73.0 5.70e-01 98.4% 45.0%
4779630 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.86 41.0 5.55e-01 73.0% 84.1%
3579978 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.84 70.0 6.94e-01 97.5% 83.2%
3884055 219.1.1.110 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1, Peptidase_C1_2 0.84 71.0 5.46e-01 100.0% 43.1%
3996394 4.8.1.39 ↗ beta barrels › SH3 › Chromo domain-like › Chromo domain-like › Peptidase_C1 0.84 60.0 7.03e-01 83.6% 100.0%
None — 0.84 68.0 4.82e-01 100.0% 31.3%
3567565 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.83 68.0 5.01e-01 98.4% 35.9%
3940173 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.83 70.0 5.50e-01 99.2% 45.7%
4855772 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.83 69.0 6.29e-01 98.4% 68.6%
3699843 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.83 69.0 4.94e-01 100.0% 33.9%
3661135 219.1.1.0 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.83 70.0 4.98e-01 99.2% 33.2%
3679431 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.83 70.0 5.10e-01 99.2% 36.0%
4268173 219.1.1.0 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.82 70.0 4.85e-01 100.0% 29.9%
3617140 219.1.1.0 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.82 67.0 4.82e-01 96.7% 33.2%
3906939 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.82 75.0 5.42e-01 99.2% 38.4%
3710887 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.82 68.0 5.63e-01 100.0% 52.2%
3244679 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.82 78.0 5.27e-01 99.2% 37.8%
3216614 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.82 72.0 5.09e-01 99.2% 34.5%
3993778 219.1.1.0 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.82 70.0 5.40e-01 99.2% 44.5%
3807595 219.1.1.0 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.81 70.0 4.89e-01 99.2% 32.1%
3650468 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.81 69.0 6.21e-01 99.2% 67.5%
3421122 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.81 71.0 5.47e-01 100.0% 44.8%
None — 0.81 71.0 4.91e-01 98.4% 32.0%
4127832 219.1.1.0 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.81 70.0 5.06e-01 100.0% 36.3%
3564430 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.81 75.0 5.30e-01 99.2% 36.6%
None — 0.81 69.0 4.84e-01 100.0% 31.8%
None — 0.81 58.0 6.71e-01 82.8% 100.0%
3836765 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.81 69.0 5.43e-01 99.2% 46.6%
4059449 219.1.1.110 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1, Peptidase_C1_2 0.81 68.0 5.16e-01 100.0% 41.2%
5033092 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.81 69.0 5.11e-01 100.0% 38.9%
3668220 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.81 69.0 5.03e-01 99.2% 37.1%
3891882 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.80 71.0 5.19e-01 99.2% 39.3%
None — 0.80 70.0 4.93e-01 100.0% 33.6%
3620332 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.80 74.0 5.12e-01 96.7% 34.6%
3486878 219.1.1.110 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1, Peptidase_C1_2 0.80 75.0 5.35e-01 99.2% 38.2%
3392327 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.80 69.0 5.28e-01 98.4% 44.0%
3497089 219.1.1.0 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.80 75.0 5.38e-01 99.2% 39.3%
3419895 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.80 70.0 5.59e-01 99.2% 50.2%
3793700 219.1.1.110 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1, Peptidase_C1_2 0.80 69.0 6.25e-01 100.0% 69.4%
3443485 219.1.1.0 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.80 71.0 4.97e-01 100.0% 32.6%
3331216 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.80 70.0 6.47e-01 100.0% 75.3%
3574352 4.1.1.332 ↗ beta barrels › SH3 › SH3 › SH3 › Peptidase_C1 0.79 66.0 6.96e-01 95.9% 96.4%
3514380 219.1.1.110 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1, Peptidase_C1_2 0.78 74.0 5.35e-01 99.2% 40.3%
4663619 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.78 74.0 5.25e-01 99.2% 41.8%
3248099 219.1.1.0 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.78 67.0 4.75e-01 99.2% 33.2%
3299435 219.1.1.0 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.78 68.0 4.89e-01 98.4% 35.8%
3433434 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.78 67.0 5.46e-01 99.2% 51.6%
3519107 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.78 75.0 5.20e-01 100.0% 37.6%
3803751 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.77 62.0 5.01e-01 100.0% 47.4%
3705335 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.77 70.0 5.28e-01 100.0% 44.6%
5032667 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.76 70.0 5.03e-01 99.2% 37.2%
3806552 219.1.1.0 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.75 70.0 6.19e-01 98.4% 72.4%
3776905 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.75 71.0 5.42e-01 100.0% 47.7%
3481577 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.75 70.0 5.48e-01 99.2% 96.2%
3865831 219.1.1.0 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.75 71.0 5.02e-01 100.0% 38.2%
3233596 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.74 65.0 4.95e-01 100.0% 43.1%
3319851 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.74 69.0 5.62e-01 98.4% 80.5%
3466659 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.74 66.0 5.28e-01 100.0% 51.1%
3699969 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.74 69.0 5.13e-01 98.4% 48.4%
3803520 4.1.1.0 ↗ beta barrels › SH3 › SH3 › SH3 0.74 68.0 6.86e-01 96.7% 100.0%
3670468 4.1.1.332 ↗ beta barrels › SH3 › SH3 › SH3 › Peptidase_C1 0.73 56.0 5.52e-01 99.2% 74.6%
3995290 4.1.1.332 ↗ beta barrels › SH3 › SH3 › SH3 › Peptidase_C1 0.73 61.0 6.38e-01 89.3% 96.4%
3824556 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.73 65.0 5.21e-01 100.0% 51.3%
4030613 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.72 69.0 5.18e-01 100.0% 51.3%
4029993 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.72 69.0 4.59e-01 100.0% 33.0%
4026925 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.72 68.0 4.94e-01 100.0% 44.2%
4415790 219.1.1.1 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1 0.72 68.0 5.05e-01 100.0% 47.7%
3813985 219.1.1.124 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › PF29469 0.72 66.0 5.31e-01 98.4% 53.3%
3798312 4.8.1.0 ↗ beta barrels › SH3 › Chromo domain-like › Chromo domain-like 0.72 41.0 5.25e-01 93.4% 98.6%
3564972 4.1.1.0 ↗ beta barrels › SH3 › SH3 › SH3 0.71 37.0 4.63e-01 84.4% 85.7%
3444353 219.1.1.0 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.69 63.0 4.99e-01 96.7% 51.5%
4215561 219.1.1.17 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1_2 0.67 63.0 4.21e-01 100.0% 36.6%
4068454 219.1.1.110 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C1, Peptidase_C1_2 0.67 62.0 4.16e-01 100.0% 37.0%
7380 219.1.1.34 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C47 0.65 51.0 4.47e-01 98.4% 57.8%
3970000 4.1.1.0 ↗ beta barrels › SH3 › SH3 › SH3 0.63 40.0 4.42e-01 91.8% 79.0%
3597789 219.1.1.4 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C2 0.61 56.0 4.10e-01 100.0% 39.1%
3931053 4.25.1.2 ↗ beta barrels › SH3 › Auxin response factor dimerization domain and ancillary domain › Auxin response factor dimerization domain and ancillary domain › BRWD_AD 0.50 38.0 4.17e-01 86.1% 99.0%