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polyprotein_1a

Euk-Vir

Mamastrovirus_3

polyprotein_1a__YP_009924300__Mamastrovirus_3__1239567

Identity

Accession:: YP_009924300 ↗
Protein ID:: polyprotein_1a
Kingdom:: euk

Quality

63.4 mean pLDDT

Taxonomy

Orthornavirae› Pisuviricota› Stelpaviricetes› Stellavirales› Astroviridae› Mamastrovirus› Mamastrovirus_3

TaxID: 1239567

Cluster

Singleton — not in a non-trivial cluster

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 6-91

PDB

D2 high residues 151-165_228-387

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF19415.4 best	Astro_1A	164.8	4.00e-48	98.9%	68.0%

CATH (3)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
7utzR02	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.55	41.0	3.54e-01	76.6%	89.0%
4f4cA01	1.20.1560.10	Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain	0.52	39.0	2.60e-01	78.3%	91.2%
3agtA00	1.20.120.50	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hemerythrin-like	0.50	32.0	3.58e-01	84.0%	82.0%

ECOD (14)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3782664	5067.1.1.0 ↗	alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain	0.63	47.0	4.19e-01	77.1%	92.2%
5067364	5067.1.1.2 ↗	alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › SecD_SecF	0.61	44.0	4.16e-01	73.1%	93.2%
5047777	604.5.1.0 ↗	alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895)	0.60	43.0	4.10e-01	72.6%	99.5%
3210972	5001.1.1.0 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like	0.58	47.0	4.06e-01	86.3%	85.8%
3525755	5001.1.1.1 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1	0.57	48.0	4.01e-01	89.1%	96.3%
3240339	5067.1.1.3 ↗	alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Patched	0.57	41.0	3.68e-01	74.3%	85.3%
3267351	5001.1.1.32 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Solute_trans_a	0.57	43.0	3.65e-01	80.0%	82.6%
3729395	633.21.1.0 ↗	alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107	0.53	37.0	4.20e-01	70.3%	99.2%
3284249	5058.1.1.0 ↗	alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region	0.53	37.0	3.30e-01	72.0%	95.8%
4032097	1075.5.1.2 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MurJ	0.53	44.0	3.63e-01	89.1%	58.1%
3292918	5001.1.1.32 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Solute_trans_a	0.52	44.0	3.84e-01	91.4%	95.9%
4000438	5001.1.1.106 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7TM_GPCR_Str	0.51	43.0	3.83e-01	91.4%	96.5%
3724992	603.1.1.17 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › SNARE	0.50	35.0	3.07e-01	77.7%	46.8%
4054419	604.12.1.78 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › FUSC	0.50	39.0	3.99e-01	84.0%	84.8%

D3 high residues 805-880

PDB

Domain cluster: rep: C-terminal_part_of_the_orf1a_product__NP_751904__Human_astrovirus__1868658__D181-255

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF12285.13 best	Astrovir_pp_1	119.9	1.40e-34	100.0%	44.4%

D4 medium residues 431-505

PDB

Domain cluster: rep: ORF1a__YP_009162618__Dromedary_astrovirus__1662272__D428-481

D5 medium residues 506-578

PDB

Domain cluster: rep: ORF1a__YP_009047079__Human_astrovirus_BF34__1518575__D522-618