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protein_E12

Euk-Vir

Elephant_endotheliotropic_herpesvirus_4

protein_E12__YP_009179253__Elephant_endotheliotropic_herpesvirus_4__548914

Identity

Accession:
YP_009179253 ↗
Protein ID:
protein_E12
Kingdom:
euk

Quality

78.1 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Proboscivirus› Elephant_endotheliotropic_herpesvirus_4

TaxID: 548914

Cluster

View cluster (23 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 3-177
PDB
Domain cluster: rep: membrane_protein_EE40__YP_009052063__Elephant_endotheliotropic_herpesvirus_5__768738__D93-233
CATH (30)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2okuA00 1.20.120.470 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Acyl-CoA dehydrogenase, C-terminal domain 0.76 51.0 6.04e-01 80.0% 97.5%
2m6uA00 1.20.81.20 Mainly Alpha › Up-down Bundle › Receptor-associated Protein › 0.72 35.0 5.04e-01 81.7% 100.0%
3o6xA02 1.20.120.1560 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.69 49.0 5.31e-01 85.1% 85.8%
3ripA02 1.20.120.1900 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Gamma-tubulin complex, C-terminal domain 0.68 59.0 5.01e-01 91.4% 58.1%
2q7rB00 1.20.120.550 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Membrane associated eicosanoid/glutathione metabolism-like domain 0.68 44.0 4.78e-01 79.4% 77.6%
4bg5B00 1.10.3160.10 Mainly Alpha › Orthogonal Bundle › Bbcrasp-1 › Bbcrasp-1 0.65 50.0 4.84e-01 80.0% 95.5%
1at9A00 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.64 44.0 4.04e-01 70.3% 72.6%
1egdA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.64 46.0 5.08e-01 83.4% 90.8%
2jswA00 1.20.1410.10 Mainly Alpha › Up-down Bundle › I/LWEQ domain › I/LWEQ domain 0.63 54.0 5.26e-01 93.1% 83.6%
4nswB01 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.62 44.0 3.81e-01 72.6% 74.2%
4x28C03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.61 44.0 4.83e-01 81.1% 88.8%
1o5hA00 1.20.120.680 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Formiminotetrahydrofolate cyclodeaminase monomer, up-and-down helical bundle 0.59 53.0 5.07e-01 96.0% 88.5%
5iduC03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.58 43.0 4.55e-01 83.4% 83.6%
5af7B03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.58 43.0 4.67e-01 82.9% 89.9%
2pg0A03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.58 44.0 4.70e-01 82.9% 90.6%
2zy9A03 1.10.357.20 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › SLC41 divalent cation transporters, integral membrane domain 0.58 33.0 3.32e-01 98.3% 52.9%
8hk0C01 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.58 44.0 4.74e-01 82.3% 91.3%
1rx0A03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.58 44.0 4.63e-01 82.9% 87.7%
4rm7A03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.58 42.0 4.70e-01 80.6% 95.0%
2jifA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.58 43.0 4.60e-01 82.9% 87.7%
1siqA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.57 45.0 4.82e-01 83.4% 96.1%
3l39A01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.55 42.0 4.06e-01 79.4% 73.0%
3vkgA02 1.20.140.100 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Dynein motor heavy chain, linker domain, N-terminal subdomain 0.53 39.0 4.24e-01 78.3% 90.5%
6c1qB02 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.53 45.0 3.84e-01 89.7% 60.6%
2kbbA00 1.20.1420.10 Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain 0.53 40.0 4.03e-01 77.7% 91.4%
4mbsA00 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.52 44.0 3.51e-01 89.1% 49.7%
3lynB00 1.20.150.10 Mainly Alpha › Up-down Bundle › Lysin › Fertilization protein 0.52 30.0 3.47e-01 71.4% 79.0%
3ctwB00 1.10.8.930 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Protein of unknown function DUF1465 0.52 32.0 3.83e-01 79.4% 90.0%
2l6xA00 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.51 39.0 3.52e-01 78.3% 72.3%
3ljbA00 1.20.120.1240 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Dynamin, middle domain 0.50 37.0 3.47e-01 75.4% 73.1%
ECOD (65)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4371068 601.1.1.101 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › FKS1_dom2 0.77 47.0 5.61e-01 70.3% 89.2%
5038569 601.1.2.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) 0.75 54.0 6.17e-01 80.0% 99.2%
4943028 601.14.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › Hemerythrin › Hemerythrin 0.73 47.0 4.99e-01 84.6% 72.3%
3466552 3755.4.1.17 ↗ alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Rx_N 0.73 55.0 6.01e-01 78.3% 93.8%
3433667 611.9.1.4 ↗ alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain › Rx_N 0.73 56.0 5.99e-01 80.0% 92.7%
3926303 611.8.1.0 ↗ alpha bundles › N-cbl like › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 0.72 52.0 5.45e-01 78.9% 80.6%
3468403 601.1.2.74 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Rx_N 0.70 52.0 5.84e-01 75.4% 97.8%
3250501 611.8.1.1 ↗ alpha bundles › N-cbl like › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › Ariadne 0.70 52.0 5.34e-01 78.9% 80.0%
3444302 611.9.1.4 ↗ alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain › Rx_N 0.69 50.0 5.63e-01 78.3% 95.6%
3426161 601.1.2.74 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Rx_N 0.69 49.0 5.59e-01 78.3% 96.9%
3686404 3755.4.1.0 ↗ alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.69 51.0 5.29e-01 77.7% 80.6%
4218530 5038.2.1.1 ↗ alpha superhelices › Cytochrome c oxidase subunit I-like › MAPEG domain-like › MAPEG domain-like › MAPEG 0.68 49.0 5.52e-01 78.3% 94.1%
3702125 611.8.1.0 ↗ alpha bundles › N-cbl like › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 0.68 47.0 5.23e-01 80.0% 87.9%
3785224 601.1.1.101 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › FKS1_dom2 0.67 46.0 5.00e-01 81.1% 83.4%
3950427 633.6.1.2 ↗ alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › ACOX 0.67 52.0 5.34e-01 92.0% 83.5%
3563705 4177.1.1.4 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › IMD 0.66 46.0 4.20e-01 70.9% 82.6%
4947432 3755.4.1.0 ↗ alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.66 50.0 4.65e-01 78.9% 80.9%
3449004 109.3.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat 0.66 51.0 5.26e-01 97.7% 84.8%
3841126 5038.2.1.0 ↗ alpha superhelices › Cytochrome c oxidase subunit I-like › MAPEG domain-like › MAPEG domain-like 0.65 45.0 4.43e-01 82.3% 64.9%
1283835 3620.1.1.1 ↗ alpha bundles › Factor H-binding protein BbCRASP-1 › Factor H-binding protein BbCRASP-1 › Factor H-binding protein BbCRASP-1 › PFam54_60 0.65 50.0 4.80e-01 80.0% 95.5%
4656380 3755.4.1.24 ↗ alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › DUF2463 0.65 49.0 4.48e-01 78.3% 81.3%
3545649 7579.1.1.66 ↗ a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › HSL_N 0.65 58.0 5.40e-01 96.6% 92.3%
3239453 601.1.2.1 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Vinculin 0.63 46.0 5.16e-01 93.1% 97.8%
3275050 5001.1.1.8 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › HlyIII 0.63 44.0 3.79e-01 70.3% 97.1%
3481085 5001.1.1.0 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like 0.62 44.0 3.67e-01 72.0% 94.2%
5048730 109.3.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat 0.61 43.0 4.38e-01 81.7% 72.4%
3230889 5082.1.1.0 ↗ alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like 0.61 45.0 4.40e-01 75.4% 97.9%
3725297 3755.4.1.45 ↗ alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › PF30922 0.61 46.0 4.97e-01 81.7% 92.7%
3391723 5073.1.1.11 ↗ alpha bundles › Calcium ATPase transmembrane domain-related › Calcium ATPase transmembrane domain-related › Calcium ATPase transmembrane domain M › Cation_ATPase_C 0.61 55.0 4.14e-01 99.4% 92.2%
3286771 633.6.1.0 ↗ alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like 0.60 45.0 4.97e-01 82.3% 95.7%
3581031 5001.1.1.1 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.60 49.0 4.93e-01 92.0% 85.1%
3994896 5067.1.1.3 ↗ alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Patched 0.59 39.0 4.16e-01 89.7% 74.8%
3940746 5067.1.1.3 ↗ alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Patched 0.59 42.0 4.08e-01 88.0% 64.0%
54352 133.2.1.0 ↗ alpha bundles › DH domain-like › Methenyltetrahydrofolate cyclohydrolase-like › Methenyltetrahydrofolate cyclohydrolase-like 0.58 53.0 5.07e-01 96.0% 89.4%
2895122 133.2.1.1 ↗ alpha bundles › DH domain-like › Methenyltetrahydrofolate cyclohydrolase-like › Methenyltetrahydrofolate cyclohydrolase-like › FTCD_C 0.58 52.0 4.91e-01 94.3% 91.2%
3617575 5067.1.1.3 ↗ alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Patched 0.58 42.0 3.72e-01 82.9% 50.4%
3292478 633.4.1.1 ↗ alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI 0.57 41.0 4.16e-01 83.4% 74.7%
3343869 5001.1.1.122 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › PF27754 0.57 49.0 4.02e-01 91.4% 62.6%
3770675 5001.1.1.1 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.56 48.0 3.98e-01 89.7% 53.9%
3460645 4177.1.1.0 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like 0.56 41.0 3.14e-01 74.9% 51.1%
3422917 633.4.1.1 ↗ alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI 0.55 36.0 3.81e-01 80.0% 71.2%
4017168 150.1.1.114 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › PF30036 0.54 41.0 4.37e-01 80.0% 89.0%
3700079 5082.1.1.1 ↗ alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation_efflux 0.54 47.0 4.32e-01 93.1% 96.4%
4978600 4177.1.1.0 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like 0.54 39.0 3.96e-01 90.9% 74.7%
3628109 5001.1.1.0 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like 0.54 46.0 3.51e-01 93.1% 81.6%
5028719 5076.2.1.0 ↗ alpha complex topology › Mitochondrial ADP/ATP carrier-like › Putative sulfate permease CysZ › Putative sulfate permease CysZ 0.54 37.0 3.34e-01 70.9% 49.0%
3936672 5001.1.1.0 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like 0.53 45.0 3.56e-01 90.3% 47.2%
3726525 7531.1.1.1 ↗ a/b three-layered sandwiches › Carbamate kinase-like › Carbamate kinase-like › Carbamate kinase-like › AA_kinase 0.53 46.0 3.56e-01 92.0% 65.3%
4946816 5067.1.1.4 ↗ alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › MMPL 0.53 42.0 4.06e-01 98.3% 74.0%
3231966 5001.1.1.0 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like 0.53 45.0 3.83e-01 92.0% 56.9%
4023423 5057.1.1.0 ↗ alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore 0.53 42.0 4.18e-01 82.9% 82.2%
4306505 5067.1.1.2 ↗ alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › SecD_SecF 0.53 43.0 4.08e-01 94.9% 72.4%
3655748 601.1.2.118 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › CASP_dom 0.52 39.0 4.21e-01 84.6% 91.9%
3534607 5001.1.1.23 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › GOST_TM 0.52 42.0 3.70e-01 89.1% 56.9%
3273178 633.21.1.0 ↗ alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 0.52 41.0 3.96e-01 93.7% 73.8%
3246412 5067.1.1.3 ↗ alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Patched 0.52 41.0 3.73e-01 95.4% 61.2%
3767178 5001.1.1.1 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.52 44.0 3.43e-01 90.3% 81.9%
4980789 304.28.1.0 ↗ a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain 0.51 39.0 3.00e-01 97.7% 33.5%
3270762 5001.1.1.31 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › GPR180-TMEM145_TM 0.51 43.0 3.78e-01 89.1% 60.4%
3579239 633.7.1.0 ↗ alpha bundles › Bromodomain-like › Bacillus cereus metalloprotein-like › Bacillus cereus metalloprotein-like 0.51 40.0 4.24e-01 84.6% 92.9%
3231443 3758.1.1.0 ↗ alpha bundles › Bacterial hemolysins-like › Bacterial hemolysins › Bacterial hemolysins 0.51 41.0 3.56e-01 83.4% 81.1%
4026688 5001.1.1.0 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like 0.51 39.0 3.45e-01 88.0% 53.2%
4286470 5067.1.1.2 ↗ alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › SecD_SecF 0.50 41.0 3.92e-01 97.1% 74.1%
3281493 5079.1.1.1 ↗ alpha duplicates or obligate multimers › Magnesium transporter MgtE membrane domain › Magnesium transporter MgtE membrane domain › Magnesium transporter MgtE membrane domain › MgtE 0.50 34.0 3.38e-01 73.7% 62.6%
3252194 5001.1.1.23 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › GOST_TM 0.50 41.0 3.62e-01 86.9% 58.8%
D2 medium residues 178-234
PDB
Domain cluster: representative
CATH (56)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2hujA00 1.20.120.440 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like 0.76 64.0 4.85e-01 91.2% 100.0%
4e4eA01 1.10.287.990 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain 0.75 64.0 5.95e-01 94.7% 95.8%
4aflA00 6.10.140.1740 Special › Helix non-globular › Helix Hairpins › 0.74 64.0 5.29e-01 96.5% 63.7%
3rklA00 6.10.140.1640 Special › Helix non-globular › Helix Hairpins › 0.74 67.0 5.95e-01 100.0% 90.0%
1ku9A02 1.10.287.450 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.74 63.0 6.12e-01 94.7% 90.6%
6vq6G02 1.20.1460.10 Mainly Alpha › Up-down Bundle › subunit c (vma5p) of the yeast v-atpase, domain 2 › subunit c (vma5p) of the yeast v-atpase, domain 2 0.74 64.0 4.44e-01 96.5% 90.8%
3lbxB01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.73 59.0 4.77e-01 87.7% 68.2%
1zkeA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.73 60.0 5.37e-01 93.0% 97.5%
4ijjB00 1.20.120.910 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › DksA, coiled-coil domain 0.73 58.0 4.46e-01 87.7% 60.0%
6r1nA01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.72 63.0 5.14e-01 96.5% 56.3%
1vx7301 1.10.287.310 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.71 64.0 5.87e-01 100.0% 89.2%
4e6nA02 6.10.140.1010 Special › Helix non-globular › Helix Hairpins › 0.71 62.0 5.88e-01 96.5% 83.3%
4h63H01 1.20.58.1710 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.71 58.0 5.35e-01 89.5% 83.3%
3lnnB03 1.10.287.470 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.71 59.0 5.66e-01 94.7% 94.0%
3n5lA03 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.71 60.0 6.09e-01 96.5% 98.2%
2b5uA02 1.10.287.620 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix Hairpins 0.70 59.0 4.30e-01 94.7% 33.5%
1ykhA00 6.10.140.200 Special › Helix non-globular › Helix Hairpins › 0.70 60.0 5.08e-01 96.5% 64.2%
3iq2A00 3.30.1520.10 Alpha Beta › 2-Layer Sandwich › PX Domain › Phox-like domain 0.69 45.0 3.43e-01 78.9% 30.9%
1fs0G02 1.10.287.80 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain 0.68 61.0 5.17e-01 96.5% 68.5%
3vovA02 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.68 57.0 4.22e-01 94.7% 51.3%
2b5dX02 1.20.1430.10 Mainly Alpha › Up-down Bundle › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase, middle domain 0.68 58.0 4.60e-01 94.7% 49.1%
3purA03 1.20.58.1360 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.67 57.0 4.73e-01 100.0% 65.5%
2etnB01 1.10.287.180 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Transcription elongation factor, GreA/GreB, N-terminal domain 0.67 55.0 5.13e-01 96.5% 75.0%
1s5jA04 1.10.287.690 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › B family DNA polymerase, finger domain 0.67 54.0 5.29e-01 91.2% 90.2%
1hr5A00 1.20.5.420 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C 0.67 49.0 5.13e-01 96.5% 95.8%
1zoyA03 1.20.58.100 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain 0.67 57.0 4.58e-01 98.2% 55.6%
4nsmA00 6.10.250.2770 Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.67 53.0 5.01e-01 89.5% 94.4%
2xokP00 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.67 54.0 5.06e-01 94.7% 81.1%
2e9xA01 1.20.58.1030 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.66 57.0 4.48e-01 100.0% 64.8%
2gtaA00 1.10.287.1080 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like 0.66 59.0 4.93e-01 100.0% 72.2%
1f45B00 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.65 54.0 4.28e-01 100.0% 80.5%
4egwA02 1.20.58.340 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region 0.64 53.0 4.35e-01 100.0% 78.2%
7oq4Z01 1.20.120.950 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Uncharacterised protein DUF5062 0.61 48.0 4.06e-01 98.2% 50.0%
5w0kA01 3.90.380.20 Alpha Beta › Alpha-Beta Complex › Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1 › Herpesvirus glycoprotein H, domain D-II 0.61 50.0 3.20e-01 100.0% 17.5%
6v88A00 3.30.710.10 Alpha Beta › 2-Layer Sandwich › Potassium Channel Kv1.1; Chain A › Potassium Channel Kv1.1; Chain A 0.61 45.0 3.62e-01 84.2% 39.7%
2qkdA04 2.60.120.1040 Mainly Beta › Sandwich › Jelly Rolls › ZPR1, A/B domain 0.60 48.0 3.72e-01 89.5% 66.1%
3f1iS00 1.20.5.1940 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.60 44.0 4.10e-01 98.2% 62.3%
1ysqA00 3.30.450.40 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › GAF domain 0.60 46.0 3.24e-01 82.5% 95.0%
1vq8V00 1.10.287.310 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.60 49.0 4.80e-01 98.2% 92.3%
1u7lA02 1.20.1460.10 Mainly Alpha › Up-down Bundle › subunit c (vma5p) of the yeast v-atpase, domain 2 › subunit c (vma5p) of the yeast v-atpase, domain 2 0.59 49.0 3.55e-01 98.2% 31.7%
3l1nA01 6.10.140.790 Special › Helix non-globular › Helix Hairpins › 0.59 43.0 4.45e-01 84.2% 96.1%
2kg7B00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.58 46.0 4.01e-01 93.0% 86.6%
3lphC00 6.10.140.630 Special › Helix non-globular › Helix Hairpins › 0.58 46.0 4.67e-01 89.5% 94.8%
5dukB00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.58 40.0 3.81e-01 75.4% 61.2%
2d2sA02 1.20.58.1220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Exo84p, C-terminal helical domain 0.58 50.0 4.13e-01 96.5% 93.1%
2lpeA01 6.10.140.1120 Special › Helix non-globular › Helix Hairpins › 0.57 46.0 4.29e-01 96.5% 78.2%
1hbkA00 1.20.80.10 Mainly Alpha › Up-down Bundle › Acyl-CoA Binding Protein › 0.56 37.0 3.30e-01 96.5% 43.8%
3lnrA00 1.20.120.1530 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.55 44.0 3.26e-01 91.2% 33.1%
3h6pC00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.55 44.0 4.50e-01 94.7% 98.2%
2ajeA00 1.10.246.220 Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › 0.54 35.0 3.02e-01 78.9% 38.1%
1m6nA04 1.10.3060.10 Mainly Alpha › Orthogonal Bundle › Helical scaffold and wing domains of SecA › Helical scaffold and wing domains of SecA 0.54 43.0 3.36e-01 89.5% 37.8%
1w5sA01 1.10.8.60 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › 0.54 39.0 3.36e-01 78.9% 48.9%
4nzpA01 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.53 37.0 2.74e-01 73.7% 29.7%
2e62A01 6.10.140.420 Special › Helix non-globular › Helix Hairpins › 0.53 41.0 4.25e-01 84.2% 100.0%
3ic9A02 1.10.287.990 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain 0.52 41.0 3.86e-01 86.0% 95.7%
2vvlG01 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.51 40.0 2.68e-01 91.2% 31.6%
ECOD (52)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3929097 4163.1.1.0 ↗ alpha bundles › GINS helical bundle-like › GINS helical bundle-like › PSF1 N-terminal domain-like 0.77 69.0 5.23e-01 100.0% 63.1%
3470995 109.4.1.470 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › INTS2 0.75 66.0 3.92e-01 98.2% 13.3%
3581368 5086.1.1.0 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.74 63.0 4.63e-01 94.7% 40.7%
3990854 192.7.1.0 ↗ alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm 0.74 63.0 5.41e-01 94.7% 65.6%
5040661 605.1.1.1 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA 0.74 64.0 5.96e-01 96.5% 88.6%
3356655 170.1.1.0 ↗ alpha bundles › Retrovirus capsid protein › Retrovirus capsid protein-C › Retrovirus capsid protein-C 0.72 60.0 5.57e-01 91.2% 72.9%
1145707 650.1.1.3 ↗ alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › HsbA 0.72 56.0 5.12e-01 94.7% 64.0%
3399808 192.2.1.0 ↗ alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.72 63.0 4.62e-01 100.0% 85.2%
3861615 150.1.1.190 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › SAP130_C 0.71 60.0 5.04e-01 96.5% 68.0%
4572974 3922.1.1.79 ↗ alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › SAP130_C 0.71 60.0 4.77e-01 96.5% 47.0%
3382610 4177.1.1.0 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like 0.71 60.0 3.87e-01 96.5% 22.6%
3599499 3755.3.1.0 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.70 61.0 4.46e-01 96.5% 38.7%
3711734 3755.3.1.297 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › KIF9 0.70 61.0 4.33e-01 96.5% 33.3%
4946656 3755.3.1.0 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.70 60.0 4.72e-01 96.5% 48.3%
4944746 5038.1.1.0 ↗ alpha superhelices › Cytochrome c oxidase subunit I-like › Cytochrome c oxidase subunit I-like › Cytochrome c oxidase subunit I-like 0.70 60.0 3.55e-01 98.2% 12.5%
3715946 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.69 57.0 4.50e-01 94.7% 52.8%
3721941 622.4.1.0 ↗ alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related 0.69 57.0 5.14e-01 93.0% 70.0%
3832267 192.5.1.0 ↗ alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat 0.69 60.0 4.94e-01 96.5% 57.0%
3795092 622.4.1.0 ↗ alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related 0.68 61.0 4.59e-01 100.0% 71.1%
3421046 101.1.1.0 ↗ alpha arrays › HTH › HTH › Three-helical HTH 0.68 59.0 5.05e-01 96.5% 64.4%
4961508 605.1.1.0 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.68 57.0 5.25e-01 96.5% 76.0%
5050590 3352.1.1.0 ↗ alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain 0.68 57.0 3.55e-01 96.5% 17.6%
4175809 5086.1.1.88 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_CyaD 0.67 56.0 4.09e-01 96.5% 35.8%
4949374 616.1.1.0 ↗ alpha arrays › S15/NS1 RNA-binding domain › S15/NS1 RNA-binding domain › S15/NS1 RNA-binding domain 0.67 54.0 5.22e-01 91.2% 81.5%
4941837 5069.1.1.0 ↗ alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes 0.67 57.0 4.39e-01 96.5% 44.6%
4197529 4992.1.1.23 ↗ extended segments › RelB-like › RelB-like › RelB-like › Seryl_tRNA_N 0.66 54.0 4.47e-01 96.5% 52.7%
2141223 5055.1.1.1 ↗ extended segments › Small-conductance potassium channel › Small-conductance potassium channel › Small-conductance potassium channel › CaMBD 0.65 52.0 4.54e-01 94.7% 72.6%
5018636 605.1.1.3 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA_2 0.65 54.0 5.09e-01 96.5% 81.4%
3574610 3755.4.1.0 ↗ alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.65 53.0 3.71e-01 94.7% 69.0%
4613904 4168.1.1.1 ↗ alpha duplicates or obligate multimers › HAMP domain › HAMP domain › HAMP domain › HAMP 0.64 44.0 4.42e-01 100.0% 70.0%
3385950 5086.1.1.0 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.64 52.0 5.01e-01 96.5% 85.7%
3794016 4106.1.1.1 ↗ few secondary structure elements › Zinc hairpin stack › Zinc hairpin stack › Zinc hairpin stack › DHHC 0.64 56.0 3.60e-01 96.5% 23.1%
3917479 3755.3.1.0 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.64 56.0 3.73e-01 96.5% 28.4%
3279822 174.1.1.0 ↗ few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.64 55.0 4.32e-01 96.5% 48.3%
3410408 3712.1.1.0 ↗ a+b complex topology › Mediator of RNA polymerase II transcription subunit 11 › Mediator of RNA polymerase II transcription subunit 11 › Mediator of RNA polymerase II transcription subunit 11 0.64 52.0 4.66e-01 94.7% 65.5%
3932729 630.1.1.0 ↗ a+b complex topology › RuBisCo LSMT C-terminal, substrate-binding domain › RuBisCo LSMT C-terminal, substrate-binding domain › RuBisCo LSMT C-terminal, substrate-binding domain 0.63 51.0 4.06e-01 93.0% 68.8%
3184140 5086.1.1.87 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › ING 0.63 51.0 4.18e-01 94.7% 74.8%
3937465 148.1.3.0 ↗ alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain 0.63 51.0 3.56e-01 96.5% 26.5%
3588980 4168.1.1.0 ↗ alpha duplicates or obligate multimers › HAMP domain › HAMP domain › HAMP domain 0.63 47.0 4.41e-01 89.5% 65.7%
3205434 4168.1.1.1 ↗ alpha duplicates or obligate multimers › HAMP domain › HAMP domain › HAMP domain › HAMP 0.62 40.0 3.91e-01 86.0% 58.5%
3693675 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.62 52.0 4.09e-01 100.0% 54.1%
3470607 109.4.1.307 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Tho2 0.61 53.0 3.40e-01 98.2% 30.2%
3670748 5086.1.1.0 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.59 51.0 3.90e-01 100.0% 51.4%
3608778 650.1.1.0 ↗ alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain 0.59 47.0 4.52e-01 94.7% 78.6%
3499862 148.1.3.0 ↗ alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain 0.58 39.0 3.09e-01 78.9% 33.3%
3323862 611.9.1.4 ↗ alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain › Rx_N 0.57 44.0 4.09e-01 94.7% 63.7%
407167 3824.1.1.1 ↗ alpha bundles › HIV Rev › HIV Rev › HIV Rev › REV 0.57 46.0 4.56e-01 93.0% 96.8%
3880333 2004.1.1.5 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ABC_tran 0.56 48.0 3.11e-01 100.0% 37.9%
5032595 2004.1.1.42 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › T2SSE 0.55 46.0 2.74e-01 94.7% 25.7%
3942799 210.1.1.1 ↗ a+b four layers › Ntn/PP2C › Ntn › Proteasome subunits › Proteasome 0.54 42.0 2.83e-01 87.7% 53.9%
3505603 101.1.2.0 ↗ alpha arrays › HTH › HTH › winged helix domain 0.54 44.0 3.94e-01 89.5% 68.8%
3930913 5.1.4.39 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › ANAPC4_WD40 0.50 39.0 2.52e-01 91.2% 17.6%