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protein_UL27
Euk-VirHuman_herpesvirus_5
protein_UL27__YP_002608241__Human_herpesvirus_5__10359
Identity
- Accession:
- YP_002608241 ↗
- Protein ID:
- protein_UL27
- Kingdom:
- euk
Quality
73.4
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Cytomegalovirus›
Human_betaherpesvirus_5
TaxID: 10359
Cluster
View cluster (26 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 202-284_314-407
Domain cluster:
rep: protein_UL27__YP_004940053__Aotine_betaherpesvirus_1__50290__D178-261_284-374
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF05999.17 best | Herpes_U5 | 158.4 | 4.10e-46 | 53.7% | 20.1% |
| PF05999.17 | Herpes_U5 | 144.0 | 9.60e-42 | 48.6% | 18.0% |
D2
medium
residues 30-84_99-149_492-533
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF05999.17 best | Herpes_U5 | 46.4 | 3.80e-12 | 58.8% | 15.4% |
CATH (5)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3dd9D02 | 6.10.140.2060 | Special › Helix non-globular › Helix Hairpins › | 0.60 | 18.0 | 3.41e-01 | 88.5% | 95.1% |
| 1iufA01 | 1.10.10.60 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like | 0.55 | 21.0 | 2.74e-01 | 73.0% | 59.7% |
| 2xzmV01 | 1.10.60.20 | Mainly Alpha › Orthogonal Bundle › Diphtheria Toxin Repressor; domain 2 › Ribosomal protein S17 | 0.54 | 21.0 | 3.01e-01 | 73.6% | 78.7% |
| 2no4A02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.52 | 24.0 | 3.26e-01 | 70.3% | 84.0% |
| 3o2iA00 | 3.30.70.2710 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.50 | 24.0 | 2.88e-01 | 93.2% | 65.6% |
ECOD (2)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3943035 | 639.2.1.0 ↗ | alpha arrays › HHA-like › Regulator of acid resistance influenced by indole (AriR) › Regulator of acid resistance influenced by indole (AriR) | 0.58 | 24.0 | 3.41e-01 | 89.9% | 83.1% |
| 3572161 | 541.1.1.12 ↗ | alpha duplicates or obligate multimers › Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit › Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit › Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit › PF30825 | 0.52 | 24.0 | 3.02e-01 | 92.6% | 71.1% |
D3
medium
residues 150-198_411-491_534-560
Domain cluster:
representative
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF05999.17 best | Herpes_U5 | 137.3 | 1.10e-39 | 57.3% | 17.6% |
| PF05999.17 | Herpes_U5 | 44.4 | 1.50e-11 | 23.6% | 7.4% |
CATH (31)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1yo7A00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.79 | 43.0 | 4.93e-01 | 79.0% | 70.8% |
| 3onjA00 | 1.20.58.400 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins | 0.75 | 44.0 | 5.52e-01 | 78.3% | 93.8% |
| 7w9wA01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.75 | 54.0 | 4.51e-01 | 73.9% | 86.6% |
| 1qkrB00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.74 | 52.0 | 4.97e-01 | 72.0% | 86.7% |
| 1xzpA02 | 1.20.120.430 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › tRNA modification GTPase MnmE domain 2 | 0.70 | 48.0 | 4.78e-01 | 70.1% | 72.9% |
| 3ajmB02 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.69 | 48.0 | 5.17e-01 | 70.7% | 85.0% |
| 1sumB02 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.69 | 42.0 | 4.76e-01 | 83.4% | 80.5% |
| 3axjB02 | 1.20.58.200 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 | 0.64 | 35.0 | 4.54e-01 | 76.4% | 96.5% |
| 3l39A01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.62 | 48.0 | 4.39e-01 | 79.0% | 83.5% |
| 1dd5A01 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.62 | 40.0 | 4.74e-01 | 82.2% | 94.5% |
| 3ck6C02 | 1.20.58.340 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region | 0.61 | 40.0 | 4.52e-01 | 83.4% | 87.4% |
| 4oydB00 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.61 | 42.0 | 4.76e-01 | 83.4% | 94.0% |
| 8ek4A01 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.60 | 44.0 | 4.78e-01 | 83.4% | 90.2% |
| 3edvB01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.60 | 40.0 | 4.29e-01 | 83.4% | 78.7% |
| 4kb2A01 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.60 | 40.0 | 4.71e-01 | 83.4% | 98.2% |
| 6xxvC00 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.59 | 39.0 | 4.54e-01 | 83.4% | 95.5% |
| 2d2sA01 | 1.20.58.1210 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Exo84p, N-terminal helical domain | 0.58 | 36.0 | 4.12e-01 | 79.0% | 82.8% |
| 3pe0A02 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.58 | 35.0 | 4.17e-01 | 79.6% | 88.7% |
| 1xwmA00 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.58 | 47.0 | 4.29e-01 | 86.0% | 81.1% |
| 1w99A01 | 1.20.190.10 | Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › Pesticidal crystal protein, N-terminal domain | 0.57 | 49.0 | 4.72e-01 | 96.8% | 81.5% |
| 2pusA04 | 6.10.140.300 | Special › Helix non-globular › Helix Hairpins › | 0.57 | 38.0 | 4.53e-01 | 98.7% | 99.1% |
| 3qsgA02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.57 | 29.0 | 3.35e-01 | 74.5% | 65.2% |
| 3uumA00 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.56 | 39.0 | 4.35e-01 | 83.4% | 91.0% |
| 2uvaG01 | 1.20.1050.120 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.56 | 37.0 | 3.97e-01 | 88.5% | 77.2% |
| 2mabA00 | 1.10.10.1350 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Spidroin domain, C-terminal domain | 0.55 | 31.0 | 3.61e-01 | 79.6% | 77.1% |
| 1zcdA00 | 1.20.1530.10 | Mainly Alpha › Up-down Bundle › Na+/H+ antiporter like fold › Na+/H+ antiporter like domain | 0.53 | 41.0 | 3.18e-01 | 82.2% | 72.9% |
| 2r40D00 | 1.10.565.10 | Mainly Alpha › Orthogonal Bundle › Retinoid X Receptor › Retinoid X Receptor | 0.52 | 41.0 | 3.68e-01 | 85.4% | 93.6% |
| 2qvaA01 | 1.20.58.190 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 1 | 0.52 | 36.0 | 3.93e-01 | 100.0% | 86.8% |
| 1t9kA01 | 1.20.120.420 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › translation initiation factor eif-2b, domain 1 | 0.51 | 34.0 | 3.56e-01 | 79.6% | 72.9% |
| 4mh6A00 | 1.10.287.1700 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.51 | 34.0 | 3.48e-01 | 70.7% | 67.3% |
| 6vxcA01 | 3.20.70.20 | Alpha Beta › Alpha-Beta Barrel › Anaerobic Ribonucleotide-triphosphate Reductase Large Chain › | 0.50 | 45.0 | 2.85e-01 | 96.8% | 75.8% |
ECOD (23)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3485322 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.71 | 42.0 | 4.62e-01 | 79.0% | 71.5% |
| 3613994 | 192.29.1.19 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › Cornichon | 0.70 | 54.0 | 5.14e-01 | 79.6% | 82.2% |
| 3293665 | 5001.1.1.0 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like | 0.68 | 50.0 | 4.08e-01 | 74.5% | 80.7% |
| 4213065 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.66 | 47.0 | 4.76e-01 | 83.4% | 72.5% |
| 3269731 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.65 | 47.0 | 5.40e-01 | 83.4% | 100.0% |
| 3733145 | 633.23.1.0 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin | 0.63 | 43.0 | 4.52e-01 | 80.9% | 76.4% |
| 4980095 | 310.2.1.0 ↗ | a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF | 0.63 | 40.0 | 4.71e-01 | 82.2% | 94.3% |
| 3578921 | 3937.1.1.2 ↗ | alpha bundles › Connexin 26 › Connexin 26 › Connexin 26 › Innexin | 0.61 | 49.0 | 3.70e-01 | 85.4% | 97.6% |
| 4668212 | 604.5.1.2 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU | 0.59 | 45.0 | 4.26e-01 | 79.0% | 80.0% |
| 3705131 | 109.4.1.1276 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › FAT, HEAT_ATR | 0.55 | 38.0 | 3.13e-01 | 70.1% | 47.3% |
| 3786830 | 109.10.1.1 ↗ | alpha superhelices › Repetitive alpha hairpins › Translin › Translin › Translin | 0.54 | 44.0 | 3.96e-01 | 86.6% | 97.7% |
| 3366153 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.54 | 43.0 | 4.19e-01 | 82.8% | 98.8% |
| 3267346 | 109.4.1.25 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › DIL | 0.54 | 44.0 | 3.19e-01 | 85.4% | 86.0% |
| 3607963 | 3883.1.1.1 ↗ | alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf | 0.54 | 42.0 | 3.93e-01 | 82.8% | 77.9% |
| 3530780 | 310.2.1.2 ↗ | a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF › MIX23 | 0.53 | 42.0 | 4.59e-01 | 85.4% | 100.0% |
| 3497110 | 109.46.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › Helical domain in TOPLESS related protein 2 (TPR2) › Helical domain in TOPLESS related protein 2 (TPR2) | 0.53 | 38.0 | 3.93e-01 | 74.5% | 78.7% |
| 3970612 | 3651.1.1.1 ↗ | alpha bundles › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › IF-2B | 0.53 | 34.0 | 3.60e-01 | 77.1% | 72.1% |
| 4974945 | 1075.5.1.8 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt_3 | 0.52 | 40.0 | 3.72e-01 | 79.6% | 74.9% |
| 3417771 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.52 | 42.0 | 3.72e-01 | 85.4% | 68.0% |
| 3640629 | 3843.1.1.0 ↗ | alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K | 0.52 | 43.0 | 4.20e-01 | 87.9% | 93.5% |
| 3405912 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.52 | 44.0 | 4.18e-01 | 91.7% | 100.0% |
| 3594379 | 109.5.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › adenylylcyclase associated protein, CAP-N › adenylylcyclase associated protein, CAP-N | 0.51 | 42.0 | 3.90e-01 | 91.7% | 90.5% |
| 3330285 | 7064.1.1.1 ↗ | alpha bundles › Transmembrane domain of VIT1 › Transmembrane domain of VIT1 › Transmembrane domain of VIT1 › VIT1 | 0.50 | 36.0 | 3.85e-01 | 73.9% | 86.7% |