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putative_5-3_exonuclease_20

Euk-Vir

Acanthamoeba_polyphaga_mimivirus

putative_5-3_exonuclease_20__YP_003987041__Acanthamoeba_polyphaga_mimivirus__212035

Identity

Accession:
YP_003987041 ↗
Protein ID:
putative_5-3_exonuclease_20
Kingdom:
euk

Quality

53.4 mean pLDDT

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 333-482
PDB
D2 medium residues 16-37_131-148_205-313
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03159.25 best XRN_N 59.4 5.30e-16 69.1% 39.0%
CATH (65)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3pieC01 3.40.50.12390 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.81 77.0 6.18e-01 100.0% 66.5%
2wteA01 3.40.50.11700 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.67 57.0 5.88e-01 89.9% 98.6%
2qtlA03 3.40.50.80 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module 0.64 48.0 4.76e-01 77.9% 100.0%
1tfrA01 3.40.50.1010 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 5'-nuclease 0.64 55.0 4.88e-01 90.6% 77.7%
3tkaA01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.62 56.0 5.17e-01 96.0% 96.7%
6yu8A01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.62 56.0 4.71e-01 100.0% 88.4%
1ygpA02 3.40.50.2000 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B; 0.62 53.0 4.00e-01 91.3% 74.1%
4wnyA00 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.61 49.0 5.12e-01 83.9% 97.0%
3k0bA02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.60 52.0 4.90e-01 93.3% 88.2%
5ktkA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.59 53.0 3.78e-01 99.3% 71.7%
5ix8A02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.58 43.0 4.24e-01 89.9% 72.3%
7zveA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.58 50.0 4.58e-01 91.9% 92.6%
3rotA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.58 43.0 4.52e-01 86.6% 84.7%
2z0mA01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.58 45.0 4.19e-01 83.2% 89.0%
2ywrA00 3.40.50.170 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Formyl transferase, N-terminal domain 0.58 48.0 4.31e-01 91.3% 90.2%
1nxzB02 3.40.1280.10 Alpha Beta › 3-Layer(aba) Sandwich › Alpha/beta knot › SPOUT methyltransferase, trefoil knot domain 0.57 47.0 4.53e-01 87.9% 89.6%
4y9tA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.57 45.0 4.27e-01 83.2% 79.5%
3lkbA01 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.57 43.0 3.84e-01 78.5% 96.3%
3p9xA00 3.40.50.170 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Formyl transferase, N-terminal domain 0.57 48.0 4.37e-01 90.6% 75.4%
4ru1A02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.57 41.0 4.14e-01 85.9% 74.3%
3zm6A03 3.90.190.20 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Mur ligase, C-terminal domain 0.57 43.0 4.34e-01 79.9% 98.0%
4ydsA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.57 48.0 4.25e-01 94.0% 85.8%
4cidA02 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.56 42.0 3.64e-01 76.5% 87.8%
3gbvA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.56 44.0 4.49e-01 83.2% 87.9%
2vk2A02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.56 45.0 4.39e-01 85.2% 83.6%
3m9wA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.56 43.0 4.20e-01 80.5% 86.4%
3cr8C02 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.56 45.0 4.10e-01 85.2% 69.2%
3d02A02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.56 44.0 4.43e-01 83.9% 88.2%
3lteD00 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.56 37.0 4.07e-01 87.2% 81.3%
6f2xA01 3.40.50.1000 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HAD superfamily/HAD-like 0.56 46.0 4.64e-01 88.6% 98.7%
1iayA02 3.40.640.10 Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) 0.55 50.0 4.21e-01 98.7% 71.6%
1gd9A02 3.40.640.10 Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) 0.55 50.0 4.38e-01 98.7% 79.4%
3ksmA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.55 42.0 4.21e-01 85.2% 78.7%
6qp2A01 3.40.640.10 Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) 0.55 50.0 4.29e-01 98.7% 71.4%
1peaA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.55 46.0 4.43e-01 91.9% 81.8%
5if3B00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.55 46.0 4.14e-01 89.9% 81.3%
3hcwA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.55 45.0 4.57e-01 87.2% 93.0%
1pyoC00 3.40.50.1460 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.55 41.0 4.07e-01 79.2% 78.9%
3hutA01 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.55 40.0 3.73e-01 77.2% 98.0%
4yo7A02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.55 43.0 4.23e-01 81.9% 87.2%
2h3hB02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.54 43.0 4.23e-01 83.2% 87.3%
4rxtA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.54 43.0 4.30e-01 85.2% 88.6%
4joqA01 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.54 41.0 4.18e-01 77.9% 94.3%
4gnrA01 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.54 40.0 3.67e-01 77.2% 97.5%
3ug7C00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.54 45.0 3.66e-01 91.3% 78.1%
5dteA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.54 43.0 4.27e-01 83.2% 87.6%
6mnuD00 3.90.550.10 Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A 0.54 42.0 3.46e-01 83.9% 92.7%
2x5dD02 3.40.640.10 Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) 0.54 48.0 4.14e-01 98.7% 74.2%
3eleA02 3.40.640.10 Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) 0.54 48.0 4.19e-01 99.3% 78.0%
8bj4A01 3.40.640.10 Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) 0.53 48.0 4.24e-01 98.7% 74.0%
5bq3A02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.53 43.0 4.34e-01 87.9% 87.7%
2egvA02 3.40.1280.10 Alpha Beta › 3-Layer(aba) Sandwich › Alpha/beta knot › SPOUT methyltransferase, trefoil knot domain 0.53 43.0 4.22e-01 87.2% 93.9%
3zdrA01 3.40.50.1970 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.53 42.0 3.93e-01 86.6% 95.3%
2rjoA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.53 43.0 4.10e-01 87.2% 76.9%
4kq9A02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.53 45.0 4.15e-01 94.6% 85.5%
2ajtA01 3.40.50.10940 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.52 40.0 3.86e-01 81.2% 78.3%
2vefB00 3.20.20.20 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Dihydropteroate synthase-like 0.52 46.0 3.82e-01 98.7% 98.2%
3g1wA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.52 41.0 4.23e-01 85.9% 88.4%
3fkdA02 3.40.640.10 Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) 0.52 46.0 4.13e-01 98.7% 72.4%
3da8B00 3.40.50.170 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Formyl transferase, N-terminal domain 0.52 47.0 4.22e-01 100.0% 96.1%
2wnwA02 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.51 45.0 3.52e-01 97.3% 91.7%
6gt9A02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.51 43.0 4.15e-01 93.3% 95.4%
1ihuA01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.51 45.0 3.85e-01 98.7% 91.0%
4aktB00 3.40.50.200 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Peptidase S8/S53 domain 0.50 43.0 3.43e-01 96.0% 85.4%
3dzzA02 3.40.640.10 Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) 0.50 44.0 3.80e-01 98.7% 69.3%
ECOD (64)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4443696 2006.1.4.5 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › XRN_N 0.89 86.0 6.33e-01 100.0% 85.1%
3400646 2006.1.4.5 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › XRN_N 0.89 84.0 6.34e-01 98.7% 94.3%
3300817 2006.1.4.0 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like 0.88 85.0 6.29e-01 100.0% 84.8%
4628515 2006.1.4.5 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › XRN_N 0.88 83.0 6.53e-01 97.3% 95.3%
3294273 2006.1.4.5 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › XRN_N 0.88 83.0 6.59e-01 98.7% 92.2%
None 0.87 81.0 6.21e-01 96.6% 95.7%
3595159 2006.1.4.0 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like 0.86 79.0 6.54e-01 95.3% 94.6%
3601601 2006.1.4.5 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › XRN_N 0.86 80.0 6.41e-01 97.3% 95.1%
4026642 2006.1.4.5 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › XRN_N 0.85 79.0 6.63e-01 96.0% 96.1%
3276794 2006.1.4.5 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › XRN_N 0.85 79.0 6.43e-01 96.6% 94.9%
3716209 2006.1.4.5 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › XRN_N 0.85 79.0 5.70e-01 96.6% 70.8%
4027656 2006.1.4.5 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › XRN_N 0.84 78.0 6.47e-01 96.6% 95.0%
3718959 2006.1.4.5 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › XRN_N 0.84 77.0 6.47e-01 95.3% 95.2%
3251911 2006.1.4.5 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › XRN_N 0.83 80.0 6.87e-01 100.0% 94.5%
3596146 2006.1.4.0 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like 0.76 71.0 6.30e-01 98.0% 97.5%
3664522 2003.1.5.31 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › GRAS 0.69 60.0 4.25e-01 93.3% 71.6%
4984062 7592.1.1.3 a/b three-layered sandwiches › CARF (CRISPR-associated Rossmann fold) domains › CARF (CRISPR-associated Rossmann fold) domains › CARF (CRISPR-associated Rossmann fold) domains › DUF6293_N 0.67 56.0 5.65e-01 89.3% 98.0%
1734342 7592.1.1.6 a/b three-layered sandwiches › CARF (CRISPR-associated Rossmann fold) domains › CARF (CRISPR-associated Rossmann fold) domains › CARF (CRISPR-associated Rossmann fold) domains › Csa3_N 0.66 57.0 5.85e-01 90.6% 97.2%
4157264 2006.1.4.4 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › 5_3_exonuc_N 0.65 56.0 5.26e-01 91.3% 95.6%
3671521 2005.1.1.43 a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › CHX17_2nd 0.65 52.0 4.82e-01 84.6% 90.3%
3722663 7514.1.1.0 a/b three-layered sandwiches › Ferredoxin reductase-like, C-terminal NADP-linked domain › Ferredoxin reductase-like, C-terminal NADP-linked domain › Ferredoxin reductase-like, C-terminal NADP-linked domain 0.64 48.0 5.34e-01 78.5% 100.0%
5039659 2006.1.4.10 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › PIN_4 0.64 52.0 4.23e-01 86.6% 67.6%
3367536 2005.1.1.41 a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › CHX17_C 0.64 50.0 4.62e-01 82.6% 89.5%
3416022 2007.1.2.30 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › IR75A_N 0.63 54.0 4.87e-01 92.6% 83.4%
2718677 2003.1.5.83 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltrans_Mon_2nd 0.62 56.0 4.66e-01 100.0% 85.4%
3744163 2003.1.5.95 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › TRM13 0.62 56.0 4.38e-01 98.0% 87.0%
3549043 2005.1.1.36 a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › SLC12 0.62 50.0 4.79e-01 85.2% 96.5%
4043476 2005.1.1.13 a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › CTP_transf_like 0.62 52.0 4.75e-01 89.9% 78.2%
3972418 2005.1.1.3 a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › Usp 0.62 50.0 5.27e-01 85.9% 97.0%
3283240 2006.1.4.4 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › 5_3_exonuc_N 0.61 52.0 4.80e-01 91.9% 96.4%
3942272 2006.1.4.4 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › 5_3_exonuc_N 0.61 52.0 4.99e-01 91.3% 98.2%
4134257 2005.1.1.13 a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › CTP_transf_like 0.61 52.0 4.66e-01 91.3% 76.1%
3435216 2005.1.1.41 a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › CHX17_C 0.61 50.0 4.77e-01 87.9% 90.9%
5068659 7512.1.1.0 a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase 0.60 52.0 4.76e-01 91.3% 97.9%
3346163 2003.1.1.82 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Slo-like_RCK 0.60 47.0 4.61e-01 82.6% 91.5%
3249477 2005.1.1.0 a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains 0.59 47.0 5.04e-01 84.6% 99.2%
4948382 2006.1.4.13 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › PIN_9 0.58 47.0 5.05e-01 87.2% 100.0%
3943425 2007.1.2.11 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_4 0.58 43.0 4.58e-01 85.9% 88.5%
3412552 2007.1.2.0 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I 0.58 51.0 4.71e-01 94.6% 85.8%
1172988 2007.1.2.0 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I 0.58 43.0 4.53e-01 86.6% 85.3%
4287898 7502.1.1.1 a/b three-layered sandwiches › Anticodon-binding domain of Class II aaRS › Anticodon-binding domain of Class II aaRS › Anticodon-binding domain of Class II aaRS › HGTP_anticodon 0.57 36.0 3.88e-01 74.5% 74.4%
3247100 2007.1.2.4 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › ANF_receptor 0.57 50.0 4.21e-01 95.3% 79.6%
3660261 2006.1.4.7 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › NYN_YacP 0.57 46.0 4.39e-01 85.2% 73.7%
3634983 2484.1.1.153 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DUF1744 0.57 47.0 4.34e-01 89.9% 94.4%
4947480 2006.1.5.2 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Arginase/deacetylase › Hist_deacetyl 0.56 42.0 3.56e-01 77.2% 70.8%
3436711 129.1.1.55 alpha arrays › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › Slo-like_RCK 0.56 47.0 4.51e-01 90.6% 78.3%
3512910 2007.1.9.1 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) › AIRC 0.55 40.0 3.81e-01 90.6% 64.7%
3029642 7577.1.1.1 a/b three-layered sandwiches › PLP-dependent transferases › PLP-dependent transferases › PLP-dependent transferases › Aminotran_1_2 0.55 50.0 4.36e-01 98.7% 71.2%
3971753 2484.3.1.1 mixed a+b and a/b › Ribonuclease H-like › Creatinase/prolidase N-terminal domain › Creatinase/prolidase N-terminal domain › Creatinase_N 0.54 40.0 4.12e-01 77.2% 82.1%
3274669 2006.1.4.6 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › Fcf1 0.54 49.0 4.86e-01 98.7% 95.0%
3266028 7590.1.1.0 a/b three-layered sandwiches › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs 0.54 41.0 4.47e-01 89.9% 95.8%
4968422 2006.1.1.18 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like › HAD_2 0.54 47.0 4.14e-01 94.6% 96.4%
1252859 2007.1.2.0 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I 0.53 39.0 4.14e-01 86.6% 88.4%
3619235 2484.1.1.153 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DUF1744 0.53 47.0 3.70e-01 97.3% 96.6%
4278728 2007.1.4.5 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Phosphofructokinase N-terminal domain › Tim54 0.53 41.0 3.36e-01 79.9% 83.2%
4034523 7577.1.1.1 a/b three-layered sandwiches › PLP-dependent transferases › PLP-dependent transferases › PLP-dependent transferases › Aminotran_1_2 0.53 48.0 3.98e-01 99.3% 57.4%
3917161 2484.1.1.153 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DUF1744 0.53 47.0 3.50e-01 96.6% 58.7%
4664847 2007.1.2.11 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_4 0.53 43.0 4.32e-01 85.9% 88.7%
4022145 2484.1.1.153 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DUF1744 0.53 47.0 3.16e-01 98.7% 38.2%
3997615 2484.1.1.153 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DUF1744 0.53 47.0 3.76e-01 97.3% 95.7%
3579905 101.1.2.0 alpha arrays › HTH › HTH › winged helix domain 0.53 48.0 4.35e-01 100.0% 86.0%
3796994 2007.1.2.0 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I 0.53 39.0 3.29e-01 77.9% 90.0%
3593129 7560.1.1.0 a/b three-layered sandwiches › Ribose/Galactose isomerase RpiB/AlsB › Ribose/Galactose isomerase RpiB/AlsB › Ribose/Galactose isomerase RpiB/AlsB 0.52 40.0 4.03e-01 82.6% 96.1%
3211938 7590.1.1.2 a/b three-layered sandwiches › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs › Piwi 0.51 39.0 3.79e-01 81.2% 75.4%
D3 medium residues 38-130_190-200
PDB
Domain cluster: representative
CATH (30)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3cxbA03 1.10.1740.30 Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › Secreted effector protein SifA helical domain 0.74 39.0 4.40e-01 100.0% 65.4%
2z0qA01 1.20.900.10 Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain 0.67 49.0 3.99e-01 76.0% 87.6%
4jgiA01 1.10.1240.10 Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain 0.67 34.0 3.87e-01 81.7% 63.7%
1ki1B01 1.20.900.10 Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain 0.66 48.0 3.91e-01 76.9% 93.5%
4yonA01 1.20.900.10 Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain 0.65 48.0 3.78e-01 77.9% 88.0%
1cunA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.64 36.0 3.69e-01 84.6% 55.9%
3kavA00 1.20.1270.360 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.63 37.0 3.82e-01 82.7% 59.8%
4oe8C00 1.10.8.1170 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › 0.62 38.0 4.13e-01 85.6% 73.6%
1t72A01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.61 36.0 3.47e-01 81.7% 50.4%
4p9fA02 1.20.120.530 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like 0.61 46.0 4.15e-01 78.8% 99.3%
1t72A02 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.60 37.0 3.81e-01 83.7% 64.3%
2wzkA03 1.20.1310.10 Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats 0.59 40.0 4.01e-01 95.2% 67.3%
3h1nA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.57 39.0 3.77e-01 71.2% 98.3%
1kz7A01 1.20.900.10 Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain 0.56 41.0 3.48e-01 77.9% 93.3%
1vctA01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.56 40.0 4.00e-01 89.4% 70.6%
3q5dA02 1.20.58.420 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › AHSP 0.56 40.0 4.21e-01 96.2% 80.4%
1j5wA02 1.20.58.180 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Class II aaRS and biotin synthetases; domain 2 0.56 31.0 3.43e-01 80.8% 68.8%
3ripA02 1.20.120.1900 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Gamma-tubulin complex, C-terminal domain 0.56 44.0 3.27e-01 84.6% 64.9%
3h3mA00 1.20.58.380 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Flagellar protein flit. 0.56 35.0 3.74e-01 93.3% 73.0%
2odvA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.55 35.0 3.43e-01 100.0% 58.9%
8ex5A01 1.20.1250.20 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains 0.55 43.0 3.47e-01 82.7% 94.8%
2odmA00 1.10.287.750 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › SO2669-like 0.55 36.0 4.11e-01 93.3% 89.9%
1m56C02 1.20.120.80 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle 0.54 49.0 3.99e-01 100.0% 66.3%
2c5iT00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.54 38.0 4.01e-01 98.1% 79.8%
1sumB01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.53 39.0 3.87e-01 99.0% 73.8%
1owaA02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.52 40.0 3.98e-01 99.0% 78.3%
1orjD00 1.20.120.340 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS 0.52 47.0 4.43e-01 100.0% 87.2%
3cwzB01 1.20.58.900 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › RUN domain 0.51 44.0 3.99e-01 97.1% 82.2%
1x42A02 1.10.150.240 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 0.50 30.0 3.33e-01 97.1% 73.5%
2prrA02 1.20.1290.10 Mainly Alpha › Up-down Bundle › AhpD-like › AhpD-like 0.50 39.0 3.67e-01 89.4% 68.5%
ECOD (37)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5028461 632.7.1.1 alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain › HSP70 0.68 40.0 4.28e-01 82.7% 66.7%
4944708 604.5.1.0 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) 0.67 38.0 4.15e-01 80.8% 66.7%
5027497 632.6.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Plasmid maintenance system epsilon/zeta, antidote epsilon subunit › Plasmid maintenance system epsilon/zeta, antidote epsilon subunit 0.66 39.0 4.41e-01 84.6% 76.2%
4406266 632.7.1.1 alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain › HSP70 0.65 37.0 3.94e-01 82.7% 63.3%
4012697 632.15.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) 0.65 35.0 3.94e-01 82.7% 67.5%
4315491 632.7.1.1 alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain › HSP70 0.64 37.0 3.69e-01 85.6% 53.6%
3826 604.5.1.2 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU 0.64 38.0 3.93e-01 83.7% 62.6%
4033482 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.63 36.0 3.90e-01 83.7% 65.6%
4954843 604.5.1.2 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU 0.62 37.0 3.91e-01 83.7% 65.3%
3942447 628.1.1.1 alpha bundles › Fatty acid responsive transcription factor FadR, C-terminal domain › Fatty acid responsive transcription factor FadR, C-terminal domain › Fatty acid responsive transcription factor FadR, C-terminal domain › FCD 0.62 46.0 4.25e-01 79.8% 100.0%
3729492 601.4.1.0 alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains 0.62 49.0 4.28e-01 83.7% 82.0%
3989535 632.6.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Plasmid maintenance system epsilon/zeta, antidote epsilon subunit › Plasmid maintenance system epsilon/zeta, antidote epsilon subunit 0.59 33.0 3.50e-01 76.9% 60.0%
4624818 621.1.1.0 alpha bundles › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain 0.59 43.0 4.57e-01 96.2% 86.7%
4025561 604.9.1.0 alpha bundles › Spectrin repeat-like › Ribosomal protein S20 › Ribosomal protein S20 0.58 35.0 3.66e-01 97.1% 64.2%
3724003 622.1.1.0 alpha bundles › YvfG-like › HSC20 (HSCB), C-terminal oligomerisation domain › HSC20 (HSCB), C-terminal oligomerisation domain 0.58 39.0 4.06e-01 99.0% 72.0%
3224363 3831.1.1.0 alpha bundles › Secreted protein of unknown function DUF1311 › Secreted protein of unknown function DUF1311 › Secreted protein of unknown function DUF1311 0.58 37.0 4.04e-01 83.7% 78.8%
3227678 632.1.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.57 37.0 3.81e-01 83.7% 69.0%
3886860 604.1.1.1 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.56 32.0 3.13e-01 81.7% 47.5%
4377228 140.1.1.5 alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon_1 0.55 38.0 3.19e-01 70.2% 71.5%
3582505 611.8.1.8 alpha bundles › N-cbl like › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › UBR4 0.55 43.0 4.09e-01 100.0% 70.4%
3975328 3718.1.1.1 alpha bundles › Flagellar protein fliT › Flagellar protein fliT › Flagellar protein fliT › FliT 0.55 35.0 3.84e-01 91.3% 78.8%
3168103 604.6.1.0 alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain 0.54 33.0 3.50e-01 98.1% 67.4%
3980245 5050.1.1.10 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_2 0.54 41.0 3.25e-01 80.8% 90.0%
3990885 164.1.1.0 alpha bundles › Chorismate mutase II › Chorismate mutase II › Chorismate mutase II 0.54 36.0 3.86e-01 99.0% 77.8%
3705964 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.54 38.0 3.89e-01 97.1% 76.0%
3607831 604.6.1.0 alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain 0.54 38.0 3.93e-01 98.1% 77.0%
3441615 3684.1.1.0 alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like 0.53 48.0 3.83e-01 100.0% 85.7%
4964044 5058.1.1.16 alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st_1 0.53 37.0 3.80e-01 84.6% 76.0%
4012069 192.29.1.0 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.53 47.0 4.07e-01 98.1% 99.4%
4442857 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.53 40.0 3.31e-01 81.7% 88.2%
4634749 102.1.3.26 alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › PAP/OAS1 substrate-binding domain › Adenylate_cycl 0.53 45.0 3.66e-01 96.2% 95.2%
3686025 604.7.1.10 alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A › Tmemb_170 0.52 43.0 3.76e-01 88.5% 67.1%
3839022 601.19.1.0 alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein 0.52 47.0 3.76e-01 100.0% 83.9%
4578804 160.1.1.4 alpha superhelices › C-terminal domain of alpha and beta subunits of F1 ATP synthase › C-terminal domain of alpha and beta subunits of F1 ATP synthase › C-terminal domain of alpha and beta subunits of F1 ATP synthase › ATP-synt_VA_C 0.51 42.0 4.12e-01 88.5% 85.2%
3900656 3831.1.1.6 alpha bundles › Secreted protein of unknown function DUF1311 › Secreted protein of unknown function DUF1311 › Secreted protein of unknown function DUF1311 › POF1B_HlH 0.51 32.0 3.56e-01 82.7% 77.6%
4300173 633.13.1.1 alpha bundles › Bromodomain-like › DsbB-like › DsbB-like › DsbB 0.51 41.0 3.71e-01 88.5% 95.1%
3579460 601.1.3.5 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › A middle domain of Talin 1 › TLN1-like_RS 0.50 44.0 3.84e-01 99.0% 75.8%
D4 medium residues 548-726
PDB