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putative_DNA_topoisomerase

Euk-Vir

Emiliania_huxleyi_virus_86

putative_DNA_topoisomerase__YP_294202__Emiliania_huxleyi_virus_86__181082

Identity

Accession:
YP_294202 ↗
Protein ID:
putative_DNA_topoisomerase
Kingdom:
euk

Quality

84.9 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 42-198
PDB
CATH (19)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1pvgA01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.95 92.0 7.69e-01 100.0% 67.6%
1s14B00 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.89 69.0 6.59e-01 96.2% 70.2%
1b63A01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.79 68.0 5.99e-01 94.9% 64.8%
1mu5A01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.76 68.0 6.12e-01 94.9% 72.4%
1h7sA01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.75 60.0 5.58e-01 94.9% 67.9%
2o1uB01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.73 58.0 5.70e-01 93.0% 78.2%
3ehgA00 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.73 44.0 4.94e-01 94.9% 76.0%
1y4uB01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.72 61.0 5.60e-01 94.3% 71.6%
1nijA02 3.30.1220.10 Alpha Beta › 2-Layer Sandwich › Hypothetical Protein Yjia; Chain: A;domain 2 › CobW-like, C-terminal domain 0.67 40.0 4.62e-01 74.5% 80.2%
2rk9B00 3.10.180.10 Alpha Beta › Roll › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 0.63 24.0 2.77e-01 86.6% 43.6%
1e8oA00 3.30.720.10 Alpha Beta › 2-Layer Sandwich › Signal recognition particle alu RNA binding heterodimer, srp9/1 › Signal recognition particle alu RNA binding heterodimer, srp9/1 0.62 24.0 3.32e-01 89.2% 68.9%
3lmmA03 3.30.565.60 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › 0.62 51.0 5.01e-01 98.1% 79.5%
4g59C01 2.60.40.2920 Mainly Beta › Sandwich › Immunoglobulin-like › 0.62 33.0 3.97e-01 90.4% 77.7%
2rs7A01 3.30.160.20 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.61 24.0 3.40e-01 87.9% 74.3%
4gt8A00 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.59 45.0 4.90e-01 96.8% 94.7%
1v4pC01 3.30.980.10 Alpha Beta › 2-Layer Sandwich › Threonyl-tRNA Synthetase; Chain A, domain 2 › Threonyl-trna Synthetase; Chain A, domain 2 0.57 39.0 4.56e-01 96.8% 100.0%
1v43A03 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.53 18.0 2.73e-01 86.0% 70.3%
1in0A02 3.30.70.990 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › YajQ-like, domain 2 0.53 32.0 3.85e-01 91.1% 97.8%
6ll8A02 3.10.310.20 Alpha Beta › Roll › Diaminopimelate Epimerase; Chain A, domain 1 › DHHA2 domain 0.50 33.0 3.71e-01 83.4% 86.7%
ECOD (61)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3789605 225.1.1.0 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.96 93.0 7.75e-01 100.0% 67.8%
3998214 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.95 92.0 7.55e-01 100.0% 61.6%
3594649 225.1.1.0 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.93 91.0 7.56e-01 100.0% 67.8%
4617838 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.93 91.0 7.53e-01 100.0% 67.8%
3317524 225.1.1.0 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.91 86.0 7.50e-01 97.5% 83.0%
4875911 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.91 88.0 7.14e-01 100.0% 65.5%
1223478 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.88 78.0 6.36e-01 96.2% 54.8%
3461648 225.1.1.0 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.88 85.0 7.14e-01 100.0% 66.7%
1223480 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.88 78.0 6.98e-01 96.2% 70.6%
4421199 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.88 81.0 6.76e-01 95.5% 69.0%
3959843 225.1.1.0 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.88 78.0 6.63e-01 96.2% 60.8%
4945731 225.1.1.38 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › DNA_gyraseB 0.87 79.0 6.82e-01 96.2% 64.3%
4027049 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.87 81.0 6.62e-01 96.2% 58.3%
4038381 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.87 79.0 6.82e-01 96.2% 65.8%
4943430 225.1.1.39 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › DNA_mis_repair 0.82 70.0 6.56e-01 94.9% 75.1%
4453541 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.81 70.0 6.20e-01 94.9% 66.2%
4107504 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.81 68.0 6.06e-01 94.9% 63.7%
3530518 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.81 71.0 6.42e-01 95.5% 71.0%
4930684 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.81 72.0 6.09e-01 95.5% 60.4%
3321967 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.81 72.0 6.29e-01 95.5% 66.4%
4233929 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.80 69.0 5.97e-01 94.9% 62.2%
3198261 225.1.1.0 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.80 72.0 6.67e-01 93.6% 79.5%
3841889 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.79 67.0 6.03e-01 95.5% 66.2%
4030281 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.79 68.0 5.73e-01 95.5% 57.1%
3549359 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.79 68.0 5.84e-01 94.9% 60.0%
4404190 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.79 68.0 5.89e-01 94.9% 62.2%
3472236 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.79 68.0 5.92e-01 94.9% 62.7%
3698469 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.79 68.0 5.90e-01 95.5% 61.7%
4927750 225.1.1.0 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.79 67.0 5.96e-01 94.3% 65.1%
3789513 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.77 68.0 5.91e-01 94.9% 63.0%
3255595 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.77 69.0 6.18e-01 93.6% 75.5%
3974412 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.77 69.0 6.24e-01 94.3% 72.7%
3421099 225.1.1.2 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HSP90,HATPase_c_3 0.77 69.0 5.68e-01 94.3% 62.3%
3308932 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.77 69.0 5.86e-01 94.3% 68.8%
3250443 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.77 70.0 6.03e-01 95.5% 70.9%
3632920 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.77 68.0 5.70e-01 95.5% 58.4%
3716539 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.76 69.0 5.85e-01 95.5% 66.7%
None 0.76 68.0 5.86e-01 94.3% 69.6%
None 0.75 67.0 5.94e-01 94.3% 76.8%
None 0.75 68.0 6.02e-01 95.5% 86.8%
3656144 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.75 67.0 5.69e-01 94.3% 65.7%
None 0.75 67.0 5.99e-01 94.3% 75.2%
4029843 212.1.1.0 a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.75 67.0 5.75e-01 94.3% 67.5%
None 0.74 67.0 5.97e-01 94.3% 75.2%
3369389 884.1.1.1 a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C 0.73 39.0 4.88e-01 70.7% 85.3%
3595333 225.1.1.0 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.72 65.0 5.82e-01 94.9% 70.4%
3495832 225.1.1.2 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HSP90,HATPase_c_3 0.72 56.0 5.45e-01 80.3% 74.6%
4464688 884.1.1.1 a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C 0.72 39.0 4.88e-01 72.6% 87.2%
4076203 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.70 63.0 5.29e-01 94.3% 64.0%
4504528 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.70 63.0 5.35e-01 94.3% 66.7%
3461740 884.1.1.1 a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C 0.69 38.0 4.68e-01 91.1% 84.8%
3313688 884.1.1.1 a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C 0.69 38.0 4.66e-01 91.1% 84.0%
3611201 884.1.1.0 a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain 0.67 39.0 4.73e-01 70.1% 85.7%
3377134 225.1.1.0 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.67 53.0 5.42e-01 92.4% 86.0%
4091857 310.3.1.4 a+b two layers › RRF/tRNA synthetase additional domain-like › General secretion pathway protein M (EpsM) periplasmic domain-related › General secretion pathway protein M (EpsM) periplasmic domain-related › GspL_C 0.61 35.0 3.78e-01 94.9% 66.2%
4010802 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.59 46.0 4.98e-01 99.4% 94.1%
3968308 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.58 47.0 5.07e-01 100.0% 99.3%
4581673 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.58 45.0 4.81e-01 99.4% 92.1%
3965082 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.57 45.0 4.94e-01 98.1% 100.0%
5081067 11.1.1.0 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.51 30.0 3.37e-01 82.8% 74.2%
4352321 243.3.1.5 a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin › FTP 0.50 32.0 3.81e-01 85.4% 100.0%
D2 high residues 394-537_575-664
PDB
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF01751.29 best Toprim 24.5 3.40e-05 51.3% 84.4%
PF16898.11 TOPRIM_C 74.9 9.60e-21 40.6% 68.0%
D3 high residues 665-816
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00521.27 best DNA_topoisoIV 188.6 2.70e-55 100.0% 35.3%
D4 high residues 963-1088
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00521.27 best DNA_topoisoIV 41.1 1.50e-10 88.9% 26.2%
CATH (64)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1bgwA03 1.10.268.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 0.91 66.0 7.08e-01 73.8% 100.0%
8gccA03 1.10.268.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 0.91 69.0 7.63e-01 78.6% 100.0%
3qx3A04 1.10.268.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 0.89 63.0 7.05e-01 72.2% 100.0%
2oduA02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.80 47.0 5.20e-01 82.5% 71.4%
1t72A01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.79 41.0 4.28e-01 85.7% 54.7%
1t72A02 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.78 39.0 4.40e-01 84.9% 62.2%
3fppA03 6.10.140.1990 Special › Helix non-globular › Helix Hairpins › 0.76 44.0 5.21e-01 83.3% 81.8%
1oahA02 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.76 46.0 4.44e-01 87.3% 53.5%
3m7gA02 1.10.8.1010 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › 0.76 42.0 4.91e-01 89.7% 74.7%
3nvoB02 1.20.58.340 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region 0.75 42.0 4.41e-01 83.3% 59.5%
1zvuA03 1.10.268.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 0.75 67.0 6.49e-01 96.8% 86.4%
1qu7A00 1.10.287.950 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein 0.72 47.0 3.74e-01 85.7% 36.1%
2i0mA01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.72 39.0 4.28e-01 83.3% 62.3%
3vbbE01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.71 48.0 4.96e-01 82.5% 72.3%
1hs7A00 1.20.58.70 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.71 38.0 4.26e-01 84.1% 67.0%
4ioeA00 1.10.287.850 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain 0.70 44.0 5.32e-01 81.7% 93.1%
2fji101 1.10.357.50 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › 0.69 43.0 3.60e-01 86.5% 36.8%
1vctA01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.68 43.0 4.64e-01 90.5% 73.4%
2ot4A03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.68 40.0 4.32e-01 78.6% 69.2%
1h7cA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.68 42.0 4.67e-01 82.5% 76.7%
2lqgA00 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.67 41.0 4.04e-01 87.3% 55.8%
3favD00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.67 41.0 5.07e-01 84.1% 100.0%
4mh6A00 1.10.287.1700 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.66 42.0 3.88e-01 85.7% 49.7%
3u0cA00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.66 47.0 4.41e-01 84.1% 60.9%
3au3A00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.65 35.0 2.62e-01 81.7% 21.6%
3ljbA00 1.20.120.1240 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Dynamin, middle domain 0.64 37.0 3.02e-01 86.5% 32.9%
1sziA02 1.20.120.340 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS 0.64 49.0 4.77e-01 79.4% 97.1%
3nuqA01 1.10.150.450 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › 0.64 24.0 2.74e-01 83.3% 45.5%
6grjB01 1.20.1170.10 Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › 0.63 44.0 3.21e-01 83.3% 28.8%
2uyyA02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.63 43.0 4.38e-01 77.8% 70.7%
4issA02 1.20.58.1700 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.63 36.0 4.47e-01 79.4% 93.4%
4u7iA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.61 33.0 3.77e-01 83.3% 68.8%
3pwxA01 1.20.1330.10 Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain 0.61 50.0 4.36e-01 85.7% 79.3%
3w6zA02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.61 42.0 4.30e-01 78.6% 72.7%
2qwoB00 1.10.287.110 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › DnaJ domain 0.60 26.0 3.03e-01 83.3% 51.1%
8cdaB03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.60 45.0 4.13e-01 88.9% 61.0%
3i01A01 1.20.1270.30 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.60 50.0 4.40e-01 88.1% 76.3%
3na7A00 1.10.287.1490 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.59 48.0 3.77e-01 85.7% 44.3%
2m6bA00 1.20.58.390 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain 0.59 42.0 4.02e-01 74.6% 97.3%
3g67A00 1.10.287.950 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein 0.59 48.0 3.94e-01 84.9% 52.1%
3vkgA12 1.10.287.2610 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.58 48.0 3.92e-01 84.9% 70.7%
2b0hA01 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.58 46.0 4.58e-01 81.7% 100.0%
4cgkA01 6.10.250.3150 Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.58 49.0 3.96e-01 86.5% 84.1%
4wpcA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.58 49.0 3.66e-01 88.1% 67.8%
3fseB02 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.58 45.0 4.31e-01 81.0% 77.1%
2rd0B00 1.10.287.1490 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.57 46.0 4.43e-01 82.5% 81.3%
4im0A04 1.20.1270.420 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.57 48.0 3.82e-01 88.9% 71.0%
3kkbA00 1.20.120.880 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Histidine kinase (KinB), sensor domain 0.57 44.0 4.44e-01 82.5% 100.0%
2ch7A00 1.10.287.950 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein 0.56 46.0 3.39e-01 85.7% 80.9%
8i3jA01 1.20.920.20 Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › 0.56 45.0 3.47e-01 82.5% 78.1%
8a1gC01 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.56 48.0 4.19e-01 89.7% 77.9%
4e40A00 1.20.1260.80 Mainly Alpha › Up-down Bundle › Ferritin › 0.56 47.0 3.68e-01 88.1% 72.2%
2c41C01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.55 44.0 4.15e-01 82.5% 81.9%
3k29A00 1.10.287.1700 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.55 45.0 4.14e-01 85.7% 69.6%
6xj1A01 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.55 47.0 3.73e-01 90.5% 77.6%
3hiuD00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.54 43.0 4.08e-01 84.1% 73.7%
6q45G01 1.10.287.80 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain 0.54 44.0 4.15e-01 84.9% 82.2%
2vxxA00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.54 46.0 4.06e-01 88.9% 72.7%
6p73A02 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.53 37.0 3.52e-01 71.4% 77.6%
2rfqC03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.51 45.0 4.00e-01 93.7% 96.0%
7dl9A01 1.20.1250.20 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains 0.51 37.0 3.22e-01 74.6% 64.9%
1fewA00 1.20.58.70 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.51 39.0 3.49e-01 79.4% 64.2%
2uuiA00 1.20.120.550 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Membrane associated eicosanoid/glutathione metabolism-like domain 0.51 43.0 3.99e-01 88.9% 80.6%
1r2jA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.50 44.0 4.22e-01 94.4% 92.4%
ECOD (81)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3600354 4016.1.1.0 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase 0.96 92.0 8.58e-01 100.0% 83.3%
3708939 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.95 92.0 8.39e-01 100.0% 80.6%
3718739 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.94 91.0 8.12e-01 100.0% 89.1%
223696 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.94 90.0 8.39e-01 100.0% 90.1%
3634044 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.93 90.0 7.62e-01 100.0% 84.7%
3276180 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.93 90.0 7.50e-01 100.0% 86.2%
3328306 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.93 90.0 7.58e-01 100.0% 85.8%
3625174 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.93 90.0 7.29e-01 100.0% 84.3%
3652359 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.93 89.0 7.89e-01 100.0% 77.1%
3789604 4016.1.1.0 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase 0.93 88.0 8.24e-01 99.2% 91.3%
3935542 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.92 86.0 7.97e-01 96.0% 83.3%
3220667 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.92 84.0 8.16e-01 94.4% 94.8%
3630114 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.91 83.0 7.89e-01 96.0% 91.7%
4878008 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.90 77.0 7.85e-01 90.5% 91.7%
3610015 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.90 86.0 7.72e-01 100.0% 86.7%
4887991 4016.1.1.0 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase 0.89 73.0 7.91e-01 88.1% 100.0%
3768919 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.88 83.0 6.06e-01 98.4% 52.3%
4238706 101.1.2.9 alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV 0.88 84.0 6.11e-01 100.0% 52.8%
4452951 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.87 82.0 7.23e-01 100.0% 88.0%
3508111 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.87 82.0 7.15e-01 100.0% 93.3%
3267708 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.85 80.0 7.62e-01 100.0% 91.0%
4830953 101.1.2.9 alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV 0.85 80.0 7.05e-01 99.2% 79.2%
2443871 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.83 78.0 7.04e-01 100.0% 89.8%
3833806 4016.1.1.0 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase 0.82 64.0 6.12e-01 81.7% 73.8%
4980165 2004.1.1.0 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.82 39.0 2.61e-01 84.1% 13.8%
5024978 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.81 75.0 7.15e-01 99.2% 88.3%
4552385 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.80 75.0 6.95e-01 100.0% 81.3%
3345589 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.78 70.0 6.07e-01 97.6% 66.3%
4174306 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.77 72.0 6.75e-01 100.0% 86.7%
5046461 101.1.2.48 alpha arrays › HTH › HTH › winged helix domain › PadR 0.77 52.0 4.37e-01 83.3% 43.5%
3219809 632.1.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.76 46.0 4.91e-01 87.3% 69.1%
4932829 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.76 70.0 6.68e-01 100.0% 88.3%
3228170 192.8.1.0 alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain 0.74 60.0 5.70e-01 84.1% 99.3%
4373100 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.74 68.0 6.50e-01 100.0% 89.0%
3990094 5086.1.1.94 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HB_LcnD 0.73 52.0 4.65e-01 83.3% 54.1%
3582505 611.8.1.8 alpha bundles › N-cbl like › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › UBR4 0.68 55.0 5.52e-01 83.3% 84.0%
3399224 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.67 41.0 3.64e-01 84.1% 43.3%
3337686 5086.1.1.64 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › Sin3_corepress 0.67 53.0 5.43e-01 83.3% 96.7%
5014330 148.1.3.402 alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › Rad50_zn_hook 0.66 44.0 4.69e-01 84.1% 77.3%
3987991 5086.1.1.94 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HB_LcnD 0.65 51.0 4.18e-01 82.5% 48.1%
3593528 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.65 48.0 4.52e-01 85.7% 64.7%
4146573 2004.1.1.429 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_15 0.64 47.0 3.04e-01 79.4% 19.2%
3272337 3922.1.1.64 alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Sin3_corepress 0.63 49.0 5.14e-01 82.5% 99.1%
3853566 604.5.1.0 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) 0.63 36.0 3.81e-01 86.5% 62.6%
3477269 3755.4.1.0 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.62 49.0 4.47e-01 84.1% 65.2%
3675934 3755.3.1.374 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › UCP030365 0.62 47.0 4.29e-01 84.1% 61.3%
3613349 5086.1.1.0 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.61 43.0 3.96e-01 88.1% 56.4%
3239667 2004.1.1.87 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N 0.59 48.0 2.87e-01 82.5% 15.1%
4994917 3834.1.1.25 alpha bundles › TcA alpha pore-forming domain › TcA alpha pore-forming domain › TcA alpha pore-forming domain › DUF7121 0.59 48.0 3.72e-01 83.3% 73.1%
4775818 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.59 48.0 4.08e-01 85.7% 55.3%
3781506 3291.1.1.0 alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related 0.59 48.0 4.43e-01 84.1% 69.7%
4534163 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.59 48.0 3.77e-01 84.1% 50.8%
3698277 3922.1.1.0 alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 0.58 51.0 4.61e-01 89.7% 71.2%
4414655 3291.1.1.0 alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related 0.58 47.0 4.12e-01 84.1% 81.7%
3699448 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.58 47.0 4.26e-01 84.1% 97.0%
3494010 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.58 47.0 3.56e-01 83.3% 39.6%
3627942 3755.4.1.1 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › PI3K_P85_iSH2 0.58 50.0 4.36e-01 88.9% 86.9%
5059556 5086.1.1.0 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.57 46.0 4.03e-01 82.5% 80.0%
3393894 3755.4.1.0 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.57 46.0 4.17e-01 83.3% 64.8%
3712648 3755.4.1.0 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.56 44.0 3.75e-01 80.2% 93.2%
3927148 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.56 45.0 3.67e-01 82.5% 69.8%
4414590 192.2.1.0 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.56 45.0 3.90e-01 82.5% 63.9%
3998961 192.29.1.0 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.56 47.0 4.06e-01 90.5% 62.1%
4520297 3939.1.1.0 alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain 0.56 50.0 3.92e-01 94.4% 88.2%
3878898 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.56 49.0 3.97e-01 91.3% 86.0%
3244448 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.55 42.0 3.85e-01 84.1% 61.9%
4015178 3755.4.1.0 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.55 45.0 4.13e-01 84.1% 69.7%
4286404 3755.1.1.14 alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related › T3SSipB 0.54 44.0 3.83e-01 84.1% 60.6%
4082395 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.54 43.0 3.77e-01 83.3% 60.0%
3831567 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.53 42.0 3.82e-01 84.1% 80.6%
3583684 148.1.3.11 alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › MT 0.52 44.0 3.46e-01 91.3% 68.1%
3871823 2004.1.1.433 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_23 0.52 41.0 2.70e-01 82.5% 21.0%
5038347 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.52 41.0 3.53e-01 82.5% 94.9%
3938473 3755.3.1.347 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › CDK5RAP3 0.52 42.0 3.28e-01 85.7% 41.3%
3097991 3758.2.1.1 alpha bundles › Bacterial hemolysins-like › Biopolymer transport protein ExbB › Biopolymer transport protein ExbB › MotA_ExbB 0.52 41.0 3.37e-01 84.1% 55.2%
3255250 109.24.1.1 alpha superhelices › Repetitive alpha hairpins › Helical domain in dedicator of cytokinesis protein 9 › Helical domain in dedicator of cytokinesis protein 9 › DHR-2_Lobe_A 0.52 35.0 3.28e-01 73.8% 54.4%
4090533 3922.1.1.0 alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 0.51 39.0 3.76e-01 83.3% 70.3%
3497316 3755.4.1.0 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.51 41.0 3.75e-01 84.1% 82.5%
4160480 3615.1.1.0 alpha bundles › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain 0.50 40.0 3.36e-01 88.1% 97.0%
3616483 3755.3.1.280 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › Spindly 0.50 42.0 3.14e-01 88.1% 58.0%
4178099 632.22.1.176 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › PF27734 0.50 40.0 3.72e-01 83.3% 79.4%
D5 medium residues 24-41_199-270
PDB
Domain cluster: representative
D6 medium residues 271-393
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00204.32 best DNA_gyraseB 28.3 1.60e-06 96.8% 54.0%
D7 medium residues 850-933
PDB
CATH (81)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3qx3B03 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.93 88.0 8.19e-01 100.0% 95.0%
8gccA02 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.92 80.0 8.00e-01 91.7% 100.0%
3l4jA04 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.91 86.0 7.99e-01 100.0% 95.1%
3lpxB02 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.84 73.0 7.06e-01 94.0% 96.8%
6bq9A02 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.81 70.0 6.78e-01 94.0% 96.8%
2kl8A00 3.30.70.600 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S10 0.71 52.0 5.26e-01 77.4% 81.2%
3dxqA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.71 47.0 4.77e-01 70.2% 68.7%
3ibwA00 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.70 51.0 5.27e-01 76.2% 83.5%
7qh2C03 3.30.70.2740 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.70 50.0 5.20e-01 76.2% 96.2%
1u8sA02 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.69 51.0 5.15e-01 77.4% 85.7%
4nohA01 3.30.70.3060 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.69 48.0 5.13e-01 75.0% 84.5%
3dfeA00 3.30.70.120 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.69 50.0 5.12e-01 77.4% 78.0%
2mq8A00 3.30.70.600 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S10 0.69 50.0 4.60e-01 77.4% 75.9%
2rhqB06 3.30.70.380 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ferrodoxin-fold anticodon-binding domain 0.69 50.0 5.04e-01 76.2% 96.4%
2b4vA03 3.30.70.1970 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.69 51.0 4.85e-01 78.6% 71.7%
1b24A01 3.10.28.10 Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases 0.69 50.0 4.82e-01 76.2% 84.2%
2jgbA01 3.30.760.10 Alpha Beta › 2-Layer Sandwich › RNA Cap, Translation Initiation Factor Eif4e › RNA Cap, Translation Initiation Factor Eif4e 0.69 49.0 3.87e-01 75.0% 44.5%
1q5yC00 3.30.70.1150 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT-like. Chain A, domain 2 0.68 49.0 4.97e-01 75.0% 81.7%
2kjwA00 3.30.70.60 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S6/Translation elongation factor EF1B 0.68 49.0 4.75e-01 76.2% 75.0%
2go8A01 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.68 47.0 4.97e-01 71.4% 81.1%
1lfwA03 3.30.70.360 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.68 53.0 5.25e-01 85.7% 100.0%
1zpvA00 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.67 49.0 4.94e-01 77.4% 84.7%
3onqA02 3.30.70.2730 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.67 49.0 4.97e-01 77.4% 84.0%
2nyiA01 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.67 48.0 4.88e-01 75.0% 82.7%
5w2fA01 3.30.780.10 Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor Eif1 › SUI1-like domain 0.67 52.0 5.22e-01 84.5% 89.5%
6gmhK00 3.30.1360.10 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › RNA polymerase, RBP11-like subunit 0.67 52.0 4.73e-01 84.5% 68.7%
4pcqA02 3.30.70.920 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain 0.66 48.0 4.83e-01 76.2% 79.8%
5suhB01 3.30.70.1710 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › BMC (bacterial microcompartment) domain 0.66 52.0 4.97e-01 85.7% 91.9%
3ezjA02 3.30.1370.120 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › 0.66 48.0 5.26e-01 77.4% 95.6%
6d9mA02 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.66 48.0 3.97e-01 77.4% 58.9%
5llwA02 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.66 47.0 3.99e-01 75.0% 62.0%
3p96A02 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.65 47.0 4.78e-01 76.2% 84.5%
6zxbA02 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.65 49.0 4.06e-01 78.6% 61.8%
2cg8B02 3.30.70.560 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK 0.64 46.0 4.03e-01 76.2% 54.5%
2f1fA01 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.64 46.0 4.79e-01 76.2% 84.8%
1r89A03 3.30.70.590 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Poly(A) polymerase predicted RNA binding domain 0.64 47.0 4.04e-01 77.4% 67.9%
7e6gA01 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.64 47.0 3.90e-01 77.4% 59.7%
1i6uA01 3.30.1370.30 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › 0.64 49.0 5.36e-01 82.1% 100.0%
5yppA00 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.64 46.0 4.56e-01 76.2% 73.3%
1sc6A03 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.64 46.0 4.69e-01 76.2% 80.5%
2m9kA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.64 47.0 4.63e-01 79.8% 73.1%
1fvqA00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.63 45.0 4.75e-01 75.0% 91.7%
2a2cA02 3.30.70.3170 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.63 45.0 4.52e-01 75.0% 85.7%
5yjlB01 3.30.460.30 Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › Glutamyl-tRNA reductase, N-terminal domain 0.63 46.0 3.72e-01 77.4% 51.6%
2dt9A01 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.63 48.0 5.10e-01 85.7% 95.9%
4qjvA01 3.30.1360.10 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › RNA polymerase, RBP11-like subunit 0.62 50.0 4.98e-01 96.4% 83.1%
2cqiA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.62 46.0 4.34e-01 78.6% 68.0%
2eabB01 2.70.98.50 Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › putative glycoside hydrolase family protein from bacillus halodurans 0.62 47.0 3.33e-01 79.8% 75.4%
1i94H01 3.30.1370.30 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › 0.62 44.0 4.57e-01 73.8% 100.0%
6ruiK00 3.30.1360.10 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › RNA polymerase, RBP11-like subunit 0.62 54.0 5.03e-01 96.4% 81.6%
3c1mA02 3.30.2130.10 Alpha Beta › 2-Layer Sandwich › VC0802-like › VC0802-like 0.62 48.0 3.98e-01 86.9% 96.3%
3i4pA02 3.30.70.920 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain 0.62 44.0 4.41e-01 75.0% 81.0%
4pg4B03 3.30.70.3100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.62 44.0 4.58e-01 75.0% 85.3%
2cpxA01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.61 45.0 4.61e-01 77.4% 88.6%
3ossD00 3.30.1370.120 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › 0.61 45.0 3.78e-01 81.0% 73.9%
3v2uC02 3.30.70.3170 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.61 44.0 4.30e-01 77.4% 81.1%
1tuwA00 3.30.70.1090 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Dimeric alpha+beta barrel. 0.61 44.0 4.12e-01 76.2% 75.5%
4efjA01 3.10.28.10 Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases 0.61 43.0 3.69e-01 75.0% 55.7%
1vkwA02 3.40.109.30 Alpha Beta › 3-Layer(aba) Sandwich › NADH Oxidase › putative nitroreductase (tm1586), domain 2 0.60 42.0 4.02e-01 71.4% 93.8%
3aawA02 3.30.2130.10 Alpha Beta › 2-Layer Sandwich › VC0802-like › VC0802-like 0.60 48.0 3.92e-01 88.1% 93.9%
2mobA00 3.90.56.10 Alpha Beta › Alpha-Beta Complex › Phenol Hydroxylase P2 Protein › Monooxygenase component MmoB/DmpM 0.60 42.0 4.13e-01 79.8% 66.0%
3c0wA02 3.10.28.10 Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases 0.60 41.0 3.91e-01 72.6% 68.9%
2clqA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.59 41.0 4.12e-01 71.4% 77.6%
2plgA01 3.30.1460.10 Alpha Beta › 2-Layer Sandwich › Yope Regulator; Chain: A, › 0.59 44.0 3.86e-01 82.1% 72.7%
4aqzA00 2.60.40.3470 Mainly Beta › Sandwich › Immunoglobulin-like › 0.58 45.0 3.85e-01 88.1% 50.7%
4m1xD00 3.30.1360.240 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.58 42.0 4.50e-01 81.0% 90.3%
3g98A00 3.10.310.40 Alpha Beta › Roll › Diaminopimelate Epimerase; Chain A, domain 1 › 0.58 49.0 4.56e-01 97.6% 98.2%
1k8kD02 3.30.1460.20 Alpha Beta › 2-Layer Sandwich › Yope Regulator; Chain: A, › 0.57 44.0 3.89e-01 85.7% 66.4%
5mmjh01 3.30.1370.30 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › 0.57 45.0 4.70e-01 84.5% 100.0%
2jvfA00 3.30.1710.10 Alpha Beta › 2-Layer Sandwich › top7, de novo designed protein › top7, de novo designed protein 0.57 41.0 4.03e-01 78.6% 100.0%
1x19A02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.55 42.0 3.37e-01 79.8% 85.6%
7pjjA03 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.55 42.0 3.69e-01 83.3% 77.7%
3evzA01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.54 40.0 3.30e-01 81.0% 85.5%
1js3A03 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.54 46.0 4.45e-01 98.8% 86.6%
1ub9A00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.53 37.0 3.53e-01 72.6% 69.0%
4eq3A02 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.53 43.0 3.97e-01 86.9% 89.8%
4e1oA03 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.53 45.0 4.35e-01 97.6% 86.7%
5o5cB02 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.52 44.0 3.90e-01 96.4% 64.8%
1yyvB00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.52 38.0 3.51e-01 77.4% 64.3%
2qmaA02 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.52 43.0 3.89e-01 96.4% 68.0%
1i8dA01 2.40.30.20 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › 0.51 39.0 3.91e-01 84.5% 79.8%
ECOD (87)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3594650 4014.1.1.0 a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase 0.94 90.0 7.00e-01 100.0% 56.9%
3277529 4014.1.1.1 a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV 0.93 89.0 6.93e-01 100.0% 58.7%
3719735 4014.1.1.1 a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV 0.93 89.0 6.85e-01 100.0% 57.0%
3789606 4014.1.1.0 a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase 0.92 88.0 6.71e-01 100.0% 58.2%
3998667 4014.1.1.1 a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV 0.92 88.0 6.43e-01 100.0% 52.8%
4624017 4014.1.1.1 a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV 0.85 79.0 6.02e-01 100.0% 58.3%
5001014 304.8.1.4 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › NikR_C 0.73 52.0 5.27e-01 75.0% 78.8%
3317802 304.8.1.45 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.72 56.0 5.44e-01 84.5% 95.8%
4994799 304.16.1.1 a+b two layers › Alpha-beta plaits › eEF-1beta-like › eEF-1beta-like › EF1_GNE 0.72 50.0 5.13e-01 72.6% 88.7%
3383879 304.8.1.0 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.71 53.0 5.57e-01 77.4% 100.0%
4317294 207.11.1.1 beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Urease accessory protein ureH › Urease accessory protein ureH › UreD 0.71 64.0 4.48e-01 98.8% 95.8%
4996908 304.8.1.4 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › NikR_C 0.71 52.0 5.16e-01 76.2% 77.3%
3655963 304.8.1.0 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.71 52.0 5.59e-01 76.2% 97.1%
4154211 304.8.1.4 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › NikR_C 0.71 51.0 5.00e-01 75.0% 74.4%
4998406 304.8.1.4 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › NikR_C 0.71 51.0 5.29e-01 76.2% 82.5%
3312923 304.8.1.0 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.70 57.0 5.51e-01 88.1% 95.8%
4977748 304.8.1.4 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › NikR_C 0.69 50.0 5.09e-01 75.0% 83.7%
5062210 305.1.1.2 a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.69 55.0 5.41e-01 85.7% 86.7%
3306024 304.8.1.0 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.69 60.0 5.52e-01 97.6% 90.0%
5052687 304.8.1.4 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › NikR_C 0.69 49.0 5.18e-01 75.0% 85.3%
184476 304.9.1.32 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › Ret2_MD 0.69 51.0 4.97e-01 78.6% 76.3%
5058967 304.8.1.4 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › NikR_C 0.69 49.0 5.17e-01 75.0% 84.0%
4980724 304.165.1.4 a+b two layers › Alpha-beta plaits › Uncharacterized protein Ta1207 › Uncharacterized protein Ta1207 › HVO_2525_N 0.68 54.0 4.46e-01 84.5% 59.3%
5028338 304.4.1.0 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.68 48.0 4.60e-01 75.0% 65.0%
3365684 306.6.1.0 a+b two layers › Glucose permease domain IIB-like › PH0987 N-terminal domain-like › PH0987 N-terminal domain-like 0.68 60.0 5.71e-01 100.0% 98.0%
4228655 207.11.1.1 beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Urease accessory protein ureH › Urease accessory protein ureH › UreD 0.68 59.0 4.20e-01 96.4% 93.7%
3666529 304.8.1.0 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.67 48.0 4.85e-01 75.0% 95.3%
3972839 310.3.1.0 a+b two layers › RRF/tRNA synthetase additional domain-like › General secretion pathway protein M (EpsM) periplasmic domain-related › General secretion pathway protein M (EpsM) periplasmic domain-related 0.67 47.0 4.08e-01 71.4% 48.0%
4078130 207.11.1.1 beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Urease accessory protein ureH › Urease accessory protein ureH › UreD 0.67 59.0 4.21e-01 98.8% 95.0%
4928850 304.4.1.0 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.67 48.0 4.74e-01 75.0% 71.1%
4059360 304.9.1.71 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › SNU71_RBD 0.67 50.0 4.72e-01 78.6% 75.0%
5057050 2.1.1.0 beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.67 49.0 4.31e-01 77.4% 52.0%
4977666 305.1.1.1 a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L 0.67 50.0 4.97e-01 81.0% 76.7%
136198 305.1.1.2 a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.67 52.0 4.63e-01 83.3% 65.5%
3252217 305.1.1.2 a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.67 52.0 4.73e-01 84.5% 68.7%
5054431 305.1.1.1 a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L 0.66 50.0 4.85e-01 81.0% 79.6%
4999334 304.165.1.4 a+b two layers › Alpha-beta plaits › Uncharacterized protein Ta1207 › Uncharacterized protein Ta1207 › HVO_2525_N 0.66 53.0 4.66e-01 86.9% 68.0%
3655967 304.8.1.0 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.66 57.0 5.53e-01 96.4% 93.7%
3810458 304.8.1.0 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.66 59.0 5.70e-01 98.8% 95.8%
4017316 304.8.1.10 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT_7 0.66 48.0 3.78e-01 77.4% 93.1%
3960213 304.156.1.5 a+b two layers › Alpha-beta plaits › DNA translocase FtsK N-terminal domain › DNA translocase FtsK N-terminal domain › PF31086 0.66 48.0 4.36e-01 77.4% 68.7%
4529236 207.11.1.1 beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Urease accessory protein ureH › Urease accessory protein ureH › UreD 0.66 57.0 4.05e-01 98.8% 93.0%
5079841 3501.1.1.0 a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 0.65 48.0 5.11e-01 78.6% 96.0%
4997133 306.3.1.1 a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like › SUI1 0.65 53.0 5.10e-01 89.3% 84.2%
5036372 320.2.1.1 a+b two layers › R3H domain-like › Ribosomal protein S8, N-terminal domain › Ribosomal protein S8, N-terminal domain › Ribosomal_S8 0.65 48.0 5.36e-01 79.8% 100.0%
3829402 304.8.1.0 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.65 56.0 5.75e-01 95.2% 100.0%
4496232 304.162.1.1 a+b two layers › Alpha-beta plaits › Competence or damage-inducible protein CinA middle domain › Competence or damage-inducible protein CinA middle domain › CinA_KH 0.65 47.0 4.80e-01 76.2% 91.3%
5052421 305.1.1.2 a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.65 55.0 5.35e-01 94.0% 87.4%
3699404 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.65 48.0 4.89e-01 78.6% 81.2%
4956868 304.102.1.0 a+b two layers › Alpha-beta plaits › Pseudouridine synthase › Pseudouridine synthase 0.65 50.0 3.69e-01 83.3% 52.9%
3607364 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.64 49.0 4.36e-01 79.8% 60.9%
3369895 304.12.1.0 a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 0.64 56.0 5.43e-01 97.6% 94.7%
4682556 304.162.1.1 a+b two layers › Alpha-beta plaits › Competence or damage-inducible protein CinA middle domain › Competence or damage-inducible protein CinA middle domain › CinA_KH 0.64 47.0 4.81e-01 78.6% 91.3%
3290113 304.8.1.13 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT_PSP_2 0.63 46.0 4.61e-01 77.4% 88.2%
4393799 320.2.1.1 a+b two layers › R3H domain-like › Ribosomal protein S8, N-terminal domain › Ribosomal protein S8, N-terminal domain › Ribosomal_S8 0.63 44.0 4.72e-01 71.4% 90.0%
3372798 304.8.1.45 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.63 56.0 5.66e-01 100.0% 100.0%
3603234 242.1.1.2 a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_2 0.63 44.0 4.07e-01 73.8% 67.3%
4398464 304.162.1.1 a+b two layers › Alpha-beta plaits › Competence or damage-inducible protein CinA middle domain › Competence or damage-inducible protein CinA middle domain › CinA_KH 0.63 45.0 4.59e-01 75.0% 88.7%
3643150 304.8.1.0 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.63 56.0 5.60e-01 98.8% 100.0%
4069329 304.162.1.1 a+b two layers › Alpha-beta plaits › Competence or damage-inducible protein CinA middle domain › Competence or damage-inducible protein CinA middle domain › CinA_KH 0.63 44.0 4.57e-01 75.0% 88.7%
4124687 304.162.1.1 a+b two layers › Alpha-beta plaits › Competence or damage-inducible protein CinA middle domain › Competence or damage-inducible protein CinA middle domain › CinA_KH 0.63 44.0 4.65e-01 75.0% 96.0%
3390426 304.163.1.1 a+b two layers › Alpha-beta plaits › ATP-binding protein TM_1403 insertion domain › ATP-binding protein TM_1403 insertion domain › R1_ABCA1 0.62 45.0 4.33e-01 77.4% 69.0%
3599549 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.62 47.0 4.52e-01 79.8% 74.7%
3990697 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.62 45.0 4.40e-01 77.4% 87.4%
3316081 304.9.1.96 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › PF26250 0.62 46.0 4.65e-01 78.6% 85.9%
4322692 304.162.1.1 a+b two layers › Alpha-beta plaits › Competence or damage-inducible protein CinA middle domain › Competence or damage-inducible protein CinA middle domain › CinA_KH 0.62 44.0 4.56e-01 76.2% 88.7%
3367684 304.8.1.45 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.62 54.0 5.43e-01 98.8% 100.0%
4065299 304.162.1.1 a+b two layers › Alpha-beta plaits › Competence or damage-inducible protein CinA middle domain › Competence or damage-inducible protein CinA middle domain › CinA_KH 0.61 43.0 4.53e-01 75.0% 94.7%
4028770 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.61 45.0 4.44e-01 78.6% 77.8%
3280205 304.28.1.0 a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain 0.60 45.0 4.33e-01 79.8% 84.2%
3164985 310.3.1.0 a+b two layers › RRF/tRNA synthetase additional domain-like › General secretion pathway protein M (EpsM) periplasmic domain-related › General secretion pathway protein M (EpsM) periplasmic domain-related 0.59 40.0 3.29e-01 70.2% 38.1%
5038027 319.3.1.1 beta sandwiches › HSP20-like › B2 domain of PilQ › B2 domain of PilQ › AMIN 0.59 46.0 4.39e-01 88.1% 71.0%
4930688 330.2.1.4 a+b two layers › dsRBD-like › Ribosome binding protein Y (YfiA homologue) › Ribosome binding protein Y (YfiA homologue) › DUF2113 0.59 44.0 4.10e-01 79.8% 84.8%
3966287 319.3.1.0 beta sandwiches › HSP20-like › B2 domain of PilQ › B2 domain of PilQ 0.58 46.0 4.14e-01 89.3% 61.7%
3964731 304.3.1.1 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain › HMA 0.58 49.0 4.66e-01 94.0% 91.0%
3634756 206.1.1.11 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › APH 0.58 52.0 3.71e-01 100.0% 94.4%
3588197 304.8.1.8 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT_4 0.57 43.0 4.31e-01 79.8% 81.2%
3190999 206.1.1.11 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › APH 0.57 50.0 3.39e-01 100.0% 89.5%
5058917 241.1.1.0 a+b two layers › Type III secretory system chaperone-like › Type III secretory system chaperone › Type III secretory system chaperone 0.56 41.0 3.69e-01 79.8% 71.2%
2583503 304.156.1.0 a+b two layers › Alpha-beta plaits › DNA translocase FtsK N-terminal domain › DNA translocase FtsK N-terminal domain 0.56 42.0 4.16e-01 82.1% 98.9%
3578125 3016.1.1.4 a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › Pyridoxal_deC 0.55 46.0 4.07e-01 97.6% 65.4%
3221750 3016.1.1.0 a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases 0.54 45.0 4.30e-01 97.6% 81.0%
3617823 3016.1.1.0 a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases 0.54 45.0 4.45e-01 97.6% 88.2%
1193010 3016.1.1.2 a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › Aminotran_3 0.54 46.0 4.37e-01 98.8% 83.5%
3722321 241.6.1.1 a+b two layers › Type III secretory system chaperone-like › Arp2/3 complex subunits › Arp2/3 complex subunits › P34-Arc 0.53 45.0 4.05e-01 96.4% 73.3%
224981 11.1.1.129 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Interfer-bind 0.53 43.0 3.97e-01 86.9% 90.7%
3981185 241.1.1.25 a+b two layers › Type III secretory system chaperone-like › Type III secretory system chaperone › Type III secretory system chaperone › PF27378 0.52 45.0 4.08e-01 96.4% 73.0%