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putative_HNH-family_endonuclease

Euk-Vir

Melbournevirus

putative_HNH-family_endonuclease__YP_009094766__Melbournevirus__1560514

Identity

Accession:
YP_009094766 ↗
Protein ID:
putative_HNH-family_endonuclease
Kingdom:
euk

Quality

74.0 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Megaviricetes› Pimascovirales› Marseilleviridae› Marseillevirus› Marseillevirus_sp._'Melbournevirus'

TaxID: 1560514

Cluster

Singleton — not in a non-trivial cluster

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 15-66
PDB
Domain cluster: representative
CATH (73)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1okjB01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.77 65.0 4.88e-01 96.2% 40.9%
2lezA00 3.30.2450.10 Alpha Beta › 2-Layer Sandwich › Secreted effector protein pipB2 fold › Secreted effector protein pipB2 0.76 52.0 3.89e-01 71.2% 57.5%
1r7lA00 3.30.2120.10 Alpha Beta › 2-Layer Sandwich › Bacillus phage protein › Bacillus phage protein-like 0.75 59.0 4.75e-01 88.5% 46.6%
1mgtA01 3.30.160.70 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › Methylated DNA-protein cysteine methyltransferase domain 0.75 63.0 5.33e-01 96.2% 64.8%
2ywqA00 3.30.160.100 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › Ribosome hibernation promotion factor-like 0.73 59.0 5.04e-01 92.3% 71.6%
2gnxA02 3.30.450.240 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › 0.73 59.0 4.70e-01 92.3% 46.8%
3tqmA00 3.30.160.100 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › Ribosome hibernation promotion factor-like 0.72 58.0 4.97e-01 94.2% 71.1%
2aehA03 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.71 59.0 4.70e-01 96.2% 51.4%
3ml4C01 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.71 58.0 4.60e-01 94.2% 43.5%
1h10A00 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.71 59.0 4.57e-01 92.3% 43.6%
5fgoA00 3.10.450.700 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.71 49.0 4.63e-01 73.1% 77.4%
4wj7D00 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.70 54.0 4.16e-01 88.5% 36.6%
2ltsA00 3.30.160.20 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.70 56.0 4.76e-01 88.5% 54.7%
1btkA00 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.70 60.0 4.30e-01 98.1% 61.9%
4tpsA00 3.30.310.250 Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › Sporulation inhibitor of replication protein SirA 0.70 49.0 3.60e-01 75.0% 100.0%
1mhxA00 3.10.20.10 Alpha Beta › Roll › Ubiquitin-like (UB roll) › 0.69 51.0 4.80e-01 78.8% 67.7%
2z0qA02 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.67 53.0 4.06e-01 88.5% 48.4%
1whqA01 3.30.160.20 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.67 53.0 4.81e-01 88.5% 67.6%
2nykA01 3.30.500.30 Alpha Beta › 2-Layer Sandwich › Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1 › 0.67 46.0 3.33e-01 73.1% 38.5%
1ddvA00 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.67 52.0 4.13e-01 92.3% 42.3%
5x6vF00 3.30.450.190 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › 0.66 51.0 4.03e-01 88.5% 39.0%
2p4bB02 3.30.200.100 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › MucB/RseB, C-terminal domain 0.65 47.0 3.88e-01 84.6% 40.8%
4khbC00 2.30.29.210 Mainly Beta › Roll › PH-domain like › FACT complex subunit Spt16p/Cdc68p 0.65 55.0 4.38e-01 96.2% 54.7%
7t8tA01 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.64 52.0 3.97e-01 92.3% 48.9%
3ozqA01 2.30.39.10 Mainly Beta › Roll › Alpha-1-antitrypsin; domain 1 › Alpha-1-antitrypsin, domain 1 0.64 48.0 3.40e-01 82.7% 39.4%
2dixA01 3.30.160.20 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.64 50.0 4.57e-01 94.2% 83.3%
5hsqA02 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.64 49.0 3.62e-01 82.7% 46.5%
2nwvA00 3.30.310.110 Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › XisI-like 0.64 44.0 3.45e-01 73.1% 50.0%
1i99I02 2.30.39.10 Mainly Beta › Roll › Alpha-1-antitrypsin; domain 1 › Alpha-1-antitrypsin, domain 1 0.64 54.0 4.17e-01 96.2% 70.1%
4m7xA01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.63 53.0 4.51e-01 98.1% 69.2%
3zm6A02 3.40.1190.10 Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Mur-like, catalytic domain 0.63 51.0 3.40e-01 92.3% 23.3%
7r97A02 3.30.160.20 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.62 51.0 4.74e-01 92.3% 76.5%
4oxwA00 3.30.1520.10 Alpha Beta › 2-Layer Sandwich › PX Domain › Phox-like domain 0.62 48.0 3.87e-01 86.5% 90.6%
2ltrA00 3.30.160.20 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.62 50.0 4.12e-01 94.2% 65.7%
3fehA02 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.62 52.0 4.03e-01 98.1% 57.3%
3ulbA01 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.62 50.0 4.32e-01 90.4% 59.0%
6lmjB00 4.10.520.10 Few Secondary Structures › Irregular › HU Protein; Chain A › IHF-like DNA-binding proteins 0.62 39.0 3.14e-01 88.5% 33.7%
2oq1A03 3.30.505.10 Alpha Beta › 2-Layer Sandwich › SHC Adaptor Protein › SH2 domain 0.61 52.0 4.30e-01 100.0% 91.0%
4g2sA00 2.60.200.20 Mainly Beta › Sandwich › Tumour Suppressor Smad4 › 0.61 49.0 3.93e-01 98.1% 44.3%
3kstA00 2.115.10.20 Mainly Beta › 5 Propeller › Tachylectin-2; Chain A › Glycosyl hydrolase domain; family 43 0.61 55.0 3.37e-01 100.0% 82.8%
2dmyA00 3.30.160.20 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.61 48.0 4.05e-01 92.3% 77.3%
1vbiA02 3.30.1370.60 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › Malate/L-lactate/L-sulpholactate dehydrogenase, NADPH binding domain 0.60 41.0 2.69e-01 71.2% 28.7%
2nugB02 3.30.160.20 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.60 50.0 4.55e-01 94.2% 71.8%
1uhzA00 3.30.160.20 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.60 46.0 3.98e-01 88.5% 78.7%
2lkoA00 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.59 48.0 3.67e-01 96.2% 37.7%
3cm1A00 2.30.31.20 Mainly Beta › Roll › Transcriptional Co-activator pc4; Chain A › Sporulation-specific cell division protein SsgB 0.59 50.0 3.81e-01 100.0% 66.9%
1di2A00 3.30.160.20 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.59 50.0 4.58e-01 94.2% 73.9%
1e8oD00 3.30.720.10 Alpha Beta › 2-Layer Sandwich › Signal recognition particle alu RNA binding heterodimer, srp9/1 › Signal recognition particle alu RNA binding heterodimer, srp9/1 0.59 51.0 4.51e-01 98.1% 67.1%
1g29102 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.59 43.0 4.51e-01 80.8% 93.3%
5c0pA00 2.115.10.20 Mainly Beta › 5 Propeller › Tachylectin-2; Chain A › Glycosyl hydrolase domain; family 43 0.59 52.0 3.24e-01 100.0% 91.9%
2giaA00 2.30.31.40 Mainly Beta › Roll › Transcriptional Co-activator pc4; Chain A › 0.59 51.0 3.71e-01 100.0% 71.4%
2yt4A03 3.30.160.20 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.59 49.0 4.05e-01 100.0% 65.4%
2zwrB00 3.60.15.10 Alpha Beta › 4-Layer Sandwich › Metallo-beta-lactamase; Chain A › Ribonuclease Z/Hydroxyacylglutathione hydrolase-like 0.58 39.0 2.70e-01 71.2% 91.3%
1txdA02 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.58 51.0 3.91e-01 100.0% 62.8%
4qt4A00 3.40.50.1470 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Peptidyl-tRNA hydrolase 0.58 46.0 3.31e-01 96.2% 43.9%
1e8oA00 3.30.720.10 Alpha Beta › 2-Layer Sandwich › Signal recognition particle alu RNA binding heterodimer, srp9/1 › Signal recognition particle alu RNA binding heterodimer, srp9/1 0.58 49.0 4.42e-01 98.1% 77.0%
1wiiA01 2.20.25.190 Mainly Beta › Single Sheet › N-terminal domain of TfIIb › 0.58 43.0 4.20e-01 88.5% 90.3%
4e1pA00 3.30.60.230 Alpha Beta › 2-Layer Sandwich › Wheat Germ Agglutinin (Isolectin 2); domain 1 › Lsr2, dimerisation domain 0.57 41.0 4.10e-01 78.8% 85.5%
3f6gA01 3.30.160.740 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.57 45.0 4.44e-01 94.2% 96.6%
1t6aA02 3.30.310.120 Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › Rbstp2229 like protein 0.57 41.0 3.65e-01 76.9% 71.8%
2p25A01 3.10.180.10 Alpha Beta › Roll › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 0.56 45.0 3.45e-01 88.5% 60.5%
2nn5A00 3.30.530.20 Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain 0.56 47.0 3.39e-01 100.0% 51.5%
3g1jA00 2.30.30.350 Mainly Beta › Roll › SH3 type barrels. › mobile metagenome of vibrio cholerae. Integron cassette protein vch_cass4. 0.55 46.0 3.99e-01 100.0% 86.7%
4hdoA03 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.55 46.0 3.78e-01 100.0% 52.2%
6htnA01 2.120.10.70 Mainly Beta › 6 Propeller › Neuraminidase › Fucose-specific lectin 0.55 47.0 3.55e-01 100.0% 75.9%
3dxpA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.54 38.0 3.25e-01 75.0% 88.2%
2r15A01 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.54 41.0 3.42e-01 94.2% 72.1%
4on1A01 2.40.128.470 Mainly Beta › Beta Barrel › Lipocalin › 0.53 42.0 3.27e-01 96.2% 85.6%
3ifvC00 3.70.10.10 Alpha Beta › Box › Proliferating Cell Nuclear Antigen › 0.53 46.0 2.98e-01 100.0% 63.7%
2gqwA03 3.30.390.30 Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › FAD/NAD-linked reductase, C-terminal dimerisation domain 0.52 40.0 3.54e-01 92.3% 76.4%
2g16B00 2.40.155.10 Mainly Beta › Beta Barrel › Green Fluorescent Protein › Green fluorescent protein 0.50 42.0 2.98e-01 94.2% 60.7%
4joiA00 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.50 39.0 3.03e-01 92.3% 62.4%
4ms4B02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.50 40.0 2.95e-01 100.0% 59.4%
ECOD (94)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3164102 252.2.1.0 ↗ a+b two layers › DNA-binding domain › GCC-box binding domain-like › GCC-box binding domain-like 0.90 74.0 7.88e-01 90.4% 100.0%
4027687 330.3.1.0 ↗ a+b two layers › dsRBD-like › Peptidyl-tRNA hydrolase domain-like › Peptidyl-tRNA hydrolase domain-like 0.82 67.0 6.63e-01 88.5% 96.4%
4028013 252.2.1.1 ↗ a+b two layers › DNA-binding domain › GCC-box binding domain-like › GCC-box binding domain-like › AP2 0.82 66.0 5.84e-01 88.5% 72.0%
4939786 2484.2.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Methylated DNA-protein cysteine methyltransferase domain › Methylated DNA-protein cysteine methyltransferase domain 0.82 64.0 5.50e-01 98.1% 55.0%
4029439 252.2.1.0 ↗ a+b two layers › DNA-binding domain › GCC-box binding domain-like › GCC-box binding domain-like 0.81 67.0 6.04e-01 88.5% 78.3%
None — 0.78 59.0 3.80e-01 80.8% 86.2%
4026577 252.2.1.1 ↗ a+b two layers › DNA-binding domain › GCC-box binding domain-like › GCC-box binding domain-like › AP2 0.77 63.0 6.21e-01 90.4% 96.4%
4646999 330.1.1.0 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like 0.77 64.0 5.44e-01 92.3% 86.7%
5076693 223.2.1.0 ↗ a+b three layers › Profilin-like › profilin-like › profilin-like 0.76 61.0 4.63e-01 88.5% 38.3%
5001238 223.2.1.0 ↗ a+b three layers › Profilin-like › profilin-like › profilin-like 0.76 56.0 4.43e-01 88.5% 38.2%
4027723 252.2.1.0 ↗ a+b two layers › DNA-binding domain › GCC-box binding domain-like › GCC-box binding domain-like 0.75 61.0 5.58e-01 90.4% 84.3%
3482603 220.1.1.0 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like 0.75 60.0 4.84e-01 90.4% 46.0%
4953129 881.1.1.0 ↗ a+b three layers › Mog1p/PsbP-like › Mog1p/PsbP-like › Mog1p/PsbP-like 0.75 55.0 4.30e-01 80.8% 38.3%
5022340 220.1.1.0 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like 0.74 56.0 5.11e-01 96.2% 61.4%
5044629 223.2.1.0 ↗ a+b three layers › Profilin-like › profilin-like › profilin-like 0.74 60.0 4.60e-01 90.4% 40.0%
3515884 220.1.1.0 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like 0.74 60.0 4.59e-01 96.2% 39.2%
4018561 223.2.1.10 ↗ a+b three layers › Profilin-like › profilin-like › profilin-like › Gtr1_RagA 0.74 60.0 4.39e-01 92.3% 36.6%
3849761 220.1.1.1 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like › PH 0.74 61.0 3.73e-01 94.2% 15.4%
3315491 220.1.1.0 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like 0.73 62.0 4.56e-01 96.2% 40.7%
3692189 223.2.1.0 ↗ a+b three layers › Profilin-like › profilin-like › profilin-like 0.73 56.0 4.26e-01 88.5% 42.2%
3305101 220.1.1.1 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like › PH 0.72 60.0 4.34e-01 94.2% 32.7%
3869434 220.1.1.1 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like › PH 0.72 59.0 4.48e-01 94.2% 37.7%
4004358 252.2.1.3 ↗ a+b two layers › DNA-binding domain › GCC-box binding domain-like › GCC-box binding domain-like › Arm-DNA-bind_1 0.71 57.0 5.86e-01 92.3% 100.0%
4108829 2484.1.1.144 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DEDD_Tnp_IS110 0.71 60.0 4.61e-01 98.1% 41.7%
4971345 223.2.1.0 ↗ a+b three layers › Profilin-like › profilin-like › profilin-like 0.71 51.0 4.19e-01 84.6% 41.0%
4027686 252.2.1.0 ↗ a+b two layers › DNA-binding domain › GCC-box binding domain-like › GCC-box binding domain-like 0.71 58.0 5.70e-01 92.3% 98.2%
3515433 330.1.1.1 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › dsrm 0.70 54.0 5.07e-01 88.5% 67.7%
3510389 330.1.1.0 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like 0.70 59.0 4.90e-01 92.3% 64.0%
3585833 330.1.1.1 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › dsrm 0.70 58.0 4.48e-01 90.4% 50.0%
3393858 220.1.1.0 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like 0.70 56.0 4.37e-01 94.2% 40.9%
3922240 3755.3.1.321 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › WHAMM-JMY_N 0.69 57.0 4.46e-01 90.4% 89.1%
3454238 220.1.1.78 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like › PH_2 0.69 55.0 4.76e-01 90.4% 64.7%
3213262 145.1.1.0 ↗ alpha arrays › F-box domain › F-box domain › F-box domain 0.68 59.0 4.77e-01 98.1% 54.0%
3989890 4958.1.1.0 ↗ a+b complex topology › second helical domain in RNA-polymerase beta-prime subunit › second helical domain in RNA-polymerase beta-prime subunit › second helical domain in RNA-polymerase beta-prime subunit 0.68 54.0 5.07e-01 88.5% 72.3%
4032084 220.1.1.76 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like › bPH_2 0.68 55.0 4.59e-01 92.3% 52.6%
3503204 330.1.1.1 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › dsrm 0.68 55.0 4.51e-01 90.4% 58.9%
3714703 1021.1.1.0 ↗ a+b two layers › C-terminal domain in RNA helicases › C-terminal domain in RNA helicases › C-terminal domain in RNA helicases 0.67 49.0 3.98e-01 78.8% 44.0%
3927128 220.1.1.0 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like 0.67 53.0 4.15e-01 94.2% 39.2%
4028916 241.15.1.0 ↗ a+b two layers › Type III secretory system chaperone-like › FP (Fbxo7/PI31) dimerization domain › FP (Fbxo7/PI31) dimerization domain 0.67 54.0 4.31e-01 92.3% 80.0%
3903260 109.4.1.2707 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PH_21 0.67 57.0 3.34e-01 94.2% 16.4%
3591064 325.1.7.0 ↗ a+b complex topology › alpha/beta-Hammerhead/Barrel-sandwich hybrid › alpha/beta-Hammerhead/Barrel-sandwich hybrid › Single hybrid motif 0.67 53.0 4.99e-01 88.5% 72.3%
3619264 330.1.1.1 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › dsrm 0.66 53.0 4.48e-01 88.5% 54.4%
3925738 330.1.1.0 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like 0.66 55.0 4.44e-01 98.1% 70.9%
3234330 330.1.1.1 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › dsrm 0.66 56.0 4.52e-01 100.0% 61.8%
3514659 330.1.1.0 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like 0.66 54.0 4.43e-01 92.3% 58.0%
3549045 330.1.1.1 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › dsrm 0.66 54.0 4.24e-01 94.2% 42.7%
3514660 330.1.1.1 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › dsrm 0.66 55.0 4.65e-01 94.2% 54.4%
3390564 330.1.1.0 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like 0.65 50.0 4.19e-01 92.3% 58.1%
943 220.1.1.47 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like › PH_16 0.65 53.0 4.33e-01 92.3% 47.0%
3718216 4051.1.1.0 ↗ a+b two layers › a+b domain in Capz › a+b domain in Capz › a+b domain in Capz 0.65 50.0 3.92e-01 88.5% 83.2%
3172575 220.1.1.0 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like 0.65 52.0 3.95e-01 92.3% 37.0%
4990229 896.1.1.0 ↗ a+b two layers › SRP9/14-like › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › Signal recognition particle alu RNA binding heterodimer SRP9/14-related 0.64 52.0 4.86e-01 98.1% 72.3%
5023931 330.1.1.0 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like 0.64 50.0 4.61e-01 88.5% 74.3%
1141882 4099.1.1.3 ↗ a+b two layers › Kinetochore globular domain-like › Kinetochore globular domain-like › Kinetochore globular domain-like › Spc24 0.64 53.0 4.75e-01 96.2% 72.4%
3496244 220.1.1.0 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like 0.64 53.0 3.97e-01 96.2% 46.4%
3286982 330.6.1.0 ↗ a+b two layers › dsRBD-like › 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain › 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 0.63 51.0 4.22e-01 96.2% 96.2%
5021439 330.1.1.1 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › dsrm 0.63 51.0 4.55e-01 90.4% 64.0%
3797523 330.1.1.0 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like 0.63 51.0 3.90e-01 94.2% 36.9%
3925891 220.1.1.0 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like 0.63 43.0 3.60e-01 71.2% 67.8%
3517153 330.1.1.1 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › dsrm 0.63 50.0 4.52e-01 96.2% 82.5%
3627817 220.1.1.47 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like › PH_16 0.63 51.0 3.18e-01 90.4% 15.9%
3797651 330.1.1.0 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like 0.62 53.0 4.40e-01 94.2% 57.8%
3709800 330.1.1.0 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like 0.62 51.0 4.36e-01 100.0% 82.1%
3514663 330.1.1.1 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › dsrm 0.62 49.0 4.45e-01 92.3% 86.7%
3768845 4294.1.1.0 ↗ few secondary structure elements › Trm112p-like › Trm112p-like › Trm112p-like 0.62 47.0 3.84e-01 86.5% 60.0%
3589974 220.1.1.0 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like 0.61 55.0 3.92e-01 98.1% 44.1%
3911301 330.1.1.1 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › dsrm 0.61 47.0 4.16e-01 90.4% 70.6%
3738473 277.1.1.1 ↗ a+b two layers › PX domain › PX domain › PX domain › PX 0.61 46.0 3.73e-01 90.4% 75.8%
3399510 896.1.1.3 ↗ a+b two layers › SRP9/14-like › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › SRP9-21 0.61 53.0 4.68e-01 98.1% 74.7%
3249582 896.1.1.3 ↗ a+b two layers › SRP9/14-like › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › SRP9-21 0.60 51.0 4.63e-01 98.1% 74.7%
4973804 220.1.1.0 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like 0.60 44.0 3.96e-01 94.2% 56.0%
5052436 319.1.1.0 ↗ beta sandwiches › HSP20-like › HSP20-like chaperones › HSP20-like chaperones 0.60 49.0 4.25e-01 90.4% 62.5%
4390303 5.1.3.238 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › PF29568 0.60 47.0 2.64e-01 84.6% 7.4%
5032371 896.1.1.0 ↗ a+b two layers › SRP9/14-like › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › Signal recognition particle alu RNA binding heterodimer SRP9/14-related 0.60 49.0 4.57e-01 98.1% 72.9%
5061930 220.1.1.0 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like 0.60 51.0 4.21e-01 98.1% 52.6%
3287903 802.1.1.1 ↗ a+b two layers › Hypothetical protein TM0160 › Hypothetical protein TM0160 › Hypothetical protein TM0160 › BFN_dom 0.60 46.0 4.70e-01 98.1% 90.0%
4991902 300.1.1.0 ↗ a+b three layers › Phospholipase D/nuclease › Phospholipase D/nuclease › Phospholipase D/nuclease 0.60 39.0 3.03e-01 71.2% 29.2%
3680499 5.1.4.369 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › EMC1_C, Beta-prop_EMC1_N 0.59 53.0 2.88e-01 100.0% 10.6%
4024503 220.1.1.0 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like 0.58 45.0 3.94e-01 90.4% 55.0%
4995609 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.58 45.0 3.45e-01 92.3% 58.6%
2332800 4059.1.1.0 ↗ a+b complex topology › Serpins › Serpins › Serpins 0.58 46.0 2.83e-01 90.4% 35.8%
4983385 212.1.1.3 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › GHMP_kinases_N 0.58 43.0 3.03e-01 80.8% 33.3%
3996686 220.1.1.47 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like › PH_16 0.58 52.0 3.68e-01 100.0% 58.0%
5028546 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.58 50.0 4.55e-01 98.1% 72.9%
1406320 896.1.1.3 ↗ a+b two layers › SRP9/14-like › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › SRP9-21 0.57 48.0 4.21e-01 98.1% 69.5%
3319159 284.2.1.1 ↗ a+b two layers › FKBP-like › Chitinase insertion domain › Chitinase insertion domain › Glyco_hydro_18 0.57 47.0 3.57e-01 98.1% 88.3%
3735661 896.1.1.0 ↗ a+b two layers › SRP9/14-like › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › Signal recognition particle alu RNA binding heterodimer SRP9/14-related 0.56 48.0 3.90e-01 100.0% 90.5%
1144827 4.1.1.79 ↗ beta barrels › SH3 › SH3 › SH3 › DUF3601 0.55 46.0 4.00e-01 100.0% 87.6%
5077064 2002.1.1.30 ↗ a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › Glyco_hydro_18 0.55 48.0 3.04e-01 100.0% 94.4%
5042834 274.1.1.0 ↗ a+b two layers › Pili subunits › Pili subunits › Pili subunits 0.55 46.0 3.36e-01 96.2% 48.0%
4932907 2005.1.1.10 ↗ a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › ETF 0.55 47.0 3.00e-01 100.0% 53.0%
3742001 10.1.1.0 ↗ beta sandwiches › jelly-roll › Concanavalin A-like › Concanavalin A-like lectins/glucanases 0.53 46.0 3.02e-01 98.1% 69.6%
4975762 101.1.8.1 ↗ alpha arrays › HTH › HTH › DNA breaking-rejoining enzymes › Phage_integrase 0.52 45.0 3.36e-01 94.2% 95.2%
4225322 4263.2.1.1 ↗ a+b two layers › TTHA1528-like › FtsH Periplasmic Domain › FtsH Periplasmic Domain › FtsH_ext 0.51 43.0 4.08e-01 100.0% 76.9%
D2 medium residues 67-127
PDB
Domain cluster: representative
CATH (8)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4bjzA01 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.57 48.0 3.55e-01 96.7% 89.3%
3rp7A01 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.56 46.0 3.43e-01 95.1% 49.4%
2eo6A01 3.30.505.10 Alpha Beta › 2-Layer Sandwich › SHC Adaptor Protein › SH2 domain 0.55 43.0 3.66e-01 88.5% 82.4%
4z3xA03 1.10.569.10 Mainly Alpha › Orthogonal Bundle › Aldehyde Ferredoxin Oxidoreductase Protein, subunit A; domain 2 › Aldehyde Ferredoxin Oxidoreductase Protein, subunit A, domain 2 0.53 46.0 3.33e-01 100.0% 51.1%
7kfuC01 3.100.10.20 Alpha Beta › Ribosomal Protein L15; Chain: K; domain 2 › Ribosomal Protein L15; Chain: K; domain 2 › CRISPR-associated endonuclease Cas1, N-terminal domain 0.52 38.0 3.58e-01 78.7% 78.7%
1h4iA00 2.140.10.10 Mainly Beta › 8 Propeller › Methanol Dehydrogenase; Chain A › Quinoprotein alcohol dehydrogenase-like superfamily 0.52 41.0 2.39e-01 90.2% 87.6%
4phtY02 3.30.420.370 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › GspL cytoplasmic domain, C-terminal subdomain 0.52 37.0 3.68e-01 75.4% 75.8%
2vouB01 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.51 40.0 2.83e-01 95.1% 36.7%
ECOD (20)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4956223 2484.1.1.34 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 0.66 48.0 3.04e-01 80.3% 15.9%
4683204 101.35.1.5 ↗ alpha arrays › HTH › DNA repair regulatory protein RecX › DNA repair regulatory protein RecX › RecX_HTH1 0.63 46.0 3.95e-01 95.1% 46.7%
3520270 101.35.1.5 ↗ alpha arrays › HTH › DNA repair regulatory protein RecX › DNA repair regulatory protein RecX › RecX_HTH1 0.62 46.0 3.92e-01 95.1% 47.6%
4009839 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.61 38.0 3.39e-01 78.7% 41.1%
3690269 2498.2.1.0 ↗ mixed a+b and a/b › Zincin-like › beta-N-acetylhexosaminidase-like domain › beta-N-acetylhexosaminidase-like domain 0.59 48.0 3.47e-01 93.4% 55.9%
5058747 56.2.1.1 ↗ beta sandwiches › Epsilon subunit of F1F0-ATP synthase-N › CO dehydrogenase accessory protein CooT › CO dehydrogenase accessory protein CooT › CooT 0.56 35.0 3.64e-01 91.8% 67.2%
3974812 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.55 39.0 2.51e-01 77.0% 38.6%
3744594 376.1.1.1 ↗ few secondary structure elements › RING/U-box-like › RING/U-box-like › RING/U-box › zf-C3HC4 0.55 32.0 2.81e-01 86.9% 34.7%
4678264 331.1.1.6 ↗ a+b two layers › TBP-like › TATA-box binding protein-like › TATA-box binding protein-like › DUF3378 0.54 36.0 3.38e-01 70.5% 83.7%
5009925 3239.1.1.1 ↗ alpha complex topology › Cas1 › Cas1 › Cas1 › Cas_Cas1 0.54 45.0 2.94e-01 98.4% 83.9%
3279244 101.1.2.0 ↗ alpha arrays › HTH › HTH › winged helix domain 0.53 42.0 3.63e-01 88.5% 86.0%
5079107 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.53 37.0 2.95e-01 75.4% 60.0%
3784980 719.2.1.1 ↗ beta barrels › XRCC4, N-terminal domain-like › NE0471 N-terminal domain-like › NE0471 N-terminal domain-like › GBBH-like_N 0.52 45.0 3.80e-01 100.0% 97.1%
4176722 719.2.1.1 ↗ beta barrels › XRCC4, N-terminal domain-like › NE0471 N-terminal domain-like › NE0471 N-terminal domain-like › GBBH-like_N 0.51 43.0 3.70e-01 95.1% 89.0%
3373330 4.1.1.337 ↗ beta barrels › SH3 › SH3 › SH3 › CSD_RNase_II 0.51 35.0 3.40e-01 73.8% 80.0%
4983508 101.1.2.0 ↗ alpha arrays › HTH › HTH › winged helix domain 0.51 44.0 4.21e-01 96.7% 98.6%
3403184 719.2.1.1 ↗ beta barrels › XRCC4, N-terminal domain-like › NE0471 N-terminal domain-like › NE0471 N-terminal domain-like › GBBH-like_N 0.51 43.0 3.67e-01 95.1% 89.0%
3857630 5.1.4.302 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40, Beta-prop_EML 0.51 43.0 2.73e-01 100.0% 38.1%
3399883 4161.1.1.0 ↗ beta complex topology › MOSC N-terminal domain-like › MOSC N-terminal domain-like › MOSC N-terminal domain-like 0.51 41.0 2.77e-01 96.7% 39.6%
5036086 101.1.2.0 ↗ alpha arrays › HTH › HTH › winged helix domain 0.50 44.0 4.04e-01 100.0% 96.2%