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putative_NS2
Euk-VirGB_virus-D
putative_NS2__YP_009256194_putative_NS2__GB_virus-D__2847088
Identity
- Accession:
- YP_009256194_putative_NS2 ↗
- Protein ID:
- putative_NS2
- Kingdom:
- euk
Quality
78.8
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Pegivirus›
GB_virus-D
TaxID: 2847088
Cluster
View cluster (7 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 17-136
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01538.24 best | HCV_NS2 | 28.6 | 1.50e-06 | 96.7% | 52.3% |
CATH (40)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4nsmA00 | 6.10.250.2770 | Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.81 | 48.0 | 6.12e-01 | 74.2% | 100.0% |
| 1owaA02 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.76 | 52.0 | 5.53e-01 | 82.5% | 79.2% |
| 1yg2A02 | 6.10.140.190 | Special › Helix non-globular › Helix Hairpins › | 0.74 | 54.0 | 6.13e-01 | 87.5% | 100.0% |
| 3uumA00 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.74 | 54.0 | 5.45e-01 | 80.8% | 74.6% |
| 3mq1A01 | 1.20.58.970 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.74 | 50.0 | 5.68e-01 | 81.7% | 90.2% |
| 1hs7A00 | 1.20.58.70 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.74 | 45.0 | 5.03e-01 | 80.8% | 76.3% |
| 1quuA01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.74 | 54.0 | 5.33e-01 | 84.2% | 72.2% |
| 3qo8A01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.73 | 47.0 | 5.03e-01 | 71.7% | 74.5% |
| 4lwsA00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.72 | 49.0 | 5.36e-01 | 70.0% | 86.0% |
| 1aj3A00 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.72 | 45.0 | 4.97e-01 | 72.5% | 77.6% |
| 4xpwA00 | 1.20.120.50 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hemerythrin-like | 0.72 | 40.0 | 3.87e-01 | 75.8% | 49.6% |
| 6r1nA01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.72 | 47.0 | 5.07e-01 | 71.7% | 77.7% |
| 1wa8A00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.72 | 49.0 | 5.31e-01 | 75.0% | 84.8% |
| 2rd0B00 | 1.10.287.1490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.71 | 51.0 | 4.84e-01 | 73.3% | 68.3% |
| 3vkgA12 | 1.10.287.2610 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.71 | 51.0 | 4.12e-01 | 73.3% | 67.4% |
| 1vctA01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.71 | 46.0 | 4.84e-01 | 77.5% | 72.5% |
| 2lw1A00 | 1.10.287.380 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Valyl-tRNA synthetase, C-terminal domain | 0.70 | 44.0 | 5.04e-01 | 73.3% | 87.1% |
| 6gy8A01 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.69 | 53.0 | 3.84e-01 | 81.7% | 66.3% |
| 2q0oC00 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.69 | 46.0 | 5.26e-01 | 81.7% | 95.3% |
| 6h9xA01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.68 | 44.0 | 4.69e-01 | 72.5% | 75.5% |
| 1qu7A00 | 1.10.287.950 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein | 0.68 | 48.0 | 3.88e-01 | 73.3% | 51.1% |
| 1fxkC00 | 1.10.287.370 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.68 | 47.0 | 4.55e-01 | 70.8% | 100.0% |
| 3efzB00 | 1.20.190.20 | Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › 14-3-3 domain | 0.67 | 46.0 | 3.75e-01 | 76.7% | 37.3% |
| 4dylA02 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.67 | 47.0 | 5.19e-01 | 72.5% | 91.5% |
| 1i4dA00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.67 | 48.0 | 4.12e-01 | 74.2% | 52.1% |
| 1hciA03 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.66 | 50.0 | 5.01e-01 | 81.7% | 78.3% |
| 4cqiA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.66 | 48.0 | 5.10e-01 | 76.7% | 86.0% |
| 2xsbA02 | 1.20.58.240 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › STAT; domain 1 | 0.66 | 41.0 | 3.81e-01 | 75.0% | 49.7% |
| 4mh6A00 | 1.10.287.1700 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.65 | 47.0 | 4.25e-01 | 73.3% | 57.2% |
| 3na7A00 | 1.10.287.1490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.65 | 46.0 | 3.68e-01 | 73.3% | 44.7% |
| 2ke4A00 | 6.10.140.470 | Special › Helix non-globular › Helix Hairpins › | 0.65 | 46.0 | 5.02e-01 | 78.3% | 90.8% |
| 3rvyA01 | 1.20.120.350 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C | 0.63 | 38.0 | 3.96e-01 | 72.5% | 62.3% |
| 1wn0A00 | 1.20.120.160 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain | 0.60 | 47.0 | 4.57e-01 | 82.5% | 90.8% |
| 3teqB00 | 1.10.287.3550 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.60 | 44.0 | 4.71e-01 | 75.8% | 94.1% |
| 8ek4A01 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.59 | 44.0 | 4.29e-01 | 77.5% | 78.9% |
| 2kg7B00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.57 | 39.0 | 4.19e-01 | 74.2% | 86.6% |
| 1f45B00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.55 | 42.0 | 4.06e-01 | 79.2% | 82.0% |
| 3rmiA00 | 1.20.59.10 | Mainly Alpha › Up-down Bundle › Chorismate Mutase Domain, subunit A › Chorismate mutase | 0.53 | 39.0 | 4.17e-01 | 95.0% | 89.5% |
| 2x1dA02 | 1.10.10.2120 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › | 0.51 | 26.0 | 3.28e-01 | 77.5% | 79.7% |
| 2xbkA00 | 1.10.630.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450 | 0.51 | 43.0 | 3.06e-01 | 94.2% | 68.8% |
ECOD (40)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3496462 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.78 | 46.0 | 5.02e-01 | 75.8% | 70.0% |
| 3608012 | 3922.1.1.0 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 | 0.76 | 51.0 | 6.01e-01 | 76.7% | 97.6% |
| 3483996 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.73 | 52.0 | 5.44e-01 | 80.0% | 79.1% |
| 3214224 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.73 | 63.0 | 5.80e-01 | 91.7% | 73.3% |
| 3741745 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.73 | 40.0 | 3.95e-01 | 74.2% | 50.0% |
| 3607086 | 4992.1.1.0 ↗ | extended segments › RelB-like › RelB-like › RelB-like | 0.73 | 48.0 | 5.67e-01 | 74.2% | 100.0% |
| 3251434 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.71 | 51.0 | 4.42e-01 | 74.2% | 81.1% |
| 4236831 | 604.6.1.50 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › DUF2524 | 0.70 | 40.0 | 4.79e-01 | 77.5% | 83.7% |
| 3766182 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.70 | 50.0 | 4.70e-01 | 73.3% | 97.2% |
| 4608200 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.70 | 53.0 | 5.22e-01 | 77.5% | 84.8% |
| 4944766 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.70 | 49.0 | 4.07e-01 | 71.7% | 48.8% |
| 4660205 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.70 | 50.0 | 4.81e-01 | 73.3% | 69.6% |
| 3484929 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.70 | 47.0 | 5.07e-01 | 80.0% | 82.0% |
| 3366371 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.69 | 53.0 | 4.04e-01 | 80.0% | 62.6% |
| 3615123 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.69 | 49.0 | 4.23e-01 | 73.3% | 48.3% |
| 3710275 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.68 | 51.0 | 4.05e-01 | 78.3% | 63.7% |
| 5057329 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.68 | 46.0 | 4.32e-01 | 74.2% | 56.6% |
| 3916825 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.68 | 47.0 | 4.38e-01 | 74.2% | 56.7% |
| 3764851 | 192.8.1.0 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain | 0.68 | 47.0 | 5.37e-01 | 75.0% | 95.6% |
| 3244448 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.68 | 47.0 | 4.29e-01 | 71.7% | 70.6% |
| 3784055 | 192.24.1.0 ↗ | alpha bundles › Long alpha-hairpin › RPC62 helical hairpin domain › RPC62 helical hairpin domain | 0.67 | 53.0 | 5.22e-01 | 84.2% | 96.2% |
| 3848917 | 3939.1.1.0 ↗ | alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain | 0.67 | 46.0 | 5.30e-01 | 75.0% | 100.0% |
| 3189020 | 2004.1.1.87 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N | 0.67 | 48.0 | 3.08e-01 | 74.2% | 49.3% |
| 3609437 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.66 | 48.0 | 4.61e-01 | 74.2% | 67.4% |
| 4015122 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.66 | 47.0 | 4.62e-01 | 73.3% | 80.8% |
| 4977923 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.66 | 49.0 | 4.49e-01 | 77.5% | 79.4% |
| 3165834 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.66 | 47.0 | 3.65e-01 | 73.3% | 87.7% |
| 3661101 | 3755.3.1.290 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › PPI_helical | 0.66 | 47.0 | 4.30e-01 | 73.3% | 94.2% |
| 4177363 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.66 | 48.0 | 4.55e-01 | 76.7% | 77.2% |
| 4972576 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.66 | 46.0 | 4.12e-01 | 71.7% | 98.2% |
| 3504306 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.66 | 41.0 | 4.33e-01 | 70.0% | 70.5% |
| 3786891 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.65 | 48.0 | 3.25e-01 | 76.7% | 90.5% |
| 4951266 | 2004.1.1.87 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N | 0.65 | 47.0 | 3.23e-01 | 75.0% | 34.3% |
| 3628737 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.64 | 45.0 | 3.57e-01 | 71.7% | 45.5% |
| 3598168 | 3755.1.1.0 ↗ | alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related | 0.64 | 45.0 | 4.08e-01 | 73.3% | 54.5% |
| 4514020 | 2004.1.1.199 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23,SbcC_Walker_B | 0.63 | 45.0 | 2.88e-01 | 73.3% | 39.8% |
| 4431851 | 3922.1.1.0 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 | 0.62 | 42.0 | 4.14e-01 | 70.0% | 63.8% |
| 3298752 | 150.5.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like | 0.61 | 41.0 | 4.25e-01 | 75.0% | 72.2% |
| 4936792 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.61 | 44.0 | 3.82e-01 | 75.8% | 100.0% |
| 3760336 | 5054.1.1.2 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › Ion_trans | 0.58 | 38.0 | 3.41e-01 | 74.2% | 45.9% |
D2
medium
residues 160-241
Domain cluster:
rep: nonstructural_protein_NS2__YP_009679008__Hepacivirus_N__2008773__D147-204
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01538.24 best | HCV_NS2 | 57.0 | 3.00e-15 | 72.0% | 29.7% |