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putative_NS2_peptide

Euk-Vir

Human_pegivirus_2

putative_NS2_peptide__YP_009227301__Human_pegivirus_2__1729141

Identity

Accession:
YP_009227301 ↗
Protein ID:
putative_NS2_peptide
Kingdom:
euk

Quality

83.8 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Pegivirus› Human_pegivirus_2

TaxID: 1729141

Cluster

View cluster (7 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 193-239
PDB
Domain cluster: representative
CATH (34)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
6oqrA01 2.40.30.20 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › 0.80 56.0 4.47e-01 74.5% 43.3%
4dt4A02 2.40.10.330 Mainly Beta › Beta Barrel › Thrombin, subunit H › 0.77 54.0 5.09e-01 74.5% 84.2%
2kr7A02 2.40.10.330 Mainly Beta › Beta Barrel › Thrombin, subunit H › 0.72 50.0 4.72e-01 74.5% 82.5%
6zxfz01 1.10.510.10 Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1 0.69 48.0 3.56e-01 74.5% 61.8%
1zarA02 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.67 47.0 3.94e-01 74.5% 65.4%
4j27A02 2.60.40.1180 Mainly Beta › Sandwich › Immunoglobulin-like › Golgi alpha-mannosidase II 0.65 45.0 3.69e-01 74.5% 43.8%
4p72A04 3.30.56.10 Alpha Beta › 2-Layer Sandwich › Phenylalanyl-tRNA Synthetase; Chain B, domain 1 › 0.61 42.0 3.67e-01 74.5% 60.5%
1ng4A02 3.30.9.10 Alpha Beta › 2-Layer Sandwich › D-Amino Acid Oxidase; Chain A, domain 2 › D-Amino Acid Oxidase, subunit A, domain 2 0.59 41.0 3.00e-01 74.5% 25.0%
1u2hA00 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.59 42.0 3.44e-01 78.7% 47.9%
2dm2A00 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.59 41.0 3.21e-01 76.6% 41.8%
2b30A02 3.30.1240.10 Alpha Beta › 2-Layer Sandwich › Hypothetical Protein, Haloacid Dehalogenase-like Hydrolase; Chain: A; domain 2 › 0.59 42.0 3.29e-01 78.7% 39.4%
2kkqA00 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.59 41.0 3.16e-01 76.6% 39.7%
1n67A01 2.60.40.1280 Mainly Beta › Sandwich › Immunoglobulin-like › 0.58 40.0 2.97e-01 74.5% 33.3%
5uv6A03 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.58 41.0 3.41e-01 76.6% 50.6%
1avaA02 2.60.40.1180 Mainly Beta › Sandwich › Immunoglobulin-like › Golgi alpha-mannosidase II 0.58 39.0 3.73e-01 74.5% 58.6%
2kdgA00 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.58 42.0 3.35e-01 78.7% 46.0%
1fhgA00 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.58 40.0 3.23e-01 76.6% 44.1%
5ao2B02 3.30.70.2760 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.57 39.0 3.34e-01 76.6% 66.3%
1owqA02 3.10.50.10 Alpha Beta › Roll › Chitinase A; domain 3 › 0.56 40.0 3.61e-01 74.5% 100.0%
3oc5A02 2.60.40.3240 Mainly Beta › Sandwich › Immunoglobulin-like › Vibrio cholerae toxin co-regulated pilus biosynthesis protein F, C-terminal domain 0.56 39.0 2.90e-01 76.6% 46.1%
3jtnB00 3.30.70.1950 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.56 47.0 3.87e-01 97.9% 86.7%
2w42B02 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.54 43.0 2.90e-01 100.0% 34.6%
1vw4F02 3.90.930.12 Alpha Beta › Alpha-Beta Complex › Outer Surface Protein A; domain 3 › Ribosomal protein L6 0.54 36.0 3.10e-01 74.5% 57.6%
1wzaA03 2.60.40.1180 Mainly Beta › Sandwich › Immunoglobulin-like › Golgi alpha-mannosidase II 0.53 37.0 3.20e-01 74.5% 48.1%
7npaA02 3.30.70.3340 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.53 36.0 3.11e-01 74.5% 51.8%
7plsA02 2.60.40.1180 Mainly Beta › Sandwich › Immunoglobulin-like › Golgi alpha-mannosidase II 0.53 37.0 3.08e-01 76.6% 78.5%
2yvsA02 3.30.70.2560 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.52 41.0 3.85e-01 89.4% 94.9%
2ql3A01 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.51 41.0 3.40e-01 97.9% 46.5%
1sjgA00 2.102.10.10 Mainly Beta › 3-layer Sandwich › Rieske Iron-sulfur Protein › Rieske [2Fe-2S] iron-sulphur domain 0.51 36.0 2.85e-01 76.6% 91.1%
1zhvA00 3.30.2130.10 Alpha Beta › 2-Layer Sandwich › VC0802-like › VC0802-like 0.51 37.0 2.85e-01 87.2% 69.4%
2bhoA00 3.30.1460.10 Alpha Beta › 2-Layer Sandwich › Yope Regulator; Chain: A, › 0.51 34.0 2.83e-01 76.6% 35.5%
1epfA01 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.51 35.0 2.92e-01 76.6% 50.0%
2qmaA02 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.50 36.0 2.78e-01 80.9% 72.0%
3h41A02 2.30.30.40 Mainly Beta › Roll › SH3 type barrels. › SH3 Domains 0.50 35.0 3.18e-01 76.6% 70.6%
ECOD (28)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4427237 3374.1.1.2 ↗ a+b complex topology › spore cortex-lytic enzyme catalytic domain › spore cortex-lytic enzyme catalytic domain › spore cortex-lytic enzyme catalytic domain › Hydrolase_2 0.75 49.0 3.53e-01 74.5% 23.7%
4105312 1.1.7.0 ↗ beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C 0.66 47.0 3.99e-01 76.6% 72.5%
4231688 1.1.7.0 ↗ beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C 0.63 44.0 3.56e-01 76.6% 69.0%
3838015 319.3.1.3 ↗ beta sandwiches › HSP20-like › B2 domain of PilQ › B2 domain of PilQ › DUF7494 0.62 44.0 3.34e-01 78.7% 88.5%
4971139 304.28.1.0 ↗ a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain 0.60 41.0 3.78e-01 74.5% 53.8%
3396884 390.1.1.1 ↗ few secondary structure elements › Hairpin loop containing domain-like › Hairpin loop containing domain-like › Hairpin loop containing domain-like › PAN_1 0.59 47.0 4.04e-01 100.0% 68.9%
4659650 331.1.1.0 ↗ a+b two layers › TBP-like › TATA-box binding protein-like › TATA-box binding protein-like 0.59 41.0 3.36e-01 74.5% 60.0%
3738408 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.59 41.0 3.57e-01 76.6% 53.8%
4127927 327.19.1.1 ↗ a+b two layers › Alpha-lytic protease prodomain-like › DNA mismatch repair protein MutL regulatory subdomain › DNA mismatch repair protein MutL regulatory subdomain › MutL_C 0.58 40.0 3.61e-01 74.5% 52.9%
5059518 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.58 40.0 3.14e-01 74.5% 46.4%
2879522 244.1.1.0 ↗ a+b two layers › FAD-linked reductases, C-terminal domain-like › FAD-linked reductases-C › FAD-linked reductases-C 0.58 43.0 3.57e-01 85.1% 87.0%
3255452 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.58 40.0 3.35e-01 74.5% 44.7%
3503686 11.1.1.97 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › I-set 0.57 40.0 3.24e-01 76.6% 51.0%
4947796 309.1.2.2 ↗ a+b two layers › LuxS, MPP, ThrRS/AlaRS common domain › LuxS, MPP, ThrRS/AlaRS common domain › ThrRS/AlaRS editing domain › tRNA_bind_4 0.57 39.0 2.78e-01 74.5% 33.7%
1811230 244.1.1.0 ↗ a+b two layers › FAD-linked reductases, C-terminal domain-like › FAD-linked reductases-C › FAD-linked reductases-C 0.57 40.0 2.95e-01 74.5% 25.2%
3548690 331.1.1.5 ↗ a+b two layers › TBP-like › TATA-box binding protein-like › TATA-box binding protein-like › OGG_N 0.57 39.0 3.47e-01 74.5% 74.7%
1877510 244.1.1.0 ↗ a+b two layers › FAD-linked reductases, C-terminal domain-like › FAD-linked reductases-C › FAD-linked reductases-C 0.56 42.0 3.58e-01 85.1% 85.9%
6702 244.1.1.4 ↗ a+b two layers › FAD-linked reductases, C-terminal domain-like › FAD-linked reductases-C › FAD-linked reductases-C › DAO 0.55 41.0 3.44e-01 85.1% 86.4%
3911210 7523.1.1.2 ↗ a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Transferrin 0.54 43.0 3.03e-01 100.0% 79.8%
1173367 304.6.1.7 ↗ a+b two layers › Alpha-beta plaits › FAD-linked oxidases, C-terminal domain › FAD-linked oxidases, C-terminal domain › DUF5639 0.54 44.0 3.55e-01 100.0% 73.3%
3500022 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.54 37.0 3.19e-01 74.5% 47.5%
4388256 4.1.1.0 ↗ beta barrels › SH3 › SH3 › SH3 0.53 37.0 2.92e-01 78.7% 86.4%
2444013 11.1.1.97 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › I-set 0.53 38.0 3.13e-01 78.7% 48.9%
3973327 7523.1.1.15 ↗ a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II › LysR_substrate 0.53 42.0 3.37e-01 93.6% 88.6%
3973484 7523.1.1.15 ↗ a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II › LysR_substrate 0.52 40.0 3.40e-01 97.9% 47.0%
3519467 304.24.1.4 ↗ a+b two layers › Alpha-beta plaits › EF-G C-terminal domain-like › EF-G C-terminal domain-like › RF3_C 0.51 43.0 3.22e-01 100.0% 71.1%
3421421 12.1.1.0 ↗ beta sandwiches › Glycosyl hydrolase domain-like › Glycosyl hydrolase domain › Glycosyl hydrolase domain 0.51 35.0 2.14e-01 78.7% 8.6%
3946905 7523.1.1.0 ↗ a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II 0.51 40.0 3.23e-01 93.6% 92.4%
D2 medium residues 4-40
PDB
D3 medium residues 41-180
PDB
Domain cluster: rep: putative_NS2_protein__YP_007905978__Rodent_pegivirus__1321391__D60-181
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01538.24 best HCV_NS2 50.0 4.10e-13 98.6% 66.1%