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putative_NS5A_peptide

Euk-Vir

Human_pegivirus_2

putative_NS5A_peptide__YP_009227297__Human_pegivirus_2__1729141

Identity

Accession:
YP_009227297 ↗
Protein ID:
putative_NS5A_peptide
Kingdom:
euk

Quality

49.2 mean pLDDT

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 17-95
PDB
Domain cluster: representative
CATH (15)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3fqmA01 2.20.25.210 Mainly Beta › Single Sheet › N-terminal domain of TfIIb › Hepatitis C NS5A, domain 1B 0.89 62.0 7.03e-01 74.7% 93.4%
3op1A02 2.40.30.30 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Riboflavin kinase-like 0.57 41.0 3.74e-01 77.2% 76.6%
1b63A01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.56 41.0 2.98e-01 77.2% 38.9%
5trdA02 2.40.30.30 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Riboflavin kinase-like 0.55 38.0 3.32e-01 74.7% 94.8%
1mu5A01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.54 40.0 2.91e-01 77.2% 44.8%
5z6pA01 2.60.120.430 Mainly Beta › Sandwich › Jelly Rolls › Galactose-binding lectin 0.54 39.0 3.11e-01 78.5% 62.9%
3kl9A02 2.40.30.40 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Peptidase M42, domain 2 0.54 37.0 3.83e-01 72.2% 100.0%
2d9rA00 2.40.30.100 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › AF2212/PG0164-like 0.54 37.0 3.68e-01 73.4% 96.5%
2jvuA00 2.60.40.2290 Mainly Beta › Sandwich › Immunoglobulin-like › 0.52 37.0 3.49e-01 74.7% 76.5%
2wjsA02 2.60.120.200 Mainly Beta › Sandwich › Jelly Rolls › 0.52 41.0 3.24e-01 88.6% 72.1%
1x99A00 2.60.270.20 Mainly Beta › Sandwich › Mutm (Fpg) Protein; Chain: A, domain 2 › Cytolysin/lectin 0.51 41.0 3.38e-01 87.3% 89.7%
3k44B00 3.30.2450.30 Alpha Beta › 2-Layer Sandwich › Secreted effector protein pipB2 fold › 0.51 40.0 3.37e-01 86.1% 85.7%
3mepA00 2.60.120.200 Mainly Beta › Sandwich › Jelly Rolls › 0.51 41.0 3.22e-01 89.9% 64.8%
3zn6A02 2.60.40.3410 Mainly Beta › Sandwich › Immunoglobulin-like › 0.51 36.0 3.50e-01 74.7% 96.6%
8a7dC01 2.60.120.200 Mainly Beta › Sandwich › Jelly Rolls › 0.51 39.0 3.00e-01 88.6% 63.4%
ECOD (14)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
119351 926.1.1.1 few secondary structure elements › HCV NS5A domain I subdomains › HCV NS5A domain I subdomains › HCV NS5A domain I subdomains › HCV_NS5a_1a 0.89 72.0 7.52e-01 87.3% 91.8%
3189294 884.1.1.0 a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain 0.60 45.0 3.80e-01 78.5% 76.0%
5046931 225.1.1.0 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.60 45.0 3.11e-01 78.5% 47.3%
3509389 10.1.1.0 beta sandwiches › jelly-roll › Concanavalin A-like › Concanavalin A-like lectins/glucanases 0.57 41.0 3.49e-01 75.9% 83.1%
4404190 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.57 41.0 2.97e-01 77.2% 37.3%
3498817 239.3.1.0 beta barrels › Ribosomal protein L25-like › FAS1 domain › FAS1 domain 0.56 44.0 3.49e-01 84.8% 78.8%
3917408 11.1.1.0 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.56 48.0 4.36e-01 94.9% 78.1%
3541953 11.1.1.108 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › C2-set_2 0.55 40.0 3.03e-01 75.9% 42.7%
4080130 1.1.7.17 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › ATP-synt_ab_N 0.55 39.0 3.99e-01 75.9% 97.3%
3715939 10.12.1.0 beta sandwiches › jelly-roll › Double-stranded beta-helix › Double-stranded beta-helix 0.55 37.0 2.82e-01 70.9% 60.0%
4883586 1.1.7.0 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C 0.55 38.0 3.78e-01 74.7% 84.9%
4273009 225.1.1.7 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.53 39.0 2.98e-01 78.5% 44.2%
3781145 239.3.1.0 beta barrels › Ribosomal protein L25-like › FAS1 domain › FAS1 domain 0.53 41.0 3.28e-01 84.8% 83.6%
3930882 1.1.7.0 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C 0.52 36.0 3.48e-01 74.7% 90.5%
D2 medium residues 106-176
PDB
Domain cluster: representative
CATH (23)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3fqmA02 2.20.25.220 Mainly Beta › Single Sheet › N-terminal domain of TfIIb › Hepatitis C virus NS5A, 1B domain 0.62 57.0 5.30e-01 100.0% 93.0%
6fndA01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.61 44.0 3.27e-01 77.5% 48.9%
4my0A02 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.61 42.0 3.36e-01 100.0% 36.4%
2vifA01 3.30.505.10 Alpha Beta › 2-Layer Sandwich › SHC Adaptor Protein › SH2 domain 0.57 42.0 3.58e-01 81.7% 80.2%
3s6gA02 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.55 40.0 3.19e-01 100.0% 37.7%
1xf8A02 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.55 43.0 3.30e-01 100.0% 37.0%
3n4pC00 3.30.420.320 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › DNA-packaging terminase, C-terminal nuclease domain 0.55 48.0 3.44e-01 100.0% 62.4%
3ey5A01 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.54 41.0 3.20e-01 100.0% 37.4%
2k5tA00 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.54 42.0 3.47e-01 100.0% 46.9%
2cntA00 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.54 42.0 3.32e-01 100.0% 40.4%
1q2yA00 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.54 42.0 3.43e-01 100.0% 44.3%
6l4lA02 3.10.310.10 Alpha Beta › Roll › Diaminopimelate Epimerase; Chain A, domain 1 › Diaminopimelate Epimerase; Chain A, domain 1 0.53 39.0 3.26e-01 100.0% 41.9%
3n7zA02 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.53 39.0 3.07e-01 100.0% 35.7%
6wqbA02 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.53 42.0 3.39e-01 100.0% 44.3%
2i00A02 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.53 38.0 3.03e-01 100.0% 35.2%
1n71B00 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.53 43.0 3.22e-01 100.0% 35.8%
2aj6A00 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.52 42.0 3.58e-01 100.0% 53.3%
1z24A00 2.40.128.20 Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain 0.52 39.0 3.02e-01 85.9% 68.3%
1y9wA01 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.52 41.0 3.67e-01 100.0% 60.6%
6d92A01 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.51 45.0 3.12e-01 98.6% 88.9%
2g3aA02 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.51 40.0 3.57e-01 100.0% 59.0%
3fixA00 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.50 40.0 3.09e-01 100.0% 37.6%
1p9rA01 3.30.450.90 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › 0.50 39.0 3.40e-01 84.5% 62.2%
ECOD (45)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4957315 213.1.1.0 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) 0.61 45.0 3.69e-01 100.0% 43.1%
5032938 213.1.1.0 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) 0.59 39.0 3.27e-01 100.0% 40.0%
2469865 213.1.1.0 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) 0.58 42.0 3.79e-01 100.0% 56.2%
5032421 213.1.1.0 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) 0.58 44.0 3.33e-01 100.0% 33.7%
4944314 223.2.1.0 a+b three layers › Profilin-like › profilin-like › profilin-like 0.57 39.0 3.32e-01 71.8% 71.2%
3960569 213.1.1.0 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) 0.56 44.0 4.01e-01 100.0% 64.2%
3973692 213.1.1.51 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › FemAB_like 0.55 44.0 3.14e-01 100.0% 29.8%
5072842 213.1.1.0 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) 0.55 44.0 3.90e-01 100.0% 61.0%
3990136 213.1.1.1 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 0.55 41.0 3.29e-01 100.0% 40.0%
5068825 213.1.1.37 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_18 0.55 42.0 3.31e-01 100.0% 40.0%
3016757 213.1.1.7 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › FemAB 0.54 43.0 3.24e-01 100.0% 35.3%
4203573 213.1.1.75 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › FemAB, Acetyltransf_6 0.54 43.0 3.25e-01 100.0% 35.9%
3290074 213.5.1.1 a+b three layers › Nat/Ivy › AlkZ C-terminal domain › AlkZ C-terminal domain › AlkZ-like 0.54 42.0 3.83e-01 100.0% 61.0%
3588798 213.1.1.1 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 0.54 42.0 3.31e-01 100.0% 40.0%
3514747 213.1.1.36 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_17 0.54 39.0 3.14e-01 100.0% 37.3%
4884528 213.1.1.1 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 0.54 43.0 3.40e-01 100.0% 42.2%
5041440 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.54 48.0 3.41e-01 100.0% 63.3%
4980036 213.1.1.1 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 0.54 41.0 3.62e-01 100.0% 54.5%
3279395 213.1.1.35 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_CG 0.54 42.0 3.87e-01 100.0% 64.2%
3277758 213.1.1.35 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_CG 0.54 42.0 3.83e-01 100.0% 62.2%
4974990 2484.1.1.77 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Terminase_6C 0.54 47.0 3.58e-01 100.0% 65.1%
4941251 213.1.1.1 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 0.53 43.0 3.41e-01 100.0% 43.4%
4985396 213.1.1.27 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_7 0.53 42.0 3.76e-01 100.0% 61.0%
4971004 213.1.1.27 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_7 0.53 41.0 3.73e-01 100.0% 60.6%
3505666 4099.1.1.2 a+b two layers › Kinetochore globular domain-like › Kinetochore globular domain-like › Kinetochore globular domain-like › Spindle_Spc25 0.53 40.0 3.78e-01 94.4% 67.1%
3278510 213.1.1.1 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 0.53 42.0 3.25e-01 100.0% 37.8%
5081053 213.1.1.31 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_10 0.53 42.0 3.38e-01 100.0% 44.3%
3668817 4099.1.1.2 a+b two layers › Kinetochore globular domain-like › Kinetochore globular domain-like › Kinetochore globular domain-like › Spindle_Spc25 0.53 40.0 2.92e-01 94.4% 30.8%
3742980 4099.1.1.4 a+b two layers › Kinetochore globular domain-like › Kinetochore globular domain-like › Kinetochore globular domain-like › CENP-O 0.53 40.0 3.34e-01 98.6% 47.9%
5031052 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.53 47.0 3.39e-01 100.0% 53.2%
5030045 213.1.1.31 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_10 0.52 41.0 3.23e-01 100.0% 39.6%
3385817 213.1.1.62 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › ATE_N+ATE_C 0.52 41.0 2.90e-01 100.0% 26.4%
3412853 213.1.1.35 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_CG 0.52 41.0 3.87e-01 100.0% 70.6%
5081097 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.52 45.0 3.38e-01 100.0% 59.5%
3943820 213.1.1.1 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 0.52 43.0 3.26e-01 100.0% 37.7%
3326622 4099.1.1.2 a+b two layers › Kinetochore globular domain-like › Kinetochore globular domain-like › Kinetochore globular domain-like › Spindle_Spc25 0.52 39.0 3.21e-01 94.4% 45.6%
4274495 246.3.1.2 a+b four layers › Carbon-nitrogen hydrolase-like › DNase I-like › DNase I-like › RNase_E_G 0.52 41.0 3.54e-01 100.0% 53.3%
5076803 213.1.1.1 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 0.51 40.0 3.25e-01 100.0% 42.8%
5068824 213.1.1.31 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_10 0.51 41.0 3.54e-01 100.0% 54.8%
3668273 246.3.1.2 a+b four layers › Carbon-nitrogen hydrolase-like › DNase I-like › DNase I-like › RNase_E_G 0.51 42.0 3.33e-01 98.6% 44.0%
3974138 213.1.1.27 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_7 0.51 43.0 3.30e-01 100.0% 40.6%
3976933 213.1.1.0 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) 0.51 38.0 3.17e-01 100.0% 43.7%
169936 213.1.1.1 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 0.50 40.0 3.13e-01 100.0% 39.0%
3423643 246.3.1.2 a+b four layers › Carbon-nitrogen hydrolase-like › DNase I-like › DNase I-like › RNase_E_G 0.50 41.0 3.50e-01 100.0% 53.6%
3163696 213.1.1.64 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › DUF535 0.50 44.0 3.20e-01 100.0% 37.6%
D3 medium residues 338-428
PDB