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putative_dihydrofolate_reductase
Euk-VirShort-finned_eel_ranavirus
putative_dihydrofolate_reductase__YP_009259384__Short-finned_eel_ranavirus__638660
Identity
- Accession:
- YP_009259384 ↗
- Protein ID:
- putative_dihydrofolate_reductase
- Kingdom:
- euk
Quality
91.4
mean pLDDT
Taxonomy
Bamfordvirae›
Nucleocytoviricota›
Megaviricetes›
Pimascovirales›
Iridoviridae›
Ranavirus›
Short-finned_eel_ranavirus
TaxID: 638660
Cluster
View cluster (29 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 1-10_34-47_130-189
Domain cluster:
representative
CATH (31)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1bozA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.92 | 86.0 | 6.35e-01 | 97.6% | 100.0% |
| 3nzbX00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.90 | 84.0 | 6.06e-01 | 98.8% | 99.0% |
| 1aoeA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.88 | 80.0 | 5.97e-01 | 97.6% | 99.5% |
| 6pf8A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.85 | 79.0 | 5.94e-01 | 96.4% | 100.0% |
| 1j3jB00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.83 | 79.0 | 5.64e-01 | 100.0% | 99.5% |
| 3vcoA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.83 | 74.0 | 5.67e-01 | 97.6% | 100.0% |
| 4eckA01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.82 | 75.0 | 5.65e-01 | 96.4% | 100.0% |
| 3k2hA01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.81 | 76.0 | 5.67e-01 | 98.8% | 97.9% |
| 5eccA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 69.0 | 5.48e-01 | 95.2% | 100.0% |
| 1ao8A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 68.0 | 5.36e-01 | 95.2% | 100.0% |
| 1dhiA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 68.0 | 5.36e-01 | 94.0% | 100.0% |
| 2w9hA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.76 | 67.0 | 5.36e-01 | 94.0% | 100.0% |
| 3ix9A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.75 | 70.0 | 5.48e-01 | 100.0% | 100.0% |
| 2h2qB01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.71 | 66.0 | 4.78e-01 | 100.0% | 92.0% |
| 2p4gA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.69 | 63.0 | 4.46e-01 | 100.0% | 93.5% |
| 2hxvA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.69 | 61.0 | 4.56e-01 | 95.2% | 100.0% |
| 2b3zA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.68 | 61.0 | 4.42e-01 | 97.6% | 97.8% |
| 6nifA01 | 3.30.900.10 | Alpha Beta › 2-Layer Sandwich › Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A › HORMA domain | 0.61 | 49.0 | 3.72e-01 | 88.1% | 88.7% |
| 4qdjA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.55 | 47.0 | 3.54e-01 | 95.2% | 70.7% |
| 4yj6A00 | 3.90.1300.10 | Alpha Beta › Alpha-Beta Complex › Amidase signature (AS) enzymes › Amidase signature (AS) domain | 0.54 | 47.0 | 2.98e-01 | 100.0% | 95.7% |
| 2y7bA00 | 2.30.29.30 | Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) | 0.53 | 32.0 | 2.76e-01 | 94.0% | 37.3% |
| 3gnlA01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.53 | 45.0 | 3.68e-01 | 96.4% | 87.3% |
| 3tmaA02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.52 | 44.0 | 3.52e-01 | 95.2% | 83.1% |
| 3a1iA02 | 3.90.1300.10 | Alpha Beta › Alpha-Beta Complex › Amidase signature (AS) enzymes › Amidase signature (AS) domain | 0.52 | 45.0 | 2.86e-01 | 97.6% | 92.1% |
| 3uwpA02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.51 | 43.0 | 3.33e-01 | 100.0% | 75.9% |
| 3tm4A02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.51 | 44.0 | 3.54e-01 | 97.6% | 83.4% |
| 4p27A00 | 3.40.33.10 | Alpha Beta › 3-Layer(aba) Sandwich › Pathogenesis-related Protein p14a › CAP | 0.51 | 40.0 | 3.33e-01 | 86.9% | 56.8% |
| 1iamA01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.51 | 32.0 | 3.31e-01 | 90.5% | 65.1% |
| 3b8bA02 | 3.40.190.80 | Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › | 0.51 | 43.0 | 4.01e-01 | 97.6% | 93.7% |
| 3c24A01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.50 | 35.0 | 2.90e-01 | 73.8% | 93.2% |
| 1vm0A00 | 3.30.110.20 | Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › Alba-like domain | 0.50 | 43.0 | 4.18e-01 | 94.0% | 92.5% |
ECOD (32)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3900511 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.93 | 87.0 | 6.45e-01 | 97.6% | 100.0% |
| 4402042 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.93 | 86.0 | 6.37e-01 | 96.4% | 100.0% |
| 3913441 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.92 | 88.0 | 6.48e-01 | 100.0% | 100.0% |
| 4667474 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.91 | 81.0 | 6.07e-01 | 92.9% | 100.0% |
| 3187913 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 85.0 | 6.04e-01 | 98.8% | 100.0% |
| 10268 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 84.0 | 6.07e-01 | 98.8% | 99.0% |
| 3056343 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.88 | 81.0 | 5.84e-01 | 97.6% | 94.8% |
| 3232633 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.86 | 78.0 | 5.79e-01 | 95.2% | 100.0% |
| 3593841 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.82 | 76.0 | 5.38e-01 | 97.6% | 95.5% |
| 4276639 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.81 | 76.0 | 5.87e-01 | 100.0% | 97.6% |
| 4652224 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.77 | 70.0 | 5.47e-01 | 96.4% | 100.0% |
| 137968 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.75 | 70.0 | 5.48e-01 | 100.0% | 100.0% |
| 169540 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.75 | 70.0 | 5.47e-01 | 100.0% | 98.8% |
| 4315799 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.68 | 59.0 | 4.70e-01 | 98.8% | 100.0% |
| 5057520 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.68 | 60.0 | 4.36e-01 | 96.4% | 94.1% |
| 3371194 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.66 | 59.0 | 4.36e-01 | 98.8% | 99.1% |
| 5001085 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.60 | 52.0 | 3.85e-01 | 100.0% | 94.9% |
| 3283335 | 7523.1.1.15 ↗ | a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II › LysR_substrate | 0.59 | 53.0 | 4.52e-01 | 100.0% | 80.7% |
| 2389059 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.58 | 49.0 | 3.68e-01 | 98.8% | 95.0% |
| None | — | 0.58 | 43.0 | 3.20e-01 | 81.0% | 100.0% | |
| 4392983 | 2003.1.5.20 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › MethyltransfD12 | 0.57 | 44.0 | 3.10e-01 | 85.7% | 93.3% |
| None | — | 0.56 | 48.0 | 3.72e-01 | 100.0% | 82.0% | |
| 3224621 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.55 | 37.0 | 3.90e-01 | 96.4% | 77.3% |
| 4932802 | 2003.1.5.24 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 | 0.54 | 46.0 | 3.63e-01 | 97.6% | 81.6% |
| 3468691 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.54 | 40.0 | 3.98e-01 | 91.7% | 74.2% |
| 3777599 | 220.1.1.0 ↗ | beta barrels › PH domain-like › PH domain-like › PH domain-like | 0.53 | 32.0 | 2.69e-01 | 94.0% | 35.7% |
| 3843802 | 220.1.1.1 ↗ | beta barrels › PH domain-like › PH domain-like › PH domain-like › PH | 0.53 | 32.0 | 2.66e-01 | 95.2% | 34.5% |
| 3187583 | 213.1.1.77 ↗ | a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1, Acetyltransf_7 | 0.53 | 43.0 | 3.35e-01 | 90.5% | 85.6% |
| 5062021 | 304.10.1.1 ↗ | a+b two layers › Alpha-beta plaits › RuBisCO, large subunit, small (N-terminal) domain › RuBisCO, large subunit, small (N-terminal) domain › RuBisCO_large_N | 0.52 | 36.0 | 3.07e-01 | 70.2% | 57.0% |
| 4935406 | 1.1.7.139 ↗ | beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › HcyBio | 0.51 | 45.0 | 3.49e-01 | 100.0% | 69.9% |
| 3027089 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.51 | 34.0 | 3.41e-01 | 92.9% | 66.7% |
| 4585065 | 2003.1.5.20 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › MethyltransfD12 | 0.50 | 43.0 | 2.62e-01 | 98.8% | 40.0% |
D2
medium
residues 48-129
Domain cluster:
rep: IMGVR_UViG_3300017956_004020-3300017956-Ga0181580_100249958__D38-113
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00186.25 best | DHFR_1 | 51.5 | 1.30e-13 | 100.0% | 43.4% |