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putative_pyrophosphohydrolase

Euk-Vir

Acanthamoeba_polyphaga_mimivirus

putative_pyrophosphohydrolase__YP_003986987__Acanthamoeba_polyphaga_mimivirus__212035

Identity

Accession:
YP_003986987 ↗
Protein ID:
putative_pyrophosphohydrolase
Kingdom:
euk

Quality

86.3 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Megaviricetes› Imitervirales› Mimiviridae› Mimivirus› Acanthamoeba_polyphaga_mimivirus

TaxID: 212035

Cluster

View cluster (12 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 16-178
PDB
Domain cluster: rep: NC_028805.1__YP_009199145.1__AVV11_gp107__00084__D66-195
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF01503.23 best PRA-PH 67.6 1.40e-18 54.0% 88.4%
PF03819.23 MazG 25.4 2.00e-05 32.5% 58.1%
CATH (55)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2v6yA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.90 41.0 6.20e-01 81.6% 97.3%
4b6xA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.82 30.0 4.84e-01 71.2% 84.1%
1cgnA00 1.20.120.10 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c/b562 0.74 47.0 5.41e-01 93.9% 84.7%
1luwA01 1.10.287.990 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain 0.73 28.0 4.45e-01 71.2% 90.6%
4u7iA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.72 40.0 5.26e-01 84.0% 95.7%
6xz3A01 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.71 47.0 5.52e-01 96.3% 93.2%
1q0gA00 1.20.120.400 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nickel-containing superoxide dismutase 0.71 43.0 5.03e-01 96.3% 83.8%
1st6A04 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.71 46.0 5.48e-01 95.1% 92.3%
7c1iA01 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.70 43.0 5.42e-01 74.2% 99.0%
4p9tA01 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.70 41.0 4.79e-01 89.6% 79.2%
6a3kA00 1.20.120.10 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c/b562 0.70 46.0 5.17e-01 94.5% 83.7%
4iggB02 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.69 42.0 4.86e-01 89.6% 81.8%
1cpqA00 1.20.120.10 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c/b562 0.69 47.0 5.22e-01 98.8% 86.0%
4k0dA00 1.20.120.1730 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.68 43.0 4.64e-01 90.8% 73.4%
2yevA03 1.20.120.80 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle 0.68 47.0 4.55e-01 71.2% 76.1%
3u8vA00 1.20.120.660 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain 0.67 35.0 4.84e-01 71.2% 100.0%
1m56C02 1.20.120.80 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle 0.67 47.0 4.38e-01 71.2% 70.4%
3ihuA02 1.20.120.530 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like 0.67 46.0 4.95e-01 84.7% 81.3%
3zc0D00 1.20.58.2140 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.67 38.0 3.69e-01 87.7% 48.7%
2jx0A00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.66 48.0 5.30e-01 74.2% 98.5%
2a0bA00 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.66 42.0 4.89e-01 76.1% 88.1%
1y4cA03 1.20.120.660 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain 0.66 45.0 5.35e-01 71.2% 100.0%
1bbhA00 1.20.120.10 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c/b562 0.65 46.0 5.05e-01 96.9% 87.8%
1nzeA00 1.20.120.290 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Oxygen-evolving enhancer protein 3 (PsbQ), four-helix up-down bundle 0.65 44.0 5.30e-01 79.8% 100.0%
5tpmB00 1.20.120.530 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like 0.65 47.0 5.02e-01 85.3% 84.4%
4p9fA02 1.20.120.530 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like 0.65 48.0 5.05e-01 88.3% 85.4%
3dzaA01 1.20.120.1940 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YfdX protein domain 0.64 37.0 4.38e-01 92.0% 79.5%
3caxA01 1.20.120.520 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › nmb1532 protein domain like 0.64 47.0 4.25e-01 75.5% 63.6%
1orjD00 1.20.120.340 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS 0.64 45.0 5.08e-01 72.4% 93.6%
3iqcA00 1.20.120.340 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS 0.64 43.0 4.94e-01 71.8% 92.4%
2b0hA01 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.63 44.0 4.95e-01 70.6% 95.3%
3zsuA00 1.20.120.290 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Oxygen-evolving enhancer protein 3 (PsbQ), four-helix up-down bundle 0.63 44.0 5.10e-01 71.2% 97.5%
3k17A02 3.30.70.890 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › GHMP kinase, C-terminal domain 0.63 40.0 4.32e-01 88.3% 74.3%
3l8rA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.62 39.0 4.77e-01 86.5% 100.0%
1wcrA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.61 37.0 4.55e-01 84.7% 95.1%
1e2aA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.61 38.0 4.64e-01 84.7% 98.0%
3ajmB02 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.61 44.0 4.84e-01 95.7% 90.2%
1wolA00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.61 44.0 5.01e-01 74.8% 100.0%
4fx5A03 1.20.120.1690 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.61 36.0 4.48e-01 77.3% 95.0%
2r9rH02 1.20.120.350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C 0.61 43.0 4.51e-01 73.0% 98.0%
4agsB04 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.61 38.0 4.10e-01 89.6% 74.4%
4x28C03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.59 40.0 4.26e-01 90.2% 77.6%
3gonA02 3.30.70.890 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › GHMP kinase, C-terminal domain 0.59 35.0 3.91e-01 87.7% 70.9%
3fnrA01 1.10.730.10 Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 0.59 42.0 4.44e-01 73.6% 81.4%
6z74C02 1.20.120.530 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like 0.59 48.0 4.92e-01 90.2% 89.9%
4g10A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.58 37.0 3.94e-01 90.2% 72.8%
3e0sA00 1.40.20.10 Mainly Alpha › Alpha solenoid › CHAD domain › CHAD domain 0.56 43.0 3.49e-01 79.1% 94.9%
2x0cA01 1.20.1420.10 Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain 0.56 44.0 4.31e-01 82.2% 86.5%
2cmrA00 1.20.58.1860 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.56 36.0 3.44e-01 84.0% 55.2%
1nu7D01 1.20.120.750 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Staphylcoagulase, helix bundle domain 1 0.53 37.0 4.02e-01 86.5% 86.7%
1vkeB00 1.20.1290.10 Mainly Alpha › Up-down Bundle › AhpD-like › AhpD-like 0.52 26.0 3.38e-01 82.8% 81.2%
1jkwA02 1.10.472.10 Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like 0.51 28.0 3.43e-01 90.2% 83.2%
1qkrB00 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.51 48.0 4.64e-01 99.4% 95.6%
2ptqA02 1.20.200.10 Mainly Alpha › Up-down Bundle › Fumarase C; Chain A, domain 2 › Fumarase/aspartase (Central domain) 0.51 43.0 3.59e-01 90.2% 83.8%
2v0pA00 1.25.40.540 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › TAP42-like family 0.51 44.0 3.99e-01 92.0% 78.0%
ECOD (55)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5030837 604.12.1.0 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.79 56.0 6.37e-01 80.4% 93.6%
5044068 632.11.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.76 40.0 5.23e-01 81.0% 89.5%
5014264 632.11.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.73 41.0 5.37e-01 88.3% 98.9%
5058485 192.29.1.0 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.71 40.0 4.78e-01 81.6% 79.1%
4942061 632.11.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.71 37.0 4.97e-01 86.5% 96.5%
4387475 601.3.1.1 ↗ alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain › Hpt 0.69 45.0 5.11e-01 73.6% 84.8%
4658843 5039.1.1.1 ↗ alpha bundles › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like › COX3 0.68 47.0 4.00e-01 71.2% 55.4%
5058748 5039.1.1.1 ↗ alpha bundles › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like › COX3 0.67 47.0 3.96e-01 71.2% 53.8%
4071210 5039.1.1.1 ↗ alpha bundles › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like › COX3 0.67 47.0 3.92e-01 71.2% 53.0%
2834659 5039.1.1.13 ↗ alpha bundles › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like › COX1 0.66 47.0 3.94e-01 71.2% 53.3%
167831 601.16.1.3 ↗ alpha bundles › Four-helical up-and-down bundle › FAT domain of focal adhesion kinase › FAT domain of focal adhesion kinase › GIT1_C 0.66 48.0 5.30e-01 74.2% 98.5%
4992943 632.18.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › hypothetical protein PA2901 › hypothetical protein PA2901 0.66 38.0 4.45e-01 86.5% 80.0%
3587850 3684.1.1.0 ↗ alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like 0.66 48.0 5.15e-01 96.9% 85.7%
5041344 601.7.1.2 ↗ alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › HEPN 0.66 47.0 5.24e-01 73.0% 100.0%
3253932 601.1.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin 0.65 45.0 5.08e-01 96.9% 91.2%
4934609 192.29.1.0 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.65 44.0 4.84e-01 96.3% 85.4%
3818491 601.18.1.1 ↗ alpha bundles › Four-helical up-and-down bundle › Oxygen-evolving enhancer protein 3 › Oxygen-evolving enhancer protein 3 › PsbQ 0.65 45.0 4.80e-01 79.1% 80.0%
3243897 3684.1.1.0 ↗ alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like 0.64 45.0 4.82e-01 70.6% 92.9%
3732358 604.12.1.42 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › DUF202 0.63 38.0 4.67e-01 85.9% 93.3%
3279246 601.7.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain 0.63 47.0 4.50e-01 76.1% 86.5%
4013947 5069.1.1.0 ↗ alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes 0.63 44.0 3.86e-01 70.6% 60.4%
4333411 601.18.1.4 ↗ alpha bundles › Four-helical up-and-down bundle › Oxygen-evolving enhancer protein 3 › Oxygen-evolving enhancer protein 3 › CYP38_PsbQ-like 0.63 47.0 5.22e-01 98.2% 95.4%
3632454 650.1.1.0 ↗ alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain 0.63 32.0 4.59e-01 81.6% 98.8%
5010095 3755.4.1.0 ↗ alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.62 38.0 4.07e-01 86.5% 69.6%
4592540 601.25.1.1 ↗ alpha bundles › Four-helical up-and-down bundle › TrmE connector domain › TrmE connector domain › MnmE_helical 0.62 44.0 4.38e-01 95.7% 69.4%
4960488 3615.1.1.0 ↗ alpha bundles › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain 0.62 44.0 3.43e-01 73.6% 74.3%
4288241 601.18.1.1 ↗ alpha bundles › Four-helical up-and-down bundle › Oxygen-evolving enhancer protein 3 › Oxygen-evolving enhancer protein 3 › PsbQ 0.62 44.0 4.68e-01 79.1% 82.6%
4141800 601.25.1.1 ↗ alpha bundles › Four-helical up-and-down bundle › TrmE connector domain › TrmE connector domain › MnmE_helical 0.61 43.0 4.27e-01 94.5% 67.1%
3603791 601.7.1.2 ↗ alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › HEPN 0.61 43.0 4.44e-01 71.2% 99.3%
3880737 601.1.2.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) 0.61 48.0 4.59e-01 81.6% 91.4%
3978850 5069.1.1.44 ↗ alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › CopD 0.61 45.0 4.72e-01 75.5% 96.6%
3690520 192.29.1.128 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › DUF202 0.61 35.0 4.26e-01 79.1% 90.0%
3900100 150.1.1.0 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.59 45.0 4.76e-01 96.3% 86.9%
5040533 5069.1.1.4 ↗ alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Ferric_reduct 0.59 43.0 4.39e-01 73.6% 89.7%
3531994 150.1.1.188 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › CC2D1A-B_DM14 0.58 44.0 4.52e-01 96.3% 81.3%
3430437 3684.1.1.2 ↗ alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › BPS1 0.58 46.0 4.02e-01 84.0% 95.1%
3181902 601.1.2.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) 0.58 43.0 4.28e-01 90.2% 75.2%
3320579 601.18.1.1 ↗ alpha bundles › Four-helical up-and-down bundle › Oxygen-evolving enhancer protein 3 › Oxygen-evolving enhancer protein 3 › PsbQ 0.57 45.0 4.74e-01 81.6% 90.5%
3307768 174.1.1.2 ↗ few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Jagunal 0.57 44.0 4.39e-01 89.0% 76.5%
3933879 192.29.1.24 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › TMEM237 0.57 45.0 4.59e-01 96.3% 83.1%
3871038 601.1.2.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) 0.56 45.0 4.34e-01 82.2% 91.1%
3185576 3755.3.1.0 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.56 32.0 3.09e-01 71.2% 51.1%
4967345 5069.1.1.15 ↗ alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Cytochrom_C_asm 0.55 41.0 4.39e-01 96.3% 89.1%
3991191 601.1.2.6 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Talin_IBS2B 0.55 43.0 4.52e-01 81.0% 92.7%
2703780 3684.1.1.0 ↗ alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like 0.55 47.0 4.60e-01 96.9% 82.8%
3735919 601.1.2.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) 0.54 41.0 4.13e-01 89.0% 77.0%
3599723 5069.1.1.0 ↗ alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes 0.54 40.0 4.37e-01 96.3% 91.9%
3980277 5069.1.1.0 ↗ alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes 0.54 43.0 4.31e-01 96.9% 81.2%
3931457 5001.1.1.44 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7TM_GPCR_Srv 0.53 49.0 3.91e-01 96.3% 72.2%
4008825 5069.1.1.15 ↗ alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Cytochrom_C_asm 0.53 43.0 3.99e-01 96.3% 68.5%
3334905 3745.1.1.1 ↗ alpha bundles › Sodium/Calcium exchanger › Sodium/Calcium exchanger › Sodium/Calcium exchanger › Na_Ca_ex 0.52 44.0 3.31e-01 89.0% 69.1%
4060723 140.1.1.4 ↗ alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › tRNA-synt_1e,DALR_2 0.52 38.0 3.96e-01 76.1% 80.7%
4988598 3883.1.1.1 ↗ alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf 0.52 45.0 4.28e-01 93.9% 81.6%
3165978 5069.1.1.0 ↗ alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes 0.52 42.0 4.21e-01 96.9% 83.0%
3703824 5054.1.1.9 ↗ alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › PKD_channel 0.51 40.0 3.37e-01 96.9% 49.1%
D2 medium residues 188-251
PDB
Domain cluster: representative
CATH (41)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3hz7A00 3.30.110.40 Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › TusA-like domain 0.74 46.0 4.47e-01 73.4% 56.2%
1in0A02 3.30.70.990 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › YajQ-like, domain 2 0.69 46.0 4.14e-01 70.3% 67.4%
2iz4A02 2.20.25.590 Mainly Beta › Single Sheet › N-terminal domain of TfIIb › 0.66 40.0 4.62e-01 78.1% 92.9%
2hc5A01 3.30.160.170 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › FlaG-like 0.65 50.0 4.36e-01 84.4% 63.3%
1i8nA00 3.50.4.10 Alpha Beta › 3-Layer(bba) Sandwich › Hepatocyte Growth Factor › Hepatocyte Growth Factor 0.63 41.0 3.74e-01 71.9% 48.3%
4mtnA01 3.30.1480.10 Alpha Beta › 2-Layer Sandwich › N Utilization Substance Protein A; Chain:P; domain 4 › NusA, N-terminal domain 0.62 47.0 4.20e-01 84.4% 78.9%
4ushA00 3.30.70.120 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.61 48.0 4.13e-01 85.9% 60.2%
1fvqA00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.60 48.0 4.62e-01 87.5% 81.9%
3ofgB00 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.60 48.0 4.35e-01 87.5% 77.0%
8gf5C01 3.30.70.470 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.60 49.0 3.87e-01 93.8% 85.2%
1ug8A00 3.30.1370.50 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › R3H-like domain 0.60 39.0 3.65e-01 70.3% 50.6%
2xmjA00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.59 46.0 4.71e-01 87.5% 90.5%
2uvaG03 3.30.70.3320 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.59 47.0 4.04e-01 90.6% 55.6%
2rrnA01 3.30.70.2040 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.59 45.0 4.19e-01 85.9% 79.5%
2x3gA00 3.30.70.1910 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.59 46.0 3.79e-01 85.9% 56.0%
1rzmA01 3.30.70.1140 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Phospho-2-dehydro-3-deoxyheptonate aldolase; domain 1 0.58 46.0 4.33e-01 87.5% 72.5%
5n1qB02 3.30.70.470 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.58 49.0 3.78e-01 95.3% 81.6%
3e1eC00 3.10.129.10 Alpha Beta › Roll › Thiol Ester Dehydrase; Chain A › Hotdog Thioesterase 0.58 45.0 3.58e-01 87.5% 78.7%
2f8mA02 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.58 44.0 4.17e-01 84.4% 81.0%
3tm4A01 3.30.2130.30 Alpha Beta › 2-Layer Sandwich › VC0802-like › 0.57 47.0 3.39e-01 92.2% 96.3%
1yj7B01 3.30.70.1530 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Hypothetical protein rpa1041 0.57 44.0 4.33e-01 85.9% 80.3%
4dmzA02 3.30.70.2880 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.57 45.0 3.54e-01 87.5% 56.9%
6ijbA01 3.30.300.30 Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › ANL, C-terminal domain 0.57 42.0 3.76e-01 82.8% 67.3%
3n0vA01 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.56 43.0 4.02e-01 87.5% 83.3%
2z9eA02 3.30.70.2590 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.55 42.0 3.60e-01 85.9% 68.8%
2hekA02 3.30.70.1370 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › HD domain like 0.55 41.0 3.76e-01 82.8% 94.3%
2yweA03 3.30.70.870 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Elongation Factor G (Translational Gtpase), domain 3 0.54 41.0 3.87e-01 85.9% 79.3%
2kl8A00 3.30.70.600 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S10 0.54 41.0 3.81e-01 85.9% 70.6%
1fu1A01 2.170.210.10 Mainly Beta › Beta Complex › Dna Repair Protein Xrcc4; Chain: A, domain 1 › DNA double-strand break repair and VJ recombination XRCC4, N-terminal 0.54 39.0 3.20e-01 76.6% 66.1%
1wiiA01 2.20.25.190 Mainly Beta › Single Sheet › N-terminal domain of TfIIb › 0.54 36.0 3.72e-01 70.3% 96.8%
1rjjA00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.53 41.0 3.52e-01 87.5% 71.2%
3ezjA02 3.30.1370.120 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › 0.53 40.0 3.96e-01 85.9% 79.4%
3qf7A01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.53 40.0 2.72e-01 87.5% 32.3%
2v4jB03 3.30.70.20 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.53 41.0 4.16e-01 89.1% 93.8%
6x6aA01 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.53 36.0 2.39e-01 71.9% 84.0%
2n3gA00 3.30.160.20 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.52 37.0 3.66e-01 78.1% 94.4%
7k0xA03 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.52 40.0 3.85e-01 87.5% 97.4%
6x4tA02 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.51 40.0 3.70e-01 87.5% 80.0%
1lwdA00 3.40.718.10 Alpha Beta › 3-Layer(aba) Sandwich › Isopropylmalate Dehydrogenase › Isopropylmalate Dehydrogenase 0.51 44.0 2.75e-01 100.0% 44.3%
2g47A03 3.30.830.10 Alpha Beta › 2-Layer Sandwich › Cytochrome Bc1 Complex; Chain A, domain 1 › Metalloenzyme, LuxS/M16 peptidase-like 0.51 41.0 2.84e-01 90.6% 78.0%
1k8kA04 3.90.640.10 Alpha Beta › Alpha-Beta Complex › Actin; Chain A, domain 4 › ATPase, substrate binding domain, subdomain 4 0.51 37.0 3.33e-01 78.1% 87.0%
ECOD (45)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3943200 159.1.4.3 ↗ alpha bundles › all-alpha NTP pyrophosphatases › all-alpha NTP pyrophosphatases › Type II deoxyuridine triphosphatase-related › PRA-PH 0.81 71.0 4.63e-01 100.0% 23.5%
4583844 327.16.1.7 ↗ a+b two layers › Alpha-lytic protease prodomain-like › Ring-building motif II in type III secretion system › Ring-building motif II in type III secretion system › Rhomboid_N 0.66 52.0 5.25e-01 85.9% 86.2%
3907671 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.66 52.0 5.00e-01 87.5% 84.0%
3925197 4.1.1.7 ↗ beta barrels › SH3 › SH3 › SH3 › KOW,ribosomal_L24 0.65 46.0 3.10e-01 75.0% 46.0%
4990916 283.2.1.0 ↗ a+b duplicates or obligate multimers › Creatinase/aminopeptidase-like › gpW/gp25-like › gpW/gp25-like 0.64 45.0 3.94e-01 75.0% 70.0%
4262166 304.54.1.0 ↗ a+b two layers › Alpha-beta plaits › CcmK-like › CcmK-like 0.63 49.0 4.65e-01 87.5% 80.0%
3172743 304.9.1.0 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.63 49.0 4.30e-01 87.5% 81.0%
3268247 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.61 43.0 2.72e-01 73.4% 93.1%
4268987 304.11.1.4 ↗ a+b two layers › Alpha-beta plaits › Probable ACP-binding domain of malonyl-CoA ACP transacylase › Probable ACP-binding domain of malonyl-CoA ACP transacylase › FAS_AT_central 0.61 49.0 4.17e-01 90.6% 55.5%
4399888 327.16.1.0 ↗ a+b two layers › Alpha-lytic protease prodomain-like › Ring-building motif II in type III secretion system › Ring-building motif II in type III secretion system 0.60 47.0 4.81e-01 84.4% 95.0%
4107632 304.36.1.1 ↗ a+b two layers › Alpha-beta plaits › YajQ-like › YajQ-like › DUF520 0.60 44.0 4.05e-01 81.2% 62.2%
3589383 885.1.1.1 ↗ a+b complex topology › Transcription factor NusA, N-terminal domain › Transcription factor NusA, N-terminal domain › Transcription factor NusA, N-terminal domain › NusA_N 0.60 46.0 3.80e-01 85.9% 86.4%
3423771 304.48.1.6 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_A 0.60 47.0 3.83e-01 87.5% 81.6%
157557 327.16.1.0 ↗ a+b two layers › Alpha-lytic protease prodomain-like › Ring-building motif II in type III secretion system › Ring-building motif II in type III secretion system 0.60 46.0 4.75e-01 85.9% 91.9%
3521467 3016.1.1.21 ↗ a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › PDXDC1-like_cen 0.59 40.0 3.62e-01 70.3% 94.4%
5063704 243.3.1.0 ↗ a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin 0.59 43.0 4.36e-01 81.2% 93.8%
3898704 304.151.1.6 ↗ a+b two layers › Alpha-beta plaits › Ferredoxin-like domain of receptor-type protein tyrosine phosphatase › Ferredoxin-like domain of receptor-type protein tyrosine phosphatase › PF29952 0.59 47.0 4.24e-01 92.2% 87.4%
5051073 304.120.1.0 ↗ a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI 0.59 46.0 4.44e-01 87.5% 96.0%
3924046 316.1.1.0 ↗ a+b three layers › Nucleotidyltransferase-like › Nucleotidyltransferase › Nucleotidyltransferase 0.59 45.0 3.32e-01 84.4% 50.0%
3686938 304.9.1.0 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.59 45.0 4.21e-01 87.5% 76.5%
4038796 327.16.1.0 ↗ a+b two layers › Alpha-lytic protease prodomain-like › Ring-building motif II in type III secretion system › Ring-building motif II in type III secretion system 0.58 45.0 4.33e-01 85.9% 76.0%
4256317 375.1.1.38 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › Topo_Zn_Ribbon 0.58 42.0 4.47e-01 79.7% 96.4%
3929357 708.1.1.0 ↗ beta complex topology › ETN0001 domain-like › ETN0001 domain-like › NAC/WRKY/GCM/WOPR domain 0.58 41.0 3.77e-01 75.0% 82.1%
3485236 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.58 47.0 3.67e-01 90.6% 82.1%
3604387 2004.1.1.308 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_21 0.57 43.0 2.83e-01 87.5% 27.9%
4992385 304.120.1.0 ↗ a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI 0.56 43.0 4.28e-01 87.5% 88.6%
3281700 243.1.1.0 ↗ a+b two layers › Cystatin-like › NTF2-like › NTF2-like 0.56 42.0 3.47e-01 84.4% 83.2%
3165551 375.1.1.38 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › Topo_Zn_Ribbon 0.56 42.0 4.32e-01 82.8% 94.8%
4854269 304.4.1.7 ↗ a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › Cyclase_polyket 0.55 42.0 3.70e-01 85.9% 70.2%
4667947 304.120.1.0 ↗ a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI 0.55 43.0 4.26e-01 87.5% 88.6%
3235660 304.151.1.4 ↗ a+b two layers › Alpha-beta plaits › Ferredoxin-like domain of receptor-type protein tyrosine phosphatase › Ferredoxin-like domain of receptor-type protein tyrosine phosphatase › PF25899 0.55 43.0 3.58e-01 89.1% 91.2%
3745161 4323.1.1.2 ↗ alpha bundles › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › V-ATPase_C 0.55 47.0 4.13e-01 100.0% 73.0%
3781763 304.9.1.0 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.55 41.0 3.68e-01 85.9% 81.0%
4207299 304.5.1.0 ↗ a+b two layers › Alpha-beta plaits › GlnB-like › GlnB-like 0.55 43.0 4.14e-01 89.1% 81.3%
3260311 10.1.1.8 ↗ beta sandwiches › jelly-roll › Concanavalin A-like › Concanavalin A-like lectins/glucanases › SPRY 0.54 41.0 2.44e-01 82.8% 70.2%
4981790 298.1.1.0 ↗ a+b two layers › FwdE/GAPDH domain-like › Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain › Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 0.54 44.0 3.63e-01 93.8% 74.6%
5023832 331.2.1.0 ↗ a+b two layers › TBP-like › Phosphoglucomutase, C-terminal domain › Phosphoglucomutase, C-terminal domain 0.54 41.0 3.96e-01 85.9% 93.3%
3186255 223.1.1.21 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › HODM_asu-like 0.54 45.0 2.97e-01 100.0% 55.0%
3265458 2004.1.1.81 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › GBP 0.53 41.0 2.63e-01 85.9% 21.8%
3784907 896.1.1.3 ↗ a+b two layers › SRP9/14-like › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › SRP9-21 0.52 37.0 3.41e-01 79.7% 57.6%
4431057 235.1.1.9 ↗ a+b complex topology › Lysozyme-like › Lysozyme-like › Lysozyme-like › SLT 0.52 36.0 2.83e-01 75.0% 57.9%
3952804 211.1.1.0 ↗ a+b two layers › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase 0.51 37.0 3.92e-01 82.8% 98.2%
5023709 244.4.1.0 ↗ a+b two layers › FAD-linked reductases, C-terminal domain-like › Ni-Fe binding domain in nickel-iron hydrogenase large subunit › Ni-Fe binding domain in nickel-iron hydrogenase large subunit 0.51 39.0 3.61e-01 85.9% 82.4%
3786625 109.4.1.165 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Dsl1_C 0.51 43.0 2.58e-01 100.0% 11.6%
4137619 286.1.1.2 ↗ a+b complex topology › Diaminopimelate epimerase-like › Diaminopimelate epimerase-like › Diaminopimelate epimerase-like › PhzC-PhzF 0.51 36.0 2.87e-01 75.0% 63.8%