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regulatory_protein_ICP22

Euk-Vir

Gallid_alphaherpesvirus_3

regulatory_protein_ICP22__NP_066907__Gallid_alphaherpesvirus_3__35250

Identity

Accession:
NP_066907 ↗
Protein ID:
regulatory_protein_ICP22
Kingdom:
euk

Quality

72.6 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Mardivirus› Gallid_alphaherpesvirus_3

TaxID: 35250

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 50-129
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02479.22 best Herpes_IE68 97.4 7.30e-28 100.0% 59.7%
CATH (41)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3kp9A01 1.20.1440.130 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › VKOR domain 0.70 53.0 4.24e-01 82.5% 88.3%
2pusA04 6.10.140.300 Special › Helix non-globular › Helix Hairpins › 0.68 52.0 4.69e-01 81.2% 64.8%
1q6aA00 1.10.1240.30 Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › KaiA/RbsU domain 0.67 46.0 4.21e-01 76.2% 53.3%
3h3mA00 1.20.58.380 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Flagellar protein flit. 0.66 47.0 4.59e-01 75.0% 76.4%
3mesA02 3.90.1200.10 Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe 0.64 44.0 3.02e-01 71.2% 31.4%
1orjD00 1.20.120.340 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS 0.63 49.0 4.16e-01 81.2% 73.6%
1orsC00 1.20.120.350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C 0.63 44.0 3.80e-01 73.8% 90.2%
5nl6A02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.63 43.0 3.96e-01 71.2% 68.5%
4jvyB00 3.30.1370.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › K Homology domain, type 1 0.63 47.0 3.65e-01 81.2% 97.9%
2ycdA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.62 51.0 4.57e-01 91.3% 82.1%
3behB01 1.20.120.540 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels 0.62 43.0 3.83e-01 72.5% 81.2%
1eyvB00 1.10.940.10 Mainly Alpha › Orthogonal Bundle › N-utilizing Substance Protein B Homolog; Chain A › NusB-like 0.62 51.0 4.37e-01 92.5% 97.7%
1vs5O00 1.10.287.10 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › S15/NS1, RNA-binding 0.61 47.0 4.56e-01 86.3% 76.1%
2ahfA00 1.50.10.10 Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › 0.61 52.0 3.41e-01 98.8% 40.3%
4dkcB00 1.20.1250.80 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › Interleukin-34 0.60 48.0 3.86e-01 87.5% 73.1%
2ra1A02 1.20.58.780 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.60 45.0 4.86e-01 82.5% 94.1%
1x0tA01 1.20.5.420 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C 0.60 37.0 4.15e-01 85.0% 82.0%
2m6bA00 1.20.58.390 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain 0.60 44.0 3.59e-01 77.5% 80.7%
1eteA00 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.59 41.0 3.50e-01 72.5% 91.8%
5dqqA01 1.20.120.350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C 0.59 43.0 3.71e-01 77.5% 85.9%
3eslA02 1.25.40.930 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.59 41.0 3.61e-01 78.8% 48.7%
3hiuD00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.59 42.0 3.47e-01 76.2% 44.7%
6yz2A01 1.20.120.350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C 0.58 49.0 4.31e-01 93.8% 95.8%
3hhcC00 1.20.1250.60 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › Interferon lambda 0.57 43.0 3.57e-01 81.2% 75.5%
1to9A00 1.20.910.10 Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like 0.57 41.0 3.01e-01 76.2% 36.0%
1xzpA02 1.20.120.430 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › tRNA modification GTPase MnmE domain 2 0.56 46.0 3.66e-01 90.0% 75.9%
2pbiA02 1.10.1240.60 Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › 0.56 39.0 3.64e-01 71.2% 78.2%
2crbA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.56 39.0 3.66e-01 71.2% 60.8%
3zheC01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.56 48.0 3.77e-01 100.0% 58.2%
3zdmB00 1.20.5.420 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C 0.56 33.0 4.09e-01 70.0% 96.0%
6ig5A01 1.10.275.10 Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) 0.56 41.0 3.52e-01 80.0% 62.3%
1sj8A02 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.55 38.0 3.36e-01 72.5% 57.4%
6f1eA01 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.55 43.0 3.59e-01 85.0% 71.9%
1lujB01 1.10.10.490 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Beta-catenin-interacting ICAT 0.54 32.0 3.62e-01 73.8% 86.8%
2ygwA01 1.20.140.90 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Malonyl-CoA decarboxylase, oligemerization domain 0.53 42.0 3.49e-01 88.7% 91.5%
2rn7A01 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.52 37.0 3.99e-01 93.8% 89.4%
8sbeA01 1.20.1250.20 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains 0.52 43.0 3.30e-01 93.8% 66.3%
2v0cA04 1.10.730.10 Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 0.52 42.0 3.46e-01 92.5% 50.3%
1jwjA01 3.90.340.10 Alpha Beta › Alpha-Beta Complex › Nitric Oxide Synthase; Chain A, domain 1 › Nitric Oxide Synthase; Chain A, domain 1 0.52 38.0 3.02e-01 78.8% 50.9%
1kblA05 1.20.80.30 Mainly Alpha › Up-down Bundle › Acyl-CoA Binding Protein › 0.52 33.0 3.23e-01 83.7% 58.4%
3zgzA04 1.10.730.10 Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 0.51 41.0 3.27e-01 91.3% 45.8%
ECOD (27)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3197897 616.1.1.0 ↗ alpha arrays › S15/NS1 RNA-binding domain › S15/NS1 RNA-binding domain › S15/NS1 RNA-binding domain 0.73 52.0 5.82e-01 76.2% 100.0%
3299130 6155.1.1.1 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › MtN3_slv 0.70 53.0 5.20e-01 80.0% 85.9%
3627770 6155.1.1.1 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › MtN3_slv 0.70 56.0 4.84e-01 87.5% 72.8%
3789688 6155.1.1.0 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter 0.70 56.0 4.84e-01 87.5% 72.8%
3494868 5086.1.1.0 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.67 50.0 3.69e-01 80.0% 32.1%
55069 603.1.1.1 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin 0.67 47.0 4.31e-01 75.0% 77.1%
3705370 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.66 47.0 4.23e-01 75.0% 74.5%
3518321 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.65 47.0 4.19e-01 76.2% 76.5%
3432510 616.1.1.0 ↗ alpha arrays › S15/NS1 RNA-binding domain › S15/NS1 RNA-binding domain › S15/NS1 RNA-binding domain 0.65 47.0 5.09e-01 82.5% 93.8%
4269155 5059.1.1.18 ↗ alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › UPF0060 0.64 53.0 4.95e-01 91.3% 96.0%
3912246 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.64 45.0 4.02e-01 73.8% 73.0%
4236831 604.6.1.50 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › DUF2524 0.64 45.0 4.54e-01 73.8% 87.5%
3934022 616.1.1.0 ↗ alpha arrays › S15/NS1 RNA-binding domain › S15/NS1 RNA-binding domain › S15/NS1 RNA-binding domain 0.64 54.0 4.99e-01 92.5% 87.0%
3306315 109.4.1.189 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR_2 0.62 47.0 4.50e-01 82.5% 75.8%
4947713 5059.1.1.0 ↗ alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter 0.62 51.0 4.63e-01 91.3% 88.2%
3738358 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.61 42.0 4.29e-01 71.2% 77.3%
5071393 5059.1.1.1 ↗ alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA 0.59 42.0 3.51e-01 76.2% 52.0%
3281911 601.4.1.2 ↗ alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › NIT 0.58 46.0 4.03e-01 85.0% 80.0%
4667275 3997.1.1.1 ↗ alpha arrays › Helical insertion domain in magnesium chelatase catalytic subunit › Helical insertion domain in magnesium chelatase catalytic subunit › Helical insertion domain in magnesium chelatase catalytic subunit › CobN-Mg_chel 0.57 43.0 3.14e-01 80.0% 78.2%
3659119 109.4.1.883 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR+PPR_2 0.56 49.0 3.22e-01 100.0% 25.1%
395453 141.1.1.1 ↗ alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases › polyprenyl_synt 0.55 44.0 3.14e-01 88.7% 55.6%
3713658 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.55 46.0 4.71e-01 91.3% 100.0%
3739053 109.4.1.590 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › NopRA1 0.55 47.0 2.73e-01 100.0% 13.9%
4037464 140.1.1.5 ↗ alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon_1 0.55 43.0 3.35e-01 88.7% 43.7%
3788546 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.54 41.0 2.80e-01 81.2% 23.2%
3423806 101.1.1.196 ↗ alpha arrays › HTH › HTH › Three-helical HTH › RWP-RK 0.53 37.0 3.26e-01 72.5% 55.7%
4298587 140.1.1.0 ↗ alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 0.52 41.0 3.30e-01 88.7% 47.1%