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regulatory_protein_ICP22

Euk-Vir

Human_alphaherpesvirus_2

regulatory_protein_ICP22__YP_009137213__Human_alphaherpesvirus_2__10310

Identity

Accession:
YP_009137213 ↗
Protein ID:
regulatory_protein_ICP22
Kingdom:
euk

Quality

51.4 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Simplexvirus› Human_alphaherpesvirus_2

TaxID: 10310

Cluster

View cluster (7 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 183-285
PDB
Domain cluster: rep: ICP22__YP_009227219__Macropodid_alphaherpesvirus_1__137443__D263-344
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02479.22 best Herpes_IE68 160.5 2.50e-47 100.0% 78.4%
CATH (26)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1rq0A01 6.10.140.160 Special › Helix non-globular › Helix Hairpins › 0.67 34.0 3.73e-01 81.6% 59.0%
3m7gA02 1.10.8.1010 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › 0.66 36.0 3.75e-01 82.5% 57.9%
7wivA01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.62 46.0 3.37e-01 80.6% 96.1%
6tqfA01 1.20.1560.10 Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain 0.62 46.0 3.17e-01 80.6% 86.2%
3t9jA00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.58 43.0 3.83e-01 95.1% 55.6%
3hiuD00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.58 41.0 3.65e-01 100.0% 50.7%
2qqyA00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.58 40.0 3.66e-01 94.2% 54.3%
8d3mA02 1.20.120.920 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › CRISPR-associated endonuclease Cas1, C-terminal domain 0.57 40.0 3.09e-01 72.8% 91.3%
2vxxA00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.57 45.0 3.77e-01 99.0% 50.0%
2chpA00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.57 42.0 3.74e-01 94.2% 54.1%
5lbmA00 1.20.58.1000 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Metal-sensitive repressor, helix protomer 0.57 30.0 3.32e-01 81.6% 61.4%
1lujB01 1.10.10.490 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Beta-catenin-interacting ICAT 0.56 28.0 3.64e-01 98.1% 90.6%
3wmeA01 1.20.1560.10 Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain 0.56 43.0 3.14e-01 83.5% 95.0%
4asvA00 1.20.5.420 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C 0.56 35.0 3.89e-01 91.3% 81.0%
2c41C01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.56 42.0 3.76e-01 95.1% 55.7%
1wfdA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.56 35.0 3.72e-01 82.5% 71.0%
3pjaJ01 1.20.58.190 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 1 0.55 38.0 3.55e-01 70.9% 82.4%
3pltA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.55 32.0 2.56e-01 80.6% 27.1%
1fioA00 1.20.58.70 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.55 42.0 3.50e-01 82.5% 89.5%
4errB00 1.20.58.1190 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.55 31.0 3.37e-01 80.6% 65.1%
1lshA02 1.25.10.20 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Vitellinogen, superhelical 0.53 40.0 2.83e-01 81.6% 43.0%
4hz4A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.52 39.0 3.85e-01 80.6% 89.3%
2odmA00 1.10.287.750 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › SO2669-like 0.51 34.0 3.80e-01 98.1% 88.6%
1j1vA00 1.10.1750.10 Mainly Alpha › Orthogonal Bundle › Chromosomal Replication Initiator Protein Dnaa; Chain: A; › DnaA protein, C-terminal DNA-binding domain 0.51 33.0 3.47e-01 98.1% 72.3%
4wp2A00 1.10.8.10 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Ubiquitin-associated (UBA) domain 0.50 23.0 2.90e-01 96.1% 72.1%
3mgdB00 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.50 37.0 3.35e-01 80.6% 73.0%
ECOD (31)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5050359 605.1.1.1 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA 0.65 34.0 4.10e-01 80.6% 75.7%
5002748 605.1.1.1 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA 0.64 33.0 3.90e-01 79.6% 70.7%
4240634 1075.4.1.1 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane 0.64 48.0 3.50e-01 82.5% 88.9%
3245498 6092.1.1.1 ↗ alpha bundles › Helical extension domain in Regulator of G-protein signaling 9 › Helical extension domain in Regulator of G-protein signaling 9 › Helical extension domain in Regulator of G-protein signaling 9 › RGS_DHEX 0.62 36.0 3.58e-01 93.2% 54.3%
3731064 633.6.1.0 ↗ alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like 0.61 36.0 3.54e-01 79.6% 54.5%
4194775 150.1.1.4 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › COQ7 0.61 47.0 3.90e-01 84.5% 81.5%
3606445 150.1.1.4 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › COQ7 0.61 46.0 3.75e-01 80.6% 87.7%
5083225 605.1.1.0 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.60 37.0 4.61e-01 79.6% 100.0%
1145756 604.12.1.1 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › MIT 0.60 37.0 3.52e-01 78.6% 53.8%
3478399 604.8.1.0 ↗ alpha bundles › Spectrin repeat-like › Smac/diablo › Smac/diablo 0.59 46.0 3.55e-01 82.5% 87.4%
3672376 226.1.1.3 ↗ a+b two layers › POZ domain › POZ domain › POZ domain › Skp1,Skp1_POZ 0.58 35.0 3.02e-01 74.8% 36.9%
4671536 3718.1.1.1 ↗ alpha bundles › Flagellar protein fliT › Flagellar protein fliT › Flagellar protein fliT › FliT 0.58 40.0 4.14e-01 98.1% 76.8%
3650518 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.58 43.0 3.24e-01 77.7% 39.4%
4980470 6155.1.1.0 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter 0.57 42.0 4.42e-01 97.1% 85.3%
4046400 150.1.1.1 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Ferritin 0.57 42.0 3.70e-01 94.2% 52.3%
4260426 3718.1.1.1 ↗ alpha bundles › Flagellar protein fliT › Flagellar protein fliT › Flagellar protein fliT › FliT 0.56 38.0 3.84e-01 98.1% 70.0%
3167993 603.1.1.97 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin, SNARE 0.56 43.0 3.40e-01 82.5% 81.8%
4681537 3718.1.1.1 ↗ alpha bundles › Flagellar protein fliT › Flagellar protein fliT › Flagellar protein fliT › FliT 0.56 37.0 3.78e-01 98.1% 70.0%
3791 603.1.1.1 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin 0.55 42.0 3.50e-01 82.5% 89.5%
3277587 6155.1.1.0 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter 0.55 46.0 4.47e-01 100.0% 80.9%
3312807 3922.1.1.7 ↗ alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Auxin_canalis 0.55 41.0 3.68e-01 93.2% 55.9%
1935160 3826.1.1.1 ↗ alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Trns_repr_metal 0.55 30.0 3.25e-01 80.6% 61.1%
3185610 109.4.1.681 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans_2 0.55 48.0 3.85e-01 98.1% 97.1%
3745853 603.2.1.1 ↗ alpha bundles › STAT-like › STAT › STAT › STAT_alpha 0.54 40.0 3.36e-01 80.6% 77.8%
3690136 611.3.1.0 ↗ alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 0.53 39.0 4.09e-01 77.7% 100.0%
4572709 3455.1.1.0 ↗ alpha arrays › WY-domain in RXLR effectors › WY-domain in RXLR effectors › WY-domain in RXLR effectors 0.53 38.0 4.03e-01 75.7% 98.9%
4357963 3718.1.1.1 ↗ alpha bundles › Flagellar protein fliT › Flagellar protein fliT › Flagellar protein fliT › FliT 0.53 36.0 3.80e-01 98.1% 77.9%
3705329 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.52 39.0 3.96e-01 84.5% 79.0%
3427404 3930.1.1.10 ↗ alpha bundles › Helical bundle insertion in helicase domains › Helical bundle in Hef helicase › Helical bundle in Hef helicase › DUF5587 0.52 45.0 3.32e-01 97.1% 93.8%
3284609 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.51 39.0 4.21e-01 100.0% 98.8%
4327553 3455.1.1.0 ↗ alpha arrays › WY-domain in RXLR effectors › WY-domain in RXLR effectors › WY-domain in RXLR effectors 0.51 37.0 3.82e-01 75.7% 98.9%