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regulatory_protein_IE1

Euk-Vir

Human_herpesvirus_5

regulatory_protein_IE1__YP_002608299__Human_herpesvirus_5__10359

Identity

Accession:
YP_002608299 ↗
Protein ID:
regulatory_protein_IE1
Kingdom:
euk

Quality

71.1 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 73-95_143-185_223-391
PDB
Domain cluster: representative
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF07340.17 best Herpes_IE1 67.7 1.60e-18 73.6% 42.1%
PF07340.17 Herpes_IE1 28.8 1.10e-06 27.2% 14.9%
CATH (12)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2qz4A02 1.10.8.60 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › 0.63 21.0 3.87e-01 72.8% 100.0%
6grjB01 1.20.1170.10 Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › 0.63 44.0 3.96e-01 70.2% 99.4%
2uuiA00 1.20.120.550 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Membrane associated eicosanoid/glutathione metabolism-like domain 0.56 29.0 3.54e-01 75.7% 75.5%
5tj5E00 1.20.120.610 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › lithium bound rotor ring of v- atpase 0.55 30.0 3.77e-01 75.7% 86.2%
1cnt200 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.55 20.0 2.72e-01 73.2% 57.7%
6fmhB01 1.10.3160.10 Mainly Alpha › Orthogonal Bundle › Bbcrasp-1 › Bbcrasp-1 0.54 30.0 3.50e-01 72.8% 73.8%
2bl2A00 1.20.120.610 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › lithium bound rotor ring of v- atpase 0.54 31.0 3.74e-01 75.7% 84.0%
2gbbB00 1.20.59.10 Mainly Alpha › Up-down Bundle › Chorismate Mutase Domain, subunit A › Chorismate mutase 0.54 28.0 3.40e-01 76.2% 74.2%
1guxB00 1.10.472.10 Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like 0.54 28.0 3.56e-01 86.4% 83.0%
3g67A00 1.10.287.950 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein 0.51 31.0 3.23e-01 83.4% 62.4%
3pltA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.51 39.0 4.08e-01 77.9% 86.9%
2iu5B00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.51 27.0 3.07e-01 85.1% 66.1%
ECOD (11)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2711996 6168.1.1.1 alpha duplicates or obligate multimers › Immediate-early 1 protein › Immediate-early 1 protein › Immediate-early 1 protein › Herpes_IE1 0.91 85.0 7.19e-01 96.2% 86.4%
1406537 6168.1.1.1 alpha duplicates or obligate multimers › Immediate-early 1 protein › Immediate-early 1 protein › Immediate-early 1 protein › Herpes_IE1 0.85 78.0 6.67e-01 94.9% 86.1%
3683542 3755.3.1.285 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › NET2A 0.57 31.0 3.08e-01 74.9% 49.2%
4996693 192.29.1.0 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.53 39.0 4.08e-01 75.3% 86.8%
3960605 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.52 30.0 3.31e-01 88.9% 68.2%
3953720 5086.1.1.221 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › MMPL 0.52 31.0 3.36e-01 88.9% 68.5%
3170622 2004.1.1.199 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23,SbcC_Walker_B 0.51 41.0 2.76e-01 82.6% 71.3%
3958570 3755.4.1.0 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.51 30.0 3.28e-01 88.5% 68.2%
3577239 4177.1.1.2 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR 0.51 36.0 3.66e-01 71.9% 96.7%
5054272 2004.1.1.198 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23 0.51 37.0 2.76e-01 74.5% 75.9%
4999293 603.2.1.0 alpha bundles › STAT-like › STAT › STAT 0.50 36.0 3.25e-01 72.8% 68.1%
D2 medium residues 96-142_186-222
PDB
Domain cluster: representative
CATH (44)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
6xxvC00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.83 71.0 6.41e-01 100.0% 68.5%
4kb2A01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.81 67.0 6.13e-01 100.0% 68.8%
6vudA01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.77 66.0 6.07e-01 96.4% 72.5%
3txsC01 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.77 51.0 5.39e-01 88.1% 76.0%
1m5iA00 1.10.287.450 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.75 57.0 5.27e-01 81.0% 65.7%
1u5pA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.74 55.0 5.02e-01 81.0% 60.2%
6qumQ00 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.73 59.0 6.24e-01 90.5% 100.0%
3lssA01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.73 49.0 4.46e-01 84.5% 51.8%
2jdiG01 1.10.287.80 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain 0.73 50.0 5.74e-01 71.4% 96.7%
4v1gA00 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.73 64.0 6.39e-01 97.6% 97.6%
5dn6J00 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.72 59.0 6.18e-01 97.6% 100.0%
3cazB00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.72 64.0 4.80e-01 100.0% 69.0%
3mq1A01 1.20.58.970 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.72 51.0 4.97e-01 75.0% 67.4%
4dylA02 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.71 61.0 5.88e-01 92.9% 81.9%
3hr0B01 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.71 53.0 5.46e-01 78.6% 84.8%
3r84A00 1.10.287.3490 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.70 49.0 5.02e-01 72.6% 87.7%
4h63K00 1.10.287.3490 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.69 49.0 4.65e-01 72.6% 63.3%
4ioeA00 1.10.287.850 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain 0.69 57.0 5.64e-01 90.5% 85.1%
4iggA01 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.69 48.0 5.25e-01 73.8% 89.6%
6tqfA01 1.20.1560.10 Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain 0.69 61.0 3.93e-01 100.0% 22.0%
2q0oC00 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.68 53.0 5.33e-01 84.5% 80.2%
3pe0A01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.68 48.0 4.49e-01 79.8% 60.4%
1urfA00 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.68 48.0 4.88e-01 73.8% 97.5%
1ydxA02 1.10.287.1120 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Bipartite methylase S protein 0.68 50.0 4.91e-01 78.6% 72.2%
1t72A02 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.67 54.0 5.12e-01 90.5% 73.5%
1gaxA05 1.10.287.380 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Valyl-tRNA synthetase, C-terminal domain 0.67 45.0 4.78e-01 83.3% 78.1%
2pusA04 6.10.140.300 Special › Helix non-globular › Helix Hairpins › 0.67 37.0 3.44e-01 82.1% 41.7%
4aflA00 6.10.140.1740 Special › Helix non-globular › Helix Hairpins › 0.67 56.0 5.25e-01 91.7% 78.4%
4nb5B02 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.67 46.0 5.18e-01 72.6% 93.8%
2y39A00 1.20.120.1490 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.66 55.0 5.10e-01 94.0% 70.9%
6r1nA01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.66 53.0 4.96e-01 92.9% 70.9%
1wleA01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.65 55.0 4.98e-01 92.9% 74.6%
3r84B00 6.10.280.160 Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Mediator of RNA polymerase II transcription subunit 22 0.65 48.0 4.97e-01 78.6% 100.0%
3fppA03 6.10.140.1990 Special › Helix non-globular › Helix Hairpins › 0.65 57.0 5.65e-01 96.4% 97.7%
2lm9A00 1.20.58.970 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.64 50.0 4.80e-01 83.3% 74.0%
3fd9A03 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.64 44.0 4.67e-01 72.6% 83.6%
1zhcA00 6.10.280.50 Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.63 45.0 4.72e-01 76.2% 89.5%
2ic6A00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 47.0 5.00e-01 81.0% 95.8%
1zpyA00 6.10.140.1960 Special › Helix non-globular › Helix Hairpins › 0.61 39.0 3.84e-01 77.4% 59.3%
4ielA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.61 43.0 3.89e-01 76.2% 53.4%
3jcuZ00 1.10.287.740 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Photosystem II PsbZ, reaction centre 0.61 41.0 4.55e-01 70.2% 95.1%
3layF00 1.20.120.1490 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.59 49.0 5.03e-01 91.7% 98.7%
1wpaA01 6.10.140.340 Special › Helix non-globular › Helix Hairpins › 0.55 51.0 4.82e-01 100.0% 91.9%
1zbtA01 6.10.140.1950 Special › Helix non-globular › Helix Hairpins › 0.53 41.0 4.19e-01 85.7% 97.6%
ECOD (36)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3733140 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.79 72.0 5.84e-01 100.0% 54.8%
3951780 4246.1.1.2 a+b complex topology › N-terminal domain in RNA-polymerase beta-prime subunit › N-terminal domain in RNA-polymerase beta-prime subunit › N-terminal domain in RNA-polymerase beta-prime subunit › RNA_pol_Rpb1_1 0.79 71.0 4.48e-01 100.0% 26.0%
4420423 5094.1.1.1 a+b duplicates or obligate multimers › OmpH-like › OmpH-like › OmpH-like › OmpH 0.79 61.0 4.89e-01 81.0% 68.4%
3697355 5086.1.1.0 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.78 71.0 5.74e-01 100.0% 54.2%
3697385 2004.1.1.87 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N 0.77 57.0 3.55e-01 77.4% 24.2%
4828003 310.2.1.0 a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF 0.77 67.0 5.92e-01 96.4% 68.6%
3294437 5086.1.1.110 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HisKA 0.76 59.0 6.10e-01 82.1% 87.5%
3339561 605.1.1.1 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA 0.76 61.0 5.71e-01 84.5% 72.0%
3750377 605.1.1.254 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › MRVI1 0.76 63.0 6.50e-01 91.7% 98.8%
4946455 605.1.1.0 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.76 56.0 5.77e-01 88.1% 81.2%
3869913 2004.1.1.442 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_21 0.76 54.0 3.34e-01 73.8% 31.0%
3287947 605.1.1.1 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA 0.75 61.0 5.98e-01 86.9% 97.8%
3385717 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.75 59.0 4.67e-01 84.5% 45.9%
3400732 604.1.1.1 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.72 59.0 5.27e-01 100.0% 62.5%
98832 2003.1.2.18 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain 0.72 59.0 3.82e-01 88.1% 20.4%
3894879 604.1.1.1 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.72 51.0 4.75e-01 78.6% 59.0%
3432720 604.1.1.118 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › GOSR1_N 0.72 59.0 4.89e-01 88.1% 52.4%
3167364 2004.1.1.481 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_29 0.71 56.0 3.51e-01 83.3% 26.0%
4875585 1075.4.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane 0.71 63.0 4.17e-01 100.0% 25.2%
3740547 5086.1.1.87 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › ING 0.71 59.0 5.41e-01 90.5% 69.1%
3597345 3291.1.1.0 alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related 0.71 62.0 5.65e-01 100.0% 77.4%
3990182 3922.1.1.226 alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Fy-3 0.70 61.0 5.60e-01 100.0% 85.2%
3918310 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.70 51.0 4.78e-01 83.3% 61.9%
3489764 604.1.1.1 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.69 56.0 5.19e-01 98.8% 69.5%
3699451 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.67 61.0 5.45e-01 98.8% 90.4%
3785916 3559.1.1.40 a+b complex topology › Mediator of RNA polymerase II transcription subunit 22 › Mediator of RNA polymerase II transcription subunit 22 › Mediator of RNA polymerase II transcription subunit 22 › Bap31 0.66 51.0 4.64e-01 82.1% 64.5%
3496957 2003.1.2.0 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain 0.65 59.0 3.51e-01 98.8% 15.4%
55069 603.1.1.1 alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin 0.65 46.0 4.20e-01 100.0% 56.9%
5077093 4323.1.1.0 alpha bundles › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C 0.65 52.0 4.45e-01 86.9% 54.8%
4930182 2498.1.1.10 mixed a+b and a/b › Zincin-like › "Metalloproteases (""zincins"") catalytic domain" › "Metalloproteases (""zincins"") catalytic domain" › Peptidase_M48 0.64 55.0 4.31e-01 98.8% 66.7%
2663455 192.7.1.0 alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm 0.64 46.0 4.98e-01 76.2% 95.6%
3477822 1147.1.1.1 alpha bundles › RNA polymerase II elongation factor ELL2 C-terminal domain › RNA polymerase II elongation factor ELL2 C-terminal domain › RNA polymerase II elongation factor ELL2 C-terminal domain › Occludin_ELL 0.64 49.0 4.39e-01 84.5% 69.6%
3979729 3755.3.1.500 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › IpaC_SipC 0.62 52.0 4.70e-01 95.2% 66.7%
3593736 192.7.1.0 alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm 0.61 51.0 4.88e-01 91.7% 93.0%
3386594 3291.1.1.197 alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › MCPsignal 0.60 53.0 4.97e-01 100.0% 82.9%
5026453 4323.1.1.0 alpha bundles › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C 0.58 48.0 4.22e-01 96.4% 63.6%