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regulatory_protein_IE1

Euk-Vir

Saimiriine_betaherpesvirus_4

regulatory_protein_IE1__YP_004940277__Saimiriine_betaherpesvirus_4__1535247

Identity

Accession:
YP_004940277 ↗
Protein ID:
regulatory_protein_IE1
Kingdom:
euk

Quality

70.3 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Cytomegalovirus› Saimiriine_betaherpesvirus_4

TaxID: 1535247

Cluster

View cluster (7 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 39-59_74-137
PDB
Domain cluster: representative
CATH (22)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3cazB00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.81 73.0 5.43e-01 100.0% 84.3%
3hr0B01 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.76 52.0 5.38e-01 92.9% 75.9%
4ioeA00 1.10.287.850 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain 0.75 61.0 6.06e-01 89.4% 83.9%
8ek4A01 1.20.120.20 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein 0.74 63.0 5.41e-01 94.1% 59.4%
3qo8A01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.72 52.0 4.79e-01 92.9% 60.4%
1w9rA00 1.20.58.440 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › choline binding protein A 0.71 54.0 4.81e-01 97.6% 58.0%
4lwsA00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.71 63.0 5.98e-01 100.0% 90.0%
2xubA05 6.10.140.1450 Special › Helix non-globular › Helix Hairpins › 0.71 54.0 5.21e-01 81.2% 100.0%
2dq0A01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.70 51.0 4.75e-01 76.5% 99.1%
4cqiA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.70 49.0 4.57e-01 100.0% 57.9%
1t72A02 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.69 52.0 4.94e-01 78.8% 71.4%
3fppA03 6.10.140.1990 Special › Helix non-globular › Helix Hairpins › 0.69 55.0 5.51e-01 85.9% 85.2%
2dw4A03 1.10.287.80 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain 0.69 57.0 5.39e-01 89.4% 75.2%
3layF00 1.20.120.1490 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.68 50.0 5.26e-01 77.6% 91.0%
1owaA02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.66 49.0 4.54e-01 81.2% 62.3%
2y39A00 1.20.120.1490 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.66 51.0 4.67e-01 82.4% 63.6%
3lbxB01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.66 48.0 4.40e-01 75.3% 62.6%
2fb5A01 1.10.287.770 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YojJ-like 0.66 47.0 5.00e-01 74.1% 93.1%
3syvA01 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.64 57.0 4.13e-01 100.0% 60.0%
1fpoC02 1.20.1280.20 Mainly Alpha › Up-down Bundle › Monooxygenase › HscB, C-terminal domain 0.62 42.0 4.12e-01 72.9% 64.8%
1wpaA01 6.10.140.340 Special › Helix non-globular › Helix Hairpins › 0.60 46.0 4.37e-01 81.2% 93.9%
4dylA02 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.59 49.0 4.74e-01 94.1% 81.9%
ECOD (6)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3990182 3922.1.1.226 ↗ alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Fy-3 0.83 74.0 6.57e-01 94.1% 72.2%
3522868 5086.1.1.0 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.73 66.0 5.95e-01 97.6% 73.9%
5039743 3755.3.1.637 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › DUF7121 0.73 65.0 5.19e-01 97.6% 78.8%
3398787 3291.1.1.1 ↗ alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Snf7 0.69 58.0 4.72e-01 92.9% 51.9%
3628940 3755.1.1.0 ↗ alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related 0.64 58.0 5.30e-01 100.0% 79.1%
3740547 5086.1.1.87 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › ING 0.64 51.0 4.70e-01 87.1% 71.8%
D2 medium residues 138-192_293-374
PDB
Domain cluster: rep: regulatory_protein_IE1__YP_081562__Human_betaherpesvirus_5__10359__D142-184_299-391
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF07340.17 best Herpes_IE1 40.9 2.30e-10 90.5% 21.2%
CATH (23)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3ljbA00 1.20.120.1240 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Dynamin, middle domain 0.74 54.0 4.57e-01 75.2% 56.6%
3s84A02 1.20.120.20 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein 0.71 49.0 4.75e-01 71.5% 89.8%
3ripA02 1.20.120.1900 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Gamma-tubulin complex, C-terminal domain 0.70 54.0 4.25e-01 80.3% 94.3%
4ys0A02 1.10.3060.10 Mainly Alpha › Orthogonal Bundle › Helical scaffold and wing domains of SecA › Helical scaffold and wing domains of SecA 0.68 47.0 4.43e-01 71.5% 100.0%
4akgA13 1.10.8.740 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › 0.67 42.0 5.01e-01 78.8% 98.8%
2bl2A00 1.20.120.610 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › lithium bound rotor ring of v- atpase 0.65 52.0 4.99e-01 85.4% 83.3%
1gzsB00 1.10.4120.10 Mainly Alpha › Orthogonal Bundle › SopE-like GEF fold › SopE-like, GEF domain 0.64 45.0 4.21e-01 71.5% 83.0%
7dl9A01 1.20.1250.20 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains 0.60 41.0 3.69e-01 75.2% 49.5%
1cnt200 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.59 34.0 3.48e-01 77.4% 56.9%
6p73A02 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.59 44.0 4.35e-01 77.4% 76.2%
4al0A00 1.20.120.550 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Membrane associated eicosanoid/glutathione metabolism-like domain 0.58 46.0 4.52e-01 83.9% 87.7%
2k3nA00 1.10.274.60 Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › Spidroin, repetitive domain 0.57 41.0 3.97e-01 75.9% 93.1%
4e40A00 1.20.1260.80 Mainly Alpha › Up-down Bundle › Ferritin › 0.56 41.0 3.41e-01 75.9% 84.5%
2q12A00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.56 40.0 3.30e-01 73.0% 77.3%
1qdbA02 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.54 39.0 3.91e-01 75.2% 79.0%
3dytA02 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.54 37.0 3.34e-01 70.8% 93.2%
1sziA02 1.20.120.340 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS 0.53 35.0 3.53e-01 70.8% 65.7%
2fcwA00 1.20.81.10 Mainly Alpha › Up-down Bundle › Receptor-associated Protein › RAP domain 0.52 37.0 4.13e-01 85.4% 95.3%
3ieeA02 1.20.58.820 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Uncharacterised protein PF12889, C-terminal DUF3829 0.51 34.0 3.93e-01 79.6% 92.2%
1w9rA00 1.20.58.440 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › choline binding protein A 0.51 34.0 3.71e-01 77.4% 79.8%
1euhA01 3.40.605.10 Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 1 › Aldehyde Dehydrogenase; Chain A, domain 1 0.51 38.0 3.02e-01 77.4% 75.9%
1u7lA02 1.20.1460.10 Mainly Alpha › Up-down Bundle › subunit c (vma5p) of the yeast v-atpase, domain 2 › subunit c (vma5p) of the yeast v-atpase, domain 2 0.50 40.0 3.64e-01 84.7% 89.1%
6vq6G02 1.20.1460.10 Mainly Alpha › Up-down Bundle › subunit c (vma5p) of the yeast v-atpase, domain 2 › subunit c (vma5p) of the yeast v-atpase, domain 2 0.50 41.0 3.72e-01 86.9% 89.1%
ECOD (31)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1406537 6168.1.1.1 ↗ alpha duplicates or obligate multimers › Immediate-early 1 protein › Immediate-early 1 protein › Immediate-early 1 protein › Herpes_IE1 0.86 82.0 5.86e-01 100.0% 66.6%
5059356 159.1.2.0 ↗ alpha bundles › all-alpha NTP pyrophosphatases › all-alpha NTP pyrophosphatases › MazG-related 0.66 50.0 5.31e-01 78.8% 95.8%
2440127 1075.5.1.1 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.64 51.0 4.39e-01 85.4% 90.2%
4981884 1075.5.1.0 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter 0.63 50.0 4.38e-01 83.9% 91.4%
3200574 601.1.2.81 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Serinc 0.63 46.0 4.92e-01 76.6% 93.3%
4981432 1076.1.1.0 ↗ alpha bundles › Intramembrane protease Rce1-related › Intramembrane protease Rce1-related › Intramembrane protease Rce1-related 0.61 54.0 4.79e-01 98.5% 95.5%
4991495 1188.1.1.0 ↗ alpha bundles › ZIP zinc transporter › ZIP zinc transporter › ZIP zinc transporter 0.60 46.0 3.78e-01 81.0% 86.8%
4994989 1076.1.1.0 ↗ alpha bundles › Intramembrane protease Rce1-related › Intramembrane protease Rce1-related › Intramembrane protease Rce1-related 0.59 51.0 4.49e-01 95.6% 91.4%
4026688 5001.1.1.0 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like 0.59 42.0 3.36e-01 72.3% 94.3%
3969836 1075.5.1.0 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter 0.59 46.0 4.02e-01 82.5% 84.3%
3388455 604.12.1.0 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.58 41.0 4.46e-01 83.2% 87.8%
3624439 611.4.1.0 ↗ alpha bundles › N-cbl like › PG0775 C-terminal domain-like › PG0775 C-terminal domain-like 0.57 45.0 4.28e-01 85.4% 69.0%
4986380 1075.5.1.0 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter 0.57 46.0 4.07e-01 85.4% 89.5%
4926779 601.1.2.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) 0.57 40.0 4.11e-01 73.0% 84.4%
4950954 1075.5.1.0 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter 0.56 42.0 3.79e-01 79.6% 88.5%
3553221 632.22.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.56 38.0 4.09e-01 71.5% 80.0%
3614399 150.1.1.0 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.56 38.0 3.48e-01 70.1% 95.8%
3266856 5001.1.1.31 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › GPR180-TMEM145_TM 0.55 49.0 3.91e-01 97.1% 58.8%
3590799 191.1.1.12 ↗ alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_C_8 0.55 44.0 4.64e-01 85.4% 97.6%
4392536 1189.1.1.11 ↗ alpha bundles › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › Tektin 0.53 37.0 3.20e-01 71.5% 80.4%
3937860 633.6.1.6 ↗ alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › ACAD9-ACADV_C 0.53 42.0 3.98e-01 85.4% 78.8%
5017126 1075.5.1.2 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MurJ 0.53 46.0 4.15e-01 93.4% 92.4%
3263401 1075.1.1.1 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain › ABC2_membrane 0.53 48.0 3.79e-01 99.3% 82.5%
3317710 611.9.1.4 ↗ alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain › Rx_N 0.53 44.0 4.30e-01 91.2% 93.3%
3252330 1075.1.1.1 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain › ABC2_membrane 0.53 47.0 3.70e-01 98.5% 85.1%
4991084 1075.5.1.0 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter 0.53 45.0 4.06e-01 91.2% 85.9%
3698208 611.7.1.0 ↗ alpha bundles › N-cbl like › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Mixed lineage kinase domain-like (MLKL) N-terminal domain 0.52 39.0 3.96e-01 79.6% 82.9%
4017411 3755.4.1.0 ↗ alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.52 41.0 4.01e-01 84.7% 90.7%
3193079 1075.1.1.1 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain › ABC2_membrane 0.51 41.0 3.67e-01 85.4% 81.1%
None — 0.51 44.0 3.60e-01 95.6% 83.5%
3932809 150.1.1.0 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.51 39.0 3.88e-01 83.2% 93.3%
D3 medium residues 193-292
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF07340.17 best Herpes_IE1 32.8 6.40e-08 97.0% 24.1%
CATH (50)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2pmsC00 6.10.140.920 Special › Helix non-globular › Helix Hairpins › 0.78 47.0 4.59e-01 80.0% 56.0%
6vudA01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.76 58.0 5.62e-01 94.0% 73.4%
8ek4A01 1.20.120.20 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein 0.75 60.0 5.42e-01 99.0% 63.9%
4oydB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.75 54.0 5.14e-01 100.0% 64.1%
4kb2A01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.71 50.0 4.86e-01 99.0% 66.1%
1txuA01 1.10.246.120 Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › 0.70 39.0 4.05e-01 95.0% 57.4%
4ke2A00 6.10.140.1860 Special › Helix non-globular › Helix Hairpins › 0.70 64.0 5.09e-01 100.0% 84.7%
1i4dA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.70 62.0 5.05e-01 99.0% 64.9%
3hr0B01 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.70 46.0 5.17e-01 95.0% 86.1%
5c4yA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.69 34.0 3.07e-01 95.0% 33.8%
1wpaA01 6.10.140.340 Special › Helix non-globular › Helix Hairpins › 0.69 53.0 5.33e-01 80.0% 83.8%
1t72A02 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.69 47.0 4.79e-01 98.0% 71.4%
1u7lA02 1.20.1460.10 Mainly Alpha › Up-down Bundle › subunit c (vma5p) of the yeast v-atpase, domain 2 › subunit c (vma5p) of the yeast v-atpase, domain 2 0.68 58.0 4.79e-01 95.0% 91.8%
4wpeA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.68 60.0 4.37e-01 98.0% 74.2%
1aj3A00 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.67 45.0 4.57e-01 72.0% 70.4%
4ioeA00 1.10.287.850 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain 0.66 50.0 5.31e-01 98.0% 92.0%
1u5pA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.66 44.0 4.30e-01 98.0% 63.0%
2i0mA02 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.66 44.0 4.41e-01 89.0% 67.3%
5u56A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.65 44.0 4.30e-01 72.0% 63.4%
3vkgA12 1.10.287.2610 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.64 52.0 4.05e-01 87.0% 40.5%
1v9dB00 1.20.58.2220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Formin, FH2 domain 0.64 45.0 3.16e-01 87.0% 22.7%
4x28C03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.64 41.0 3.64e-01 72.0% 45.5%
1owaA02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.64 44.0 4.38e-01 76.0% 67.9%
4mh6A00 1.10.287.1700 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.63 52.0 4.52e-01 91.0% 75.5%
1cunA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.63 43.0 4.36e-01 79.0% 69.6%
1s35A02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.63 42.0 4.14e-01 80.0% 62.7%
2efkA01 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.63 53.0 4.00e-01 96.0% 80.2%
4m70I00 1.20.5.4130 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.63 41.0 4.06e-01 74.0% 62.0%
6tqfA01 1.20.1560.10 Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain 0.62 54.0 3.59e-01 94.0% 29.4%
6h2dS01 1.20.1170.10 Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › 0.62 51.0 4.02e-01 91.0% 54.3%
2rd0B00 1.10.287.1490 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.62 50.0 4.49e-01 87.0% 62.6%
3qo8A01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.62 45.0 4.51e-01 78.0% 100.0%
5nl6A02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.61 42.0 4.15e-01 71.0% 65.7%
1avoB00 1.20.120.180 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Proteasome activator pa28, C-terminal domain 0.61 51.0 4.64e-01 94.0% 75.7%
1wdzA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.61 53.0 4.13e-01 98.0% 72.7%
1quuA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.61 42.0 3.94e-01 79.0% 57.1%
3ok8A00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.61 53.0 4.18e-01 99.0% 72.1%
2ch7A00 1.10.287.950 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein 0.60 51.0 3.65e-01 94.0% 96.4%
3edvA02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.60 47.0 3.85e-01 91.0% 45.4%
3o6xA02 1.20.120.1560 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.60 43.0 3.80e-01 91.0% 50.7%
5dqqA02 1.10.287.70 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.60 55.0 4.96e-01 100.0% 100.0%
2uxwA04 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.59 42.0 3.88e-01 74.0% 60.8%
2d1lA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.59 51.0 3.90e-01 99.0% 70.3%
3fb2A01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.59 42.0 4.17e-01 93.0% 71.4%
2rdcA00 1.10.287.800 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › protein ne1242 0.58 45.0 4.15e-01 87.0% 62.4%
7zxkC01 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.55 38.0 3.29e-01 70.0% 74.0%
2fcwA00 1.20.81.10 Mainly Alpha › Up-down Bundle › Receptor-associated Protein › RAP domain 0.55 41.0 4.07e-01 80.0% 91.5%
3pe0A02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.54 39.0 3.93e-01 81.0% 72.6%
3hpcX00 3.30.1520.10 Alpha Beta › 2-Layer Sandwich › PX Domain › Phox-like domain 0.54 41.0 3.61e-01 85.0% 52.9%
1g2nA00 1.10.565.10 Mainly Alpha › Orthogonal Bundle › Retinoid X Receptor › Retinoid X Receptor 0.51 36.0 2.76e-01 73.0% 82.9%
ECOD (59)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4980098 3834.1.1.0 ↗ alpha bundles › TcA alpha pore-forming domain › TcA alpha pore-forming domain › TcA alpha pore-forming domain 0.81 75.0 5.39e-01 100.0% 47.2%
3175421 3922.1.1.312 ↗ alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › PF30554 0.77 69.0 6.19e-01 100.0% 89.3%
4843090 310.2.1.0 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF 0.75 50.0 4.84e-01 100.0% 60.7%
3482265 601.19.1.36 ↗ alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein › DUF4455 0.71 65.0 5.23e-01 100.0% 58.4%
3209632 604.5.1.0 ↗ alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) 0.70 52.0 5.08e-01 98.0% 70.9%
3404485 601.19.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein 0.69 61.0 4.88e-01 99.0% 67.8%
1565080 191.1.1.38 ↗ alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_C_5-like 0.69 34.0 3.07e-01 95.0% 33.8%
3239453 601.1.2.1 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Vinculin 0.69 40.0 3.61e-01 100.0% 41.5%
3845925 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.69 48.0 4.44e-01 73.0% 57.6%
5064797 4177.1.1.0 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like 0.68 62.0 4.79e-01 100.0% 46.4%
4976711 150.1.1.0 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.68 56.0 4.77e-01 88.0% 79.4%
3630257 4177.1.1.0 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like 0.68 63.0 5.11e-01 100.0% 55.6%
3519300 1147.1.1.1 ↗ alpha bundles › RNA polymerase II elongation factor ELL2 C-terminal domain › RNA polymerase II elongation factor ELL2 C-terminal domain › RNA polymerase II elongation factor ELL2 C-terminal domain › Occludin_ELL 0.68 53.0 4.97e-01 83.0% 69.2%
3259629 192.29.1.0 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.68 49.0 4.96e-01 92.0% 75.0%
4094168 547.1.1.1 ↗ alpha duplicates or obligate multimers › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › GlutR_dimer 0.68 50.0 5.08e-01 90.0% 78.0%
4995305 604.5.1.2 ↗ alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU 0.67 40.0 4.17e-01 99.0% 63.2%
4593595 3835.1.1.0 ↗ alpha bundles › Type I hyperactive antifreeze protein › Type I hyperactive antifreeze protein › Type I hyperactive antifreeze protein 0.67 59.0 4.64e-01 100.0% 65.6%
3611166 3755.3.1.0 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.66 55.0 4.42e-01 91.0% 47.0%
3624539 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.66 42.0 4.38e-01 91.0% 68.4%
3898385 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.65 44.0 3.89e-01 71.0% 46.7%
1157010 604.5.1.2 ↗ alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU 0.65 43.0 4.39e-01 99.0% 69.4%
3844590 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.65 45.0 4.05e-01 74.0% 53.3%
3928340 310.2.1.0 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF 0.64 59.0 4.76e-01 100.0% 65.9%
3504302 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.64 38.0 3.85e-01 94.0% 58.0%
3456370 192.2.1.0 ↗ alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.64 53.0 4.64e-01 91.0% 77.4%
4963289 3877.1.1.0 ↗ alpha bundles › Membrane protein insertase YidC-related › Membrane protein insertase YidC-related › Membrane protein insertase YidC 0.64 53.0 4.29e-01 90.0% 48.4%
3741745 632.22.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.64 46.0 4.27e-01 76.0% 73.1%
3767239 4177.1.1.1 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH 0.63 55.0 3.99e-01 98.0% 74.9%
3705964 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.63 41.0 4.19e-01 82.0% 67.0%
3164951 5094.1.1.1 ↗ a+b duplicates or obligate multimers › OmpH-like › OmpH-like › OmpH-like › OmpH 0.63 55.0 4.68e-01 100.0% 87.1%
4025544 4177.1.1.0 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like 0.63 52.0 4.48e-01 92.0% 93.3%
3428852 3755.4.1.0 ↗ alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.62 55.0 5.03e-01 100.0% 99.3%
3750000 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.62 43.0 4.29e-01 80.0% 67.6%
3730112 190.1.1.1 ↗ alpha arrays › HMG-box-like › HMG-box › HMG-box › HMG_box 0.62 52.0 4.62e-01 93.0% 85.2%
3976126 1079.1.1.1 ↗ alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › DsbD 0.62 37.0 2.85e-01 77.0% 27.4%
3799136 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.62 48.0 3.73e-01 87.0% 36.5%
3917085 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.61 39.0 4.01e-01 97.0% 67.4%
3712359 150.3.1.0 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › 4-helical cytokines › 4-helical cytokine 0.61 54.0 4.56e-01 100.0% 68.8%
3245538 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.61 41.0 4.11e-01 71.0% 66.7%
3400732 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.61 44.0 4.23e-01 86.0% 65.0%
4937585 5058.1.1.0 ↗ alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region 0.61 44.0 4.37e-01 92.0% 72.4%
3436634 633.4.1.0 ↗ alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor 0.60 38.0 3.26e-01 99.0% 40.6%
4296017 632.22.1.1 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › EzrA 0.60 47.0 4.30e-01 93.0% 64.6%
3521280 604.1.1.256 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Wbp11 0.60 42.0 3.79e-01 92.0% 54.1%
3600869 3567.1.1.0 ↗ a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer 0.59 47.0 4.58e-01 99.0% 77.4%
3574755 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.59 43.0 4.22e-01 94.0% 70.0%
3929285 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.58 40.0 4.00e-01 71.0% 69.0%
3841673 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.58 40.0 4.10e-01 73.0% 72.0%
3631342 3559.1.1.1 ↗ a+b complex topology › Mediator of RNA polymerase II transcription subunit 22 › Mediator of RNA polymerase II transcription subunit 22 › Mediator of RNA polymerase II transcription subunit 22 › Med22 0.58 46.0 4.57e-01 88.0% 84.8%
3197870 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.58 49.0 4.47e-01 95.0% 70.4%
3330281 4992.1.1.0 ↗ extended segments › RelB-like › RelB-like › RelB-like 0.57 42.0 4.08e-01 97.0% 69.1%
4595958 632.22.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.57 42.0 4.15e-01 82.0% 70.9%
3979099 361.1.1.0 ↗ few secondary structure elements › DnaJ/Hsp40 cysteine-rich domain › DnaJ/Hsp40 cysteine-rich domain › DnaJ/Hsp40 cysteine-rich domain 0.57 42.0 3.72e-01 79.0% 54.2%
3629164 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.56 44.0 4.15e-01 98.0% 68.0%
3935030 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.56 38.0 3.77e-01 98.0% 64.8%
4949471 3877.1.1.0 ↗ alpha bundles › Membrane protein insertase YidC-related › Membrane protein insertase YidC-related › Membrane protein insertase YidC 0.55 45.0 3.80e-01 90.0% 55.4%
3285171 604.39.1.0 ↗ alpha bundles › Spectrin repeat-like › S-component of energy-coupling factor (ECF) transporters › S-component of energy-coupling factor (ECF) transporters 0.55 40.0 3.23e-01 76.0% 96.5%
3758959 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.55 37.0 2.61e-01 71.0% 20.9%
3170639 103.1.1.0 ↗ alpha arrays › RuvA-C › RuvA-C, UBA, CRAL/TRIO-N, HBS1 › UBA-like domain 0.53 42.0 4.54e-01 98.0% 100.0%