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regulatory_protein_IE1

Euk-Vir

Human_betaherpesvirus_5

regulatory_protein_IE1__YP_081562__Human_betaherpesvirus_5__10359

Identity

Accession:
YP_081562 ↗
Protein ID:
regulatory_protein_IE1
Kingdom:
euk

Quality

70.8 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 71-141_185-224_279-298
PDB
Domain cluster: representative
CATH (25)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3edvA02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.78 54.0 4.74e-01 71.8% 49.7%
3s84A02 1.20.120.20 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein 0.77 65.0 6.08e-01 88.5% 98.1%
1wdzA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.71 57.0 4.68e-01 84.0% 68.0%
4nqiD00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.70 55.0 4.59e-01 84.0% 60.8%
2b5uA02 1.10.287.620 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix Hairpins 0.70 49.0 4.63e-01 72.5% 66.5%
4mh6A00 1.10.287.1700 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.70 54.0 5.02e-01 79.4% 66.0%
3k29A00 1.10.287.1700 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.70 53.0 4.97e-01 80.2% 69.6%
4bejB02 1.20.120.1240 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Dynamin, middle domain 0.69 55.0 4.61e-01 84.7% 63.7%
1fewA00 1.20.58.70 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.67 45.0 4.07e-01 70.2% 50.9%
3u0cA00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.67 53.0 5.12e-01 84.0% 92.1%
1qu7A00 1.10.287.950 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein 0.67 51.0 4.21e-01 79.4% 51.1%
2bl2A00 1.20.120.610 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › lithium bound rotor ring of v- atpase 0.66 49.0 4.69e-01 78.6% 72.4%
2wb7A03 1.20.120.870 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › pT26-6p, five-helical bundle domain 0.66 45.0 4.49e-01 75.6% 66.9%
8a1gC01 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.65 52.0 4.67e-01 84.7% 66.3%
1kmiZ02 1.10.287.500 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.65 48.0 4.77e-01 75.6% 90.3%
2oexA02 1.20.140.50 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › alix/aip1 like domains 0.64 54.0 4.78e-01 93.1% 98.0%
1xwjA01 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.64 42.0 4.29e-01 70.2% 67.7%
1uruA01 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.63 52.0 4.48e-01 89.3% 95.7%
2ipcA04 1.10.3060.10 Mainly Alpha › Orthogonal Bundle › Helical scaffold and wing domains of SecA › Helical scaffold and wing domains of SecA 0.62 53.0 4.41e-01 94.7% 87.2%
3g67A00 1.10.287.950 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein 0.61 46.0 3.88e-01 77.9% 51.2%
1i4dA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.59 46.0 4.13e-01 83.2% 68.1%
3g9gA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.57 49.0 3.95e-01 91.6% 86.4%
6vq6G02 1.20.1460.10 Mainly Alpha › Up-down Bundle › subunit c (vma5p) of the yeast v-atpase, domain 2 › subunit c (vma5p) of the yeast v-atpase, domain 2 0.54 40.0 3.57e-01 77.1% 79.3%
4akgA02 1.20.140.100 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Dynein motor heavy chain, linker domain, N-terminal subdomain 0.52 41.0 3.80e-01 86.3% 66.1%
6zhiB02 1.20.1270.10 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.50 31.0 3.71e-01 71.8% 96.4%
ECOD (15)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4024699 3871.1.1.1 alpha duplicates or obligate multimers › PHIST › PHIST › PHIST › PRESAN 0.77 59.0 5.74e-01 80.9% 84.1%
3733140 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.74 56.0 5.29e-01 78.6% 76.8%
3697355 5086.1.1.0 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.73 55.0 5.22e-01 78.6% 76.8%
3437287 5086.1.1.199 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › PF31016 0.65 51.0 4.65e-01 82.4% 69.1%
3340986 601.51.1.0 alpha bundles › Four-helical up-and-down bundle › alpha-helical domain in phase 1 flagellin › alpha-helical domain in phase 1 flagellin 0.65 47.0 3.98e-01 73.3% 99.5%
5002671 3755.3.1.637 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › DUF7121 0.65 50.0 4.70e-01 80.2% 76.9%
3569037 632.7.1.1 alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain › HSP70 0.65 39.0 4.58e-01 72.5% 86.7%
4296017 632.22.1.1 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › EzrA 0.63 53.0 5.36e-01 90.1% 96.9%
3235297 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.62 47.0 4.20e-01 79.4% 78.9%
3400959 4177.1.1.8 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR_3 0.62 53.0 4.18e-01 93.1% 80.7%
5039275 2004.1.1.198 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23 0.61 44.0 2.86e-01 74.0% 25.0%
5022961 1075.5.1.0 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter 0.60 45.0 3.88e-01 77.1% 77.4%
2462244 1075.5.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.59 45.0 3.79e-01 79.4% 88.5%
3499315 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.57 48.0 5.11e-01 90.8% 98.3%
3377464 3755.3.1.285 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › NET2A 0.57 46.0 4.27e-01 84.0% 73.8%
D2 medium residues 142-184_299-391
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF07340.17 best Herpes_IE1 30.1 4.40e-07 68.4% 22.2%
CATH (15)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3ripA02 1.20.120.1900 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Gamma-tubulin complex, C-terminal domain 0.68 49.0 3.88e-01 75.0% 96.1%
2bl2A00 1.20.120.610 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › lithium bound rotor ring of v- atpase 0.59 42.0 4.09e-01 74.3% 84.0%
2uuiA00 1.20.120.550 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Membrane associated eicosanoid/glutathione metabolism-like domain 0.58 42.0 4.07e-01 74.3% 75.5%
2fupA00 1.20.58.300 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › FlgN-like 0.57 29.0 3.04e-01 77.2% 52.0%
6opmD01 1.20.120.920 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › CRISPR-associated endonuclease Cas1, C-terminal domain 0.56 44.0 3.68e-01 83.8% 64.3%
2zy9A03 1.10.357.20 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › SLC41 divalent cation transporters, integral membrane domain 0.53 38.0 3.54e-01 75.0% 75.9%
1guxB00 1.10.472.10 Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like 0.53 40.0 3.95e-01 84.6% 75.2%
5d18A00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.53 40.0 3.51e-01 79.4% 66.3%
6c1qB02 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.53 41.0 3.32e-01 83.8% 59.9%
6fmhB01 1.10.3160.10 Mainly Alpha › Orthogonal Bundle › Bbcrasp-1 › Bbcrasp-1 0.52 44.0 4.10e-01 93.4% 87.2%
2d05A02 1.20.141.10 Mainly Alpha › Up-down Bundle › Chitosanase, subunit A; domain 1 › Chitosanase, subunit A, domain 1 0.52 30.0 3.24e-01 74.3% 64.9%
4o6mA02 1.20.120.1760 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › CDP-alcohol phosphotransferase transmembrane (TM) domain 0.51 42.0 3.78e-01 89.7% 80.0%
4alyB00 1.10.3160.10 Mainly Alpha › Orthogonal Bundle › Bbcrasp-1 › Bbcrasp-1 0.51 42.0 3.84e-01 91.2% 79.7%
1nzeA00 1.20.120.290 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Oxygen-evolving enhancer protein 3 (PsbQ), four-helix up-down bundle 0.50 38.0 4.10e-01 86.0% 95.5%
2iu5B00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.50 41.0 3.79e-01 91.2% 67.8%
ECOD (27)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2711996 6168.1.1.1 alpha duplicates or obligate multimers › Immediate-early 1 protein › Immediate-early 1 protein › Immediate-early 1 protein › Herpes_IE1 0.94 86.0 6.02e-01 93.4% 66.8%
1406537 6168.1.1.1 alpha duplicates or obligate multimers › Immediate-early 1 protein › Immediate-early 1 protein › Immediate-early 1 protein › Herpes_IE1 0.92 81.0 5.72e-01 91.2% 66.9%
3786208 1075.5.1.5 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Rft-1 0.68 48.0 3.99e-01 72.1% 86.5%
4996465 1075.5.1.0 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter 0.67 47.0 4.07e-01 71.3% 94.6%
5025472 1075.5.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.67 48.0 4.13e-01 73.5% 92.4%
3279521 1075.5.1.0 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter 0.67 47.0 4.19e-01 72.1% 90.5%
4872236 109.3.1.0 alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat 0.66 56.0 5.29e-01 92.6% 98.8%
5002996 1075.5.1.4 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt 0.65 46.0 4.02e-01 72.1% 91.2%
4996790 1075.5.1.8 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt_3 0.63 45.0 3.60e-01 72.8% 73.2%
5040450 3281.1.1.1 alpha complex topology › Sodium/proton antiporter subunits-like › Sodium/proton antiporter subunits-like › NADH-quinone oxidoreductase subunit L (NuoL)-related › Proton_antipo_M 0.60 42.0 2.89e-01 71.3% 65.7%
4994989 1076.1.1.0 alpha bundles › Intramembrane protease Rce1-related › Intramembrane protease Rce1-related › Intramembrane protease Rce1-related 0.60 48.0 4.17e-01 86.0% 94.8%
4024388 5082.1.1.1 alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation_efflux 0.58 42.0 3.49e-01 72.8% 80.9%
3249406 3896.1.1.2 alpha duplicates or obligate multimers › Intramembrane CDP-DAG synthetase-related › Intramembrane CDP-DAG synthetase-related › Intramembrane CDP-DAG synthetase › DUF92 0.57 51.0 4.14e-01 100.0% 88.7%
3279978 1075.5.1.0 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter 0.56 45.0 4.05e-01 85.3% 87.6%
3944827 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.54 44.0 4.02e-01 86.8% 75.0%
3700563 5073.1.2.7 alpha bundles › Calcium ATPase transmembrane domain-related › Calcium ATPase transmembrane domain-related › Copper efflux ATPase transmembrane domain › PhoLip_ATPase_C 0.54 44.0 3.78e-01 88.2% 87.3%
5014970 1075.5.1.4 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt 0.54 43.0 3.75e-01 85.3% 82.4%
5029479 1075.5.1.4 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt 0.54 43.0 3.76e-01 85.3% 83.9%
4974860 1075.5.1.4 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt 0.54 44.0 3.98e-01 90.4% 81.5%
3249055 3447.1.1.5 alpha bundles › Isoprenylcysteine carboxyl methyltransferase (ICMT) › Isoprenylcysteine carboxyl methyltransferase (ICMT) › Isoprenylcysteine carboxyl methyltransferase (ICMT) › Steroid_dh 0.53 38.0 3.52e-01 74.3% 99.4%
5073173 3542.1.1.0 alpha arrays › Presenilin family intramembrane aspartate proteases › Presenilin family intramembrane aspartate proteases › Presenilin family intramembrane aspartate proteases 0.52 45.0 3.55e-01 94.1% 94.8%
3481132 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.52 44.0 3.10e-01 94.9% 68.8%
3741452 3881.1.1.1 alpha bundles › CNOT9 binding domain CN9BD (DUF3819) › CNOT9 binding domain CN9BD (DUF3819) › CNOT9 binding domain CN9BD (DUF3819) › DUF3819 0.52 39.0 3.32e-01 78.7% 96.9%
5020612 1075.5.1.4 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt 0.51 42.0 3.72e-01 89.7% 72.7%
3969836 1075.5.1.0 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter 0.51 42.0 3.64e-01 89.0% 69.0%
5020664 1075.5.1.4 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt 0.51 42.0 3.69e-01 91.2% 72.4%
3480514 604.12.1.0 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.50 36.0 3.58e-01 74.3% 90.3%
D3 medium residues 225-278
PDB
Domain cluster: representative
CATH (2)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2kp8A00 1.20.5.170 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.63 51.0 4.82e-01 100.0% 80.6%
3h1nA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.58 49.0 3.91e-01 100.0% 47.5%
ECOD (6)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5054168 632.11.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.82 58.0 5.41e-01 74.1% 63.1%
4385343 632.7.1.1 alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain › HSP70 0.75 54.0 4.78e-01 77.8% 52.5%
4946914 6155.1.1.0 alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter 0.71 62.0 4.58e-01 100.0% 79.3%
3679700 601.33.1.0 alpha bundles › Four-helical up-and-down bundle › CHAD domain › CHAD domain 0.70 60.0 4.69e-01 96.3% 47.0%
3965346 5069.1.1.0 alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes 0.65 55.0 3.71e-01 100.0% 25.3%
3261478 3826.1.1.0 alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) 0.65 52.0 4.62e-01 90.7% 67.5%