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regulatory_protein_IE2

Euk-Vir

Human_betaherpesvirus_7

regulatory_protein_IE2__YP_073823__Human_betaherpesvirus_7__10372

Identity

Accession:
YP_073823 ↗
Protein ID:
regulatory_protein_IE2
Kingdom:
euk

Quality

39.7 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Roseolovirus› Human_betaherpesvirus_7

TaxID: 10372

Cluster

View cluster (2 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 1035-1204
PDB
Domain cluster: rep: regulatory_protein_IE2__YP_004940130__Aotine_betaherpesvirus_1__50290__D403-485_519-583
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03361.21 best Herpes_IE2_3 179.5 5.10e-53 93.5% 98.8%
CATH (49)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3n79A01 3.30.70.1710 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › BMC (bacterial microcompartment) domain 0.73 35.0 5.08e-01 75.9% 100.0%
3dfeA00 3.30.70.120 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.71 36.0 4.97e-01 77.1% 98.8%
2kl8A00 3.30.70.600 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S10 0.70 35.0 4.75e-01 74.1% 95.3%
1s7hA01 3.30.70.930 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.69 35.0 4.80e-01 75.3% 100.0%
3ce8A00 3.30.70.120 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.68 36.0 4.87e-01 78.2% 97.8%
3mgjA00 3.30.70.2690 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › LOR/SDH bifunctional enzyme, conserved domain 0.68 38.0 4.98e-01 80.0% 97.9%
2go8A01 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.68 31.0 4.59e-01 74.7% 100.0%
1vk8A00 3.30.70.930 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.68 36.0 4.70e-01 78.2% 93.5%
2ca9A02 3.30.70.1150 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT-like. Chain A, domain 2 0.67 36.0 4.87e-01 76.5% 100.0%
1lxjA00 3.30.70.930 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.67 37.0 4.69e-01 80.0% 89.3%
3onqA02 3.30.70.2730 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.65 32.0 4.34e-01 74.1% 95.1%
2efpA02 3.30.70.920 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain 0.65 35.0 4.42e-01 80.0% 88.8%
5d4nC00 3.30.70.120 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.64 37.0 4.71e-01 80.6% 96.9%
2nyiA02 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.63 34.0 4.46e-01 75.3% 96.7%
2rilA00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.63 36.0 4.66e-01 75.9% 98.9%
2e44A01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.63 30.0 4.30e-01 70.6% 100.0%
2yq1C00 3.30.70.390 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Epstein Barr virus nuclear antigen-1, DNA-binding domain 0.63 36.0 4.09e-01 79.4% 73.3%
7q4lA01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.62 31.0 3.67e-01 72.9% 66.9%
2od4B01 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.62 34.0 4.48e-01 73.5% 100.0%
1qm9A01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.62 34.0 4.26e-01 77.6% 89.8%
6gdxA00 3.30.70.120 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.62 37.0 4.53e-01 82.4% 93.5%
3ahpA00 3.30.70.120 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.61 38.0 4.74e-01 86.5% 100.0%
1vw4F02 3.90.930.12 Alpha Beta › Alpha-Beta Complex › Outer Surface Protein A; domain 3 › Ribosomal protein L6 0.61 31.0 4.11e-01 71.2% 90.2%
5w0hA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.61 31.0 4.18e-01 72.4% 100.0%
4iyqA00 3.30.70.120 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.60 38.0 4.64e-01 84.1% 99.1%
2ypyA00 3.30.70.390 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Epstein Barr virus nuclear antigen-1, DNA-binding domain 0.60 35.0 3.92e-01 79.4% 72.4%
2zomA00 3.30.70.120 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.60 37.0 4.53e-01 84.1% 97.2%
5o60I00 3.30.70.1730 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein L10, N-terminal RNA-binding domain 0.60 33.0 3.88e-01 74.7% 74.6%
4tqrA01 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.60 30.0 3.85e-01 77.1% 81.6%
3lo3A00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.59 33.0 4.33e-01 73.5% 98.9%
1j2vA00 3.30.70.120 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.59 35.0 4.46e-01 81.2% 100.0%
2mzqA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.59 31.0 3.86e-01 82.4% 83.2%
2cq0A00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.58 32.0 4.00e-01 86.5% 88.3%
6lpnA03 3.30.70.2190 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.57 34.0 4.11e-01 74.1% 88.6%
2m88A01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.57 28.0 3.68e-01 74.1% 88.4%
2hzmG01 3.30.310.180 Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › 0.56 35.0 4.11e-01 77.1% 89.6%
6ifnA01 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.56 38.0 3.82e-01 79.4% 68.0%
3mtkA00 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.56 33.0 3.42e-01 78.2% 60.7%
4ewtA02 3.30.70.360 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.55 37.0 4.46e-01 74.7% 100.0%
3gnnA01 3.90.1170.20 Alpha Beta › Alpha-Beta Complex › Aldehyde Oxidoreductase; domain 3 › Quinolinate phosphoribosyl transferase, N-terminal domain 0.55 34.0 3.79e-01 77.1% 76.1%
3pm9A03 3.30.70.2190 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.55 35.0 4.05e-01 77.1% 88.4%
1sjrA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.55 33.0 4.01e-01 81.2% 93.5%
1rlhA02 3.40.1520.10 Alpha Beta › 3-Layer(aba) Sandwich › hypothetical protein tt1634 › Ta1353-like 0.54 33.0 4.12e-01 72.9% 100.0%
5ujeA01 3.30.1760.10 Alpha Beta › 2-Layer Sandwich › Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, domain 2 › Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, domain 2 0.53 33.0 3.99e-01 87.6% 94.6%
5zspA01 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.53 29.0 3.29e-01 90.0% 68.2%
2iiiA00 3.60.90.10 Alpha Beta › 4-Layer Sandwich › S-adenosylmethionine decarboxylase › S-adenosylmethionine decarboxylase 0.52 36.0 4.13e-01 87.6% 97.5%
2yweA04 3.30.70.240 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.52 35.0 4.12e-01 89.4% 100.0%
4uw2B03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.50 30.0 3.31e-01 79.4% 70.7%
7c51A01 3.30.70.2970 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Protein of unknown function (DUF541), domain 2 0.50 33.0 3.92e-01 74.1% 100.0%
ECOD (44)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2324003 304.15.1.3 ↗ a+b two layers › Alpha-beta plaits › Viral DNA-binding domain › Viral DNA-binding domain › Herpes_IE2_3 0.69 65.0 6.69e-01 96.5% 100.0%
3184298 304.4.1.0 ↗ a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.68 32.0 4.65e-01 71.2% 100.0%
5082143 304.26.1.1 ↗ a+b two layers › Alpha-beta plaits › MTH1187/YkoF-like › MTH1187/YkoF-like › Thiamine_BP 0.65 35.0 4.41e-01 77.6% 84.8%
2538977 304.51.1.5 ↗ a+b two layers › Alpha-beta plaits › CRISPR transcript (pre-crRNA) processing endoribonuclease-related › CRISPR transcript (pre-crRNA) processing endoribonuclease-related › Cas_Csy4 0.64 36.0 4.73e-01 74.1% 98.9%
3472736 304.9.1.1 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.64 32.0 3.73e-01 76.5% 65.0%
3227424 331.18.1.8 ↗ a+b two layers › TBP-like › C-terminal TBP-like domain of Roc › C-terminal TBP-like domain of Roc › BBS7_pf 0.64 37.0 4.59e-01 73.5% 91.4%
4946289 304.4.1.0 ↗ a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.64 33.0 4.32e-01 75.9% 92.2%
3685020 304.9.1.1 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.64 37.0 4.72e-01 83.5% 100.0%
5189 304.4.1.0 ↗ a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.63 35.0 4.48e-01 76.5% 93.0%
1122231 304.15.1.4 ↗ a+b two layers › Alpha-beta plaits › Viral DNA-binding domain › Viral DNA-binding domain › LANA1_DNA-bd 0.63 36.0 4.09e-01 79.4% 73.3%
4629521 304.5.1.3 ↗ a+b two layers › Alpha-beta plaits › GlnB-like › GlnB-like › CutA1 0.63 38.0 4.77e-01 82.9% 99.0%
4931771 304.4.1.0 ↗ a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.63 34.0 4.25e-01 78.8% 88.0%
5051637 304.33.1.1 ↗ a+b two layers › Alpha-beta plaits › CheY-binding domain of CheA › CheY-binding domain of CheA › P2 0.62 37.0 4.24e-01 79.4% 80.0%
3701279 304.107.1.10 ↗ a+b two layers › Alpha-beta plaits › Aminomethyltransferase folate-binding domain › Aminomethyltransferase folate-binding domain › BBS7_pf 0.62 35.0 4.58e-01 74.1% 98.9%
4945381 304.3.1.0 ↗ a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.61 31.0 4.32e-01 74.7% 98.8%
5024216 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.61 39.0 3.94e-01 86.5% 62.3%
1120754 304.15.1.4 ↗ a+b two layers › Alpha-beta plaits › Viral DNA-binding domain › Viral DNA-binding domain › LANA1_DNA-bd 0.61 36.0 3.92e-01 79.4% 70.3%
3892177 304.9.1.104 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_PARP14_2 0.61 31.0 4.17e-01 73.5% 93.3%
4666950 304.60.1.0 ↗ a+b two layers › Alpha-beta plaits › Ribosomal protein L10-like › Ribosomal protein L10-like 0.60 34.0 3.50e-01 75.3% 55.9%
4944847 304.5.1.0 ↗ a+b two layers › Alpha-beta plaits › GlnB-like › GlnB-like 0.60 37.0 4.61e-01 84.7% 100.0%
3512817 304.107.1.10 ↗ a+b two layers › Alpha-beta plaits › Aminomethyltransferase folate-binding domain › Aminomethyltransferase folate-binding domain › BBS7_pf 0.60 39.0 4.49e-01 87.1% 88.8%
4220559 304.162.1.1 ↗ a+b two layers › Alpha-beta plaits › Competence or damage-inducible protein CinA middle domain › Competence or damage-inducible protein CinA middle domain › CinA_KH 0.60 30.0 4.14e-01 71.8% 100.0%
4944621 304.4.1.0 ↗ a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.59 36.0 4.12e-01 87.1% 80.8%
4943756 304.4.1.0 ↗ a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.59 36.0 4.14e-01 87.1% 83.3%
3736578 304.9.1.1 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.59 31.0 3.72e-01 77.1% 75.5%
3898132 304.5.1.3 ↗ a+b two layers › Alpha-beta plaits › GlnB-like › GlnB-like › CutA1 0.58 36.0 3.99e-01 83.5% 75.0%
3704224 304.9.1.0 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.58 29.0 3.69e-01 72.9% 81.1%
3306417 304.9.1.1 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.57 31.0 3.33e-01 77.1% 59.3%
3478318 304.9.1.1 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.57 35.0 4.20e-01 85.3% 90.4%
3286826 304.6.1.1 ↗ a+b two layers › Alpha-beta plaits › FAD-linked oxidases, C-terminal domain › FAD-linked oxidases, C-terminal domain › FAD-oxidase_C 0.57 31.0 2.81e-01 71.2% 37.4%
3327415 304.9.1.1 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.57 30.0 3.08e-01 74.7% 50.3%
3385766 304.28.1.2 ↗ a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain › Sec_GG 0.56 30.0 3.90e-01 74.1% 94.4%
4946216 304.4.1.83 ↗ a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › HTH_24 0.56 36.0 4.13e-01 86.5% 88.0%
4283611 304.9.1.1 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.55 30.0 3.74e-01 75.9% 85.7%
3382121 304.9.1.1 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.55 32.0 3.37e-01 76.5% 63.3%
3966036 304.28.1.0 ↗ a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain 0.54 34.0 4.14e-01 77.6% 97.3%
3582370 304.9.1.1 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.52 31.0 3.64e-01 74.7% 84.3%
2649926 304.160.1.1 ↗ a+b two layers › Alpha-beta plaits › Gas vesicle protein GvpF › Gas vesicle protein GvpF › GvpL_GvpF 0.52 36.0 4.10e-01 79.4% 93.8%
4649590 304.9.1.1 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.51 35.0 4.04e-01 89.4% 97.5%
4949497 304.8.1.111 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › MCR_D 0.51 39.0 4.13e-01 78.2% 89.3%
4961231 304.128.1.0 ↗ a+b two layers › Alpha-beta plaits › ferredoxin-like domain in periplasmic region of MacB › ferredoxin-like domain in periplasmic region of MacB 0.51 31.0 3.83e-01 72.9% 100.0%
1524343 304.48.1.31 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Cas10-Cmr2_palm2 0.51 37.0 3.69e-01 80.0% 70.8%
4654857 304.60.1.8 ↗ a+b two layers › Alpha-beta plaits › Ribosomal protein L10-like › Ribosomal protein L10-like › Ribosomal_L10, PF27436 0.50 35.0 3.50e-01 87.6% 69.4%
3509425 304.4.1.0 ↗ a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.50 36.0 4.00e-01 76.5% 92.6%