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replicase

Euk-Vir

Euphorbia_ringspot_virus

replicase__YP_009310048__Euphorbia_ringspot_virus__291286

Identity

Accession:
YP_009310048 ↗
Protein ID:
replicase
Kingdom:
euk

Quality

94.7 mean pLDDT

Cluster

View cluster (450 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 17-30_65-225_276-314
PDB
Domain cluster: rep: NIb__YP_009221991__Jasmine_virus_T__1775963__D1-51_64-80_112-210_276-312
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00680.26 best RdRP_1 99.6 2.60e-28 80.4% 40.4%
D2 medium residues 31-64_412-502
PDB
Domain cluster: rep: NIb_protein__YP_006280739__Tomato_necrotic_stunt_virus__1176153__D28-67_411-488
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00680.26 best RdRP_1 28.7 8.20e-07 57.6% 12.0%
D3 medium residues 226-275_394-411
PDB
Domain cluster: rep: NIb_segment__YP_008992252__Zucchini_tigre_mosaic_virus__1406816__D219-250_339-356_384-408
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00680.26 best RdRP_1 36.1 4.60e-09 100.0% 14.7%
D4 medium residues 315-393
PDB
Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5B__YP_009679023__Hepacivirus_L__2008771__D289-359
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00680.26 best RdRP_1 51.6 9.10e-14 100.0% 17.3%
CATH (23)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1khvA03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.83 76.0 6.38e-01 100.0% 68.5%
3h5xA03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.82 74.0 6.48e-01 100.0% 67.2%
2ckwA03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.80 73.0 6.33e-01 100.0% 67.2%
6qwtA02 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.74 66.0 5.39e-01 97.5% 56.0%
1s48A04 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.71 62.0 5.49e-01 94.9% 90.1%
1mukA02 3.90.1850.10 Alpha Beta › Alpha-Beta Complex › RNA-directed RNA polymerase lambda-3 › RNA-directed RNA polymerase lambda-3 0.67 59.0 3.60e-01 100.0% 48.8%
7a2dA01 6.10.20.90 Special › Helix non-globular › Arc Repressor Mutant, subunit A › Hk620 tailspike protein, N-terminal domain-like 0.66 53.0 5.50e-01 93.7% 98.6%
1ewqA04 1.10.1420.10 Mainly Alpha › Orthogonal Bundle › MutS, DNA mismatch repair protein; Chain A, domain 3 › 0.64 47.0 3.98e-01 96.2% 45.6%
3thxB04 1.10.1420.10 Mainly Alpha › Orthogonal Bundle › MutS, DNA mismatch repair protein; Chain A, domain 3 › 0.63 46.0 3.98e-01 96.2% 48.4%
6tznA01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.63 53.0 4.89e-01 97.5% 90.7%
1yrtA01 3.30.70.1720 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.61 51.0 4.25e-01 94.9% 63.1%
3u1nB01 1.10.3210.10 Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 0.60 47.0 3.14e-01 84.8% 65.9%
4le5A02 3.30.300.10 Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › 0.58 49.0 4.17e-01 96.2% 71.5%
4alzA01 3.30.1340.30 Alpha Beta › 2-Layer Sandwich › Histidine-containing Protein; Chain: A; › 0.58 42.0 4.50e-01 84.8% 98.4%
2nvmA00 3.30.310.110 Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › XisI-like 0.58 46.0 4.29e-01 89.9% 94.2%
7q5yB01 3.30.460.80 Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › NADH:ubiquinone oxidoreductase Nqo5 subunit 0.56 45.0 3.97e-01 88.6% 74.2%
1zcdA00 1.20.1530.10 Mainly Alpha › Up-down Bundle › Na+/H+ antiporter like fold › Na+/H+ antiporter like domain 0.54 44.0 2.93e-01 92.4% 74.2%
1owxA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.54 43.0 3.97e-01 93.7% 67.3%
4em2A00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.54 41.0 3.40e-01 84.8% 74.0%
2kgsA01 3.40.1520.20 Alpha Beta › 3-Layer(aba) Sandwich › hypothetical protein tt1634 › 0.53 43.0 3.93e-01 92.4% 85.5%
1vw4502 3.30.160.20 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.52 36.0 3.49e-01 73.4% 97.8%
1dkqA02 3.40.50.1240 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Phosphoglycerate mutase-like 0.52 39.0 3.42e-01 82.3% 100.0%
3vs8H00 3.40.47.10 Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase 0.51 40.0 2.63e-01 87.3% 28.1%
ECOD (31)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5366 304.48.1.15 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_3 0.86 75.0 4.69e-01 94.9% 20.6%
5364 304.48.1.8 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 0.84 73.0 4.55e-01 93.7% 21.8%
1875037 304.48.1.8 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 0.82 71.0 4.43e-01 92.4% 21.6%
5065044 304.120.1.0 ↗ a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI 0.71 56.0 5.58e-01 87.3% 83.7%
3513621 3261.1.1.1 ↗ a+b two layers › amino-terminal domain of OmpATb › amino-terminal domain of OmpATb › amino-terminal domain of OmpATb › BON 0.68 46.0 5.24e-01 70.9% 100.0%
3388102 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.66 44.0 4.79e-01 79.7% 84.6%
5030203 5104.1.1.1 ↗ a+b three layers › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › DHHA1 0.64 43.0 3.67e-01 74.7% 42.3%
3970933 3261.1.1.1 ↗ a+b two layers › amino-terminal domain of OmpATb › amino-terminal domain of OmpATb › amino-terminal domain of OmpATb › BON 0.64 53.0 5.35e-01 94.9% 93.7%
3952678 242.1.1.0 ↗ a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases 0.62 42.0 4.06e-01 81.0% 61.1%
5024720 310.3.1.0 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › General secretion pathway protein M (EpsM) periplasmic domain-related › General secretion pathway protein M (EpsM) periplasmic domain-related 0.62 46.0 4.99e-01 89.9% 98.5%
3397653 7523.1.1.0 ↗ a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II 0.59 43.0 4.08e-01 79.7% 86.0%
3408055 304.9.1.0 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.58 47.0 4.61e-01 92.4% 94.4%
4457759 327.16.1.3 ↗ a+b two layers › Alpha-lytic protease prodomain-like › Ring-building motif II in type III secretion system › Ring-building motif II in type III secretion system › Secretin_N 0.57 41.0 4.01e-01 75.9% 85.6%
4965158 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.56 41.0 4.22e-01 86.1% 84.0%
3448829 149.1.1.1 ↗ alpha arrays › Cytochrome P450 › Cytochrome P450 › Cytochrome P450 › p450 0.56 41.0 2.85e-01 78.5% 50.2%
3289385 3433.1.2.1 ↗ a+b duplicates or obligate multimers › ParB dimerization domain › ParB dimerization domain › Chromosome-encoded ParB dimerization domain › ParB_dimer 0.55 35.0 4.08e-01 78.5% 100.0%
3968902 2006.1.6.15 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › vWA-like › DUF58 0.55 47.0 3.26e-01 91.1% 85.0%
3697964 206.1.1.74 ↗ a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase, PK_Tyr_Ser-Thr 0.55 43.0 2.84e-01 87.3% 43.8%
4015646 206.1.1.0 ↗ a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase 0.55 44.0 3.25e-01 88.6% 48.4%
3786162 192.2.1.1 ↗ alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin_2 0.54 34.0 3.22e-01 92.4% 52.6%
5067113 205.1.1.16 ↗ a+b two layers › 4Fe-4S ferredoxin › 4Fe-4S ferredoxin › 4Fe-4S ferredoxin › Fer4_7 0.54 39.0 4.20e-01 86.1% 95.4%
4126575 101.1.2.15 ↗ alpha arrays › HTH › HTH › winged helix domain › MarR 0.53 42.0 3.47e-01 86.1% 75.2%
3748248 5001.1.1.1 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.53 42.0 2.76e-01 83.5% 47.0%
3730381 109.4.1.356 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans 0.52 45.0 2.85e-01 100.0% 29.1%
5060556 3016.1.1.5 ↗ a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › SHMT 0.52 46.0 3.58e-01 98.7% 97.6%
3951792 7581.1.1.26 ↗ a/b three-layered sandwiches › Thiolase-like › Thiolase-like › Thiolase-like › Chal_sti_synt_N, Chal_sti_synt_C, ACP_syn_III 0.51 44.0 2.91e-01 100.0% 71.7%
4236657 633.21.1.18 ↗ alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › CASP_dom 0.51 42.0 3.34e-01 87.3% 93.5%
3597564 220.1.1.0 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like 0.51 39.0 3.77e-01 83.5% 92.2%
3604297 2484.1.1.68 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RNase_H_2 0.51 36.0 2.86e-01 74.7% 96.0%
3789547 859.1.1.3 ↗ a+b two layers › The spindle assembly checkpoint protein mad2 › The spindle assembly checkpoint protein mad2 › The spindle assembly checkpoint protein mad2 › ATG101 0.51 43.0 3.34e-01 92.4% 94.9%
3353555 4267.1.1.0 ↗ a+b duplicates or obligate multimers › YefM-like › YefM-like › YefM-like 0.51 31.0 3.36e-01 79.7% 76.7%