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replicase_polyprotein

Euk-Vir

Pepper_enamovirus

replicase_polyprotein__YP_009465710__Pepper_enamovirus__2073163

Identity

Accession:: YP_009465710 ↗
Protein ID:: replicase_polyprotein
Kingdom:: euk

Quality

67.4 mean pLDDT

Cluster

View cluster (38 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 1125-1175

PDB

Domain cluster: representative

CATH (14)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4ielA02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.73	64.0	4.96e-01	100.0%	61.2%
3ppuB02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.71	63.0	4.85e-01	100.0%	60.2%
4w4kA00	1.10.287.850	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain	0.68	49.0	4.25e-01	78.4%	75.6%
1qnrA00	3.20.20.80	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases	0.68	59.0	3.58e-01	100.0%	50.3%
7nc3F01	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.66	56.0	4.43e-01	100.0%	65.8%
6axgA01	1.20.870.10	Mainly Alpha › Up-down Bundle › Son of sevenless (SoS) protein; Chain S, domain 1 › Son of sevenless (SoS) protein Chain: S domain 1	0.63	55.0	4.62e-01	100.0%	64.0%
4z5qA00	1.10.630.10	Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450	0.63	54.0	3.27e-01	100.0%	23.1%
4bwiB02	3.30.450.40	Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › GAF domain	0.62	51.0	3.56e-01	96.1%	95.7%
4n4gA01	1.20.920.10	Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like	0.62	43.0	3.52e-01	78.4%	40.5%
2bskE00	1.10.287.810	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Mitochondrial import inner membrane translocase subunit tim13 like domains	0.61	44.0	4.10e-01	76.5%	71.4%
2wjeA00	3.20.20.140	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Metal-dependent hydrolases	0.61	44.0	2.92e-01	100.0%	17.2%
2lfrA00	1.10.287.130	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain	0.60	43.0	3.42e-01	78.4%	40.5%
1b5lA00	1.20.1250.10	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; ›	0.58	48.0	3.53e-01	100.0%	96.7%
6wimA02	3.10.20.310	Alpha Beta › Roll › Ubiquitin-like (UB roll) › membrane protein fhac	0.52	43.0	3.90e-01	96.1%	82.4%

ECOD (9)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4045132	192.8.1.0 ↗	alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain	0.67	51.0	3.94e-01	78.4%	52.7%
4311175	304.48.1.0 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like	0.67	48.0	2.98e-01	72.5%	14.4%
2756960	633.1.1.1 ↗	alpha bundles › Bromodomain-like › Bromodomain › Bromodomain › Bromodomain	0.67	53.0	3.88e-01	88.2%	77.5%
4026181	138.1.1.0 ↗	alpha arrays › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain	0.66	57.0	4.65e-01	100.0%	69.0%
3672810	109.4.1.423 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PP4R3	0.66	52.0	3.56e-01	96.1%	24.2%
3890229	603.1.1.64 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › CUPID	0.64	53.0	4.50e-01	100.0%	72.6%
5010630	6132.1.1.0 ↗	alpha bundles › Nudix hydrolase N-terminal dimerization domain › Nudix hydrolase N-terminal dimerization domain › Nudix hydrolase N-terminal dimerization domain	0.64	53.0	5.03e-01	100.0%	92.3%
3602359	5065.1.1.2 ↗	alpha bundles › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › FecCD	0.64	54.0	3.34e-01	100.0%	59.7%
3190774	316.1.1.25 ↗	a+b three layers › Nucleotidyltransferase-like › Nucleotidyltransferase › Nucleotidyltransferase › Nrap_D4	0.59	46.0	3.09e-01	80.4%	20.0%

D2 medium residues 289-304_396-474_498-515

PDB

D3 medium residues 305-395_475-497_516-540

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02122.22 best	Peptidase_S39	48.3	1.30e-12	68.3%	43.8%

CATH (4)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2sfaA01	2.40.10.10	Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases	0.67	43.0	5.14e-01	73.4%	97.8%
1faxA02	2.40.10.10	Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases	0.67	50.0	5.64e-01	87.1%	100.0%
1arbA02	2.40.10.10	Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases	0.65	50.0	5.03e-01	79.1%	95.6%
3otpA01	2.40.10.120	Mainly Beta › Beta Barrel › Thrombin, subunit H ›	0.60	51.0	4.46e-01	90.6%	93.1%

ECOD (8)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4205419	1.1.17.3 ↗	beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 › Trypsin_2	0.72	53.0	4.38e-01	74.8%	90.0%
2710030	1.1.5.12 ↗	beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › Peptidase_S39	0.71	61.0	5.37e-01	89.2%	92.7%
3525486	1.1.17.1 ↗	beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 › Trypsin	0.66	55.0	4.60e-01	87.8%	91.7%
3760665	1.1.17.1 ↗	beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 › Trypsin	0.65	55.0	4.35e-01	87.8%	86.5%
22055	1.1.17.1 ↗	beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 › Trypsin	0.65	47.0	4.20e-01	74.1%	99.5%
3290317	327.1.1.6 ↗	a+b two layers › Alpha-lytic protease prodomain-like › Alpha-lytic protease prodomain › Alpha-lytic protease prodomain › Trypsin	0.64	46.0	3.55e-01	74.8%	69.4%
3452728	1.1.17.3 ↗	beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 › Trypsin_2	0.61	52.0	4.50e-01	89.2%	94.1%
3277840	1.1.17.1 ↗	beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 › Trypsin	0.57	47.0	4.18e-01	88.5%	95.6%

D4 medium residues 698-776_892-917

PDB

Domain cluster: representative

CATH (2)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2fphX01	3.30.1370.160	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 ›	0.53	24.0	2.82e-01	75.2%	58.4%
3sxxC01	3.10.450.40	Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, ›	0.50	33.0	3.43e-01	90.5%	69.6%

D5 medium residues 818-891_918-938_1015-1052

PDB

Domain cluster: rep: hypothetical_protein_2__YP_009337098__Changjiang_polero-like_virus_1__1922799__D1-82_112-138

CATH (5)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2l02A00	1.10.10.10	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	0.59	29.0	3.60e-01	72.2%	74.4%
2l01A00	1.10.10.10	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	0.53	31.0	3.92e-01	71.4%	100.0%
4mdcD02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.53	36.0	3.81e-01	83.5%	77.2%
4pdyA02	3.90.1200.10	Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe	0.52	43.0	3.62e-01	90.2%	85.0%
5jpoD02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.52	38.0	3.89e-01	86.5%	78.2%

ECOD (3)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1279063	304.48.1.13 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5	0.74	69.0	4.68e-01	99.2%	48.1%
3522050	109.3.1.131 ↗	alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › INT_SG_DDX_CT_C	0.56	31.0	4.02e-01	72.9%	97.3%
4090047	3921.1.1.1 ↗	alpha complex topology › Na(+)-translocating NADH-quinone reductase subunit D › Na(+)-translocating NADH-quinone reductase subunit D › Na(+)-translocating NADH-quinone reductase subunit D › Rnf-Nqr	0.51	37.0	3.27e-01	75.9%	71.0%