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reverse_transcriptase

Euk-Vir

Human_immunodeficiency_virus_1

reverse_transcriptase__NP_705927__Human_immunodeficiency_virus_1__11676

Identity

Accession:
NP_705927 ↗
Protein ID:
reverse_transcriptase
Kingdom:
euk

Quality

85.7 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D2 high residues 97-113_156-231
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00078.33 best RVT_1 49.0 9.80e-13 97.9% 33.5%
D3 high residues 252-315
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF06817.20 best RVT_thumb 75.5 3.20e-21 82.8% 81.8%
D4 high residues 321-421
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF06815.20 best RVT_connect 151.0 1.30e-44 98.0% 97.1%
D5 high residues 425-553
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00075.31 best RNase_H 113.2 1.60e-32 91.5% 94.3%
CATH (27)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1bqnA05 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.95 90.0 9.02e-01 100.0% 96.9%
1f21A00 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.91 81.0 7.57e-01 91.5% 89.5%
2hb5A00 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.88 84.0 7.92e-01 100.0% 91.3%
4e19A00 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.87 77.0 7.66e-01 91.5% 94.7%
2ehgA00 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.87 76.0 7.15e-01 90.7% 86.6%
3u3gA00 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.86 76.0 7.40e-01 92.2% 94.3%
7oufB01 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.68 52.0 5.01e-01 89.1% 70.5%
3gocA00 3.30.2170.10 Alpha Beta › 2-Layer Sandwich › archaeoglobus fulgidus dsm 4304 fold › archaeoglobus fulgidus dsm 4304 superfamily 0.66 61.0 4.99e-01 100.0% 85.5%
1asuA00 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.64 53.0 4.94e-01 93.0% 71.0%
2qh9A00 3.30.2170.10 Alpha Beta › 2-Layer Sandwich › archaeoglobus fulgidus dsm 4304 fold › archaeoglobus fulgidus dsm 4304 superfamily 0.63 55.0 4.90e-01 93.0% 96.1%
4ifeA02 3.30.420.240 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › 0.61 51.0 4.23e-01 90.7% 85.9%
3htvA01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.54 41.0 4.43e-01 79.8% 99.1%
3n8hA01 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.54 42.0 3.85e-01 84.5% 77.3%
1ufvA01 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.53 42.0 3.85e-01 84.5% 79.1%
3cssA00 3.40.50.1360 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.53 43.0 3.43e-01 87.6% 97.0%
3e15A00 3.40.50.1360 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.52 42.0 3.27e-01 86.8% 91.8%
1rifA02 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.52 39.0 3.46e-01 79.1% 85.9%
4gicA01 3.40.50.1980 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nitrogenase molybdenum iron protein domain 0.52 47.0 4.55e-01 100.0% 100.0%
3cjeA00 3.30.300.20 Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › K homology (KH) domain 0.51 37.0 3.52e-01 72.9% 90.0%
4gkpB00 3.40.850.20 Alpha Beta › 3-Layer(aba) Sandwich › Kinesin › 0.51 41.0 3.34e-01 86.8% 89.4%
6vsxA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.51 36.0 3.39e-01 72.1% 82.4%
2ri0A00 3.40.50.1360 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.51 41.0 3.38e-01 86.0% 97.9%
2f9wA01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.51 41.0 4.17e-01 87.6% 93.9%
3eniC00 2.50.10.10 Mainly Beta › Clam › Bacteriochlorophyll-a Protein › Bacteriochlorophyll A 0.50 38.0 2.81e-01 80.6% 80.6%
4twbA01 3.40.50.2020 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.50 39.0 3.74e-01 82.9% 96.1%
1fs5A00 3.40.50.1360 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.50 39.0 3.17e-01 84.5% 90.2%
2y0cB01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.50 42.0 3.64e-01 90.7% 72.7%
ECOD (74)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
136740 2484.1.1.4 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RNase_H 0.96 94.0 8.99e-01 100.0% 95.1%
5064572 2484.1.1.4 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RNase_H 0.90 79.0 7.92e-01 90.7% 96.2%
3650067 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.89 80.0 7.36e-01 93.8% 80.6%
3218178 2484.1.1.4 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RNase_H 0.89 80.0 7.56e-01 93.8% 88.7%
4969849 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.89 77.0 7.59e-01 89.9% 93.3%
3296387 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.89 80.0 7.18e-01 93.8% 76.3%
3220657 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.89 77.0 7.72e-01 89.9% 96.9%
5041220 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.88 78.0 7.70e-01 91.5% 94.8%
4947486 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.88 76.0 7.49e-01 89.1% 94.8%
5016440 2484.1.1.4 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RNase_H 0.88 79.0 7.64e-01 93.0% 96.4%
3418019 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.88 80.0 7.29e-01 93.8% 80.6%
5035771 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.88 78.0 7.80e-01 91.5% 96.2%
3833907 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.88 79.0 7.41e-01 93.0% 84.7%
5075022 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.88 76.0 7.67e-01 90.7% 97.7%
4626944 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.88 77.0 7.88e-01 91.5% 98.4%
3526923 2484.1.1.4 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RNase_H 0.87 83.0 8.16e-01 99.2% 100.0%
3958207 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.87 77.0 7.43e-01 91.5% 90.7%
3834310 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.87 83.0 7.80e-01 100.0% 95.3%
165511 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.87 76.0 7.15e-01 90.7% 86.6%
3818469 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.86 71.0 7.27e-01 85.3% 92.8%
3815341 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.86 77.0 7.35e-01 92.2% 88.2%
3830941 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.86 77.0 7.13e-01 93.8% 80.5%
3808254 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.86 76.0 7.10e-01 92.2% 81.3%
5073342 2484.1.1.4 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RNase_H 0.86 73.0 7.76e-01 87.6% 100.0%
3808123 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.86 78.0 7.34e-01 95.3% 85.6%
3458417 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.86 77.0 7.08e-01 93.8% 80.6%
3317463 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.86 74.0 7.10e-01 89.9% 91.0%
3460760 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.86 76.0 7.06e-01 92.2% 89.0%
3355734 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.86 65.0 7.15e-01 78.3% 100.0%
3804102 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.86 77.0 7.07e-01 93.8% 80.0%
3300901 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.86 78.0 7.14e-01 94.6% 80.0%
3830251 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.85 77.0 6.87e-01 93.8% 75.3%
3313644 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.85 62.0 6.87e-01 74.4% 100.0%
3802664 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.85 77.0 7.13e-01 93.8% 82.6%
3302604 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.85 77.0 6.88e-01 93.8% 73.5%
3220656 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.85 76.0 5.52e-01 94.6% 43.4%
3417357 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.85 76.0 6.90e-01 93.8% 78.2%
3803688 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.85 75.0 6.95e-01 92.2% 89.0%
3444879 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.84 77.0 7.23e-01 94.6% 85.3%
3806227 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.84 75.0 6.92e-01 93.8% 80.0%
4985543 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.84 73.0 7.36e-01 89.9% 93.8%
3819047 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.84 73.0 7.05e-01 89.9% 94.3%
3307236 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.81 63.0 6.52e-01 79.8% 96.7%
3353667 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.80 70.0 6.70e-01 90.7% 95.2%
4004191 2484.1.1.99 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Peptidase_A17 0.80 71.0 5.97e-01 92.2% 65.0%
3927914 2484.1.1.212 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RT_RNaseH 0.80 70.0 6.96e-01 92.2% 91.1%
3616473 2484.1.1.99 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Peptidase_A17 0.79 70.0 5.95e-01 92.2% 68.2%
3370560 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.77 52.0 6.07e-01 82.2% 94.7%
3298618 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.76 59.0 6.51e-01 80.6% 99.0%
4039156 2484.1.1.174 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › UvrC_RNaseH 0.72 56.0 6.04e-01 92.2% 95.5%
3314097 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.72 41.0 5.11e-01 82.2% 91.3%
5064060 896.1.1.4 a+b two layers › SRP9/14-like › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › DDE_Tnp_IS66 0.71 34.0 4.57e-01 80.6% 85.7%
3589031 2484.1.1.101 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DDE_Tnp_IS240 0.68 53.0 4.76e-01 90.7% 60.0%
3506451 2484.1.1.26 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Piwi 0.67 52.0 4.77e-01 82.9% 75.3%
5043517 2484.1.1.43 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Endonuclease_5 0.67 62.0 5.38e-01 100.0% 90.5%
4961901 2484.1.1.66 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DDE_3 0.66 58.0 5.12e-01 96.1% 72.9%
4986795 2484.1.1.66 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DDE_3 0.64 54.0 4.96e-01 89.9% 69.7%
5030453 2484.1.1.101 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DDE_Tnp_IS240 0.63 50.0 4.12e-01 91.5% 46.8%
1695398 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.60 51.0 4.19e-01 91.5% 85.7%
3609915 2484.8.1.1 mixed a+b and a/b › Ribonuclease H-like › Separase pseudo-protease domain (PPD) › Separase pseudo-protease domain (PPD) › Peptidase_C50 0.59 48.0 3.63e-01 86.0% 91.1%
3712208 2484.8.1.0 mixed a+b and a/b › Ribonuclease H-like › Separase pseudo-protease domain (PPD) › Separase pseudo-protease domain (PPD) 0.59 47.0 3.61e-01 84.5% 92.6%
1830108 2484.8.1.1 mixed a+b and a/b › Ribonuclease H-like › Separase pseudo-protease domain (PPD) › Separase pseudo-protease domain (PPD) › Peptidase_C50 0.58 46.0 3.53e-01 83.7% 86.5%
3589803 2484.1.1.144 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DEDD_Tnp_IS110 0.57 38.0 4.24e-01 82.2% 87.0%
4275784 7510.1.1.5 a/b three-layered sandwiches › Isocitrate/Isopropylmalate dehydrogenase-like › Isocitrate/Isopropylmalate dehydrogenase-like › Isocitrate/Isopropylmalate dehydrogenase-like › PdxA 0.56 44.0 3.88e-01 85.3% 91.8%
4384064 2006.1.6.33 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › vWA-like › VWA_4 0.55 45.0 3.71e-01 86.8% 82.7%
3224627 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.54 37.0 3.32e-01 78.3% 47.9%
5071391 2004.1.1.146 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATPase 0.53 43.0 3.50e-01 86.8% 64.9%
4988476 2004.1.1.0 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.52 42.0 3.53e-01 86.0% 70.0%
5000690 7573.1.1.2 a/b three-layered sandwiches › PRTase-like › PRTase-like › PRTase-like › Pribosyltran_N 0.52 39.0 3.74e-01 78.3% 86.2%
4947514 2004.1.1.0 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.52 41.0 3.31e-01 85.3% 63.1%
4960575 7512.1.1.31 a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyco_trans_4_4 0.51 40.0 3.35e-01 83.7% 88.7%
4955850 2004.1.1.146 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATPase 0.51 41.0 3.38e-01 86.8% 66.5%
3385434 2484.1.1.261 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › PF27038 0.50 42.0 4.12e-01 89.1% 97.1%
4985003 2004.1.1.146 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATPase 0.50 40.0 3.35e-01 86.8% 64.4%