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ribonucleotide_reductase_large_subunit
Euk-VirAfrican_swine_fever_virus
ribonucleotide_reductase_large_subunit__YP_009702612__African_swine_fever_virus__10497
Identity
- Accession:
- YP_009702612 ↗
- Protein ID:
- ribonucleotide_reductase_large_subunit
- Kingdom:
- euk
Quality
87.0
mean pLDDT
Taxonomy
Bamfordvirae›
Nucleocytoviricota›
Pokkesviricetes›
Asfuvirales›
Asfarviridae›
Asfivirus›
African_swine_fever_virus
TaxID: 10497
Cluster
View cluster (122 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 23-82
Domain cluster:
representative
CATH (14)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3umvA02 | 1.25.40.80 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.67 | 53.0 | 3.82e-01 | 86.7% | 45.6% |
| 6xssA01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.65 | 46.0 | 4.45e-01 | 75.0% | 71.0% |
| 3o10C00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.63 | 45.0 | 3.59e-01 | 78.3% | 46.3% |
| 3h20A04 | 1.10.1240.50 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › | 0.63 | 43.0 | 3.84e-01 | 70.0% | 56.2% |
| 2q00B00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.63 | 46.0 | 3.80e-01 | 81.7% | 51.6% |
| 2i9cA01 | 1.25.40.70 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Phosphatidylinositol 3-kinase, accessory domain (PIK) | 0.63 | 42.0 | 3.50e-01 | 71.7% | 37.8% |
| 2gxaE01 | 1.10.10.510 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Zinc finger, large T-antigen D1 domain | 0.61 | 41.0 | 3.88e-01 | 70.0% | 61.6% |
| 3l9tA01 | 1.10.1240.70 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › | 0.61 | 43.0 | 3.89e-01 | 75.0% | 57.8% |
| 3feyA02 | 1.25.40.180 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.55 | 41.0 | 3.01e-01 | 85.0% | 77.6% |
| 1l5jA01 | 1.25.40.310 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Aconitate B, HEAT-like domain | 0.54 | 40.0 | 3.07e-01 | 83.3% | 68.3% |
| 4u04B01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.54 | 37.0 | 3.42e-01 | 75.0% | 89.8% |
| 1qrvA00 | 1.10.30.10 | Mainly Alpha › Orthogonal Bundle › DNA Binding (I), subunit A › High mobility group box domain | 0.54 | 38.0 | 3.62e-01 | 75.0% | 94.5% |
| 2iqcA00 | 1.25.40.490 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.52 | 44.0 | 3.20e-01 | 95.0% | 60.7% |
| 5dmmA00 | 3.20.20.330 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Homocysteine-binding-like domain | 0.51 | 42.0 | 2.76e-01 | 93.3% | 28.1% |
ECOD (9)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2320584 | 103.2.1.2 ↗ | alpha arrays › RuvA-C › ATP cone › ATP cone › ATP-cone | 0.77 | 64.0 | 5.39e-01 | 90.0% | 63.9% |
| 3437032 | 4085.1.1.1 ↗ | alpha arrays › RbcX-like › RbcX-like › RbcX-like › RbcX | 0.75 | 51.0 | 4.08e-01 | 78.3% | 35.8% |
| 4094229 | 208.1.1.25 ↗ | beta duplicates or obligate multimers › Single-stranded left-handed beta-helix › Trimeric LpxA-like enzymes › Trimeric LpxA-like enzymes › Acetyltransf_11 | 0.74 | 52.0 | 3.42e-01 | 75.0% | 18.5% |
| 5074415 | 2004.1.3.1 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › Pyruvate-ferredoxin oxidoreductase, PFOR, domain III › POR | 0.71 | 52.0 | 3.67e-01 | 78.3% | 92.4% |
| 5049865 | 601.7.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain | 0.69 | 51.0 | 3.86e-01 | 80.0% | 63.4% |
| 3412027 | 109.4.1.1142 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_IFT80_172 | 0.65 | 47.0 | 3.97e-01 | 76.7% | 51.0% |
| 3193317 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.62 | 51.0 | 3.12e-01 | 91.7% | 28.8% |
| 3829643 | 109.4.1.109 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Sel1 | 0.59 | 49.0 | 2.82e-01 | 93.3% | 65.5% |
| 3496385 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.57 | 46.0 | 3.39e-01 | 93.3% | 83.7% |
D2
medium
residues 83-166
Domain cluster:
rep: ribonucleotide_reductase_large_subunit__YP_232955__Vaccinia_virus__10245__D133-214
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00317.27 best | Ribonuc_red_lgN | 42.7 | 6.60e-11 | 66.7% | 50.6% |
CATH (2)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4ye6A01 | 1.10.8.1290 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1, domain 1 | 0.56 | 39.0 | 3.73e-01 | 100.0% | 59.6% |
| 3smvA02 | 1.10.150.750 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › | 0.50 | 32.0 | 3.33e-01 | 82.1% | 68.8% |
ECOD (21)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3277072 | 1074.1.1.1 ↗ | alpha arrays › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Ribonuc_red_lgN | 0.99 | 90.0 | 7.03e-01 | 100.0% | 51.0% |
| 3519243 | 1074.1.1.0 ↗ | alpha arrays › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases | 0.99 | 90.0 | 6.48e-01 | 100.0% | 39.5% |
| 3594035 | 1074.1.1.0 ↗ | alpha arrays › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases | 0.93 | 90.0 | 7.51e-01 | 100.0% | 64.6% |
| 3966685 | 1074.1.1.1 ↗ | alpha arrays › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Ribonuc_red_lgN | 0.92 | 82.0 | 7.12e-01 | 100.0% | 65.8% |
| 4990405 | 1074.1.1.1 ↗ | alpha arrays › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Ribonuc_red_lgN | 0.90 | 75.0 | 6.77e-01 | 100.0% | 67.3% |
| 2791176 | 1074.1.1.1 ↗ | alpha arrays › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Ribonuc_red_lgN | 0.89 | 84.0 | 7.25e-01 | 100.0% | 69.4% |
| 3515890 | 1074.1.1.1 ↗ | alpha arrays › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Ribonuc_red_lgN | 0.89 | 84.0 | 7.17e-01 | 100.0% | 68.0% |
| 5034061 | 148.1.3.400 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › Ribonuc_red_lgN | 0.87 | 61.0 | 4.50e-01 | 71.4% | 32.6% |
| 4934524 | 1074.1.1.1 ↗ | alpha arrays › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Ribonuc_red_lgN | 0.87 | 60.0 | 4.64e-01 | 71.4% | 80.0% |
| 3948801 | 1074.1.1.1 ↗ | alpha arrays › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Ribonuc_red_lgN | 0.87 | 82.0 | 7.03e-01 | 100.0% | 72.8% |
| 4983262 | 1074.1.1.1 ↗ | alpha arrays › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Ribonuc_red_lgN | 0.87 | 60.0 | 5.74e-01 | 71.4% | 67.4% |
| 4993733 | 2500.1.1.0 ↗ | a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel | 0.87 | 60.0 | 3.53e-01 | 71.4% | 11.3% |
| 4976420 | 1074.1.1.0 ↗ | alpha arrays › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases | 0.87 | 60.0 | 5.50e-01 | 71.4% | 61.0% |
| 3954937 | 103.2.1.1 ↗ | alpha arrays › RuvA-C › ATP cone › ATP cone › Ribonuc_red_lgN | 0.86 | 59.0 | 6.12e-01 | 71.4% | 78.8% |
| 1338066 | 103.2.1.1 ↗ | alpha arrays › RuvA-C › ATP cone › ATP cone › Ribonuc_red_lgN | 0.84 | 58.0 | 4.85e-01 | 70.2% | 53.0% |
| 3935488 | 5051.1.1.6 ↗ | alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Aa_trans | 0.54 | 42.0 | 2.84e-01 | 89.3% | 65.1% |
| 5007668 | 101.1.9.17 ↗ | alpha arrays › HTH › HTH › Putative DNA-binding domain › MerR_1 | 0.53 | 38.0 | 3.40e-01 | 100.0% | 51.2% |
| 4580985 | 101.1.2.603 ↗ | alpha arrays › HTH › HTH › winged helix domain › RNA_pol_Rpc82, HTH_9 | 0.52 | 36.0 | 2.39e-01 | 72.6% | 16.8% |
| 4151293 | 7513.1.1.1 ↗ | a/b three-layered sandwiches › CofD-like › CofD-like › CofD-like › CofD | 0.52 | 40.0 | 2.76e-01 | 96.4% | 21.5% |
| 4488952 | 101.1.9.82 ↗ | alpha arrays › HTH › HTH › Putative DNA-binding domain › MerR-DNA-bind, MerR_1 | 0.51 | 38.0 | 3.54e-01 | 100.0% | 62.7% |
| 3931909 | 103.4.1.1 ↗ | alpha arrays › RuvA-C › Elongation factor TFIIS domain 2/ Kix domain of creb binding protein › Elongation factor TFIIS domain 2/ Kix domain of creb binding protein › KIX | 0.51 | 38.0 | 3.43e-01 | 83.3% | 92.0% |
D3
medium
residues 167-192_438-631_692-708
Domain cluster:
rep: rr1__YP_009552690__Operophtera_brumata_nucleopolyhedrovirus__1046267__D445-618_684-706
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02867.21 best | Ribonuc_red_lgC | 197.3 | 6.10e-58 | 92.0% | 35.9% |
D4
medium
residues 193-308_393-437_709-757
Domain cluster:
rep: ribonucleotide_reductase_large_subunit__YP_009702292__African_swine_fever_virus__10497__D187-309_381-436_716-757
Pfam (3)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02867.21 best | Ribonuc_red_lgC | 111.9 | 4.70e-32 | 55.7% | 21.6% |
| PF02867.21 | Ribonuc_red_lgC | 38.4 | 8.90e-10 | 23.3% | 8.2% |
| PF02867.21 | Ribonuc_red_lgC | 28.0 | 1.30e-06 | 21.9% | 8.0% |
D5
medium
residues 309-392
Domain cluster:
rep: IMGVR_UViG_3300007266_000133-3300007266-Ga0101450_1063125__D8-101
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02867.21 best | Ribonuc_red_lgC | 41.8 | 8.00e-11 | 100.0% | 12.8% |
CATH (7)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 7powA01 | 1.20.120.1760 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › CDP-alcohol phosphotransferase transmembrane (TM) domain | 0.57 | 40.0 | 3.13e-01 | 75.0% | 67.2% |
| 1z0pA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.57 | 29.0 | 3.16e-01 | 100.0% | 57.5% |
| 3lssA01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.55 | 30.0 | 2.73e-01 | 100.0% | 39.3% |
| 4i6vA01 | 3.20.20.140 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Metal-dependent hydrolases | 0.55 | 38.0 | 2.56e-01 | 71.4% | 72.4% |
| 4q20A01 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.54 | 26.0 | 2.72e-01 | 100.0% | 46.3% |
| 7nc3F01 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.53 | 37.0 | 3.36e-01 | 72.6% | 92.1% |
| 4r2fA01 | 3.40.190.10 | Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II | 0.51 | 38.0 | 3.00e-01 | 81.0% | 44.1% |
ECOD (5)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5067694 | 3883.1.1.1 ↗ | alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf | 0.53 | 38.0 | 2.84e-01 | 76.2% | 67.7% |
| 3387211 | 3883.1.1.1 ↗ | alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf | 0.52 | 36.0 | 2.72e-01 | 72.6% | 67.1% |
| 4946402 | 2006.1.3.11 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › TOP6A-Spo11_Toprim | 0.52 | 38.0 | 3.03e-01 | 81.0% | 63.2% |
| 3278005 | 142.1.1.7 ↗ | alpha complex topology › Sigma2 domain-like › Sigma2 domain of RNA polymerase sigma factors › Sigma2 domain of RNA polymerase sigma factors › Phosphatase-like_N | 0.52 | 36.0 | 4.00e-01 | 75.0% | 93.8% |
| 5060572 | 3883.1.1.1 ↗ | alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf | 0.50 | 36.0 | 2.53e-01 | 75.0% | 35.3% |
D6
medium
residues 632-691
Domain cluster:
rep: IMGVR_UViG_3300006567_000026-3300006567-Ga0099958_11086953__D213-268
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02867.21 best | Ribonuc_red_lgC | 39.8 | 3.30e-10 | 100.0% | 11.3% |