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ribonucleotide_reductase_subunit_1

Euk-Vir

Meleagrid_alphaherpesvirus_1

ribonucleotide_reductase_subunit_1__NP_073333__Meleagrid_alphaherpesvirus_1__37108

Identity

Accession:
NP_073333 ↗
Protein ID:
ribonucleotide_reductase_subunit_1
Kingdom:
euk

Quality

88.0 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Mardivirus› Meleagrid_alphaherpesvirus_1

TaxID: 37108

Cluster

View cluster (122 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 42-120
PDB
Domain cluster: rep: ribonucleotide_reductase_subunit_1__YP_009342364__Spheniscid_alphaherpesvirus_1__2560777__D8-83
CATH (41)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2hjmA01 1.20.120.460 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › protein pf1176 like 0.73 59.0 5.79e-01 87.3% 90.7%
2guzA00 1.10.287.110 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › DnaJ domain 0.70 43.0 4.55e-01 93.7% 69.0%
3u8vA00 1.20.120.660 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain 0.68 49.0 4.89e-01 75.9% 72.3%
2bvlA01 1.20.58.1190 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.68 54.0 5.23e-01 84.8% 91.9%
2nrjA01 1.20.1170.10 Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › 0.64 55.0 3.68e-01 100.0% 73.0%
3iqcA00 1.20.120.340 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS 0.63 50.0 4.42e-01 87.3% 66.4%
1vs5O00 1.10.287.10 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › S15/NS1, RNA-binding 0.62 47.0 4.51e-01 78.5% 70.5%
3i5xA02 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.61 50.0 3.47e-01 88.6% 84.6%
3uumA00 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.61 43.0 3.77e-01 74.7% 75.4%
3ezhA00 1.20.120.960 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Histidine kinase NarX, sensor domain 0.61 46.0 4.14e-01 83.5% 69.3%
2radA03 1.20.1440.30 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Biosynthetic Protein domain 0.60 50.0 4.33e-01 93.7% 69.3%
2ef8A00 1.10.260.40 Mainly Alpha › Orthogonal Bundle › 434 Repressor (Amino-terminal Domain) › lambda repressor-like DNA-binding domains 0.59 50.0 4.96e-01 100.0% 88.1%
3h36A00 1.10.10.400 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Polyribonucleotide nucleotidyltransferase, RNA-binding domain 0.59 42.0 4.27e-01 74.7% 83.3%
4acoA01 1.10.150.130 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Tyrosine recombinase, N-terminal domain 0.59 42.0 3.75e-01 74.7% 65.5%
1dlwA00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.59 43.0 3.84e-01 78.5% 87.9%
1cg5B00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.58 48.0 4.05e-01 93.7% 92.2%
3axjB01 1.20.58.190 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 1 0.58 40.0 3.26e-01 73.4% 48.4%
5b00A00 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.58 45.0 3.21e-01 86.1% 42.9%
3ubcA00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.57 44.0 3.77e-01 83.5% 90.1%
2gkmA00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.57 43.0 3.68e-01 79.7% 79.5%
1cunA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.57 42.0 3.87e-01 77.2% 88.2%
1cqxA01 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.57 43.0 3.58e-01 83.5% 80.7%
2wdqD00 1.20.1300.10 Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit 0.56 39.0 3.60e-01 73.4% 85.7%
1e6vA03 1.20.840.10 Mainly Alpha › Up-down Bundle › Methyl-coenzyme M Reductase; Chain B, domain 2 › Methyl-coenzyme M reductase, alpha/beta subunit, C-terminal 0.56 43.0 3.20e-01 86.1% 56.5%
2jbrA01 1.10.540.10 Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain 0.55 38.0 3.38e-01 78.5% 47.9%
2vxgA02 1.10.220.100 Mainly Alpha › Orthogonal Bundle › Annexin V; domain 1 › conserved c-terminal region of ge- 1 0.55 46.0 4.56e-01 91.1% 96.5%
1lqsL01 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.55 48.0 4.48e-01 98.7% 86.0%
3egoA02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.55 47.0 4.17e-01 100.0% 81.0%
3pe0A01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.54 42.0 3.86e-01 82.3% 100.0%
2ap3A00 1.20.120.570 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YkyA-like 0.54 40.0 3.06e-01 79.7% 63.5%
1q6aA00 1.10.1240.30 Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › KaiA/RbsU domain 0.54 43.0 3.90e-01 87.3% 67.3%
1uurA01 1.20.58.240 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › STAT; domain 1 0.54 39.0 3.54e-01 77.2% 82.7%
3dtoA01 1.10.472.50 Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › HD-domain/PDEase-like 0.53 45.0 4.36e-01 93.7% 88.6%
6ig5A01 1.10.275.10 Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) 0.53 48.0 3.99e-01 100.0% 63.0%
3hwrA02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.53 45.0 3.95e-01 100.0% 68.2%
2e9fB01 1.10.275.10 Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) 0.52 45.0 4.22e-01 94.9% 83.3%
2wcoA01 1.50.10.100 Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › Chondroitin AC/alginate lyase 0.51 43.0 2.76e-01 91.1% 25.6%
5m9dA00 1.25.40.90 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.51 37.0 3.19e-01 78.5% 79.7%
3ktdD02 1.10.3660.10 Mainly Alpha › Orthogonal Bundle › 6-phosphogluconate dehydrogenase C-terminal fold › 6-phosphogluconate dehydrogenase C-terminal like domain 0.51 35.0 3.23e-01 73.4% 67.0%
1ks9A02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.51 43.0 3.83e-01 100.0% 68.3%
4od4A02 1.20.120.1780 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › UbiA prenyltransferase 0.50 37.0 3.33e-01 79.7% 61.3%
ECOD (41)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3789529 604.12.1.4 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › ATG1-like_MIT1 0.73 53.0 4.41e-01 74.7% 84.6%
3913790 192.29.1.0 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.71 54.0 4.74e-01 79.7% 63.5%
3728950 650.1.1.0 ↗ alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain 0.69 43.0 4.47e-01 91.1% 66.7%
3248081 601.7.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain 0.68 53.0 4.56e-01 82.3% 65.0%
3591212 604.12.1.0 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.68 51.0 3.61e-01 78.5% 37.8%
3257705 632.22.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.68 51.0 4.86e-01 81.0% 100.0%
3950032 5082.1.1.1 ↗ alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation_efflux 0.67 61.0 4.42e-01 100.0% 57.6%
3583776 192.29.1.0 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.66 46.0 3.81e-01 72.2% 62.1%
4020850 3758.1.1.0 ↗ alpha bundles › Bacterial hemolysins-like › Bacterial hemolysins › Bacterial hemolysins 0.66 58.0 3.98e-01 100.0% 58.8%
3253313 601.4.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains 0.66 48.0 3.53e-01 77.2% 49.0%
3628698 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.66 47.0 4.14e-01 74.7% 83.5%
4958744 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.66 46.0 4.13e-01 73.4% 77.3%
3972604 5069.1.1.15 ↗ alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Cytochrom_C_asm 0.65 47.0 3.92e-01 77.2% 60.0%
3507982 632.2.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Bacterial immunoglobulin/albumin-binding domains › Bacterial immunoglobulin/albumin-binding domains 0.65 57.0 5.14e-01 96.2% 90.5%
4525691 601.27.1.1 ↗ alpha bundles › Four-helical up-and-down bundle › MW0975(SA0943)-like › MW0975(SA0943)-like › YkyA 0.65 46.0 3.47e-01 74.7% 57.4%
5042381 2004.1.1.198 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23 0.64 51.0 3.18e-01 100.0% 16.9%
3913487 604.1.1.124 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin_6 0.63 45.0 4.04e-01 74.7% 93.6%
3226377 7022.1.1.1 ↗ alpha bundles › central core domain of D-alanyl transfer protein › central core domain of D-alanyl transfer protein › central core domain of D-alanyl transfer protein › MBOAT 0.63 45.0 3.40e-01 75.9% 53.8%
3168248 109.4.1.598 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Mak10 0.63 51.0 3.32e-01 88.6% 38.9%
3590383 5082.1.1.1 ↗ alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation_efflux 0.62 57.0 4.14e-01 100.0% 60.0%
3654164 109.4.1.1156 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › E_motif 0.61 38.0 3.09e-01 73.4% 32.7%
4130660 140.1.1.11 ↗ alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › DALR_1 0.60 45.0 3.35e-01 81.0% 36.3%
4300205 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.59 42.0 3.94e-01 74.7% 87.0%
3680798 109.4.1.1269 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, E_motif 0.59 36.0 3.39e-01 74.7% 48.0%
3593724 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.59 42.0 3.68e-01 75.9% 67.2%
3598054 604.12.1.0 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.59 44.0 3.60e-01 79.7% 80.7%
3507472 633.1.1.1 ↗ alpha bundles › Bromodomain-like › Bromodomain › Bromodomain › Bromodomain 0.58 50.0 4.49e-01 100.0% 78.3%
5065366 601.1.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin 0.57 40.0 3.54e-01 73.4% 65.0%
4098211 604.6.1.0 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain 0.57 42.0 4.04e-01 77.2% 95.6%
3705139 604.12.1.0 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.57 40.0 3.31e-01 74.7% 81.4%
3791250 601.4.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains 0.57 40.0 3.34e-01 77.2% 51.0%
3721147 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.56 42.0 3.42e-01 82.3% 66.3%
3449262 604.6.1.2 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › ANTH 0.55 39.0 3.19e-01 74.7% 52.5%
3324034 1015.1.1.7 ↗ alpha complex topology › Insulin-induced gene (Insig) homologs › Insulin-induced gene (Insig) homologs › Insulin-induced gene (Insig) homologs › Yip1 0.54 44.0 3.52e-01 89.9% 57.6%
3179301 109.4.1.356 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans 0.54 46.0 2.84e-01 94.9% 24.0%
4033669 601.27.1.1 ↗ alpha bundles › Four-helical up-and-down bundle › MW0975(SA0943)-like › MW0975(SA0943)-like › YkyA 0.54 41.0 3.13e-01 82.3% 69.4%
5068948 109.4.1.3068 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › DUF2225 0.52 43.0 3.65e-01 91.1% 58.5%
3245538 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.52 37.0 3.34e-01 73.4% 85.7%
4965784 3455.1.1.17 ↗ alpha arrays › WY-domain in RXLR effectors › WY-domain in RXLR effectors › WY-domain in RXLR effectors › DUF7853 0.51 44.0 4.32e-01 100.0% 89.4%
3375388 604.6.1.2 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › ANTH 0.51 40.0 3.32e-01 83.5% 61.5%
3559718 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.51 39.0 3.52e-01 83.5% 89.1%
D2 medium residues 126-261
PDB
Domain cluster: rep: ribonucleotide_reductase_subunit_1__YP_401655__Human_gammaherpesvirus_4__10376__D15-179
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00317.27 best Ribonuc_red_lgN 50.1 3.20e-13 65.4% 94.8%
D3 medium residues 371-428
PDB
Domain cluster: rep: orf61__YP_009044444__Alcelaphine_gammaherpesvirus_2__138184__D298-350
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02867.21 best Ribonuc_red_lgC 27.7 1.50e-06 100.0% 10.1%
D4 medium residues 670-799
PDB
Domain cluster: rep: ribonucleotide_reductase_subunit_1__NP_040142__Human_alphaherpesvirus_3__10335__D627-726
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02867.21 best Ribonuc_red_lgC 85.4 5.00e-24 96.9% 21.9%