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ribonucleotide_reductase_subunit_1

Euk-Vir

Human_alphaherpesvirus_2

ribonucleotide_reductase_subunit_1__YP_009137191__Human_alphaherpesvirus_2__10310

Identity

Accession:
YP_009137191 ↗
Protein ID:
ribonucleotide_reductase_subunit_1
Kingdom:
euk

Quality

70.3 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Simplexvirus› Human_alphaherpesvirus_2

TaxID: 10310

Cluster

View cluster (122 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 585-808_1096-1121
PDB
Domain cluster: rep: IMGVR_UViG_3300028089_000252-3300028089-Ga0255299_10029802__D277-388_452-478
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02867.21 best Ribonuc_red_lgC 182.3 2.10e-53 90.4% 42.8%
D2 medium residues 371-445
PDB
Domain cluster: representative
CATH (34)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1y4cA03 1.20.120.660 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain 0.80 55.0 4.77e-01 72.0% 69.9%
2rldA00 1.20.1440.60 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence 0.78 70.0 6.08e-01 100.0% 93.0%
1vs5O00 1.10.287.10 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › S15/NS1, RNA-binding 0.77 58.0 5.46e-01 78.7% 80.7%
2qwoB00 1.10.287.110 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › DnaJ domain 0.76 65.0 6.15e-01 96.0% 85.9%
4dmvA01 1.20.58.1190 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.73 57.0 5.55e-01 85.3% 100.0%
4g80T00 1.20.120.350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C 0.72 49.0 3.97e-01 70.7% 59.7%
4oydB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.71 45.0 3.82e-01 100.0% 41.0%
3if8B02 1.20.58.730 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.71 49.0 4.52e-01 73.3% 62.0%
4w8pA02 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.70 49.0 4.09e-01 73.3% 61.5%
2rgnB01 1.20.900.10 Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain 0.69 59.0 4.41e-01 100.0% 75.0%
3ab3D00 1.10.167.10 Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › Regulator of G-protein Signalling 4, domain 2 0.69 55.0 4.33e-01 89.3% 89.1%
1yxrA01 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.68 47.0 4.77e-01 72.0% 91.9%
2oduA02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.68 49.0 4.38e-01 76.0% 88.6%
3uumA00 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.68 48.0 4.10e-01 74.7% 79.5%
3uo2B02 1.20.1280.20 Mainly Alpha › Up-down Bundle › Monooxygenase › HscB, C-terminal domain 0.67 47.0 4.52e-01 100.0% 65.5%
2fonA04 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.66 52.0 4.37e-01 85.3% 89.9%
3h36A00 1.10.10.400 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Polyribonucleotide nucleotidyltransferase, RNA-binding domain 0.65 45.0 4.50e-01 72.0% 85.9%
1skvA00 1.10.287.660 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.65 46.0 4.95e-01 100.0% 85.9%
4fm3A00 1.20.1270.390 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.65 45.0 4.19e-01 72.0% 77.9%
2nn4A00 1.10.287.760 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YqgQ-like 0.65 47.0 5.03e-01 89.3% 96.8%
2x0cA01 1.20.1420.10 Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain 0.64 44.0 3.40e-01 73.3% 55.1%
4l8jA04 1.10.287.470 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.62 45.0 5.02e-01 100.0% 96.6%
1vf7A03 1.10.287.470 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.62 45.0 4.93e-01 100.0% 95.0%
3tklB01 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 45.0 4.88e-01 98.7% 91.9%
4l8iB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.62 45.0 3.99e-01 78.7% 90.2%
5xtck00 1.10.287.3510 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.61 42.0 3.93e-01 72.0% 74.2%
2y44A00 1.20.1260.80 Mainly Alpha › Up-down Bundle › Ferritin › 0.59 50.0 3.89e-01 100.0% 78.3%
4ioeA00 1.10.287.850 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain 0.58 44.0 4.22e-01 100.0% 70.1%
1qguB04 1.20.89.10 Mainly Alpha › Up-down Bundle › Nitrogenase Molybdenum-iron Protein, subunit B; domain 4 › Nitrogenase Molybdenum-iron Protein, subunit B, domain 4 0.57 41.0 4.00e-01 81.3% 68.7%
4rflA02 1.20.1090.10 Mainly Alpha › Up-down Bundle › Dehydroquinate synthase-like, alpha domain › Dehydroquinate synthase-like - alpha domain 0.57 47.0 3.63e-01 97.3% 77.4%
2lm9A00 1.20.58.970 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.57 47.0 4.28e-01 100.0% 68.8%
4ehsA00 1.10.860.10 Mainly Alpha › Orthogonal Bundle › DNAb Helicase; Chain A › DNAb Helicase; Chain A 0.57 51.0 4.25e-01 97.3% 75.0%
3lk5A00 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.52 41.0 2.86e-01 96.0% 34.2%
4w4kA00 1.10.287.850 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain 0.51 47.0 4.56e-01 100.0% 96.3%
ECOD (38)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3813600 633.4.1.1 ↗ alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI 0.79 71.0 5.85e-01 100.0% 94.1%
3704641 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.77 56.0 3.86e-01 77.3% 35.6%
3728304 604.12.1.24 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › DUF6604 0.74 51.0 4.66e-01 72.0% 93.0%
4944333 633.10.1.0 ↗ alpha bundles › Bromodomain-like › IVS-encoded protein-like › IVS-encoded protein-like 0.73 65.0 5.51e-01 100.0% 92.8%
3175922 1075.4.1.2 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane_2 0.73 50.0 3.21e-01 72.0% 70.0%
3231865 604.33.1.1 ↗ alpha bundles › Spectrin repeat-like › Repulsive guidance molecule (RGM) N-terminal domain › Repulsive guidance molecule (RGM) N-terminal domain › RGM_N 0.72 52.0 5.41e-01 76.0% 94.3%
3593555 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.72 51.0 3.82e-01 74.7% 41.6%
5007608 633.22.1.0 ↗ alpha bundles › Bromodomain-like › Vitamin K epoxide reductase (VKOR) › Vitamin K epoxide reductase (VKOR) 0.72 63.0 5.47e-01 98.7% 99.1%
3828 604.6.1.1 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › GAT 0.70 52.0 4.49e-01 77.3% 80.4%
3389416 140.1.1.0 ↗ alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 0.70 49.0 4.49e-01 73.3% 84.0%
3592632 604.12.1.0 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.70 48.0 4.45e-01 70.7% 81.1%
4982026 150.1.1.209 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › DUF7121 0.70 59.0 4.96e-01 100.0% 74.3%
3832084 605.1.1.0 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.69 48.0 4.88e-01 73.3% 96.0%
4936976 633.10.1.2 ↗ alpha bundles › Bromodomain-like › IVS-encoded protein-like › IVS-encoded protein-like › Bbp7-like 0.69 59.0 5.36e-01 98.7% 94.3%
3260973 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.69 48.0 4.30e-01 74.7% 84.5%
5007621 632.11.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.68 47.0 4.40e-01 73.3% 86.3%
3505507 1134.1.1.0 ↗ alpha bundles › C-terminal helical domain of alanine-tRNA ligase › C-terminal helical domain of alanine-tRNA ligase › Eukaryotic C-Ala helical domain 0.67 51.0 5.27e-01 80.0% 97.1%
2755018 3843.1.1.1 ↗ alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › Oxidored_q2 0.67 45.0 4.09e-01 98.7% 53.1%
3943720 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.66 48.0 3.96e-01 77.3% 75.0%
3388894 133.1.1.12 ↗ alpha bundles › DH domain-like › DBL homology domain (DH-domain) › DBL homology domain (DH-domain) › DH_ALS2 0.66 58.0 4.43e-01 100.0% 82.2%
3505964 604.33.1.1 ↗ alpha bundles › Spectrin repeat-like › Repulsive guidance molecule (RGM) N-terminal domain › Repulsive guidance molecule (RGM) N-terminal domain › RGM_N 0.64 45.0 4.54e-01 73.3% 90.7%
4550964 3843.1.1.28 ↗ alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › MbhD 0.64 44.0 4.42e-01 73.3% 86.1%
3463858 192.29.1.0 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.63 43.0 3.95e-01 70.7% 81.0%
4015065 1075.4.1.0 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold 0.63 46.0 3.04e-01 78.7% 80.9%
3703277 604.3.1.0 ↗ alpha bundles › Spectrin repeat-like › BAG domain › BAG domain 0.62 43.0 4.44e-01 73.3% 98.6%
3913307 192.4.1.0 ↗ alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) 0.61 50.0 4.68e-01 88.0% 78.9%
4542879 5086.1.1.0 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.61 52.0 4.22e-01 97.3% 91.0%
3968318 1075.4.1.1 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane 0.60 52.0 3.49e-01 100.0% 50.2%
3732399 622.1.1.0 ↗ alpha bundles › YvfG-like › HSC20 (HSCB), C-terminal oligomerisation domain › HSC20 (HSCB), C-terminal oligomerisation domain 0.58 48.0 4.53e-01 90.7% 76.7%
5060383 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.57 47.0 4.75e-01 89.3% 89.3%
3977185 1075.4.1.1 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane 0.57 51.0 3.37e-01 100.0% 53.0%
3446311 1075.4.1.1 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane 0.57 48.0 3.32e-01 100.0% 52.3%
4007555 1075.4.1.2 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane_2 0.56 48.0 3.26e-01 100.0% 54.4%
3789324 1075.4.1.1 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane 0.56 47.0 3.15e-01 100.0% 74.8%
4022519 622.1.1.0 ↗ alpha bundles › YvfG-like › HSC20 (HSCB), C-terminal oligomerisation domain › HSC20 (HSCB), C-terminal oligomerisation domain 0.55 42.0 4.06e-01 81.3% 94.1%
3662103 6155.1.1.7 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › CLPTM1 0.55 43.0 3.95e-01 90.7% 64.0%
3280363 150.5.1.11 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › T7SS_ESX_EspC 0.52 38.0 3.51e-01 100.0% 60.0%
5045968 2004.1.1.42 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › T2SSE 0.51 42.0 2.62e-01 92.0% 35.5%
D3 medium residues 446-578
PDB
Domain cluster: rep: ribonucleotide_reductase_subunit_1__NP_077434__Cercopithecine_alphaherpesvirus_9__35246__D89-165
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00317.27 best Ribonuc_red_lgN 51.7 1.00e-13 63.2% 93.5%
D4 medium residues 814-990
PDB
Domain cluster: rep: rr1__YP_009552690__Operophtera_brumata_nucleopolyhedrovirus__1046267__D445-618_684-706
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02867.21 best Ribonuc_red_lgC 171.9 3.10e-50 100.0% 33.6%