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ribonucleotide_reductase_subunit_2
Euk-VirBovine_alphaherpesvirus_1
ribonucleotide_reductase_subunit_2__NP_045318__Bovine_alphaherpesvirus_1__10320
Identity
- Accession:
- NP_045318 ↗
- Protein ID:
- ribonucleotide_reductase_subunit_2
- Kingdom:
- euk
Quality
85.4
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Varicellovirus›
bovine_alphaherpesvirus_1
TaxID: 10320
Cluster
View cluster (59 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 25-147
Domain cluster:
rep: JM118__YP_238421__Macaca_fuscata_rhadinovirus__272551__D34-136
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00268.28 best | Ribonuc_red_sm | 80.5 | 2.00e-22 | 98.4% | 41.3% |
CATH (35)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1h0oA00 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.91 | 88.0 | 6.40e-01 | 100.0% | 43.1% |
| 4bmoA00 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.90 | 85.0 | 6.19e-01 | 100.0% | 42.1% |
| 3ee4A00 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.90 | 83.0 | 6.07e-01 | 100.0% | 41.2% |
| 2rccA01 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.88 | 82.0 | 6.26e-01 | 100.0% | 46.7% |
| 2aniA00 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.88 | 83.0 | 5.92e-01 | 100.0% | 38.5% |
| 5olkB01 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.87 | 79.0 | 5.89e-01 | 100.0% | 42.3% |
| 1rtwB00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.85 | 54.0 | 4.45e-01 | 76.4% | 38.5% |
| 3u52D00 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.83 | 77.0 | 5.55e-01 | 100.0% | 66.8% |
| 4a5dB00 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.81 | 73.0 | 5.67e-01 | 92.7% | 78.9% |
| 1mhyD00 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.80 | 75.0 | 4.84e-01 | 100.0% | 80.0% |
| 2ib0A01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.80 | 49.0 | 4.74e-01 | 74.0% | 56.3% |
| 1mhyB00 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.78 | 72.0 | 5.02e-01 | 100.0% | 35.5% |
| 6bl6B01 | 1.20.1560.10 | Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain | 0.77 | 57.0 | 4.13e-01 | 76.4% | 44.6% |
| 1uddA00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.77 | 52.0 | 4.26e-01 | 76.4% | 39.5% |
| 3pvtA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.75 | 60.0 | 4.37e-01 | 82.9% | 85.2% |
| 7zdtD01 | 1.20.1560.10 | Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain | 0.74 | 55.0 | 3.96e-01 | 76.4% | 44.5% |
| 3wmeA01 | 1.20.1560.10 | Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain | 0.73 | 54.0 | 3.97e-01 | 78.0% | 45.1% |
| 5ux1D00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.71 | 57.0 | 4.81e-01 | 83.7% | 75.6% |
| 4iloA00 | 1.10.287.1490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.69 | 48.0 | 3.84e-01 | 70.7% | 86.9% |
| 2lm9A00 | 1.20.58.970 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.68 | 50.0 | 5.61e-01 | 76.4% | 100.0% |
| 2q0oC00 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.67 | 46.0 | 5.32e-01 | 74.0% | 100.0% |
| 2ntxA01 | 1.20.58.2010 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › PRONE domain, subdomain 1 | 0.67 | 50.0 | 4.21e-01 | 78.9% | 81.9% |
| 3r6nB01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.66 | 47.0 | 3.77e-01 | 78.9% | 40.2% |
| 1fpoC02 | 1.20.1280.20 | Mainly Alpha › Up-down Bundle › Monooxygenase › HscB, C-terminal domain | 0.65 | 44.0 | 5.08e-01 | 74.8% | 92.3% |
| 3l39A01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.65 | 49.0 | 4.18e-01 | 78.9% | 89.0% |
| 1y6xA00 | 1.10.287.1080 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like | 0.65 | 43.0 | 5.08e-01 | 70.7% | 95.4% |
| 3kp9A01 | 1.20.1440.130 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › VKOR domain | 0.64 | 52.0 | 4.70e-01 | 85.4% | 98.8% |
| 4fxdA04 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.64 | 49.0 | 4.57e-01 | 80.5% | 96.7% |
| 3mvuA00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.62 | 55.0 | 4.41e-01 | 97.6% | 51.8% |
| 2e9xA01 | 1.20.58.1030 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.61 | 43.0 | 4.32e-01 | 73.2% | 81.2% |
| 2fji101 | 1.10.357.50 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › | 0.60 | 49.0 | 4.15e-01 | 88.6% | 66.0% |
| 2i0mA02 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.59 | 46.0 | 4.99e-01 | 82.1% | 100.0% |
| 4ocqA01 | 3.90.1200.10 | Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe | 0.56 | 39.0 | 3.17e-01 | 70.7% | 40.0% |
| 3hhcC00 | 1.20.1250.60 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › Interferon lambda | 0.55 | 45.0 | 4.22e-01 | 97.6% | 70.2% |
| 4nooB00 | 1.10.8.1160 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.51 | 36.0 | 4.14e-01 | 81.3% | 94.7% |
ECOD (41)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 151585 | 150.1.2.1 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Heme oxygenase/Ribonucleotide reductase › Ribonuc_red_sm | 0.93 | 90.0 | 6.70e-01 | 100.0% | 46.3% |
| 4481595 | 150.1.2.1 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Heme oxygenase/Ribonucleotide reductase › Ribonuc_red_sm | 0.93 | 88.0 | 6.18e-01 | 100.0% | 36.7% |
| 3274715 | 150.1.2.1 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Heme oxygenase/Ribonucleotide reductase › Ribonuc_red_sm | 0.91 | 87.0 | 6.98e-01 | 100.0% | 57.2% |
| 3807411 | 150.1.1.174 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Ribonuc_red_sm | 0.90 | 84.0 | 7.96e-01 | 99.2% | 85.0% |
| 4026999 | 150.1.2.1 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Heme oxygenase/Ribonucleotide reductase › Ribonuc_red_sm | 0.89 | 85.0 | 6.12e-01 | 100.0% | 40.6% |
| 4267558 | 150.1.2.1 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Heme oxygenase/Ribonucleotide reductase › Ribonuc_red_sm | 0.89 | 83.0 | 5.90e-01 | 100.0% | 37.3% |
| 3774065 | 150.1.1.136 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › PF27107 | 0.84 | 56.0 | 5.12e-01 | 76.4% | 53.5% |
| 3406416 | 601.11.1.5 ↗ | alpha bundles › Four-helical up-and-down bundle › Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain › Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain › PF27107 | 0.82 | 53.0 | 4.95e-01 | 73.2% | 55.2% |
| 5005119 | 150.1.1.3 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Rubrerythrin | 0.81 | 59.0 | 5.32e-01 | 82.9% | 57.5% |
| 3690443 | 192.4.1.0 ↗ | alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) | 0.78 | 61.0 | 6.62e-01 | 88.6% | 96.2% |
| 1171038 | 3755.3.1.148 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › CT398_CC | 0.77 | 54.0 | 4.53e-01 | 70.7% | 99.0% |
| 3279990 | 150.1.2.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Heme oxygenase/Ribonucleotide reductase | 0.77 | 72.0 | 5.32e-01 | 100.0% | 94.5% |
| 3996264 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.74 | 53.0 | 4.69e-01 | 73.2% | 94.7% |
| 4393704 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.74 | 52.0 | 3.43e-01 | 72.4% | 36.8% |
| 3627942 | 3755.4.1.1 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › PI3K_P85_iSH2 | 0.73 | 55.0 | 4.86e-01 | 78.0% | 94.3% |
| 3935779 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.71 | 52.0 | 4.17e-01 | 75.6% | 63.8% |
| 4963973 | 1203.1.2.0 ↗ | alpha bundles › Shroom domain 2 › Shroom domain 2 › Human SD2 | 0.70 | 52.0 | 4.67e-01 | 78.0% | 69.4% |
| 3476998 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.70 | 52.0 | 4.25e-01 | 78.0% | 72.0% |
| 3221766 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.69 | 50.0 | 5.46e-01 | 78.0% | 87.6% |
| 3233751 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.69 | 52.0 | 4.20e-01 | 78.0% | 70.7% |
| 4960932 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.69 | 50.0 | 4.27e-01 | 74.8% | 79.5% |
| 3460111 | 4121.1.1.0 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like | 0.69 | 54.0 | 3.82e-01 | 81.3% | 40.0% |
| 3245978 | 622.4.1.0 ↗ | alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related | 0.67 | 51.0 | 4.39e-01 | 78.9% | 59.5% |
| 3267401 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.67 | 47.0 | 3.93e-01 | 72.4% | 72.2% |
| 5049613 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.66 | 49.0 | 4.19e-01 | 78.0% | 77.0% |
| 4033317 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.64 | 47.0 | 4.01e-01 | 76.4% | 75.5% |
| 4014071 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.64 | 46.0 | 3.75e-01 | 74.8% | 67.4% |
| 4600416 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.64 | 49.0 | 4.14e-01 | 81.3% | 70.8% |
| 3969975 | 3758.2.1.0 ↗ | alpha bundles › Bacterial hemolysins-like › Biopolymer transport protein ExbB › Biopolymer transport protein ExbB | 0.63 | 49.0 | 4.02e-01 | 80.5% | 90.2% |
| 3494037 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.63 | 51.0 | 4.04e-01 | 86.2% | 64.4% |
| 5058174 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.62 | 47.0 | 3.97e-01 | 79.7% | 74.9% |
| 3642887 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.62 | 48.0 | 3.93e-01 | 81.3% | 66.4% |
| 3484908 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.60 | 47.0 | 5.06e-01 | 82.1% | 97.1% |
| 5079159 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.60 | 48.0 | 4.05e-01 | 84.6% | 71.0% |
| 3980637 | 3758.2.1.0 ↗ | alpha bundles › Bacterial hemolysins-like › Biopolymer transport protein ExbB › Biopolymer transport protein ExbB | 0.58 | 45.0 | 3.82e-01 | 81.3% | 72.0% |
| 4989411 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.58 | 44.0 | 3.72e-01 | 81.3% | 65.6% |
| 3580332 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.58 | 44.0 | 4.11e-01 | 80.5% | 94.8% |
| 3886845 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.57 | 47.0 | 3.93e-01 | 95.1% | 50.7% |
| 4001562 | 5050.1.1.6 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › OATP | 0.57 | 45.0 | 3.05e-01 | 86.2% | 33.1% |
| 3350068 | 633.22.1.1 ↗ | alpha bundles › Bromodomain-like › Vitamin K epoxide reductase (VKOR) › Vitamin K epoxide reductase (VKOR) › VKOR | 0.55 | 50.0 | 4.54e-01 | 100.0% | 84.8% |
| 3678110 | 593.1.1.1 ↗ | alpha bundles › GroEL equatorial domain-like › GroEL equatorial domain-like › GroEL equatorial domain-like › Cpn60_TCP1 | 0.53 | 44.0 | 3.46e-01 | 90.2% | 81.2% |
D2
medium
residues 148-283
Domain cluster:
rep: ribonucleoside-diphosphate_reductase_small_chain__YP_009001342__Pithovirus_sibericum__1450746__D163-306
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00268.28 best | Ribonuc_red_sm | 101.2 | 9.40e-29 | 97.8% | 47.0% |