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surface_glycoprotein
Euk-VirHuman_coronavirus_229E
surface_glycoprotein__NP_073551__Human_coronavirus_229E__11137
Identity
- Accession:
- NP_073551 ↗
- Protein ID:
- surface_glycoprotein
- Kingdom:
- euk
Quality
64.5
mean pLDDT
Taxonomy
Orthornavirae›
Pisuviricota›
Pisoniviricetes›
Nidovirales›
Coronaviridae›
Alphacoronavirus›
Human_coronavirus_229E
TaxID: 11137
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 297-436
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01600.22 best | CoV_S1 | 134.3 | 6.70e-39 | 95.7% | 32.5% |
CATH (11)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 6vv5A01 | 2.60.40.3130 | Mainly Beta › Sandwich › Immunoglobulin-like › Coronavirus S1 glycoprotein, central receptor binding domain (RBD) | 0.92 | 72.0 | 7.78e-01 | 93.6% | 93.4% |
| 3kbhE00 | 2.60.40.3130 | Mainly Beta › Sandwich › Immunoglobulin-like › Coronavirus S1 glycoprotein, central receptor binding domain (RBD) | 0.85 | 65.0 | 7.32e-01 | 87.9% | 100.0% |
| 4f2mE00 | 2.60.40.3130 | Mainly Beta › Sandwich › Immunoglobulin-like › Coronavirus S1 glycoprotein, central receptor binding domain (RBD) | 0.82 | 74.0 | 7.32e-01 | 95.7% | 98.0% |
| 3v9fA03 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.58 | 43.0 | 4.61e-01 | 78.6% | 98.3% |
| 4a2lB03 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.56 | 42.0 | 4.43e-01 | 77.9% | 100.0% |
| 4hgzA02 | 2.20.25.570 | Mainly Beta › Single Sheet › N-terminal domain of TfIIb › | 0.56 | 26.0 | 3.56e-01 | 85.7% | 95.0% |
| 2pn5A06 | 2.20.130.20 | Mainly Beta › Single Sheet › S-adenosyl-L-methionine-dependent methyltransferases › | 0.55 | 36.0 | 4.22e-01 | 81.4% | 100.0% |
| 8ediA02 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.54 | 35.0 | 4.11e-01 | 78.6% | 100.0% |
| 4f7kA02 | 2.60.40.420 | Mainly Beta › Sandwich › Immunoglobulin-like › Cupredoxins - blue copper proteins | 0.53 | 46.0 | 4.64e-01 | 95.0% | 100.0% |
| 5k6uA01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.52 | 34.0 | 3.95e-01 | 77.1% | 100.0% |
| 1r0aH01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.50 | 35.0 | 3.75e-01 | 72.9% | 100.0% |
ECOD (7)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2551834 | 4169.1.2.1 ↗ | a+b three layers › Coronavirus spike protein receptor-binding domain › Coronavirus spike protein receptor-binding domain › Alpha-coronavirus spike protein receptor-binding domain › CoV_S1 | 0.95 | 90.0 | 8.70e-01 | 98.6% | 89.5% |
| 2132423 | 4169.1.2.1 ↗ | a+b three layers › Coronavirus spike protein receptor-binding domain › Coronavirus spike protein receptor-binding domain › Alpha-coronavirus spike protein receptor-binding domain › CoV_S1 | 0.90 | 75.0 | 7.64e-01 | 100.0% | 88.2% |
| 2890705 | 4169.1.2.1 ↗ | a+b three layers › Coronavirus spike protein receptor-binding domain › Coronavirus spike protein receptor-binding domain › Alpha-coronavirus spike protein receptor-binding domain › CoV_S1 | 0.85 | 78.0 | 7.64e-01 | 95.0% | 98.0% |
| 2568561 | 4169.1.2.1 ↗ | a+b three layers › Coronavirus spike protein receptor-binding domain › Coronavirus spike protein receptor-binding domain › Alpha-coronavirus spike protein receptor-binding domain › CoV_S1 | 0.85 | 81.0 | 7.83e-01 | 100.0% | 97.4% |
| 3263255 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.54 | 39.0 | 4.37e-01 | 79.3% | 96.4% |
| 4958505 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.53 | 40.0 | 4.08e-01 | 79.3% | 99.3% |
| 4662296 | 331.12.1.1 ↗ | a+b two layers › TBP-like › YugN-like › YugN-like › YugN | 0.50 | 27.0 | 2.96e-01 | 72.1% | 62.4% |
D2
high
residues 502-563
Domain cluster:
representative
CATH (2)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2pjzA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.56 | 36.0 | 2.37e-01 | 88.7% | 15.7% |
| 3wdhA01 | 2.60.40.2320 | Mainly Beta › Sandwich › Immunoglobulin-like › | 0.51 | 42.0 | 3.64e-01 | 90.3% | 89.6% |
D3
high
residues 580-588_951-1045
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01601.22 best | CoV_S2 | 94.4 | 9.20e-27 | 93.3% | 17.3% |
ECOD (8)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4915325 | 1042.1.1.1 ↗ | a+b complex topology › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › CoV_S2 | 0.96 | 66.0 | 4.10e-01 | 70.2% | 92.6% |
| 2568557 | 1042.1.1.1 ↗ | a+b complex topology › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › CoV_S2 | 0.95 | 82.0 | 5.06e-01 | 89.4% | 93.1% |
| 2319447 | 1042.1.1.1 ↗ | a+b complex topology › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › CoV_S2 | 0.85 | 72.0 | 4.60e-01 | 89.4% | 97.1% |
| 3037624 | 1042.1.1.1 ↗ | a+b complex topology › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › CoV_S2 | 0.79 | 66.0 | 4.16e-01 | 87.5% | 93.2% |
| 2860236 | 1042.1.1.1 ↗ | a+b complex topology › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › CoV_S2 | 0.78 | 63.0 | 4.04e-01 | 85.6% | 96.8% |
| 1033396 | 243.4.1.1 ↗ | a+b two layers › Cystatin-like › DsbC/DsbG N-terminal domain-like › DsbC/DsbG N-terminal domain-like › DsbC_N | 0.52 | 35.0 | 4.08e-01 | 77.9% | 97.3% |
| 4966867 | 4.6.1.4 ↗ | beta barrels › SH3 › PRC-barrel domain › PRC-barrel domain › DUF5749 | 0.51 | 33.0 | 3.67e-01 | 85.6% | 85.0% |
| 3556708 | 247.1.1.38 ↗ | a+b four layers › Metallo-hydrolase/oxidoreductase › Metallo-hydrolase/oxidoreductase › Metallo-hydrolase/oxidoreductase › CPSF73-100_C | 0.50 | 25.0 | 2.92e-01 | 84.6% | 65.3% |
D4
medium
residues 56-124_191-268
Domain cluster:
representative
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01600.22 best | CoV_S1 | 109.4 | 2.50e-31 | 53.7% | 18.6% |
| PF01600.22 | CoV_S1 | 87.1 | 1.50e-24 | 48.3% | 17.4% |
CATH (9)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 7u6rA01 | 2.60.120.960 | Mainly Beta › Sandwich › Jelly Rolls › Spike glycoprotein, N-terminal domain | 0.66 | 61.0 | 4.98e-01 | 100.0% | 89.2% |
| 6accA01 | 2.60.120.960 | Mainly Beta › Sandwich › Jelly Rolls › Spike glycoprotein, N-terminal domain | 0.66 | 61.0 | 4.96e-01 | 100.0% | 93.0% |
| 3jclA01 | 2.60.120.960 | Mainly Beta › Sandwich › Jelly Rolls › Spike glycoprotein, N-terminal domain | 0.65 | 59.0 | 4.73e-01 | 100.0% | 87.5% |
| 4bpzA00 | 2.60.120.200 | Mainly Beta › Sandwich › Jelly Rolls › | 0.58 | 40.0 | 3.37e-01 | 71.4% | 76.1% |
| 1yllA01 | 2.60.120.10 | Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls | 0.57 | 35.0 | 4.32e-01 | 76.9% | 97.8% |
| 2uwaA00 | 2.60.120.200 | Mainly Beta › Sandwich › Jelly Rolls › | 0.56 | 43.0 | 3.48e-01 | 79.6% | 88.3% |
| 3azwA01 | 2.60.120.200 | Mainly Beta › Sandwich › Jelly Rolls › | 0.54 | 41.0 | 3.54e-01 | 78.2% | 96.5% |
| 4ylmX00 | 3.60.130.10 | Alpha Beta › 4-Layer Sandwich › Double-stranded beta-helix › Clavaminate synthase-like | 0.54 | 39.0 | 3.21e-01 | 75.5% | 94.2% |
| 5ocqA00 | 2.60.120.200 | Mainly Beta › Sandwich › Jelly Rolls › | 0.51 | 43.0 | 3.54e-01 | 92.5% | 79.7% |
ECOD (17)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4875124 | 10.1.1.14 ↗ | beta sandwiches › jelly-roll › Concanavalin A-like › Concanavalin A-like lectins/glucanases › CoV_S1 | 0.94 | 91.0 | 7.81e-01 | 100.0% | 90.7% |
| 4915322 | 10.1.1.14 ↗ | beta sandwiches › jelly-roll › Concanavalin A-like › Concanavalin A-like lectins/glucanases › CoV_S1 | 0.89 | 74.0 | 6.27e-01 | 85.0% | 87.2% |
| 2132422 | 10.1.1.14 ↗ | beta sandwiches › jelly-roll › Concanavalin A-like › Concanavalin A-like lectins/glucanases › CoV_S1 | 0.87 | 84.0 | 6.96e-01 | 100.0% | 88.1% |
| 2320613 | 10.1.1.0 ↗ | beta sandwiches › jelly-roll › Concanavalin A-like › Concanavalin A-like lectins/glucanases | 0.72 | 67.0 | 5.72e-01 | 100.0% | 95.1% |
| 1890046 | 10.1.1.0 ↗ | beta sandwiches › jelly-roll › Concanavalin A-like › Concanavalin A-like lectins/glucanases | 0.56 | 51.0 | 4.71e-01 | 97.3% | 97.8% |
| 4416002 | 10.32.1.4 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like › EMP24_GP25L | 0.56 | 35.0 | 3.99e-01 | 78.9% | 82.7% |
| 3686285 | 10.32.1.4 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like › EMP24_GP25L | 0.55 | 33.0 | 3.68e-01 | 76.9% | 75.7% |
| 3598492 | 10.32.1.0 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like | 0.53 | 39.0 | 3.56e-01 | 74.1% | 76.7% |
| 4373119 | 1.1.7.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C | 0.53 | 33.0 | 4.04e-01 | 80.3% | 100.0% |
| 5050377 | 10.1.2.0 ↗ | beta sandwiches › jelly-roll › Concanavalin A-like › GOLD domain-like (DEPRECATED) | 0.53 | 33.0 | 3.77e-01 | 78.9% | 82.7% |
| 4464442 | 10.32.1.4 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like › EMP24_GP25L | 0.53 | 33.0 | 3.80e-01 | 76.2% | 83.6% |
| 3780422 | 10.1.1.88 ↗ | beta sandwiches › jelly-roll › Concanavalin A-like › Concanavalin A-like lectins/glucanases › GBD_ELAPOR1 | 0.51 | 34.0 | 3.19e-01 | 78.2% | 54.4% |
| 3601923 | 10.32.1.0 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like | 0.51 | 37.0 | 3.41e-01 | 74.1% | 79.5% |
| 3601261 | 10.32.1.0 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like | 0.51 | 39.0 | 3.59e-01 | 81.0% | 62.1% |
| 4584441 | 1.1.7.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C | 0.51 | 34.0 | 3.94e-01 | 87.1% | 97.1% |
| 5068911 | 10.1.2.0 ↗ | beta sandwiches › jelly-roll › Concanavalin A-like › GOLD domain-like (DEPRECATED) | 0.51 | 32.0 | 3.60e-01 | 78.9% | 81.7% |
| 3435055 | 10.32.1.4 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like › EMP24_GP25L | 0.50 | 33.0 | 3.49e-01 | 78.2% | 74.6% |
D5
medium
residues 125-190
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01600.22 best | CoV_S1 | 57.6 | 1.30e-15 | 100.0% | 15.7% |
CATH (48)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2bbhA01 | 3.30.460.20 | Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › CorA soluble domain-like | 0.73 | 47.0 | 3.55e-01 | 81.8% | 29.1% |
| 4iykA02 | 2.60.40.2060 | Mainly Beta › Sandwich › Immunoglobulin-like › | 0.66 | 52.0 | 4.30e-01 | 86.4% | 87.3% |
| 7vd7A01 | 3.10.450.530 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › Ribonuclease toxin, BrnT, of type II toxin-antitoxin system | 0.65 | 49.0 | 4.44e-01 | 95.5% | 58.7% |
| 7rpyA01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.65 | 47.0 | 4.11e-01 | 78.8% | 77.7% |
| 4yg6B00 | 2.60.120.200 | Mainly Beta › Sandwich › Jelly Rolls › | 0.62 | 54.0 | 4.07e-01 | 98.5% | 47.9% |
| 2it9A00 | 2.30.31.10 | Mainly Beta › Roll › Transcriptional Co-activator pc4; Chain A › Transcriptional Coactivator Pc4; Chain A | 0.61 | 43.0 | 3.59e-01 | 92.4% | 41.7% |
| 1l3aA00 | 2.30.31.10 | Mainly Beta › Roll › Transcriptional Co-activator pc4; Chain A › Transcriptional Coactivator Pc4; Chain A | 0.61 | 52.0 | 3.86e-01 | 93.9% | 89.8% |
| 3jtzA00 | 3.30.160.390 | Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › Integrase, DNA-binding domain | 0.60 | 48.0 | 4.55e-01 | 100.0% | 72.7% |
| 3v6oB01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.60 | 53.0 | 4.63e-01 | 98.5% | 87.0% |
| 2dmkA01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.60 | 51.0 | 4.52e-01 | 98.5% | 84.5% |
| 1yqfB00 | 3.10.280.10 | Alpha Beta › Roll › Mitochondrial Matrix Protein; Chain A › Mitochondrial glycoprotein | 0.60 | 52.0 | 3.83e-01 | 97.0% | 67.2% |
| 1gyvA00 | 2.60.40.1230 | Mainly Beta › Sandwich › Immunoglobulin-like › Gamma-adaptin ear (GAE) domain | 0.60 | 51.0 | 4.19e-01 | 95.5% | 74.2% |
| 4qakA00 | 3.90.1140.10 | Alpha Beta › Alpha-Beta Complex › Cyclic Phosphodiesterase; Chain: A, › Cyclic phosphodiesterase | 0.59 | 44.0 | 3.36e-01 | 81.8% | 99.4% |
| 2bolA03 | 2.60.40.790 | Mainly Beta › Sandwich › Immunoglobulin-like › | 0.59 | 40.0 | 3.55e-01 | 83.3% | 49.5% |
| 3s98A01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.59 | 47.0 | 4.46e-01 | 90.9% | 87.8% |
| 4n6mB00 | 3.10.450.10 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.59 | 48.0 | 3.98e-01 | 89.4% | 63.8% |
| 3hn3A02 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.57 | 50.0 | 4.33e-01 | 100.0% | 85.6% |
| 7xc8A02 | 2.60.40.760 | Mainly Beta › Sandwich › Immunoglobulin-like › Expansin, cellulose-binding-like domain | 0.57 | 48.0 | 4.32e-01 | 100.0% | 81.4% |
| 2e3nA00 | 3.30.530.20 | Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain | 0.57 | 48.0 | 3.35e-01 | 95.5% | 39.8% |
| 4e5xG00 | 2.60.40.3530 | Mainly Beta › Sandwich › Immunoglobulin-like › | 0.57 | 48.0 | 4.31e-01 | 100.0% | 66.7% |
| 3tesA00 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.57 | 47.0 | 4.30e-01 | 98.5% | 81.9% |
| 4frwA02 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.56 | 44.0 | 3.98e-01 | 87.9% | 78.1% |
| 1fnfA01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.56 | 48.0 | 4.33e-01 | 98.5% | 85.1% |
| 1bquA01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.56 | 46.0 | 4.20e-01 | 100.0% | 82.0% |
| 1olzA03 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.56 | 48.0 | 4.41e-01 | 97.0% | 85.4% |
| 1y8cA02 | 2.20.25.110 | Mainly Beta › Single Sheet › N-terminal domain of TfIIb › S-adenosyl-L-methionine-dependent methyltransferases | 0.56 | 40.0 | 4.14e-01 | 93.9% | 85.0% |
| 2v5yA04 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.56 | 48.0 | 4.17e-01 | 97.0% | 83.3% |
| 1krlA00 | 6.20.50.130 | Special › Other non-globular › N-terminal domain of TfIIb › | 0.56 | 36.0 | 3.96e-01 | 83.3% | 97.7% |
| 1u7bA00 | 3.70.10.10 | Alpha Beta › Box › Proliferating Cell Nuclear Antigen › | 0.56 | 47.0 | 3.17e-01 | 93.9% | 49.0% |
| 3l5iA03 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.55 | 46.0 | 4.29e-01 | 98.5% | 92.0% |
| 1tdqA02 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.55 | 46.0 | 4.29e-01 | 98.5% | 87.8% |
| 1cb8A03 | 2.60.220.10 | Mainly Beta › Sandwich › Chondroitinase Ac; Chain A, domain 3 › Polysaccharide lyase family 8-like, C-terminal | 0.55 | 45.0 | 3.89e-01 | 95.5% | 64.5% |
| 3lohE05 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.55 | 46.0 | 3.83e-01 | 98.5% | 90.6% |
| 4inaA02 | 3.30.360.10 | Alpha Beta › 2-Layer Sandwich › Dihydrodipicolinate Reductase; domain 2 › Dihydrodipicolinate Reductase; domain 2 | 0.55 | 42.0 | 3.15e-01 | 89.4% | 100.0% |
| 1lwrA00 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.53 | 44.0 | 3.96e-01 | 95.5% | 82.3% |
| 2cuhA01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.53 | 45.0 | 4.15e-01 | 100.0% | 86.4% |
| 2yd9A03 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.53 | 42.0 | 3.97e-01 | 95.5% | 79.3% |
| 1nc7A00 | 2.60.290.11 | Mainly Beta › Sandwich › Hypothetical Protein Tm1070; Chain: A › TM1070-like | 0.53 | 44.0 | 3.70e-01 | 100.0% | 54.3% |
| 6u5uG07 | 3.30.1120.100 | Alpha Beta › 2-Layer Sandwich › Arylsulfatase, C-terminal domain › | 0.52 | 44.0 | 3.58e-01 | 98.5% | 79.5% |
| 6u5vB07 | 3.30.1120.100 | Alpha Beta › 2-Layer Sandwich › Arylsulfatase, C-terminal domain › | 0.52 | 44.0 | 3.62e-01 | 98.5% | 79.1% |
| 4ntqB00 | 3.30.2450.20 | Alpha Beta › 2-Layer Sandwich › Secreted effector protein pipB2 fold › | 0.52 | 46.0 | 3.59e-01 | 100.0% | 46.9% |
| 3k50A02 | 2.30.42.10 | Mainly Beta › Roll › Pdz3 Domain › PDZ domain | 0.52 | 42.0 | 3.85e-01 | 100.0% | 94.0% |
| 1ej6A05 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.51 | 42.0 | 3.84e-01 | 98.5% | 90.5% |
| 2ltjA00 | 2.20.230.10 | Mainly Beta › Single Sheet › Resuscitation-promoting factor rpfb fold › Resuscitation-promoting factor rpfb. | 0.51 | 40.0 | 3.37e-01 | 84.8% | 59.5% |
| 4ydzA00 | 2.60.40.790 | Mainly Beta › Sandwich › Immunoglobulin-like › | 0.51 | 42.0 | 3.40e-01 | 93.9% | 63.0% |
| 1kyfA01 | 2.60.40.1230 | Mainly Beta › Sandwich › Immunoglobulin-like › Gamma-adaptin ear (GAE) domain | 0.50 | 43.0 | 3.52e-01 | 100.0% | 83.6% |
| 1vbfA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.50 | 45.0 | 3.09e-01 | 98.5% | 64.7% |
| 3hdjA01 | 3.30.1780.10 | Alpha Beta › 2-Layer Sandwich › ornithine cyclodeaminase, domain 1 › ornithine cyclodeaminase, domain 1 | 0.50 | 42.0 | 3.34e-01 | 95.5% | 45.7% |
ECOD (28)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3505182 | 2.1.1.0 ↗ | beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein | 0.71 | 48.0 | 4.51e-01 | 86.4% | 57.5% |
| 3904084 | 11.1.1.2 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › fn3 | 0.64 | 52.0 | 4.68e-01 | 87.9% | 73.3% |
| 4998047 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.60 | 52.0 | 4.11e-01 | 97.0% | 67.6% |
| 3924930 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.59 | 50.0 | 4.07e-01 | 98.5% | 61.5% |
| 3573755 | 11.1.1.2 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › fn3 | 0.59 | 50.0 | 4.05e-01 | 98.5% | 59.3% |
| 3793224 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.58 | 49.0 | 4.01e-01 | 98.5% | 61.5% |
| 3622820 | 11.1.1.2 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › fn3 | 0.58 | 50.0 | 3.82e-01 | 100.0% | 50.9% |
| 3226168 | 11.1.1.2 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › fn3 | 0.58 | 48.0 | 4.30e-01 | 98.5% | 75.0% |
| 4981112 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.57 | 46.0 | 4.20e-01 | 89.4% | 77.8% |
| 3415837 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.57 | 43.0 | 3.89e-01 | 86.4% | 83.0% |
| 4651619 | 10.1.1.0 ↗ | beta sandwiches › jelly-roll › Concanavalin A-like › Concanavalin A-like lectins/glucanases | 0.57 | 47.0 | 3.36e-01 | 100.0% | 31.6% |
| 3496039 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.56 | 48.0 | 3.74e-01 | 98.5% | 62.6% |
| 3771466 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.56 | 46.0 | 4.38e-01 | 100.0% | 85.9% |
| None | — | 0.55 | 49.0 | 3.11e-01 | 100.0% | 78.9% | |
| 4952370 | 881.1.1.0 ↗ | a+b three layers › Mog1p/PsbP-like › Mog1p/PsbP-like › Mog1p/PsbP-like | 0.55 | 46.0 | 3.54e-01 | 93.9% | 45.8% |
| 3756131 | 11.1.1.2 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › fn3 | 0.55 | 46.0 | 4.28e-01 | 97.0% | 84.7% |
| 4030216 | 5.1.4.0 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed | 0.55 | 46.0 | 3.03e-01 | 100.0% | 37.7% |
| 3898775 | 11.1.1.178 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Ig_2 | 0.54 | 45.0 | 3.70e-01 | 100.0% | 49.6% |
| 4981695 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.53 | 44.0 | 3.91e-01 | 98.5% | 76.2% |
| 2327038 | 11.1.1.326 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › GldM_3rd | 0.53 | 46.0 | 4.27e-01 | 98.5% | 80.0% |
| 4152523 | 11.1.1.129 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Interfer-bind | 0.53 | 43.0 | 3.93e-01 | 98.5% | 88.0% |
| 3608102 | 330.1.1.0 ↗ | a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like | 0.53 | 38.0 | 3.73e-01 | 84.8% | 68.6% |
| 3597001 | 295.1.1.0 ↗ | a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain | 0.53 | 44.0 | 3.27e-01 | 92.4% | 40.6% |
| 4941520 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.53 | 42.0 | 3.94e-01 | 97.0% | 85.6% |
| 4981079 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.53 | 43.0 | 3.95e-01 | 98.5% | 84.2% |
| 4026006 | 330.1.1.0 ↗ | a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like | 0.52 | 40.0 | 3.76e-01 | 87.9% | 67.5% |
| 5069243 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.52 | 43.0 | 3.87e-01 | 98.5% | 85.0% |
| 4056691 | 319.1.1.0 ↗ | beta sandwiches › HSP20-like › HSP20-like chaperones › HSP20-like chaperones | 0.51 | 44.0 | 3.60e-01 | 93.9% | 68.3% |
D6
medium
residues 269-296_437-501
Domain cluster:
representative
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01600.22 best | CoV_S1 | 28.0 | 1.20e-06 | 67.7% | 8.7% |
| PF19209.6 | CoV_S1_C | 81.8 | 3.70e-23 | 62.4% | 96.5% |
CATH (1)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4o1pD02 | 1.10.510.10 | Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1 | 0.53 | 43.0 | 3.22e-01 | 89.2% | 63.7% |
ECOD (12)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4915323 | 1043.1.1.3 ↗ | beta complex topology › Beta domain of coronavirus spike glycoprotein › Beta domain of coronavirus spike glycoprotein › Beta domain of coronavirus spike glycoprotein › CoV_S2 | 0.90 | 62.0 | 5.41e-01 | 76.3% | 50.4% |
| 2568559 | 1043.1.1.1 ↗ | beta complex topology › Beta domain of coronavirus spike glycoprotein › Beta domain of coronavirus spike glycoprotein › Beta domain of coronavirus spike glycoprotein › CoV_S1_C | 0.89 | 61.0 | 5.12e-01 | 71.0% | 44.9% |
| 2664577 | 1043.1.1.1 ↗ | beta complex topology › Beta domain of coronavirus spike glycoprotein › Beta domain of coronavirus spike glycoprotein › Beta domain of coronavirus spike glycoprotein › CoV_S1_C | 0.76 | 53.0 | 5.25e-01 | 72.0% | 69.4% |
| 4888259 | 1043.1.1.0 ↗ | beta complex topology › Beta domain of coronavirus spike glycoprotein › Beta domain of coronavirus spike glycoprotein › Beta domain of coronavirus spike glycoprotein | 0.76 | 53.0 | 4.89e-01 | 72.0% | 64.1% |
| 2532011 | 1043.1.1.1 ↗ | beta complex topology › Beta domain of coronavirus spike glycoprotein › Beta domain of coronavirus spike glycoprotein › Beta domain of coronavirus spike glycoprotein › CoV_S1_C | 0.76 | 55.0 | 4.62e-01 | 75.3% | 52.0% |
| 3008683 | 4169.1.1.0 ↗ | a+b three layers › Coronavirus spike protein receptor-binding domain › Coronavirus spike protein receptor-binding domain › Beta-coronavirus spike protein receptor-binding domain | 0.76 | 63.0 | 4.42e-01 | 89.2% | 100.0% |
| 4903310 | 1043.1.1.1 ↗ | beta complex topology › Beta domain of coronavirus spike glycoprotein › Beta domain of coronavirus spike glycoprotein › Beta domain of coronavirus spike glycoprotein › CoV_S1_C | 0.73 | 53.0 | 4.84e-01 | 74.2% | 63.9% |
| 5049448 | 375.1.1.0 ↗ | few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related | 0.59 | 27.0 | 3.75e-01 | 71.0% | 100.0% |
| 3989372 | 375.1.1.0 ↗ | few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related | 0.57 | 29.0 | 3.84e-01 | 78.5% | 92.0% |
| 3875901 | 206.1.1.71 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase, Kdo | 0.55 | 44.0 | 3.15e-01 | 89.2% | 53.6% |
| 3779026 | 206.1.1.1 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase | 0.55 | 44.0 | 3.24e-01 | 89.2% | 60.8% |
| 4205352 | 375.14.1.0 ↗ | few secondary structure elements › Rubredoxin-like › Rubredoxin-like domain in leucyl-tRNA synthetase (LS1) › Rubredoxin-like domain in leucyl-tRNA synthetase (LS1) | 0.51 | 26.0 | 3.44e-01 | 74.2% | 90.0% |
D7
medium
residues 599-653_882-949
Domain cluster:
representative
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01601.22 best | CoV_S2 | 115.0 | 5.20e-33 | 56.9% | 13.0% |
| PF01601.22 | CoV_S2 | 63.9 | 1.60e-17 | 46.3% | 10.5% |
CATH (3)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 6h9xA01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.66 | 36.0 | 3.94e-01 | 76.4% | 64.7% |
| 6ygiB01 | 1.10.4090.10 | Mainly Alpha › Orthogonal Bundle › Hepatitis B viral capsid (hbcag) fold › Viral capsid, core domain supefamily, Hepatitis B virus | 0.62 | 35.0 | 3.31e-01 | 82.9% | 45.9% |
| 1st6A02 | 1.20.120.810 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Vinculin, Vh2 four-helix bundle | 0.53 | 46.0 | 3.74e-01 | 95.9% | 96.2% |
ECOD (15)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3037624 | 1042.1.1.1 ↗ | a+b complex topology › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › CoV_S2 | 0.94 | 90.0 | 5.82e-01 | 100.0% | 71.3% |
| 2860236 | 1042.1.1.1 ↗ | a+b complex topology › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › CoV_S2 | 0.94 | 90.0 | 5.88e-01 | 100.0% | 75.6% |
| 2568557 | 1042.1.1.1 ↗ | a+b complex topology › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › CoV_S2 | 0.94 | 90.0 | 5.72e-01 | 100.0% | 72.2% |
| 4915325 | 1042.1.1.1 ↗ | a+b complex topology › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › CoV_S2 | 0.93 | 89.0 | 5.75e-01 | 100.0% | 74.7% |
| 2319447 | 1042.1.1.1 ↗ | a+b complex topology › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › CoV_S2 | 0.91 | 87.0 | 5.69e-01 | 100.0% | 73.7% |
| 2758018 | 1042.1.1.1 ↗ | a+b complex topology › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › CoV_S2 | 0.90 | 85.0 | 5.61e-01 | 100.0% | 75.7% |
| 3927738 | 632.8.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › alpha-2-Macroglobulin receptor associated protein (RAP) domain 1 › alpha-2-Macroglobulin receptor associated protein (RAP) domain 1 | 0.68 | 37.0 | 4.15e-01 | 83.7% | 68.4% |
| 3839497 | 150.5.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like | 0.68 | 36.0 | 4.33e-01 | 88.6% | 76.5% |
| 3752923 | 601.4.1.42 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › TMEM138 | 0.65 | 39.0 | 3.57e-01 | 83.7% | 46.5% |
| 3638080 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.64 | 48.0 | 4.49e-01 | 78.0% | 93.3% |
| 3597530 | 633.6.1.0 ↗ | alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like | 0.60 | 37.0 | 3.57e-01 | 95.1% | 54.3% |
| 4853145 | 1042.1.1.1 ↗ | a+b complex topology › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › S2 subunit of coronavirus spike glycoprotein › CoV_S2 | 0.58 | 52.0 | 4.39e-01 | 99.2% | 60.6% |
| 3592441 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.55 | 41.0 | 3.76e-01 | 76.4% | 86.9% |
| 3411860 | 633.6.1.6 ↗ | alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › ACAD9-ACADV_C | 0.54 | 43.0 | 3.99e-01 | 82.1% | 79.3% |
| 5029889 | 5076.2.1.0 ↗ | alpha complex topology › Mitochondrial ADP/ATP carrier-like › Putative sulfate permease CysZ › Putative sulfate permease CysZ | 0.52 | 43.0 | 3.28e-01 | 87.0% | 64.8% |
D8
medium
residues 804-881