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tegument_protein_UL37

Euk-Vir

Panine_betaherpesvirus_2

tegument_protein_UL37__NP_612690__Panine_betaherpesvirus_2__188763

Identity

Accession:: NP_612690 ↗
Protein ID:: tegument_protein_UL37
Kingdom:: euk

Quality

77.2 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Cytomegalovirus› Panine_betaherpesvirus_2

TaxID: 188763

Cluster

View cluster (39 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 546-677

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF04523.19 best	Herpes_U30	66.5	1.90e-18	99.2%	12.7%

CATH (24)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2d4xA00	1.20.1330.10	Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain	0.77	55.0	4.64e-01	73.5%	81.3%
3u8vA00	1.20.120.660	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain	0.75	47.0	5.78e-01	74.2%	100.0%
1y4cA03	1.20.120.660	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain	0.75	54.0	5.84e-01	74.2%	94.7%
2hujA00	1.20.120.440	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like	0.73	51.0	5.21e-01	71.2%	97.6%
3iqtA01	1.20.120.160	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain	0.71	51.0	5.49e-01	75.8%	86.8%
2yfaB01	1.20.1440.210	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) ›	0.69	57.0	6.03e-01	90.2%	95.8%
3rvyA01	1.20.120.350	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C	0.65	48.0	5.17e-01	78.0%	100.0%
2prrA02	1.20.1290.10	Mainly Alpha › Up-down Bundle › AhpD-like › AhpD-like	0.64	34.0	3.53e-01	71.2%	53.5%
1zvzA02	1.20.120.230	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like	0.62	53.0	5.45e-01	92.4%	95.2%
3rkgA02	1.20.58.340	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region	0.62	44.0	4.05e-01	72.0%	95.7%
1x5bA01	1.25.40.90	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.58	40.0	4.05e-01	71.2%	75.6%
4crwA00	1.25.40.180	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.57	51.0	4.30e-01	100.0%	88.1%
7cj3A01	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.57	52.0	4.14e-01	100.0%	61.2%
7xxiA01	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.56	48.0	3.76e-01	93.2%	81.0%
5xnyA02	1.20.200.10	Mainly Alpha › Up-down Bundle › Fumarase C; Chain A, domain 2 › Fumarase/aspartase (Central domain)	0.56	48.0	3.93e-01	93.2%	79.1%
7e4gA01	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.55	47.0	4.09e-01	91.7%	76.1%
3feyA02	1.25.40.180	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.54	42.0	3.72e-01	81.8%	85.4%
7ys6A01	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.53	45.0	3.59e-01	91.7%	84.6%
1v5kA00	1.10.418.10	Mainly Alpha › Orthogonal Bundle › Actin-binding Protein, T-fimbrin; domain 1 › Calponin-like domain	0.53	33.0	3.54e-01	90.2%	70.4%
7wjlA01	3.40.800.20	Alpha Beta › 3-Layer(aba) Sandwich › Arginase; Chain A › Histone deacetylase domain	0.53	42.0	2.94e-01	84.8%	55.7%
4xaiB02	1.10.565.10	Mainly Alpha › Orthogonal Bundle › Retinoid X Receptor › Retinoid X Receptor	0.52	38.0	3.42e-01	77.3%	99.0%
1hbgA00	1.10.490.10	Mainly Alpha › Orthogonal Bundle › Globin-like › Globins	0.51	34.0	3.34e-01	80.3%	60.5%
3mpiA01	1.10.540.10	Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain	0.51	37.0	3.89e-01	78.0%	94.2%
6t4hA03	1.10.3060.10	Mainly Alpha › Orthogonal Bundle › Helical scaffold and wing domains of SecA › Helical scaffold and wing domains of SecA	0.51	30.0	2.76e-01	88.6%	43.0%

ECOD (11)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4134938	601.3.1.14 ↗	alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain › PF27870	0.69	51.0	5.41e-01	93.2%	88.7%
3668007	601.51.1.0 ↗	alpha bundles › Four-helical up-and-down bundle › alpha-helical domain in phase 1 flagellin › alpha-helical domain in phase 1 flagellin	0.68	49.0	3.94e-01	75.0%	71.2%
5043625	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.67	46.0	4.46e-01	70.5%	80.7%
3714093	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.62	45.0	5.07e-01	81.8%	100.0%
3693664	601.16.1.19 ↗	alpha bundles › Four-helical up-and-down bundle › FAT domain of focal adhesion kinase › FAT domain of focal adhesion kinase › DUF3433	0.59	52.0	4.62e-01	93.2%	91.1%
3890890	109.4.1.342 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › SBF2	0.55	44.0	3.57e-01	87.1%	64.4%
5044679	5059.1.1.1 ↗	alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA	0.55	38.0	3.00e-01	71.2%	86.4%
3776730	5001.1.1.9 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › TAS2R	0.55	50.0	3.71e-01	98.5%	65.9%
3202137	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.54	43.0	4.25e-01	96.2%	81.4%
3243887	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.53	38.0	3.33e-01	73.5%	72.2%
3760719	109.4.1.445 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Vps54_N	0.50	45.0	3.50e-01	98.5%	53.4%

D2 high residues 711-904

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF04523.19 best	Herpes_U30	57.9	7.40e-16	96.9%	19.5%

CATH (36)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2lm9A00	1.20.58.970	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.83	38.0	5.48e-01	70.1%	90.6%
3uumA00	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.78	43.0	5.37e-01	78.4%	85.2%
1quuA01	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.77	40.0	4.92e-01	82.0%	77.0%
3u0cA00	1.20.120.330	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2	0.73	44.0	4.91e-01	72.7%	74.8%
3mq1A01	1.20.58.970	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.73	36.0	5.19e-01	73.7%	100.0%
6p73A02	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.73	34.0	3.93e-01	84.5%	59.4%
6h2dS01	1.20.1170.10	Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; ›	0.71	57.0	5.43e-01	82.5%	90.6%
2i0mA01	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.71	35.0	4.51e-01	82.0%	83.0%
1fewA00	1.20.58.70	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.69	46.0	4.90e-01	79.9%	75.7%
6gy8A01	1.20.1170.10	Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; ›	0.68	59.0	4.90e-01	91.8%	82.5%
2wb7A03	1.20.120.870	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › pT26-6p, five-helical bundle domain	0.68	33.0	3.91e-01	92.3%	65.4%
7p3rA01	1.20.1170.10	Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; ›	0.67	57.0	4.73e-01	89.2%	87.1%
4q4hA01	1.20.1560.10	Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain	0.67	44.0	3.69e-01	74.2%	39.6%
6grjB01	1.20.1170.10	Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; ›	0.66	58.0	4.89e-01	92.3%	82.7%
3ofnY00	1.10.287.80	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain	0.65	39.0	4.94e-01	74.7%	99.1%
2gd5A00	6.10.140.1230	Special › Helix non-globular › Helix Hairpins ›	0.65	42.0	4.89e-01	75.8%	89.4%
2d4uB00	1.20.120.30	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain	0.65	38.0	4.16e-01	92.3%	70.3%
2q12A00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.64	51.0	4.76e-01	83.0%	73.1%
4mrsA01	1.20.1560.10	Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain	0.64	42.0	3.47e-01	74.2%	36.8%
8a1gC01	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.64	49.0	5.14e-01	80.4%	85.6%
1tjlA00	1.20.120.910	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › DksA, coiled-coil domain	0.64	39.0	4.44e-01	99.0%	80.7%
4ke2A00	6.10.140.1860	Special › Helix non-globular › Helix Hairpins ›	0.62	40.0	4.05e-01	90.2%	64.3%
2lw1A00	1.10.287.380	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Valyl-tRNA synthetase, C-terminal domain	0.62	29.0	4.06e-01	73.7%	95.3%
4dciA00	6.10.140.1110	Special › Helix non-globular › Helix Hairpins ›	0.61	41.0	4.62e-01	97.4%	87.1%
6xj1A01	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.60	44.0	4.03e-01	73.7%	74.7%
4e40A00	1.20.1260.80	Mainly Alpha › Up-down Bundle › Ferritin ›	0.60	48.0	4.45e-01	83.0%	80.0%
2v0xA01	1.10.287.3160	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.59	46.0	4.96e-01	87.1%	92.9%
2p7vA00	1.20.120.1370	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Regulator of RNA polymerase sigma(70) subunit, domain 4	0.59	31.0	3.48e-01	92.3%	63.6%
4fzsA00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.59	48.0	4.70e-01	86.1%	91.4%
2efkA01	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.58	45.0	4.06e-01	79.4%	79.8%
3aonA00	1.10.287.3240	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.58	41.0	4.20e-01	72.2%	91.5%
3syvA01	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.57	44.0	4.08e-01	80.4%	77.6%
1wdzA00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.57	45.0	4.28e-01	82.5%	84.4%
2yfaB01	1.20.1440.210	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) ›	0.56	35.0	4.26e-01	91.2%	99.2%
6tqfA01	1.20.1560.10	Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain	0.56	47.0	3.64e-01	87.1%	47.8%
2cmrA00	1.20.58.1860	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.51	40.0	4.09e-01	93.8%	83.3%

ECOD (18)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3739176	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.74	49.0	3.58e-01	70.1%	26.9%
3667580	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.73	55.0	4.85e-01	76.3%	64.9%
5048800	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.73	42.0	4.31e-01	78.4%	58.4%
3972236	3755.3.1.42 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › CheZ	0.73	51.0	5.29e-01	70.6%	80.0%
4937739	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.69	46.0	5.48e-01	90.2%	97.0%
3611289	3291.1.1.0 ↗	alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related	0.68	47.0	5.43e-01	71.1%	97.9%
3416429	2004.1.1.442 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_21	0.66	48.0	3.75e-01	74.7%	75.7%
3795763	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.65	52.0	3.77e-01	83.0%	48.6%
3600956	3922.1.1.0 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3	0.64	51.0	5.16e-01	82.5%	90.5%
3991276	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.62	50.0	4.40e-01	83.0%	64.7%
3946332	1075.4.1.1 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane	0.62	43.0	3.59e-01	74.7%	40.6%
3417442	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.61	49.0	4.26e-01	82.5%	66.7%
3503397	1075.4.1.1 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane	0.61	47.0	3.59e-01	78.9%	37.4%
5020818	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.61	50.0	3.68e-01	86.6%	42.1%
3935140	3755.4.1.0 ↗	alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain	0.60	51.0	5.31e-01	88.7%	100.0%
3699787	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.59	49.0	4.52e-01	86.1%	83.7%
3596860	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.57	47.0	4.40e-01	86.1%	74.2%
3342680	1075.4.1.1 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane	0.53	43.0	3.57e-01	85.6%	89.6%

D3 medium residues 4-142

PDB

Domain cluster: rep: tegument_protein_UL37__YP_004940219__Saimiriine_betaherpesvirus_4__1535247__D1-106

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF04523.19 best	Herpes_U30	49.6	2.50e-13	96.4%	14.7%

CATH (22)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4rl5A00	1.20.1280.170	Mainly Alpha › Up-down Bundle › Monooxygenase › Exocyst complex component Exo70	0.71	65.0	4.47e-01	97.8%	40.8%
3tjzB00	1.25.10.10	Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant	0.62	47.0	3.80e-01	88.5%	42.0%
2fefA01	1.20.1440.70	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › PA2201 N-terminal domain-like	0.61	40.0	4.21e-01	71.2%	72.8%
1bf5A01	1.20.1050.20	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › STAT transcription factor, all-alpha domain	0.61	44.0	4.17e-01	74.8%	91.1%
2xs1A01	1.25.40.280	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › alix/aip1 like domains	0.61	51.0	3.85e-01	92.1%	52.9%
3woyA00	1.25.10.10	Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant	0.61	52.0	4.25e-01	91.4%	51.6%
3ha4B00	1.20.58.690	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.60	43.0	4.62e-01	76.3%	97.5%
5k29A00	1.20.920.10	Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like	0.58	36.0	4.25e-01	72.7%	89.7%
4p3gD00	1.10.3450.40	Mainly Alpha › Orthogonal Bundle › Hyaluronidase domain-like › Signal recognition particle, SRP68 subunit, RNA-binding domain	0.57	48.0	4.32e-01	92.1%	76.4%
8amzS01	1.25.40.570	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.56	46.0	3.38e-01	89.9%	60.2%
1vu2201	1.20.58.1070	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.56	46.0	4.32e-01	89.2%	72.4%
2ppqA02	3.90.1200.10	Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe	0.56	39.0	3.39e-01	70.5%	96.7%
5lnkJ01	1.20.120.1200	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ	0.54	30.0	2.81e-01	70.5%	42.6%
4abnA01	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.53	43.0	3.40e-01	84.9%	47.3%
4xhcA01	1.50.10.10	Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase ›	0.53	44.0	3.48e-01	94.2%	55.2%
1r0dA00	1.20.1410.10	Mainly Alpha › Up-down Bundle › I/LWEQ domain › I/LWEQ domain	0.53	45.0	4.06e-01	93.5%	97.4%
6vptA01	1.50.10.160	Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase ›	0.52	38.0	3.31e-01	74.8%	51.4%
6ketA01	3.20.20.30	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Luciferase-like domain	0.51	42.0	3.20e-01	89.2%	59.4%
7zxkC01	1.20.1250.10	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; ›	0.51	33.0	3.27e-01	87.1%	58.7%
2j1dG01	1.20.58.2220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Formin, FH2 domain	0.51	43.0	3.20e-01	93.5%	69.6%
2jqqA00	1.20.58.1240	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.50	44.0	4.31e-01	95.0%	87.0%
1s0pA01	1.25.40.330	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Adenylate cyclase-associated CAP, N-terminal domain	0.50	39.0	3.66e-01	82.0%	81.3%

ECOD (30)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1283715	3852.1.1.1 ↗	alpha superhelices › UL37 N-terminal half › UL37 N-terminal half › UL37 N-terminal half › Herpes_UL37_1	0.75	69.0	4.68e-01	99.3%	39.4%
3834460	109.4.1.2069 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF30216	0.65	55.0	4.79e-01	90.6%	67.6%
3702456	109.4.1.44 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Vps35	0.65	56.0	3.78e-01	92.8%	32.9%
3249835	109.4.1.85 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Nop52	0.65	58.0	4.46e-01	98.6%	63.1%
3611416	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.65	58.0	4.74e-01	98.6%	81.9%
3468708	109.4.1.75 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › IFRD	0.64	58.0	4.08e-01	100.0%	83.1%
3229891	5057.1.1.0 ↗	alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore	0.63	42.0	4.29e-01	88.5%	68.9%
3373370	603.2.1.15 ↗	alpha bundles › STAT-like › STAT › STAT › DUF6857	0.63	52.0	4.46e-01	89.2%	82.7%
3424799	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.63	47.0	5.13e-01	91.4%	96.5%
3781862	109.4.1.414 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › MMS19_N	0.61	52.0	3.99e-01	93.5%	39.7%
3274248	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.61	55.0	3.23e-01	100.0%	18.7%
3682441	109.4.1.177 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Cnd3	0.61	51.0	3.26e-01	92.1%	20.1%
3828650	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.60	43.0	4.28e-01	89.9%	70.3%
3598215	601.1.1.0 ↗	alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin	0.60	49.0	4.61e-01	87.8%	95.3%
3667724	109.4.1.420 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR	0.59	45.0	3.75e-01	85.6%	45.3%
3594741	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.59	48.0	4.30e-01	88.5%	60.0%
3376868	109.4.1.177 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Cnd3	0.59	50.0	3.01e-01	92.1%	14.0%
3941020	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.59	48.0	4.43e-01	87.8%	87.2%
3725161	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.59	45.0	4.93e-01	89.2%	97.4%
5041952	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.58	43.0	4.42e-01	77.7%	93.3%
3462423	109.4.1.218 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › SNAP	0.58	48.0	4.49e-01	91.4%	79.4%
3368262	109.4.1.189 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR_2	0.57	45.0	4.35e-01	91.4%	74.2%
3193680	109.4.1.2431 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ARM_5	0.56	48.0	3.51e-01	95.7%	69.4%
3586523	604.12.1.45 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › PPP1R21_helical	0.56	43.0	4.00e-01	79.9%	72.6%
3652879	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.56	41.0	3.58e-01	77.0%	51.2%
3314940	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.55	47.0	3.90e-01	93.5%	72.2%
3480118	109.4.1.276 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › EDC4_C	0.55	44.0	4.30e-01	85.6%	85.2%
3910128	3736.1.1.1 ↗	alpha superhelices › NLRC4 helical domain HD2 › NLRC4 helical domain HD2 › NLRC4 helical domain HD2 › NLRC4_HD2	0.53	41.0	4.24e-01	88.5%	87.7%
3268975	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.52	40.0	3.92e-01	79.1%	82.0%
3587778	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.50	46.0	4.37e-01	100.0%	87.3%

D4 medium residues 171-218_502-519

PDB

Domain cluster: representative

CATH (25)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2ca5A00	1.20.58.90	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.81	50.0	5.15e-01	72.7%	66.1%
6tkvA01	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.79	55.0	5.46e-01	72.7%	75.0%
3zgxA02	6.10.140.1720	Special › Helix non-globular › Helix Hairpins ›	0.78	54.0	4.86e-01	72.7%	71.4%
2ic6A00	1.20.58.90	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.77	52.0	5.14e-01	71.2%	94.4%
1lrzA03	1.20.58.90	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.77	53.0	5.48e-01	72.7%	88.7%
4dciA00	6.10.140.1110	Special › Helix non-globular › Helix Hairpins ›	0.77	53.0	4.09e-01	72.7%	34.7%
4adzA00	1.20.58.1000	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Metal-sensitive repressor, helix protomer	0.76	53.0	4.78e-01	72.7%	53.3%
5dn6J00	1.20.20.10	Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C	0.76	52.0	5.04e-01	71.2%	100.0%
2cazD00	6.10.140.820	Special › Helix non-globular › Helix Hairpins ›	0.76	53.0	5.54e-01	72.7%	91.7%
4l0rB00	1.20.58.90	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.76	52.0	5.03e-01	72.7%	64.4%
4nb5B02	1.10.287.160	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat	0.75	52.0	5.30e-01	72.7%	76.6%
4iggA01	1.10.287.160	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat	0.73	51.0	5.09e-01	72.7%	92.5%
3ehfD01	1.20.5.1930	Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces ›	0.73	50.0	5.17e-01	72.7%	81.0%
1zhcA00	6.10.280.50	Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.73	50.0	4.83e-01	72.7%	63.2%
1a36A04	1.10.132.10	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 ›	0.73	49.0	3.65e-01	72.7%	26.9%
1x4tA01	1.10.287.660	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin	0.72	50.0	5.31e-01	72.7%	82.8%
2wmmA01	1.20.5.420	Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C	0.72	49.0	5.44e-01	72.7%	93.9%
2jdiG01	1.10.287.80	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain	0.71	48.0	5.03e-01	71.2%	77.0%
1ku9A02	1.10.287.450	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin	0.69	48.0	4.87e-01	72.7%	76.6%
6gy8A01	1.20.1170.10	Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; ›	0.68	59.0	3.74e-01	97.0%	81.3%
4h63K00	1.10.287.3490	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.68	46.0	4.08e-01	71.2%	69.4%
3pwfA01	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.67	46.0	3.76e-01	72.7%	39.7%
2rp4A00	6.10.280.60	Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Transcription factor p53, C-terminal domain	0.67	46.0	4.52e-01	72.7%	67.6%
1t72A02	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.62	53.0	4.65e-01	93.9%	95.9%
1zbpA01	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.51	36.0	3.38e-01	81.8%	58.8%

ECOD (12)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3682747	101.1.2.0 ↗	alpha arrays › HTH › HTH › winged helix domain	0.83	58.0	3.74e-01	72.7%	17.8%
3935107	192.7.1.0 ↗	alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm	0.80	56.0	4.66e-01	72.7%	43.6%
3613914	3922.1.1.0 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3	0.79	55.0	5.28e-01	72.7%	64.0%
3693881	192.2.1.0 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin	0.77	53.0	5.27e-01	72.7%	82.9%
3605626	192.12.1.0 ↗	alpha bundles › Long alpha-hairpin › Transcriptional repressor TraM › Transcriptional repressor TraM	0.76	52.0	4.50e-01	72.7%	45.7%
3987802	192.7.1.1 ↗	alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › FemAB	0.76	52.0	5.38e-01	71.2%	88.3%
3515350	192.7.1.0 ↗	alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm	0.72	50.0	4.40e-01	72.7%	52.0%
3274161	4163.1.1.1 ↗	alpha bundles › GINS helical bundle-like › GINS helical bundle-like › PSF1 N-terminal domain-like › Sld5	0.71	49.0	3.92e-01	72.7%	35.6%
3981585	5086.1.1.84 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_MFP_RND	0.70	47.0	4.59e-01	71.2%	94.7%
4929294	601.7.1.0 ↗	alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain	0.65	58.0	4.18e-01	98.5%	68.3%
3634960	603.1.1.5 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin-6_N	0.64	55.0	4.66e-01	95.5%	94.5%
3221478	3922.1.1.0 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3	0.63	52.0	4.52e-01	90.9%	84.0%

D5 medium residues 292-369_388-429_449-501

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF04523.19 best	Herpes_U30	27.7	1.00e-06	45.7%	7.6%

CATH (5)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4cb8A00	1.25.10.10	Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant	0.54	47.0	3.40e-01	94.8%	84.0%
4atgA00	1.25.40.770	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › TAF6, C-terminal HEAT repeat domain	0.53	44.0	4.22e-01	87.3%	83.6%
7zcvA02	1.25.40.400	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.53	40.0	3.83e-01	80.9%	69.0%
6n7pX01	1.25.40.180	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.53	43.0	3.60e-01	86.1%	81.9%
3onkA00	1.25.40.90	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.51	37.0	4.05e-01	79.2%	92.7%

ECOD (11)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3656007	109.4.1.2 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Arm	0.57	47.0	3.18e-01	89.6%	54.5%
3936823	109.4.1.259 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Tra1_ring	0.56	51.0	3.54e-01	100.0%	61.5%
3938725	109.4.1.1276 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › FAT, HEAT_ATR	0.56	44.0	3.74e-01	82.7%	75.9%
3716106	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.55	49.0	3.06e-01	98.8%	37.1%
3684480	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.54	35.0	4.01e-01	79.2%	94.8%
3683778	611.3.1.0 ↗	alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	0.53	33.0	3.90e-01	74.6%	96.2%
3686247	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.52	42.0	3.08e-01	84.4%	45.4%
3486255	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.52	43.0	4.08e-01	90.8%	89.3%
4162551	611.3.1.1 ↗	alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Med26	0.52	39.0	4.15e-01	79.8%	100.0%
3988788	109.4.1.275 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Rgg_C	0.50	39.0	3.73e-01	82.1%	70.2%
3493291	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.50	38.0	3.89e-01	80.9%	80.0%