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tegument_protein_UL37

Euk-Vir

Human_alphaherpesvirus_1

tegument_protein_UL37__YP_009137112__Human_alphaherpesvirus_1__10298

Identity

Accession:
YP_009137112 ↗
Protein ID:
tegument_protein_UL37
Kingdom:
euk

Quality

73.1 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 68-194_208-227_521-580
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03970.19 best Herpes_UL37_1 217.4 3.20e-64 74.4% 58.4%
CATH (11)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4k0dA00 1.20.120.1730 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.61 41.0 4.80e-01 71.5% 97.9%
2z1qB04 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.61 30.0 3.66e-01 84.1% 70.6%
3pwxA01 1.20.1330.10 Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain 0.59 40.0 4.25e-01 71.5% 77.2%
1m57A00 1.20.210.10 Mainly Alpha › Up-down Bundle › Cytochrome C Oxidase; Chain A › Cytochrome c oxidase-like, subunit I domain 0.56 49.0 3.64e-01 94.7% 69.3%
3uonA01 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.53 46.0 4.18e-01 92.8% 77.4%
4c0eA01 1.25.40.790 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.53 38.0 3.40e-01 82.1% 52.7%
1w07A03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.53 32.0 3.54e-01 85.5% 72.6%
2id3A02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.52 32.0 3.79e-01 78.3% 88.0%
4b0zA00 1.25.40.990 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.52 35.0 3.45e-01 71.5% 61.7%
3ucaA00 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.52 45.0 4.15e-01 95.2% 98.9%
4bejB02 1.20.120.1240 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Dynamin, middle domain 0.50 31.0 3.06e-01 79.7% 55.2%
ECOD (13)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2098130 3852.1.1.1 alpha superhelices › UL37 N-terminal half › UL37 N-terminal half › UL37 N-terminal half › Herpes_UL37_1 0.98 69.0 6.09e-01 71.0% 58.2%
1283715 3852.1.1.1 alpha superhelices › UL37 N-terminal half › UL37 N-terminal half › UL37 N-terminal half › Herpes_UL37_1 0.89 83.0 6.02e-01 95.7% 94.2%
3709939 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.64 57.0 5.16e-01 96.6% 78.6%
3425142 5000.4.1.3 alpha arrays › Toxins' membrane translocation domains › delta-Endotoxin (insectocide), N-terminal domain › delta-Endotoxin (insectocide), N-terminal domain › DUF4220 0.62 55.0 5.08e-01 95.7% 88.5%
3458947 604.5.1.72 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › DUF4220 0.61 54.0 5.14e-01 95.2% 90.6%
3253843 109.4.1.470 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › INTS2 0.57 33.0 3.43e-01 90.8% 58.9%
3741179 601.3.1.13 alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain › TMEM33_Pom33 0.55 39.0 3.82e-01 72.0% 98.7%
3228662 5001.1.1.0 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like 0.55 47.0 4.30e-01 93.2% 72.5%
3369382 604.5.1.7 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › ALMT 0.54 41.0 3.84e-01 77.3% 91.4%
3708648 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.54 48.0 4.12e-01 95.2% 66.2%
4947466 3281.1.1.1 alpha complex topology › Sodium/proton antiporter subunits-like › Sodium/proton antiporter subunits-like › NADH-quinone oxidoreductase subunit L (NuoL)-related › Proton_antipo_M 0.53 47.0 3.67e-01 98.1% 73.4%
3366419 109.4.1.628 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Sec7-like_HUS 0.51 38.0 2.47e-01 82.6% 18.4%
3715189 109.3.1.0 alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat 0.50 44.0 3.86e-01 93.7% 77.4%
D2 medium residues 242-306
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03970.19 best Herpes_UL37_1 80.3 1.90e-22 92.3% 21.7%
CATH (36)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3oxfA05 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.71 61.0 5.82e-01 95.4% 89.3%
1yxrA01 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.68 57.0 5.53e-01 95.4% 100.0%
4ikhA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.68 54.0 4.35e-01 87.7% 68.5%
4aifA00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.67 56.0 4.34e-01 93.8% 61.1%
3fp3A01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.66 59.0 4.58e-01 96.9% 64.4%
4it4A02 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.66 55.0 4.90e-01 90.8% 84.6%
4fnvA01 1.50.10.100 Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › Chondroitin AC/alginate lyase 0.65 58.0 3.61e-01 100.0% 30.5%
2d9dA00 1.20.58.120 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain 0.65 55.0 4.99e-01 95.4% 93.3%
2i2xB01 1.10.1240.10 Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain 0.64 54.0 4.82e-01 100.0% 94.0%
3kfwX03 1.20.58.1460 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.64 55.0 5.25e-01 95.4% 94.7%
1s35A02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.63 52.0 4.50e-01 95.4% 91.8%
2guzB00 1.10.287.110 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › DnaJ domain 0.62 45.0 4.55e-01 80.0% 86.2%
4l7nA01 1.20.142.10 Mainly Alpha › Up-down Bundle › Poly(ADP-ribose) Polymerase; domain 1 › Poly(ADP-ribose) polymerase, regulatory domain 0.62 44.0 3.47e-01 84.6% 35.0%
3nzpB03 1.20.58.930 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 51.0 4.81e-01 93.8% 86.1%
3h36A00 1.10.10.400 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Polyribonucleotide nucleotidyltransferase, RNA-binding domain 0.60 45.0 4.29e-01 81.5% 82.1%
6vudA01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.60 47.0 4.09e-01 90.8% 91.7%
4qhpA05 1.25.50.10 Mainly Alpha › Alpha Horseshoe › Zincin-like fold › Peptidase M1, alanyl aminopeptidase, C-terminal domain 0.59 50.0 3.27e-01 100.0% 27.2%
6xxvC00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.59 45.0 3.89e-01 86.2% 85.6%
5bovB00 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.58 49.0 3.21e-01 96.9% 74.8%
4jdxF00 6.10.140.1840 Special › Helix non-globular › Helix Hairpins › 0.57 40.0 3.68e-01 87.7% 54.4%
3fbzA01 1.20.58.800 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.57 43.0 3.78e-01 83.1% 60.8%
1dtoA01 1.10.287.30 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › E2 (early) protein, N terminal domain, subdomain 1 0.57 45.0 3.94e-01 89.2% 92.2%
4j0eA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.57 40.0 2.90e-01 76.9% 32.7%
3di1A00 3.20.20.70 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I 0.57 42.0 2.71e-01 78.5% 41.7%
1cpcB00 1.10.490.20 Mainly Alpha › Orthogonal Bundle › Globin-like › Phycocyanins 0.56 44.0 3.30e-01 87.7% 53.5%
2v40A02 1.10.300.10 Mainly Alpha › Orthogonal Bundle › Adenylosuccinate Synthetase, subunit A; domain 2 › Adenylosuccinate Synthetase, subunit A, domain 2 0.56 45.0 4.13e-01 90.8% 65.9%
2jexA01 1.10.287.30 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › E2 (early) protein, N terminal domain, subdomain 1 0.56 44.0 3.92e-01 89.2% 97.9%
1f6kC00 3.20.20.70 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I 0.55 43.0 2.78e-01 83.1% 43.2%
1nklA00 1.10.225.10 Mainly Alpha › Orthogonal Bundle › NK-Lysin › Saposin-like 0.55 39.0 3.73e-01 78.5% 62.8%
4n4pD00 3.20.20.70 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I 0.54 42.0 2.74e-01 83.1% 42.4%
1b8dA00 1.10.490.20 Mainly Alpha › Orthogonal Bundle › Globin-like › Phycocyanins 0.54 43.0 3.30e-01 89.2% 52.4%
7lvlA01 3.20.20.70 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I 0.53 42.0 2.77e-01 87.7% 20.8%
4xkyA00 3.20.20.70 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I 0.51 41.0 2.74e-01 92.3% 41.3%
3cprA00 3.20.20.70 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I 0.51 41.0 2.64e-01 87.7% 29.8%
1np7A02 1.25.40.80 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.51 40.0 3.42e-01 92.3% 61.3%
1pc3A01 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.51 41.0 3.29e-01 92.3% 94.3%
ECOD (22)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2098130 3852.1.1.1 alpha superhelices › UL37 N-terminal half › UL37 N-terminal half › UL37 N-terminal half › Herpes_UL37_1 0.94 89.0 5.62e-01 100.0% 23.6%
3588615 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.70 59.0 5.37e-01 96.9% 97.8%
4380838 109.4.1.45 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › BTAD 0.69 57.0 4.28e-01 90.8% 56.9%
3285486 109.4.1.45 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › BTAD 0.69 59.0 4.45e-01 95.4% 98.8%
3583791 196.1.1.1 alpha bundles › Regulator of G-protein signaling, RGS › Regulator of G-protein signaling, RGS › Regulator of G-protein signaling, RGS › RGS 0.69 55.0 4.28e-01 86.2% 48.1%
4014764 109.4.1.913 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ARM_TBCD 0.68 48.0 3.15e-01 75.4% 18.6%
5051158 3651.1.1.0 alpha bundles › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain 0.66 58.0 4.91e-01 100.0% 91.8%
3882300 7087.1.1.1 alpha bundles › Emopamil binding protein (EBP) transmembrane domain › Emopamil binding protein (EBP) transmembrane domain › Emopamil binding protein (EBP) transmembrane domain › EBP 0.66 56.0 4.13e-01 95.4% 58.9%
3555742 103.1.1.0 alpha arrays › RuvA-C › RuvA-C, UBA, CRAL/TRIO-N, HBS1 › UBA-like domain 0.65 54.0 5.09e-01 100.0% 89.4%
3170874 109.4.1.2352 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF29558, PF29954, PF29957 0.65 55.0 3.22e-01 100.0% 16.1%
5029796 192.2.1.0 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.64 44.0 3.62e-01 72.3% 60.8%
3621979 3198.1.1.1 alpha bundles › ABA-1 repeat unit › ABA-1 repeat unit › ABA-1 repeat unit › NPA 0.63 49.0 4.12e-01 87.7% 50.8%
4466183 4967.1.1.0 alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases 0.63 52.0 4.56e-01 95.4% 87.6%
3224841 633.21.1.0 alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 0.61 51.0 4.11e-01 92.3% 72.8%
3188288 109.4.1.268 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › LARP1_HEAT 0.59 48.0 4.11e-01 98.5% 90.8%
4365191 141.1.1.2 alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases › SQS_PSY 0.57 49.0 3.03e-01 95.4% 32.6%
3941188 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.56 47.0 3.99e-01 100.0% 80.0%
5079626 316.1.1.18 a+b three layers › Nucleotidyltransferase-like › Nucleotidyltransferase › Nucleotidyltransferase › AbiEii 0.54 46.0 3.28e-01 100.0% 40.0%
4958038 2002.1.1.29 a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › DHDPS 0.54 40.0 2.60e-01 78.5% 41.0%
3798361 193.1.1.0 alpha bundles › CH domain-like › Calponin-homology domain-like › Calponin-homology domain-like 0.53 40.0 3.30e-01 83.1% 66.4%
3495156 109.58.1.1 alpha superhelices › Repetitive alpha hairpins › DNA repair protein Rev1 C-terminal domain › DNA repair protein Rev1 C-terminal domain › REV1_C 0.53 42.0 3.97e-01 92.3% 77.6%
1395462 4953.1.1.0 beta barrels › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like 0.52 39.0 3.30e-01 86.2% 51.6%
D3 medium residues 307-370
PDB
Domain cluster: representative
CATH (2)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
5hzlB01 3.80.10.10 Alpha Beta › Alpha-Beta Horseshoe › Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) › Ribonuclease Inhibitor 0.53 43.0 3.12e-01 92.2% 61.6%
3p2hA00 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.52 38.0 2.84e-01 81.2% 59.2%
D4 medium residues 371-520
PDB
CATH (12)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2wzkA03 1.20.1310.10 Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats 0.65 46.0 5.31e-01 99.3% 99.1%
7ldgA00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.59 46.0 4.08e-01 99.3% 55.9%
2l1lB00 1.20.1440.250 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 0.57 37.0 4.01e-01 71.3% 76.4%
4crwA00 1.25.40.180 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.54 41.0 3.65e-01 96.7% 54.0%
5cy5B00 1.20.1200.10 Mainly Alpha › Up-down Bundle › Hypothetical Protein Ta1238; Chain: A; › Cobalamin adenosyltransferase-like 0.53 41.0 4.12e-01 79.3% 91.3%
1wcrA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.53 35.0 4.16e-01 93.3% 99.0%
2qibB00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.52 40.0 3.60e-01 100.0% 58.2%
2onkC00 1.10.3720.10 Mainly Alpha › Orthogonal Bundle › MetI-like fold › MetI-like 0.52 43.0 3.62e-01 87.3% 76.2%
4hkuB00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.51 42.0 4.01e-01 100.0% 75.1%
2ajaA00 1.25.40.20 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Ankyrin repeat-containing domain 0.51 43.0 3.35e-01 91.3% 43.4%
4dloB02 1.25.40.610 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.51 35.0 3.82e-01 88.7% 88.9%
3zc0D00 1.20.58.2140 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.50 43.0 4.01e-01 93.3% 90.9%
ECOD (18)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1283715 3852.1.1.1 alpha superhelices › UL37 N-terminal half › UL37 N-terminal half › UL37 N-terminal half › Herpes_UL37_1 0.92 76.0 5.09e-01 100.0% 26.3%
4132802 507.1.1.1 alpha arrays › DnaB helicase N-terminal domain-related › DnaB helicase N-terminal domain-related › DnaB helicase N-terminal domain-related › DnaB 0.60 36.0 3.65e-01 87.3% 58.7%
3601804 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.56 50.0 4.08e-01 100.0% 88.5%
3853711 109.4.1.1224 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_DOCK9 0.56 49.0 3.79e-01 97.3% 66.9%
3453655 174.1.1.0 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.55 33.0 3.56e-01 93.3% 68.0%
5047093 3883.1.1.1 alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf 0.54 39.0 3.58e-01 74.0% 76.4%
3435257 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.54 34.0 3.67e-01 96.0% 74.4%
3476318 109.34.1.1 alpha superhelices › Repetitive alpha hairpins › 26S proteasome subunit Rpn2 N-terminal domain › 26S proteasome subunit Rpn2 N-terminal domain › RPN1_RPN2_N 0.53 38.0 3.04e-01 100.0% 34.9%
3866268 109.4.1.235 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › SRP68 0.53 45.0 3.80e-01 94.7% 55.9%
4017969 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.53 47.0 3.26e-01 100.0% 56.7%
3250614 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.52 44.0 3.93e-01 93.3% 70.9%
3910413 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.51 40.0 3.70e-01 89.3% 63.1%
3808736 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.51 45.0 3.84e-01 99.3% 89.0%
3405149 5000.6.1.1 alpha arrays › Toxins' membrane translocation domains › Tethering factor for nuclear proteasome cut8 › Tethering factor for nuclear proteasome cut8 › Cut8 0.50 43.0 3.96e-01 98.7% 71.8%
3655114 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.50 38.0 3.89e-01 94.7% 84.3%
5071234 4070.1.1.2 alpha arrays › FtsH protease domain-like › FtsH protease domain-like › FtsH protease domain-like › Peptidase_M50 0.50 38.0 3.53e-01 79.3% 84.5%
3252711 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.50 43.0 2.98e-01 100.0% 24.8%
3801633 3684.1.1.0 alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like 0.50 39.0 3.86e-01 80.7% 95.5%
D5 medium residues 597-729
PDB
Domain cluster: representative
CATH (19)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1tqgA00 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.77 58.0 6.43e-01 77.4% 100.0%
1y4cA03 1.20.120.660 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain 0.76 56.0 6.02e-01 75.9% 98.2%
3kyiA00 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.75 55.0 5.63e-01 75.9% 82.0%
3pwxA01 1.20.1330.10 Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain 0.75 58.0 5.19e-01 81.2% 70.7%
3u8vA00 1.20.120.660 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain 0.74 46.0 5.70e-01 74.4% 100.0%
1sj7C00 1.20.1420.10 Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain 0.73 54.0 5.00e-01 75.9% 74.7%
4w8pA02 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.72 53.0 5.43e-01 76.7% 95.4%
2kmfA01 1.20.58.810 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Photosystem II Pbs27 0.72 53.0 5.97e-01 86.5% 100.0%
4o6yB00 1.20.120.1770 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.70 64.0 5.48e-01 100.0% 91.9%
2vpzC00 1.20.1630.10 Mainly Alpha › Up-down Bundle › Formate dehydrogenase/DMSO reductase fold › Formate dehydrogenase/DMSO reductase domain 0.67 52.0 4.26e-01 82.7% 92.4%
1bbhA00 1.20.120.10 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c/b562 0.67 50.0 5.12e-01 78.9% 100.0%
1q0gA00 1.20.120.400 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nickel-containing superoxide dismutase 0.64 52.0 5.54e-01 85.7% 100.0%
3fhnA03 1.10.357.100 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Dsl1p vesicle tethering complex, Tip20p subunit, domain C 0.58 42.0 3.86e-01 74.4% 81.0%
5dqqA01 1.20.120.350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C 0.58 45.0 4.59e-01 82.0% 95.3%
3tm8B00 1.10.3210.10 Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 0.57 45.0 3.49e-01 83.5% 84.7%
4qreA03 1.10.730.10 Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 0.54 45.0 4.17e-01 90.2% 94.2%
1izmA00 1.20.120.740 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YgfB uncharacterised protein family PF03695 0.53 44.0 4.10e-01 90.2% 78.2%
2xgjA03 1.10.3380.30 Mainly Alpha › Orthogonal Bundle › Sec63 N-terminal domain-like fold › 0.53 43.0 3.73e-01 88.7% 80.0%
7dswA01 1.20.1530.20 Mainly Alpha › Up-down Bundle › Na+/H+ antiporter like fold › 0.53 44.0 3.22e-01 94.0% 74.3%
ECOD (20)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5074120 601.28.1.0 alpha bundles › Four-helical up-and-down bundle › VPS28 C-terminal domain-like › VPS28 C-terminal domain-like 0.74 52.0 5.98e-01 88.7% 100.0%
3519442 192.29.1.0 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.72 56.0 5.28e-01 80.5% 89.7%
3718416 601.16.1.0 alpha bundles › Four-helical up-and-down bundle › FAT domain of focal adhesion kinase › FAT domain of focal adhesion kinase 0.72 60.0 5.71e-01 88.7% 80.0%
3487768 601.16.1.0 alpha bundles › Four-helical up-and-down bundle › FAT domain of focal adhesion kinase › FAT domain of focal adhesion kinase 0.71 54.0 5.35e-01 78.9% 97.9%
5074606 601.28.1.0 alpha bundles › Four-helical up-and-down bundle › VPS28 C-terminal domain-like › VPS28 C-terminal domain-like 0.71 51.0 5.76e-01 78.9% 100.0%
3401856 601.34.1.1 alpha bundles › Four-helical up-and-down bundle › F-actin binding domain of Abl › F-actin binding domain of Abl › F_actin_bind 0.68 53.0 5.71e-01 81.2% 100.0%
3704187 601.28.1.1 alpha bundles › Four-helical up-and-down bundle › VPS28 C-terminal domain-like › VPS28 C-terminal domain-like › VPS28 0.68 51.0 5.51e-01 91.7% 94.5%
3464862 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.68 52.0 4.26e-01 79.7% 70.0%
4609538 192.29.1.0 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.67 51.0 5.46e-01 79.7% 91.3%
2539030 601.2.1.4 alpha bundles › Four-helical up-and-down bundle › Cytochromes › Cytochromes › Cytochrom_C_2 0.67 53.0 5.76e-01 86.5% 100.0%
4944703 192.29.1.0 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.65 51.0 5.21e-01 83.5% 100.0%
5010969 5069.1.1.105 alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › DUF973 0.65 55.0 5.38e-01 99.2% 82.8%
4879693 5054.1.1.0 alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels 0.64 50.0 5.01e-01 82.0% 92.7%
3261143 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.58 46.0 4.21e-01 83.5% 83.9%
5018475 192.29.1.0 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.58 46.0 4.78e-01 97.0% 94.2%
3727319 601.1.1.77 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › DUF3176 0.56 47.0 4.26e-01 92.5% 93.5%
4998788 3236.1.1.1 alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_Exchanger 0.55 47.0 3.40e-01 94.0% 72.5%
3703129 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.55 41.0 3.65e-01 79.7% 78.0%
4376682 604.39.1.26 alpha bundles › Spectrin repeat-like › S-component of energy-coupling factor (ECF) transporters › S-component of energy-coupling factor (ECF) transporters › 5TM-5TMR_LYT 0.52 41.0 3.75e-01 84.2% 98.9%
3355425 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.51 39.0 3.67e-01 82.0% 77.1%
D6 medium residues 741-972
PDB
CATH (28)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3uumA00 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.80 43.0 5.89e-01 83.2% 99.2%
1bf5A01 1.20.1050.20 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › STAT transcription factor, all-alpha domain 0.80 50.0 5.83e-01 71.1% 85.7%
3l8rA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.79 36.0 5.47e-01 86.2% 100.0%
1sumB01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.77 37.0 5.38e-01 70.7% 100.0%
1vctA01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.76 37.0 5.35e-01 88.8% 98.2%
6t0bc02 1.20.120.80 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle 0.76 38.0 4.25e-01 90.9% 58.6%
2i0mA01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.76 37.0 5.34e-01 90.5% 100.0%
1quuA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.76 42.0 5.54e-01 83.2% 97.6%
1t72A01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.76 39.0 5.50e-01 91.4% 100.0%
3rkgA02 1.20.58.340 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region 0.74 45.0 5.29e-01 86.6% 84.1%
3l39A01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.74 36.0 3.89e-01 83.2% 53.0%
2iiuA00 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.69 35.0 3.75e-01 84.9% 53.4%
6h2dS01 1.20.1170.10 Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › 0.67 53.0 5.46e-01 81.0% 90.6%
1dn1B00 1.20.58.70 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.64 46.0 4.71e-01 72.4% 80.2%
4oydB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.62 32.0 4.49e-01 96.6% 100.0%
6p73A02 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.60 29.0 3.73e-01 98.7% 75.5%
2v0xA01 1.10.287.3160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.59 37.0 4.31e-01 83.6% 86.3%
3kavA00 1.20.1270.360 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.59 23.0 3.56e-01 91.4% 85.3%
4fzsA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.58 41.0 4.32e-01 71.1% 88.5%
4hr1A00 1.20.1270.410 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.56 25.0 3.55e-01 90.9% 83.9%
3i9wA00 1.20.58.920 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.55 38.0 3.62e-01 77.6% 60.0%
3qweA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.54 39.0 3.74e-01 72.4% 81.9%
7zo9A01 1.20.1560.10 Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain 0.54 37.0 3.32e-01 94.8% 49.5%
4wpeA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.53 38.0 3.59e-01 72.8% 79.3%
1v9dB00 1.20.58.2220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Formin, FH2 domain 0.52 49.0 4.32e-01 100.0% 86.6%
4im0A04 1.20.1270.420 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.51 38.0 3.80e-01 75.0% 76.9%
1xwmA00 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.51 39.0 4.09e-01 90.1% 84.9%
2v0oB00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.51 37.0 3.50e-01 73.3% 77.1%
ECOD (28)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1760269 3567.1.1.0 a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer 0.84 43.0 6.07e-01 70.3% 99.1%
4026675 603.1.1.172 alpha bundles › STAT-like › t-snare proteins › t-snare proteins › DUF1617 0.82 42.0 5.91e-01 76.3% 100.0%
3282593 4121.1.1.1 a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › CorA 0.81 48.0 4.76e-01 86.2% 56.7%
5067572 604.5.1.0 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) 0.80 38.0 5.62e-01 86.6% 100.0%
4985142 604.5.1.1 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU_div 0.79 38.0 3.98e-01 70.3% 49.8%
3394455 3602.1.1.17 alpha bundles › Kinase suppressor of Ras 1 helical hairpin domain › Kinase suppressor of Ras 1 helical hairpin domain › Kinase suppressor of Ras 1 helical hairpin domain › KIF21A_4th 0.77 52.0 4.63e-01 74.1% 50.2%
4535653 604.5.1.1 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU_div 0.72 37.0 3.85e-01 81.5% 52.1%
3583890 603.1.1.3 alpha bundles › STAT-like › t-snare proteins › t-snare proteins › V-SNARE 0.70 38.0 4.79e-01 87.9% 84.8%
3494933 632.22.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.67 47.0 4.10e-01 70.7% 49.0%
3639947 603.1.1.1 alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin 0.65 42.0 4.64e-01 87.9% 80.0%
3699731 109.4.1.1375 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_SYVN1_N 0.64 32.0 3.08e-01 79.3% 41.2%
3758651 633.23.1.34 alpha bundles › Bromodomain-like › Claudin › Claudin › CD20 0.64 42.0 4.58e-01 75.4% 78.9%
5001630 604.5.1.2 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU 0.61 35.0 4.03e-01 86.6% 74.7%
4991905 3684.1.1.0 alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like 0.61 53.0 4.94e-01 91.8% 83.9%
4013285 4121.1.1.0 a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like 0.60 46.0 4.55e-01 84.9% 75.8%
3491073 5001.1.1.1 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.58 48.0 4.22e-01 85.3% 80.6%
4018104 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.57 41.0 3.81e-01 73.7% 64.1%
4549103 3755.4.1.54 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › PF30340 0.57 45.0 3.69e-01 80.2% 82.4%
3726222 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.57 37.0 3.74e-01 79.3% 63.9%
3168919 4177.1.1.1 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH 0.56 40.0 3.71e-01 72.4% 77.1%
5082020 3922.1.1.0 alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 0.55 42.0 3.60e-01 78.9% 68.6%
3779631 4177.1.1.0 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like 0.54 39.0 4.21e-01 100.0% 85.5%
3614118 2004.1.1.87 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N 0.52 38.0 2.85e-01 73.3% 89.0%
3599997 2004.1.1.0 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.52 40.0 2.67e-01 79.7% 92.5%
3713380 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.51 42.0 4.02e-01 86.6% 74.1%
4033880 604.5.1.1 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU_div 0.51 35.0 3.80e-01 91.4% 81.0%
3173337 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.50 42.0 3.79e-01 85.8% 93.1%
3250469 7015.1.1.0 alpha bundles › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain 0.50 45.0 4.20e-01 96.1% 77.5%