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tegument_protein_UL37

Euk-Vir

Human_alphaherpesvirus_2

tegument_protein_UL37__YP_009137189__Human_alphaherpesvirus_2__10310

Identity

Accession:
YP_009137189 ↗
Protein ID:
tegument_protein_UL37
Kingdom:
euk

Quality

75.3 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 54-123_144-163
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03970.19 best Herpes_UL37_1 82.4 4.50e-23 76.7% 24.7%
CATH (11)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1t72A01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.68 50.0 4.62e-01 77.8% 88.9%
4atgA00 1.25.40.770 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › TAF6, C-terminal HEAT repeat domain 0.65 57.0 4.47e-01 98.9% 52.3%
4hxiB03 1.20.1310.10 Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats 0.60 44.0 4.31e-01 78.9% 86.9%
4adnA01 1.20.1280.250 Mainly Alpha › Up-down Bundle › Monooxygenase › 0.60 40.0 4.11e-01 71.1% 72.9%
4k0dA00 1.20.120.1730 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.58 42.0 3.71e-01 77.8% 61.5%
6pwkA02 3.20.20.450 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › EAL domain 0.57 48.0 3.59e-01 93.3% 57.6%
1oj6A00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.56 40.0 3.44e-01 74.4% 92.5%
1a7eA00 1.20.120.50 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hemerythrin-like 0.56 40.0 3.66e-01 74.4% 63.6%
2wl8C00 1.20.120.900 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Pex19, mPTS binding domain 0.54 35.0 3.35e-01 95.6% 55.0%
1peqA02 3.20.70.20 Alpha Beta › Alpha-Beta Barrel › Anaerobic Ribonucleotide-triphosphate Reductase Large Chain › 0.53 44.0 2.85e-01 95.6% 57.7%
6wfqC01 1.20.120.530 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like 0.53 36.0 3.13e-01 70.0% 78.9%
ECOD (16)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2098130 3852.1.1.1 alpha superhelices › UL37 N-terminal half › UL37 N-terminal half › UL37 N-terminal half › Herpes_UL37_1 0.98 94.0 6.34e-01 98.9% 39.6%
1283715 3852.1.1.1 alpha superhelices › UL37 N-terminal half › UL37 N-terminal half › UL37 N-terminal half › Herpes_UL37_1 0.88 82.0 5.00e-01 100.0% 21.4%
3240652 109.4.1.643 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › COG2_C 0.68 60.0 3.69e-01 100.0% 30.6%
2770625 109.4.1.75 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › IFRD 0.66 57.0 3.91e-01 97.8% 88.1%
4565292 109.4.1.1911 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF30136 0.66 57.0 4.24e-01 97.8% 38.7%
3563504 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.64 57.0 3.89e-01 100.0% 37.0%
3246978 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.63 47.0 4.34e-01 78.9% 84.3%
3632112 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.60 51.0 4.90e-01 93.3% 92.4%
3412402 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.58 40.0 3.69e-01 78.9% 55.7%
3688112 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.57 48.0 3.77e-01 94.4% 48.0%
3730713 109.4.1.194 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_10 0.57 48.0 4.53e-01 95.6% 90.0%
54604 601.14.1.0 alpha bundles › Four-helical up-and-down bundle › Hemerythrin › Hemerythrin 0.55 39.0 3.65e-01 74.4% 63.6%
3561335 3755.4.1.37 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › TPR-like_Epg5_mid 0.55 46.0 4.20e-01 93.3% 91.2%
5050812 2498.1.1.0 mixed a+b and a/b › Zincin-like › "Metalloproteases (""zincins"") catalytic domain" › "Metalloproteases (""zincins"") catalytic domain" 0.55 43.0 3.14e-01 97.8% 29.8%
3500309 4967.1.1.0 alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases 0.51 40.0 4.01e-01 100.0% 81.1%
3358920 150.1.1.133 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › PIEZO 0.51 36.0 3.29e-01 76.7% 73.8%
D2 medium residues 124-143_164-207
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03970.19 best Herpes_UL37_1 43.7 2.80e-11 78.1% 13.9%
CATH (15)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3k59A06 1.10.287.690 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › B family DNA polymerase, finger domain 0.75 53.0 5.98e-01 73.4% 100.0%
2i9cA01 1.25.40.70 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Phosphatidylinositol 3-kinase, accessory domain (PIK) 0.74 51.0 4.28e-01 84.4% 42.3%
3r2qA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.73 56.0 4.69e-01 84.4% 79.6%
3nymA00 6.10.290.10 Special › Helix non-globular › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.70 58.0 4.71e-01 93.8% 52.4%
4bx8A03 3.90.830.10 Alpha Beta › Alpha-Beta Complex › Syntaxin Binding Protein 1; Chain A, domain 2 › Sec1/Munc18 (SM) protein, domain 3a 0.70 55.0 4.62e-01 85.9% 50.9%
2mpkA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.68 56.0 5.33e-01 90.6% 87.8%
2v6yA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.67 47.0 4.48e-01 78.1% 62.7%
4h63H01 1.20.58.1710 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.67 51.0 4.94e-01 84.4% 73.6%
1k04A02 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.67 60.0 5.04e-01 98.4% 64.4%
1z0jB00 4.10.860.20 Few Secondary Structures › Irregular › DNA Excision Repair, Uvrb; Chain A › Rabenosyn, Rab binding domain 0.66 47.0 5.07e-01 84.4% 96.1%
1z0pA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.64 52.0 5.02e-01 93.8% 80.8%
1ydxA02 1.10.287.1120 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Bipartite methylase S protein 0.64 50.0 4.53e-01 87.5% 74.4%
2crbA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.62 49.0 4.36e-01 89.1% 66.0%
4h63K00 1.10.287.3490 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.62 47.0 4.19e-01 92.2% 55.1%
1m5iA00 1.10.287.450 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.59 46.0 3.99e-01 87.5% 89.5%
ECOD (10)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3486248 6132.1.1.0 alpha bundles › Nudix hydrolase N-terminal dimerization domain › Nudix hydrolase N-terminal dimerization domain › Nudix hydrolase N-terminal dimerization domain 0.82 58.0 5.80e-01 82.8% 72.3%
3482224 192.10.1.0 alpha bundles › Long alpha-hairpin › DnaK suppressor protein DksA, alpha-hairpin domain › DnaK suppressor protein DksA, alpha-hairpin domain 0.81 57.0 5.76e-01 82.8% 72.3%
5071514 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.76 53.0 5.07e-01 73.4% 70.7%
3383427 192.17.1.14 alpha bundles › Long alpha-hairpin › Rabenosyn-5 Rab-binding domain-like › Rabenosyn-5 Rab-binding domain-like › DUF3755 0.72 54.0 4.97e-01 79.7% 71.2%
3738041 192.5.1.1 alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat › HR1 0.71 56.0 5.09e-01 85.9% 70.6%
3614078 3922.1.1.0 alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 0.67 53.0 4.38e-01 89.1% 49.2%
4945931 192.2.1.0 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.64 49.0 4.80e-01 87.5% 77.1%
4386662 3291.1.1.158 alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Seryl_tRNA_N 0.64 48.0 4.02e-01 82.8% 70.4%
3960783 605.1.1.1 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA 0.63 49.0 4.66e-01 87.5% 70.0%
3863804 5.1.4.17 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › CPSF_A,MMS1_N 0.53 41.0 2.33e-01 84.4% 29.1%
D3 medium residues 208-285
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03970.19 best Herpes_UL37_1 116.0 2.60e-33 100.0% 27.3%
CATH (13)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2pmsC00 6.10.140.920 Special › Helix non-globular › Helix Hairpins › 0.63 51.0 4.61e-01 89.7% 83.5%
3ns4A00 1.10.357.110 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Vacuolar protein sorting-associated protein 53, C-terminus 0.62 54.0 4.04e-01 100.0% 51.2%
3nbxX03 1.20.58.1510 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 45.0 4.17e-01 78.2% 89.1%
3mq1A01 1.20.58.970 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 41.0 3.89e-01 70.5% 57.6%
4mhcA01 1.20.58.1780 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.59 47.0 3.35e-01 88.5% 96.3%
4hojA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.57 48.0 4.43e-01 93.6% 91.3%
2wvlB00 3.90.550.10 Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A 0.57 48.0 3.03e-01 91.0% 75.1%
3apzA00 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.56 48.0 3.33e-01 100.0% 74.6%
6lumD01 1.20.1300.10 Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit 0.56 45.0 3.94e-01 91.0% 71.2%
4ie5A02 1.20.58.1470 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › FTO C-terminal domain 0.55 48.0 4.01e-01 96.2% 76.9%
1gwiA00 1.10.630.10 Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450 0.54 45.0 2.89e-01 94.9% 67.2%
1cmjA00 1.10.630.10 Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450 0.52 45.0 2.84e-01 94.9% 27.3%
1yxrA01 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.52 38.0 3.93e-01 92.3% 83.8%
ECOD (22)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2098130 3852.1.1.1 alpha superhelices › UL37 N-terminal half › UL37 N-terminal half › UL37 N-terminal half › Herpes_UL37_1 0.96 92.0 6.03e-01 100.0% 28.4%
4232718 4006.1.1.1 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF 0.74 59.0 5.48e-01 87.2% 86.0%
3710154 2007.2.3.9 a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › PTPlike_phytase 0.70 50.0 3.73e-01 74.4% 71.1%
4009532 2004.1.1.73 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › MMR_HSR1 0.68 56.0 3.79e-01 88.5% 89.8%
4129436 4006.1.1.1 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF 0.68 53.0 4.83e-01 85.9% 79.0%
3225544 4006.1.1.0 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain 0.68 53.0 4.92e-01 85.9% 76.0%
3684830 4006.1.1.1 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF 0.66 51.0 4.79e-01 85.9% 76.0%
4293733 4006.1.1.1 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF 0.66 52.0 4.78e-01 87.2% 81.0%
4682501 4006.1.1.1 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF 0.65 51.0 4.79e-01 87.2% 82.0%
3518386 192.1.1.0 alpha bundles › Long alpha-hairpin › GreA transcript cleavage protein, N-terminal domain › GreA transcript cleavage protein, N-terminal domain 0.65 51.0 5.21e-01 93.6% 86.7%
3646025 632.22.1.67 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › DUF842 0.65 45.0 3.74e-01 71.8% 51.9%
3631582 604.7.1.0 alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A 0.64 42.0 3.93e-01 70.5% 53.0%
3996074 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.63 44.0 3.05e-01 73.1% 31.9%
3473592 605.1.1.244 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › XK-related 0.62 42.0 4.08e-01 92.3% 61.1%
3261105 632.11.1.2 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like › DOCK_N 0.59 49.0 4.64e-01 93.6% 74.7%
3276975 3826.1.1.0 alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) 0.58 45.0 3.78e-01 83.3% 60.0%
4970557 604.12.1.0 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.58 42.0 4.41e-01 91.0% 84.3%
3698336 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.57 47.0 4.60e-01 89.7% 84.7%
3177273 5069.1.1.4 alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Ferric_reduct 0.56 48.0 3.44e-01 100.0% 35.7%
3581466 604.12.1.1 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › MIT 0.55 46.0 4.61e-01 98.7% 88.7%
5074225 604.5.1.0 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) 0.52 44.0 4.23e-01 92.3% 83.3%
4319899 142.1.1.1 alpha complex topology › Sigma2 domain-like › Sigma2 domain of RNA polymerase sigma factors › Sigma2 domain of RNA polymerase sigma factors › Sigma70_r1_2,Sigma70_r2 0.51 42.0 2.95e-01 97.4% 61.0%