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tegument_protein_UL37

Euk-Vir

Suid_alphaherpesvirus_1

tegument_protein_UL37__YP_068340__Suid_alphaherpesvirus_1__10345

Identity

Accession:: YP_068340 ↗
Protein ID:: tegument_protein_UL37
Kingdom:: euk

Quality

84.1 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Varicellovirus› Suid_alphaherpesvirus_1

TaxID: 10345

Cluster

View cluster (39 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 494-635

PDB

Domain cluster: rep: tegument_protein_UL37__YP_009137112__Human_alphaherpesvirus_1__10298__D597-729

D2 medium residues 1-110

PDB

Domain cluster: rep: tegument_protein_UL37__YP_009137189__Human_alphaherpesvirus_2__10310__D54-123_144-163

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03970.19 best	Herpes_UL37_1	51.0	1.70e-13	96.4%	38.6%

CATH (18)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4i2zA03	1.25.10.10	Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant	0.64	57.0	3.90e-01	100.0%	32.8%
1fmiA00	1.50.10.10	Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase ›	0.63	57.0	3.78e-01	100.0%	28.1%
2v8iA01	1.50.10.20	Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase ›	0.63	57.0	3.86e-01	100.0%	31.6%
1nxcA00	1.50.10.10	Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase ›	0.63	57.0	3.74e-01	100.0%	28.7%
4i1eA03	1.25.10.30	Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › IP3 receptor type 1 binding core, RIH domain	0.63	43.0	3.99e-01	70.0%	91.4%
1b3uA00	1.25.10.10	Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant	0.63	54.0	3.41e-01	100.0%	17.9%
3lpzA01	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.63	54.0	3.96e-01	100.0%	34.8%
4k0dA00	1.20.120.1730	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) ›	0.63	43.0	3.99e-01	70.9%	57.3%
2gz6A00	1.50.10.10	Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase ›	0.60	53.0	3.67e-01	98.2%	40.6%
4u2xF00	1.25.10.10	Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant	0.59	52.0	4.57e-01	100.0%	73.1%
1t5oA01	1.20.120.420	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › translation initiation factor eif-2b, domain 1	0.58	42.0	3.97e-01	98.2%	60.3%
1at9A00	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.57	39.0	3.13e-01	71.8%	39.1%
1wzzA00	1.50.10.10	Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase ›	0.56	50.0	3.63e-01	99.1%	46.4%
5kbwB00	1.10.1760.20	Mainly Alpha › Orthogonal Bundle › Arp2/3 complex 21 kDa subunit ARPC3 ›	0.55	43.0	3.78e-01	84.5%	56.1%
3anwA01	1.20.58.1030	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.53	37.0	3.67e-01	70.9%	86.7%
3rlbA00	1.10.1760.20	Mainly Alpha › Orthogonal Bundle › Arp2/3 complex 21 kDa subunit ARPC3 ›	0.52	41.0	3.60e-01	86.4%	95.5%
7yb9A01	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.51	43.0	3.52e-01	99.1%	47.7%
7wf8B01	1.10.167.10	Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › Regulator of G-protein Signalling 4, domain 2	0.50	32.0	3.17e-01	81.8%	57.0%

ECOD (27)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1283715	3852.1.1.1 ↗	alpha superhelices › UL37 N-terminal half › UL37 N-terminal half › UL37 N-terminal half › Herpes_UL37_1	1.00	98.0	6.07e-01	100.0%	22.8%
2098130	3852.1.1.1 ↗	alpha superhelices › UL37 N-terminal half › UL37 N-terminal half › UL37 N-terminal half › Herpes_UL37_1	0.92	88.0	6.28e-01	100.0%	42.9%
3379198	109.4.1.299 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Ltn1_1st	0.71	63.0	3.70e-01	99.1%	13.8%
3626760	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.69	61.0	4.77e-01	100.0%	46.5%
3926014	109.4.1.156 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › UNC45-central	0.65	56.0	4.87e-01	99.1%	61.1%
3332657	109.4.1.1269 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, E_motif	0.64	51.0	5.17e-01	100.0%	85.5%
3303906	109.4.1.420 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR	0.64	51.0	4.77e-01	100.0%	68.9%
3710552	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.64	55.0	3.28e-01	100.0%	12.7%
3430171	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.63	57.0	3.79e-01	100.0%	24.7%
3663224	109.4.1.299 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Ltn1_1st	0.63	56.0	3.26e-01	99.1%	13.3%
3520817	109.4.1.93 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TAF6_C	0.63	56.0	4.17e-01	100.0%	56.6%
3610156	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.63	57.0	5.36e-01	100.0%	84.4%
4025075	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.63	56.0	3.98e-01	100.0%	35.9%
3466128	109.4.1.420 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR	0.61	50.0	4.64e-01	99.1%	70.0%
3608418	109.4.1.1403 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ARM_TBCD, ARM_TBCD_2nd	0.61	53.0	3.42e-01	100.0%	21.2%
4945946	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.60	54.0	4.48e-01	100.0%	56.4%
3644352	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.58	45.0	4.39e-01	99.1%	74.4%
4078449	1002.1.1.1 ↗	alpha complex topology › Fluoride ion channel › Fluoride ion channel › Fluoride ion channel › CRCB	0.58	44.0	4.28e-01	81.8%	91.9%
3712286	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.57	50.0	3.96e-01	99.1%	73.3%
3709348	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.57	48.0	4.79e-01	98.2%	89.6%
3183030	101.1.2.519 ↗	alpha arrays › HTH › HTH › winged helix domain › DUF7791	0.56	50.0	4.09e-01	100.0%	83.4%
3699486	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.56	48.0	4.49e-01	99.1%	77.1%
3688112	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.55	48.0	4.01e-01	100.0%	57.0%
3817666	109.4.1.585 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › DUF627	0.54	45.0	3.54e-01	100.0%	40.8%
None	—		0.54	44.0	3.41e-01	88.2%	48.6%
4131976	3651.1.1.1 ↗	alpha bundles › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › IF-2B	0.53	45.0	4.07e-01	98.2%	68.7%
3504428	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.51	42.0	3.98e-01	99.1%	73.8%

D3 medium residues 111-197_435-485

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03970.19 best	Herpes_UL37_1	52.9	4.70e-14	71.0%	33.7%

CATH (10)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4p9tA01	1.20.120.230	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like	0.65	33.0	3.58e-01	83.3%	55.8%
8a1gC01	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.63	40.0	3.64e-01	79.0%	48.1%
4aflA00	6.10.140.1740	Special › Helix non-globular › Helix Hairpins ›	0.60	36.0	4.13e-01	81.9%	80.4%
2aniA00	1.10.620.20	Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A	0.58	52.0	3.95e-01	97.8%	72.9%
2xokP00	1.20.20.10	Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C	0.57	30.0	3.85e-01	72.5%	91.9%
1dowA00	1.20.120.230	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like	0.53	43.0	3.81e-01	98.6%	59.0%
5an3A01	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.52	31.0	3.23e-01	84.8%	62.0%
3g67A00	1.10.287.950	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein	0.52	39.0	3.35e-01	79.0%	50.7%
3v0aB02	1.20.1120.10	Mainly Alpha › Up-down Bundle › "Clostridium botulinum neurotoxin B, ""coiled-coil"" domain" › "Clostridium botulinum neurotoxin b, ""coiled-coil"" domain"	0.52	45.0	3.41e-01	94.9%	95.5%
3zdqA01	1.20.1560.10	Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain	0.50	41.0	3.11e-01	87.7%	37.2%

ECOD (15)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1283715	3852.1.1.1 ↗	alpha superhelices › UL37 N-terminal half › UL37 N-terminal half › UL37 N-terminal half › Herpes_UL37_1	0.99	93.0	6.02e-01	95.7%	76.6%
4640120	621.1.1.3 ↗	alpha bundles › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Sey1_3HB	0.67	48.0	3.47e-01	74.6%	51.2%
4213023	621.1.1.3 ↗	alpha bundles › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Sey1_3HB	0.64	49.0	3.92e-01	81.2%	75.8%
4029887	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.61	52.0	4.01e-01	92.8%	75.8%
3960659	150.8.1.1 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › PPE › PPE › PPE	0.61	35.0	3.70e-01	79.7%	62.5%
3612683	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.60	51.0	4.24e-01	94.2%	80.8%
3260171	621.1.1.3 ↗	alpha bundles › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Sey1_3HB	0.57	39.0	3.62e-01	70.3%	77.8%
3472115	310.2.1.0 ↗	a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF	0.55	41.0	4.26e-01	94.2%	84.0%
3635376	3755.3.1.298 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › ING	0.52	39.0	4.03e-01	79.0%	86.7%
4993207	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.51	43.0	4.32e-01	91.3%	89.3%
4092812	1075.4.1.1 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane	0.51	43.0	3.26e-01	90.6%	39.1%
2321068	109.4.1.128 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › MIF4G_like_2	0.51	44.0	3.49e-01	94.2%	49.8%
4015178	3755.4.1.0 ↗	alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain	0.51	38.0	3.72e-01	79.0%	71.0%
3713723	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.50	44.0	3.18e-01	99.3%	84.5%
4663129	3922.1.1.0 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3	0.50	37.0	2.98e-01	77.5%	97.0%

D4 medium residues 198-295

PDB

Domain cluster: rep: tegument_protein_UL37__YP_009176900__Testudinid_alphaherpesvirus_3__2560801__D261-389

CATH (24)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1htmD00	3.90.20.10	Alpha Beta › Alpha-Beta Complex › Hemagglutinin Ectodomain; Chain B ›	0.63	37.0	3.44e-01	95.9%	45.5%
2imiB02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.62	45.0	3.96e-01	74.5%	78.6%
2xmoA02	1.10.246.180	Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 ›	0.58	32.0	3.38e-01	73.5%	58.1%
4malA00	1.20.58.2200	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.56	33.0	3.78e-01	74.5%	89.8%
2diwA01	1.25.40.90	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.55	41.0	3.68e-01	79.6%	90.8%
2hujA00	1.20.120.440	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like	0.54	46.0	4.30e-01	93.9%	91.2%
2y1vA04	2.60.40.10	Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins	0.54	42.0	3.37e-01	81.6%	69.7%
4kvmA01	1.25.40.1040	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.54	40.0	2.59e-01	91.8%	15.5%
2lqgA00	1.20.120.230	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like	0.54	38.0	3.41e-01	73.5%	63.0%
2np3A00	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.54	38.0	3.43e-01	75.5%	84.5%
6wb9201	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.53	46.0	3.28e-01	94.9%	35.3%
3qc1A01	1.25.40.540	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › TAP42-like family	0.53	45.0	3.94e-01	93.9%	80.8%
2nwbA02	1.20.58.480	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.52	38.0	2.97e-01	78.6%	84.8%
1yhuB00	1.10.490.10	Mainly Alpha › Orthogonal Bundle › Globin-like › Globins	0.52	36.0	3.18e-01	70.4%	56.2%
1hssA00	1.10.110.10	Mainly Alpha › Orthogonal Bundle › Hydrophobic Seed Protein › Plant lipid-transfer and hydrophobic proteins	0.52	43.0	4.14e-01	90.8%	92.8%
2c0kB00	1.10.490.10	Mainly Alpha › Orthogonal Bundle › Globin-like › Globins	0.52	35.0	3.10e-01	70.4%	56.4%
4jgwA01	1.20.870.10	Mainly Alpha › Up-down Bundle › Son of sevenless (SoS) protein; Chain S, domain 1 › Son of sevenless (SoS) protein Chain: S domain 1	0.51	42.0	3.58e-01	87.8%	66.0%
3q18A02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.51	41.0	3.91e-01	85.7%	78.4%
2zs0A00	1.10.490.10	Mainly Alpha › Orthogonal Bundle › Globin-like › Globins	0.51	35.0	3.16e-01	71.4%	58.6%
2yfaB01	1.20.1440.210	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) ›	0.51	43.0	4.07e-01	93.9%	97.5%
2ooeA01	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.50	40.0	3.26e-01	92.9%	44.7%
1orjD00	1.20.120.340	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS	0.50	44.0	4.05e-01	95.9%	80.8%
2wbpA00	3.60.130.10	Alpha Beta › 4-Layer Sandwich › Double-stranded beta-helix › Clavaminate synthase-like	0.50	37.0	2.66e-01	80.6%	80.7%
1wrdA00	1.20.58.160	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.50	36.0	3.68e-01	76.5%	80.6%

ECOD (11)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1283715	3852.1.1.1 ↗	alpha superhelices › UL37 N-terminal half › UL37 N-terminal half › UL37 N-terminal half › Herpes_UL37_1	0.95	92.0	5.63e-01	100.0%	20.3%
4927922	604.12.1.0 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain	0.61	36.0	4.36e-01	74.5%	95.0%
3295404	10.12.1.38 ↗	beta sandwiches › jelly-roll › Double-stranded beta-helix › Double-stranded beta-helix › PCO_ADO	0.61	52.0	3.94e-01	94.9%	96.3%
5014005	614.1.1.0 ↗	alpha duplicates or obligate multimers › L27 domain › L27 domain › L27 domain	0.59	32.0	3.50e-01	74.5%	62.5%
3724188	109.3.1.93 ↗	alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › DUF6987	0.54	42.0	3.27e-01	82.7%	68.8%
3616727	603.1.1.98 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › SNARE, Syntaxin_2	0.54	43.0	3.33e-01	84.7%	89.0%
3967556	601.3.1.0 ↗	alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain	0.53	43.0	4.29e-01	86.7%	84.0%
3935262	109.27.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › BACK domain › BACK domain	0.53	37.0	3.33e-01	85.7%	52.6%
3550587	109.4.1.15 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › VHS	0.52	40.0	3.46e-01	83.7%	80.0%
3710371	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.51	41.0	3.52e-01	87.8%	63.1%
4023501	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.50	39.0	3.65e-01	85.7%	67.5%

D5 medium residues 296-434

PDB

Domain cluster: representative

CATH (13)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2nwbA02	1.20.58.480	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.58	46.0	3.89e-01	84.9%	90.7%
5hayA02	1.25.40.440	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Nucleoporin, helical domain, central subdomain	0.58	32.0	4.02e-01	79.1%	92.4%
1c8iA01	1.10.520.10	Mainly Alpha › Orthogonal Bundle › Peroxidase; domain 1 ›	0.56	42.0	3.77e-01	77.7%	92.7%
1wy6A00	1.25.40.350	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.55	38.0	3.70e-01	92.8%	62.3%
8amzS01	1.25.40.570	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.54	49.0	3.56e-01	100.0%	57.5%
2radA03	1.20.1440.30	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Biosynthetic Protein domain	0.54	39.0	4.11e-01	75.5%	87.4%
3i9wA00	1.20.58.920	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.53	40.0	3.24e-01	78.4%	53.3%
4ga6A02	1.20.970.50	Mainly Alpha › Up-down Bundle › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 ›	0.53	47.0	4.62e-01	97.1%	89.5%
3v39A01	3.40.710.10	Alpha Beta › 3-Layer(aba) Sandwich › Beta-lactamase › DD-peptidase/beta-lactamase superfamily	0.52	41.0	3.47e-01	84.9%	83.7%
3i5pA01	1.25.40.450	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Nucleoporin, helical domain, N-terminal subdomain	0.51	40.0	4.11e-01	92.8%	89.3%
3am6A00	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.50	44.0	3.83e-01	98.6%	75.9%
2l7nA00	1.20.1420.10	Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain	0.50	39.0	3.73e-01	84.2%	86.9%
3onkA00	1.25.40.90	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.50	41.0	4.20e-01	94.2%	92.0%

ECOD (17)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1283715	3852.1.1.1 ↗	alpha superhelices › UL37 N-terminal half › UL37 N-terminal half › UL37 N-terminal half › Herpes_UL37_1	0.99	97.0	6.33e-01	100.0%	28.8%
3295931	109.4.1.1286 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_8, TPR_12	0.56	46.0	3.25e-01	88.5%	79.8%
3920036	109.4.1.33 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HEAT	0.56	50.0	3.16e-01	100.0%	39.6%
4997380	3543.1.1.0 ↗	alpha complex topology › Acid-activated urea channel › Acid-activated urea channel › Acid-activated urea channel	0.55	44.0	4.12e-01	87.8%	81.1%
3974696	604.5.1.33 ↗	alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › FUSC	0.54	38.0	3.55e-01	71.9%	93.5%
3573605	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.53	45.0	4.19e-01	92.1%	90.3%
3297307	109.4.1.1567 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Frigida	0.53	46.0	4.33e-01	92.8%	89.1%
3248898	109.4.1.3408 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › mTOR_dom, HEAT_EZ, HEAT_GCN1, TPR_IMB1	0.53	45.0	2.71e-01	95.7%	12.7%
3334664	109.4.1.1304 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_8, TPR_10, TPR_12	0.53	48.0	3.44e-01	100.0%	67.9%
5012495	3281.1.1.1 ↗	alpha complex topology › Sodium/proton antiporter subunits-like › Sodium/proton antiporter subunits-like › NADH-quinone oxidoreductase subunit L (NuoL)-related › Proton_antipo_M	0.53	46.0	3.39e-01	99.3%	91.1%
3226678	109.4.1.504 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Ndc1_Nup	0.53	45.0	4.10e-01	97.8%	90.0%
3598735	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.52	47.0	3.62e-01	100.0%	53.1%
3167384	109.4.1.85 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Nop52	0.51	45.0	3.78e-01	99.3%	77.3%
5036519	5052.1.1.0 ↗	alpha complex topology › Proton glutamate symport protein › Proton glutamate symport protein › Proton glutamate symport protein	0.51	39.0	3.12e-01	80.6%	84.5%
3438263	109.4.1.1129 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_TRAPPC9-Trs120	0.50	44.0	3.94e-01	100.0%	80.0%
3821366	109.4.1.198 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_12	0.50	44.0	3.87e-01	97.8%	65.1%
None	—		0.50	44.0	4.39e-01	99.3%	97.9%

D6 medium residues 662-855

PDB

Domain cluster: rep: tegument_protein_UL37__NP_612690__Panine_betaherpesvirus_2__188763__D711-904

CATH (19)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3u0cA00	1.20.120.330	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2	0.79	46.0	5.22e-01	74.7%	74.2%
2gl2B00	1.10.287.1700	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.75	41.0	5.35e-01	71.6%	94.5%
3ck6C02	1.20.58.340	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region	0.71	35.0	4.40e-01	82.0%	76.5%
2rd0B00	1.10.287.1490	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.70	48.0	5.74e-01	89.7%	97.8%
2lm9A00	1.20.58.970	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.70	34.0	4.70e-01	70.1%	93.8%
1i4dA00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.67	51.0	5.24e-01	78.4%	83.5%
1avoB00	1.20.120.180	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Proteasome activator pa28, C-terminal domain	0.67	37.0	4.36e-01	71.1%	75.0%
2gd5A00	6.10.140.1230	Special › Helix non-globular › Helix Hairpins ›	0.66	43.0	5.03e-01	73.2%	88.7%
2ap3A00	1.20.120.570	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YkyA-like	0.65	43.0	4.39e-01	86.6%	66.7%
2q12A00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.64	50.0	4.64e-01	79.9%	71.1%
4ke2A00	6.10.140.1860	Special › Helix non-globular › Helix Hairpins ›	0.63	37.0	3.74e-01	90.7%	57.1%
1uruA01	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.59	48.0	4.71e-01	84.0%	80.4%
2v0xA01	1.10.287.3160	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.59	46.0	5.01e-01	84.5%	93.5%
4wpeA00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.56	47.0	4.13e-01	88.1%	79.3%
4kc9A02	1.20.120.1750	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) ›	0.54	35.0	3.38e-01	88.1%	56.1%
3syvA01	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.54	44.0	4.07e-01	85.6%	75.9%
1wdzA00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.53	44.0	4.10e-01	85.1%	81.0%
6iknD01	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.53	43.0	3.83e-01	84.0%	85.8%
3c1yA02	1.20.1260.110	Mainly Alpha › Up-down Bundle › Ferritin › DNA integrity scanning linker region	0.52	34.0	3.92e-01	100.0%	87.2%

ECOD (36)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3240682	192.2.1.0 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin	0.83	44.0	5.91e-01	76.3%	92.7%
3964486	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.81	46.0	5.12e-01	73.2%	68.8%
4937739	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.76	49.0	5.92e-01	90.2%	93.3%
3218199	192.4.1.0 ↗	alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p)	0.75	34.0	4.98e-01	85.1%	93.3%
4932148	3755.4.1.0 ↗	alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain	0.75	47.0	5.91e-01	70.6%	98.4%
3858356	632.22.1.0 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats	0.74	42.0	4.79e-01	72.2%	73.8%
3254077	601.1.2.0 ↗	alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608)	0.72	41.0	4.56e-01	83.0%	69.0%
4030678	3684.1.1.0 ↗	alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like	0.68	40.0	4.55e-01	88.1%	75.9%
3479129	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.68	52.0	4.79e-01	78.4%	78.8%
3996264	3755.4.1.0 ↗	alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain	0.67	50.0	5.35e-01	91.2%	87.1%
5051407	1075.4.1.1 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane	0.67	46.0	3.80e-01	73.7%	40.9%
3201057	3291.1.1.1 ↗	alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Snf7	0.66	47.0	4.87e-01	85.6%	75.7%
3627942	3755.4.1.1 ↗	alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › PI3K_P85_iSH2	0.65	50.0	5.26e-01	91.2%	86.9%
3712649	2004.1.1.199 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23,SbcC_Walker_B	0.63	49.0	3.59e-01	80.9%	83.2%
5020818	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.62	50.0	3.64e-01	83.5%	40.8%
3921802	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.62	44.0	4.82e-01	73.2%	95.2%
4969098	3926.1.1.0 ↗	alpha bundles › V-type proton ATPase subunit D › V-type proton ATPase subunit D › V-type proton ATPase subunit D	0.61	48.0	5.06e-01	91.2%	90.3%
3505596	1075.4.1.9 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_tran+ABC_membrane	0.61	40.0	3.09e-01	70.6%	30.2%
3697399	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.61	44.0	4.86e-01	90.7%	90.6%
4978123	1075.4.1.0 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold	0.60	39.0	3.34e-01	71.6%	40.3%
4395939	192.2.1.0 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin	0.59	41.0	3.76e-01	91.2%	53.3%
2462955	1075.4.1.1 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane	0.59	39.0	3.25e-01	73.2%	39.1%
4277985	2004.1.1.481 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_29	0.58	47.0	3.70e-01	84.5%	70.5%
4940099	2004.1.1.198 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23	0.58	46.0	3.61e-01	82.0%	93.7%
3583915	192.29.1.51 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › TMEM138	0.58	37.0	4.20e-01	88.1%	86.4%
3396625	4177.1.1.12 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FAM92	0.57	46.0	4.32e-01	83.0%	73.9%
3182496	3922.1.1.0 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3	0.56	49.0	3.83e-01	91.2%	90.1%
3490130	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.55	47.0	4.11e-01	88.1%	76.4%
3383463	150.1.1.0 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin	0.55	41.0	4.44e-01	78.4%	96.5%
4944553	1075.4.1.1 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane	0.54	36.0	3.15e-01	71.6%	43.4%
98832	2003.1.2.18 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain	0.54	46.0	3.59e-01	95.9%	45.8%
5046916	1075.4.1.1 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane	0.54	36.0	3.09e-01	72.2%	40.3%
3614118	2004.1.1.87 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N	0.53	46.0	3.29e-01	90.7%	88.6%
5048803	2004.1.1.87 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N	0.52	45.0	3.61e-01	90.7%	83.0%
4940229	2004.1.1.87 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N	0.51	44.0	3.53e-01	90.7%	85.1%
3258825	2004.1.1.87 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N	0.51	43.0	3.44e-01	90.7%	83.0%