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tegument_protein_VP13_14
Euk-VirSpheniscid_alphaherpesvirus_1
tegument_protein_VP13_14__YP_009342356__Spheniscid_alphaherpesvirus_1__2560777
Identity
- Accession:
- YP_009342356 ↗
- Protein ID:
- tegument_protein_VP13_14
- Kingdom:
- euk
Quality
67.6
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Mardivirus›
Spheniscid_alphaherpesvirus_1
TaxID: 2560777
Cluster
View cluster (31 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 286-300_320-492
Domain cluster:
rep: tegument_protein_VP13_14__NP_040134__Human_alphaherpesvirus_3__10335__D404-464_489-536_676-686_746-787
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03362.19 best | Herpes_UL47 | 73.5 | 2.30e-20 | 98.9% | 37.2% |
CATH (5)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3kyiA00 | 1.20.120.160 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain | 0.56 | 24.0 | 2.93e-01 | 97.9% | 58.6% |
| 3ay5A01 | 1.20.1420.10 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain | 0.53 | 26.0 | 2.99e-01 | 94.1% | 60.9% |
| 3wvoC02 | 1.10.132.100 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › | 0.53 | 30.0 | 3.49e-01 | 100.0% | 77.7% |
| 3w0lD02 | 3.40.50.10490 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glucose-6-phosphate isomerase like protein; domain 1 | 0.51 | 44.0 | 3.61e-01 | 92.0% | 95.6% |
| 3piwA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.50 | 24.0 | 2.62e-01 | 92.6% | 50.6% |
D2
medium
residues 301-319_650-702
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03362.19 best | Herpes_UL47 | 33.3 | 3.40e-08 | 93.1% | 11.0% |
ECOD (3)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3260070 | 2008.1.1.7 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › ERCC4 | 0.54 | 46.0 | 3.47e-01 | 97.2% | 86.8% |
| 5011801 | 2006.1.4.2 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › PIN | 0.51 | 47.0 | 3.87e-01 | 100.0% | 94.4% |
| 4255579 | 7502.1.1.0 ↗ | a/b three-layered sandwiches › Anticodon-binding domain of Class II aaRS › Anticodon-binding domain of Class II aaRS › Anticodon-binding domain of Class II aaRS | 0.51 | 25.0 | 2.69e-01 | 80.6% | 50.0% |
D3
medium
residues 493-649
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03362.19 best | Herpes_UL47 | 65.5 | 6.00e-18 | 100.0% | 34.4% |
CATH (71)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3a8pA02 | 6.10.140.680 | Special › Helix non-globular › Helix Hairpins › | 0.78 | 39.0 | 4.56e-01 | 100.0% | 66.7% |
| 2yfaB01 | 1.20.1440.210 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.77 | 57.0 | 6.43e-01 | 90.4% | 100.0% |
| 1nzeA00 | 1.20.120.290 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Oxygen-evolving enhancer protein 3 (PsbQ), four-helix up-down bundle | 0.73 | 49.0 | 5.63e-01 | 83.4% | 93.8% |
| 3na7A00 | 1.10.287.1490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.73 | 41.0 | 3.51e-01 | 98.1% | 37.1% |
| 1dn1B00 | 1.20.58.70 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.72 | 52.0 | 4.55e-01 | 73.2% | 53.2% |
| 1fewA00 | 1.20.58.70 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.72 | 51.0 | 4.96e-01 | 72.6% | 77.5% |
| 1y4cA03 | 1.20.120.660 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain | 0.71 | 50.0 | 5.79e-01 | 87.3% | 100.0% |
| 1jmwA00 | 1.20.120.30 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain | 0.71 | 60.0 | 6.24e-01 | 96.8% | 97.3% |
| 3pwfA01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.71 | 34.0 | 3.77e-01 | 100.0% | 56.5% |
| 3k29A00 | 1.10.287.1700 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.70 | 37.0 | 3.76e-01 | 98.7% | 49.7% |
| 8ek4A01 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.70 | 50.0 | 5.34e-01 | 72.6% | 96.2% |
| 2oo2A00 | 1.20.1270.90 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AF1782-like | 0.69 | 30.0 | 4.32e-01 | 70.7% | 85.5% |
| 4i1mB01 | 1.20.120.1700 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.69 | 51.0 | 5.55e-01 | 89.8% | 91.5% |
| 2l10A00 | 1.20.1420.10 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain | 0.69 | 53.0 | 5.34e-01 | 91.1% | 79.7% |
| 5ziyA01 | 1.20.1330.10 | Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain | 0.69 | 63.0 | 5.88e-01 | 98.1% | 87.6% |
| 4iloA00 | 1.10.287.1490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.69 | 40.0 | 3.44e-01 | 98.1% | 37.3% |
| 3lwjA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.67 | 43.0 | 4.03e-01 | 77.7% | 51.8% |
| 4p9tA01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.67 | 48.0 | 5.38e-01 | 86.0% | 95.8% |
| 3ls1A00 | 1.20.120.290 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Oxygen-evolving enhancer protein 3 (PsbQ), four-helix up-down bundle | 0.67 | 50.0 | 5.41e-01 | 91.1% | 91.7% |
| 2x0cA01 | 1.20.1420.10 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain | 0.67 | 57.0 | 5.44e-01 | 95.5% | 80.3% |
| 4m70I00 | 1.20.5.4130 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.66 | 45.0 | 5.37e-01 | 90.4% | 100.0% |
| 6i9kA00 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.66 | 50.0 | 3.97e-01 | 78.3% | 75.2% |
| 3ajmB02 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.66 | 46.0 | 4.97e-01 | 83.4% | 85.0% |
| 1quuA01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.66 | 45.0 | 4.96e-01 | 72.0% | 86.5% |
| 6gy8A01 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.66 | 55.0 | 4.34e-01 | 90.4% | 97.6% |
| 4cgkA01 | 6.10.250.3150 | Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.66 | 45.0 | 4.08e-01 | 70.1% | 96.3% |
| 2hujA00 | 1.20.120.440 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like | 0.65 | 49.0 | 5.47e-01 | 87.3% | 100.0% |
| 1h7cA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.65 | 39.0 | 4.68e-01 | 100.0% | 90.3% |
| 1io1A01 | 1.20.1330.10 | Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain | 0.64 | 59.0 | 5.75e-01 | 98.1% | 93.5% |
| 3oduB01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.63 | 47.0 | 3.92e-01 | 78.3% | 76.5% |
| 1w33A00 | 1.10.3160.10 | Mainly Alpha › Orthogonal Bundle › Bbcrasp-1 › Bbcrasp-1 | 0.63 | 47.0 | 4.53e-01 | 78.3% | 86.2% |
| 1uruA01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.62 | 45.0 | 4.13e-01 | 74.5% | 91.4% |
| 8a1gC01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.62 | 46.0 | 4.41e-01 | 76.4% | 97.8% |
| 1cpqA00 | 1.20.120.10 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c/b562 | 0.62 | 47.0 | 5.13e-01 | 84.1% | 95.3% |
| 6q45G01 | 1.10.287.80 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain | 0.62 | 36.0 | 3.80e-01 | 96.8% | 61.6% |
| 2l6hA00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.62 | 50.0 | 5.05e-01 | 94.3% | 86.4% |
| 8gccA03 | 1.10.268.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 | 0.62 | 40.0 | 4.95e-01 | 89.8% | 100.0% |
| 2uxwA01 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.61 | 42.0 | 3.95e-01 | 81.5% | 57.5% |
| 4nqiD00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.61 | 44.0 | 3.91e-01 | 75.2% | 84.9% |
| 1wdzA00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.60 | 45.0 | 3.97e-01 | 77.1% | 90.5% |
| 2ot4A03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.60 | 36.0 | 4.36e-01 | 73.2% | 88.8% |
| 2m6bA00 | 1.20.58.390 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain | 0.60 | 51.0 | 5.25e-01 | 97.5% | 96.7% |
| 5unhA02 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.58 | 50.0 | 4.19e-01 | 93.0% | 86.9% |
| 4kc9A02 | 1.20.120.1750 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.58 | 47.0 | 4.21e-01 | 86.0% | 68.3% |
| 2yn7A00 | 1.10.3160.10 | Mainly Alpha › Orthogonal Bundle › Bbcrasp-1 › Bbcrasp-1 | 0.57 | 44.0 | 3.98e-01 | 79.6% | 83.2% |
| 1xioA00 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.57 | 48.0 | 4.38e-01 | 91.1% | 84.3% |
| 2cmrA00 | 1.20.58.1860 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.57 | 52.0 | 4.85e-01 | 98.7% | 83.9% |
| 4wjg400 | 1.20.1260.80 | Mainly Alpha › Up-down Bundle › Ferritin › | 0.57 | 44.0 | 3.65e-01 | 79.0% | 80.8% |
| 6k41R00 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.57 | 46.0 | 4.02e-01 | 86.6% | 82.7% |
| 6fmhB01 | 1.10.3160.10 | Mainly Alpha › Orthogonal Bundle › Bbcrasp-1 › Bbcrasp-1 | 0.57 | 43.0 | 4.19e-01 | 79.0% | 89.0% |
| 6c1qB02 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.56 | 49.0 | 4.09e-01 | 95.5% | 87.1% |
| 5b2nA00 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.56 | 49.0 | 4.18e-01 | 96.2% | 81.0% |
| 3m9vA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.56 | 40.0 | 4.08e-01 | 79.0% | 73.9% |
| 3ddlA00 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.56 | 50.0 | 4.26e-01 | 97.5% | 84.1% |
| 2wbiB03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.56 | 39.0 | 3.96e-01 | 80.3% | 70.9% |
| 2rfqC03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.56 | 44.0 | 4.26e-01 | 82.8% | 78.9% |
| 4ib4A01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.56 | 47.0 | 3.93e-01 | 93.0% | 82.5% |
| 1foeA01 | 1.20.900.10 | Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain | 0.55 | 40.0 | 3.77e-01 | 75.8% | 76.0% |
| 1e7pC00 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.55 | 47.0 | 4.07e-01 | 94.3% | 70.9% |
| 6p73A02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.55 | 36.0 | 3.77e-01 | 79.0% | 71.3% |
| 1gqeA01 | 1.20.58.410 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Release factor | 0.55 | 38.0 | 4.45e-01 | 71.3% | 100.0% |
| 1zk8B02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.55 | 36.0 | 3.92e-01 | 80.9% | 79.5% |
| 2ficB00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.54 | 40.0 | 3.71e-01 | 75.8% | 94.0% |
| 1oahA02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.54 | 34.0 | 3.60e-01 | 80.3% | 69.7% |
| 4iu9B02 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.53 | 43.0 | 4.01e-01 | 86.0% | 66.5% |
| 4bjmC00 | 1.20.58.1680 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.53 | 34.0 | 3.08e-01 | 97.5% | 47.9% |
| 3o7pA01 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.52 | 47.0 | 4.26e-01 | 100.0% | 97.7% |
| 3vkgA12 | 1.10.287.2610 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.52 | 41.0 | 3.65e-01 | 97.5% | 59.5% |
| 2chnB03 | 1.20.58.460 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Hyaluronidase post-catalytic domain-like | 0.52 | 41.0 | 3.91e-01 | 87.9% | 71.1% |
| 6gpxB00 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.52 | 44.0 | 3.76e-01 | 93.0% | 88.6% |
| 3tdvA02 | 3.90.1200.10 | Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe | 0.51 | 36.0 | 3.29e-01 | 73.2% | 73.3% |
ECOD (72)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4935333 | 3755.3.1.637 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › DUF7121 | 0.79 | 38.0 | 3.94e-01 | 98.1% | 48.7% |
| 4045134 | 601.4.1.3 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › 4HB_MCP_1 | 0.78 | 62.0 | 6.73e-01 | 94.3% | 99.2% |
| 5056869 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.78 | 40.0 | 3.90e-01 | 98.1% | 45.1% |
| 4014222 | 3684.1.1.0 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like | 0.74 | 64.0 | 6.13e-01 | 95.5% | 80.6% |
| 3586386 | 3939.1.1.0 ↗ | alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain | 0.72 | 38.0 | 2.96e-01 | 98.7% | 25.0% |
| 4030678 | 3684.1.1.0 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like | 0.72 | 57.0 | 5.98e-01 | 93.6% | 90.3% |
| 4136919 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.72 | 42.0 | 3.96e-01 | 97.5% | 49.2% |
| 3414399 | 5086.1.1.106 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › DUF725 | 0.72 | 38.0 | 3.69e-01 | 98.1% | 46.5% |
| 3949246 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.71 | 59.0 | 5.86e-01 | 96.8% | 83.0% |
| 4565794 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.71 | 60.0 | 6.28e-01 | 89.8% | 99.3% |
| 3587850 | 3684.1.1.0 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like | 0.70 | 59.0 | 6.24e-01 | 90.4% | 100.0% |
| 3517342 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.69 | 60.0 | 5.73e-01 | 93.6% | 80.5% |
| 2492086 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.69 | 59.0 | 6.14e-01 | 96.8% | 99.3% |
| 3517682 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.68 | 47.0 | 4.66e-01 | 71.3% | 67.5% |
| 4593081 | 601.1.2.139 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › PF30710 | 0.67 | 56.0 | 5.79e-01 | 93.0% | 93.8% |
| 1877520 | 604.1.1.7 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › SR_plectin_7 | 0.67 | 48.0 | 5.38e-01 | 72.0% | 95.8% |
| 4012742 | 5069.1.1.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes | 0.67 | 62.0 | 5.16e-01 | 99.4% | 94.7% |
| 3496091 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.67 | 54.0 | 5.76e-01 | 96.2% | 100.0% |
| 3167394 | 874.1.1.0 ↗ | a+b duplicates or obligate multimers › Smc hinge domain › Smc hinge domain › Smc hinge domain | 0.66 | 42.0 | 3.47e-01 | 98.1% | 38.5% |
| 3199450 | 5001.1.1.0 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like | 0.65 | 50.0 | 4.13e-01 | 79.0% | 94.1% |
| 3790952 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.64 | 55.0 | 5.74e-01 | 95.5% | 100.0% |
| 4095698 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.64 | 45.0 | 5.30e-01 | 83.4% | 99.1% |
| 4212526 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.63 | 46.0 | 5.29e-01 | 75.2% | 100.0% |
| 3629560 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.63 | 47.0 | 4.76e-01 | 78.3% | 77.4% |
| 4333962 | 3922.1.1.0 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 | 0.63 | 42.0 | 3.71e-01 | 97.5% | 48.8% |
| 3411384 | 601.1.2.2 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › I_LWEQ | 0.63 | 45.0 | 4.23e-01 | 73.2% | 98.9% |
| 4379165 | 5082.1.1.1 ↗ | alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation_efflux | 0.62 | 51.0 | 4.55e-01 | 86.0% | 89.8% |
| 3519438 | 601.1.2.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) | 0.62 | 41.0 | 4.29e-01 | 78.3% | 72.4% |
| 4235156 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.61 | 45.0 | 5.17e-01 | 80.9% | 98.3% |
| 3599499 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.61 | 40.0 | 4.16e-01 | 97.5% | 70.0% |
| 3711434 | 604.5.1.0 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) | 0.60 | 52.0 | 4.59e-01 | 92.4% | 66.7% |
| 3649076 | 3939.1.1.207 ↗ | alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › NET2A | 0.60 | 56.0 | 5.20e-01 | 98.1% | 90.0% |
| 3637309 | 4323.1.1.0 ↗ | alpha bundles › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C | 0.59 | 54.0 | 5.06e-01 | 98.1% | 83.7% |
| 4296017 | 632.22.1.1 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › EzrA | 0.58 | 41.0 | 4.54e-01 | 75.8% | 86.9% |
| 4517020 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.58 | 41.0 | 3.00e-01 | 100.0% | 28.2% |
| 5059402 | 5069.1.1.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes | 0.58 | 48.0 | 5.00e-01 | 89.2% | 96.6% |
| 3904567 | 4177.1.1.0 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like | 0.58 | 42.0 | 3.52e-01 | 74.5% | 83.8% |
| 5026456 | 5045.1.1.0 ↗ | alpha bundles › F1F0 ATP synthase subunit A › F1F0 ATP synthase subunit A › F1F0 ATP synthase subunit A | 0.58 | 47.0 | 3.91e-01 | 87.9% | 88.4% |
| 5028674 | 129.1.1.5 ↗ | alpha arrays › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › Ferric_reduct | 0.58 | 46.0 | 4.15e-01 | 86.6% | 60.0% |
| 3656892 | 611.9.1.4 ↗ | alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain › Rx_N | 0.57 | 44.0 | 4.83e-01 | 93.0% | 97.7% |
| 4927311 | 5069.1.3.1 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits › Sdh_cyt | 0.57 | 39.0 | 4.55e-01 | 73.2% | 100.0% |
| 3756948 | 601.19.1.17 ↗ | alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein › Niban2 | 0.56 | 46.0 | 4.53e-01 | 87.9% | 84.1% |
| 3464835 | 611.9.1.4 ↗ | alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain › Rx_N | 0.56 | 42.0 | 4.72e-01 | 86.6% | 98.4% |
| 3530101 | 601.19.1.17 ↗ | alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein › Niban2 | 0.56 | 48.0 | 4.05e-01 | 92.4% | 83.4% |
| 4680407 | 3684.1.1.0 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like | 0.56 | 49.0 | 4.76e-01 | 97.5% | 86.3% |
| 4102297 | 3834.1.1.10 ↗ | alpha bundles › TcA alpha pore-forming domain › TcA alpha pore-forming domain › TcA alpha pore-forming domain › PF27870 | 0.56 | 46.0 | 3.50e-01 | 97.5% | 39.4% |
| 4001188 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.56 | 40.0 | 2.88e-01 | 72.6% | 45.7% |
| 3437911 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.55 | 43.0 | 4.76e-01 | 80.9% | 100.0% |
| 4020122 | 1075.5.1.5 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Rft-1 | 0.55 | 48.0 | 3.33e-01 | 95.5% | 39.5% |
| 3404485 | 601.19.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein | 0.55 | 40.0 | 3.71e-01 | 75.2% | 85.4% |
| 4225234 | 3615.1.1.0 ↗ | alpha bundles › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain | 0.55 | 43.0 | 4.19e-01 | 82.8% | 76.7% |
| 3875649 | 601.19.1.17 ↗ | alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein › Niban2 | 0.55 | 47.0 | 3.68e-01 | 93.6% | 53.8% |
| 3696555 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.55 | 41.0 | 3.89e-01 | 76.4% | 84.9% |
| 3213527 | 4177.1.1.1 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH | 0.55 | 40.0 | 3.33e-01 | 75.2% | 84.6% |
| 4934609 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.55 | 43.0 | 4.61e-01 | 93.6% | 100.0% |
| 4947851 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.55 | 47.0 | 4.87e-01 | 93.0% | 98.0% |
| 3766955 | 192.7.1.17 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › FAM186A-B_C | 0.55 | 46.0 | 4.80e-01 | 90.4% | 95.9% |
| 4515899 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.54 | 37.0 | 3.65e-01 | 98.1% | 64.1% |
| 3316949 | 4006.1.1.0 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain | 0.54 | 44.0 | 4.78e-01 | 85.4% | 99.3% |
| 3608199 | 1189.1.1.0 ↗ | alpha bundles › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor | 0.54 | 41.0 | 3.93e-01 | 79.6% | 91.9% |
| 3928356 | 5001.1.1.1 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 | 0.54 | 47.0 | 3.68e-01 | 95.5% | 80.9% |
| 3560590 | 3755.3.1.142 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › FAM186A-B_C | 0.54 | 45.0 | 4.64e-01 | 90.4% | 92.7% |
| 3567180 | 4177.1.1.61 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › PLC-beta_C | 0.53 | 40.0 | 3.45e-01 | 76.4% | 93.8% |
| 3910311 | 5001.1.1.1 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 | 0.53 | 45.0 | 3.66e-01 | 93.6% | 81.2% |
| 3934550 | 3562.1.1.1 ↗ | alpha bundles › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › Orai-1 | 0.53 | 48.0 | 4.51e-01 | 96.8% | 82.6% |
| 3381175 | 192.8.1.0 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain | 0.53 | 40.0 | 3.39e-01 | 98.1% | 50.8% |
| 3066555 | 109.3.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat | 0.53 | 47.0 | 3.88e-01 | 96.8% | 60.3% |
| 5002537 | 1075.5.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE | 0.52 | 40.0 | 3.58e-01 | 82.8% | 55.7% |
| 3733397 | 109.42.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › E3 ubiquitin-protein ligase SHPRH first helical domain › E3 ubiquitin-protein ligase SHPRH first helical domain | 0.52 | 47.0 | 4.45e-01 | 98.7% | 100.0% |
| 4165476 | 2004.1.1.799 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_27, AAA_29 | 0.51 | 43.0 | 2.94e-01 | 98.1% | 28.9% |
| 4509127 | 1075.5.1.2 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MurJ | 0.51 | 40.0 | 3.67e-01 | 86.6% | 63.9% |
| 3656227 | 633.7.1.0 ↗ | alpha bundles › Bromodomain-like › Bacillus cereus metalloprotein-like › Bacillus cereus metalloprotein-like | 0.50 | 33.0 | 3.66e-01 | 71.3% | 81.5% |
D4
medium
residues 703-759
Domain cluster:
representative