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thymidine_kinase

Euk-Vir

Human_alphaherpesvirus_3

thymidine_kinase__NP_040159__Human_alphaherpesvirus_3__10335

Identity

Accession:
NP_040159 ↗
Protein ID:
thymidine_kinase
Kingdom:
euk

Quality

89.2 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Varicellovirus› Human_alphaherpesvirus_3

TaxID: 10335

Cluster

View cluster (35 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 14-41_126-320
PDB
Domain cluster: rep: thymidina_kinase__YP_009664657__Bubaline_alphaherpesvirus_1__202910__D121-329
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00693.25 best Herpes_TK 270.6 2.00e-80 78.9% 62.1%
D2 medium residues 42-125_321-341
PDB
Domain cluster: rep: thymidine_kinase__NP_077451__Cercopithecine_alphaherpesvirus_9__35246__D21-128_316-337
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00693.25 best Herpes_TK 113.4 1.70e-32 88.6% 30.7%
CATH (12)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1osnC00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.86 80.0 5.45e-01 97.1% 89.5%
1e2jA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.83 79.0 5.44e-01 100.0% 91.5%
3anwB00 1.20.58.2050 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.70 44.0 3.79e-01 90.5% 40.7%
4kb2A01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.68 46.0 4.56e-01 82.9% 67.0%
4ielA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.58 37.0 3.58e-01 91.4% 56.9%
1vcsA00 1.20.58.400 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins 0.58 37.0 3.78e-01 89.5% 64.7%
2e9xD01 1.20.58.1030 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.55 42.0 3.86e-01 80.0% 81.8%
2jaeA03 1.20.1440.240 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 0.54 41.0 4.18e-01 93.3% 83.2%
3t0yA01 1.10.1740.10 Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif 0.54 31.0 3.64e-01 96.2% 87.9%
1qsdA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.53 40.0 4.09e-01 92.4% 84.3%
4cqiA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.52 39.0 3.96e-01 90.5% 80.4%
3t69A02 3.30.420.310 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › 2-keto-3-deoxy-galactonokinase, C-terminal domain 0.50 36.0 2.87e-01 73.3% 97.8%
ECOD (22)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
9546 2004.1.1.52 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK 0.91 85.0 5.72e-01 97.1% 89.5%
9545 2004.1.1.52 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK 0.87 83.0 5.58e-01 100.0% 89.8%
1322887 2004.1.1.52 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK 0.82 78.0 5.38e-01 100.0% 90.8%
4015612 616.1.1.0 ↗ alpha arrays › S15/NS1 RNA-binding domain › S15/NS1 RNA-binding domain › S15/NS1 RNA-binding domain 0.68 38.0 4.20e-01 93.3% 68.2%
None — 0.65 42.0 3.08e-01 85.7% 24.6%
5066143 5041.1.1.0 ↗ extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C 0.65 39.0 4.51e-01 91.4% 82.7%
5043291 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.64 39.0 4.45e-01 86.7% 80.0%
2075297 3559.1.1.0 ↗ a+b complex topology › Mediator of RNA polymerase II transcription subunit 22 › Mediator of RNA polymerase II transcription subunit 22 › Mediator of RNA polymerase II transcription subunit 22 0.63 39.0 3.76e-01 80.0% 53.8%
3256763 192.4.1.0 ↗ alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) 0.62 48.0 4.43e-01 85.7% 63.7%
3616077 174.1.1.0 ↗ few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.58 43.0 3.59e-01 76.2% 63.8%
4149728 547.1.1.1 ↗ alpha duplicates or obligate multimers › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › GlutR_dimer 0.58 42.0 4.64e-01 99.0% 100.0%
3614715 310.2.1.0 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF 0.58 43.0 3.51e-01 80.0% 76.1%
3581757 11.12.1.2 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Nicotinic receptor ligand binding domain-like › Nicotinic receptor ligand binding domain-like › Neur_chan_LBD,Neur_chan_memb 0.56 42.0 3.26e-01 78.1% 65.8%
3720672 109.4.1.1591 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › U-box 0.56 45.0 3.28e-01 84.8% 52.1%
5007234 601.7.1.23 ↗ alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › DUF294_C 0.56 39.0 3.57e-01 82.9% 54.3%
3462396 5050.1.1.57 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Nodulin-like, NFD4_C 0.55 44.0 2.87e-01 87.6% 36.4%
3691750 376.1.1.8 ↗ few secondary structure elements › RING/U-box-like › RING/U-box-like › RING/U-box › U-box 0.55 43.0 3.87e-01 83.8% 96.0%
3770290 4177.1.1.41 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › EVC2_like 0.55 49.0 4.01e-01 100.0% 81.0%
3267835 284.1.3.1 ↗ a+b two layers › FKBP-like › FKBP-like › WNK1 autoinhibitory domain › SNF5 0.54 43.0 4.34e-01 94.3% 84.8%
3701245 604.7.1.1 ↗ alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A › TBCA 0.54 40.0 4.00e-01 89.5% 76.4%
3468553 328.7.1.0 ↗ a+b two layers › IF3-like › Smr domain › Smr domain 0.54 45.0 4.06e-01 94.3% 76.5%
168906 3132.1.1.1 ↗ alpha complex topology › Core protein VP6 › Core protein VP6 › Core protein VP6 › Sigma_1_2 0.53 45.0 3.04e-01 93.3% 89.3%