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thymidine_kinase

Euk-Vir

Bovine_alphaherpesvirus_1

thymidine_kinase__NP_045336__Bovine_alphaherpesvirus_1__10320

Identity

Accession:
NP_045336 ↗
Protein ID:
thymidine_kinase
Kingdom:
euk

Quality

87.7 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Varicellovirus› bovine_alphaherpesvirus_1

TaxID: 10320

Cluster

View cluster (35 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 1-42_130-330
PDB
Domain cluster: rep: thymidina_kinase__YP_009664657__Bubaline_alphaherpesvirus_1__202910__D121-329
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00693.25 best Herpes_TK 180.7 5.10e-53 80.7% 67.9%
D2 medium residues 43-129_331-352
PDB
Domain cluster: rep: ORF38_gene_product__YP_006273018__Equid_alphaherpesvirus_8__39637__D59-120_334-352
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00693.25 best Herpes_TK 31.5 1.60e-07 81.7% 22.1%
CATH (24)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2ic6A00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.73 46.0 5.58e-01 89.9% 97.2%
4e4eA01 1.10.287.990 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain 0.73 45.0 5.41e-01 87.2% 94.4%
2e9xA01 1.20.58.1030 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.72 55.0 5.20e-01 94.5% 68.0%
3nrxA00 1.20.58.1520 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.70 44.0 4.25e-01 94.5% 56.9%
2crbA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.69 44.0 4.63e-01 86.2% 72.2%
7p3rA01 1.20.1170.10 Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › 0.68 52.0 3.67e-01 79.8% 68.6%
1v9dB00 1.20.58.2220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Formin, FH2 domain 0.67 48.0 3.44e-01 94.5% 25.2%
3anwA01 1.20.58.1030 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.65 45.0 4.49e-01 94.5% 68.1%
3sjqC00 1.10.287.70 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.64 42.0 4.72e-01 84.4% 91.3%
4aflA00 6.10.140.1740 Special › Helix non-globular › Helix Hairpins › 0.62 46.0 4.73e-01 77.1% 82.4%
4v1gA00 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.62 41.0 4.52e-01 86.2% 85.9%
1br0A00 1.20.58.70 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 48.0 4.67e-01 95.4% 75.0%
1ydxA02 1.10.287.1120 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Bipartite methylase S protein 0.62 45.0 4.90e-01 89.9% 90.0%
3nymA00 6.10.290.10 Special › Helix non-globular › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.60 47.0 4.53e-01 83.5% 97.6%
1s35A01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.59 40.0 4.15e-01 93.6% 74.3%
3h6pC00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.59 31.0 4.24e-01 88.1% 100.0%
4ijjB00 1.20.120.910 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › DksA, coiled-coil domain 0.58 45.0 4.27e-01 95.4% 68.5%
1i5nB00 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.58 33.0 3.20e-01 97.2% 49.2%
4mrsA01 1.20.1560.10 Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain 0.57 51.0 3.62e-01 100.0% 38.6%
4h33A00 1.10.287.70 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.55 43.0 4.65e-01 82.6% 100.0%
1txdA01 1.20.900.10 Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain 0.55 45.0 3.59e-01 95.4% 42.9%
4wpeA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.53 46.0 3.53e-01 98.2% 72.4%
1dd5A01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.53 38.0 3.83e-01 95.4% 72.5%
2b5uA02 1.10.287.620 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix Hairpins 0.52 45.0 3.91e-01 92.7% 79.5%
ECOD (60)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4638004 192.29.1.1 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB_dom 0.79 50.0 6.16e-01 80.7% 100.0%
3887418 633.21.1.46 ↗ alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › TMEM125 0.77 49.0 4.32e-01 78.9% 46.7%
3853458 192.29.1.1 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB_dom 0.74 50.0 5.37e-01 86.2% 78.9%
3258925 192.8.1.0 ↗ alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain 0.74 44.0 5.43e-01 92.7% 94.3%
3529043 3922.1.1.179 ↗ alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › bMERB_dom 0.73 50.0 4.20e-01 87.2% 42.2%
5069780 5086.1.1.0 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.72 48.0 5.18e-01 89.9% 78.9%
4086322 5086.1.1.205 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › PF30209 0.70 46.0 4.01e-01 87.2% 44.2%
3928718 5086.1.1.0 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.70 48.0 4.37e-01 87.2% 54.3%
3315495 192.8.1.0 ↗ alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain 0.70 48.0 5.37e-01 87.2% 90.6%
3924665 604.1.1.136 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin_7 0.70 48.0 4.88e-01 92.7% 72.4%
3315414 3291.1.1.0 ↗ alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related 0.69 47.0 3.94e-01 89.9% 42.2%
3488979 192.5.1.0 ↗ alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat 0.69 49.0 4.66e-01 96.3% 63.2%
4033755 3922.1.1.0 ↗ alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 0.69 43.0 3.90e-01 90.8% 47.6%
3400926 3758.1.1.45 ↗ alpha bundles › Bacterial hemolysins-like › Bacterial hemolysins › Bacterial hemolysins › Not3 0.69 47.0 4.63e-01 94.5% 66.1%
3766400 622.4.1.0 ↗ alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related 0.68 48.0 4.84e-01 85.3% 71.8%
3389690 174.1.1.29 ↗ few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › DUF4728 0.68 45.0 4.19e-01 90.8% 53.3%
3389713 174.1.1.29 ↗ few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › DUF4728 0.68 44.0 4.10e-01 88.1% 51.4%
3437925 605.1.1.132 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › DUF641 0.68 44.0 4.73e-01 93.6% 75.8%
4935068 192.2.1.0 ↗ alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.67 45.0 5.27e-01 89.9% 98.7%
3180581 192.8.1.0 ↗ alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain 0.67 48.0 5.42e-01 90.8% 96.5%
3222544 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.67 45.0 4.27e-01 92.7% 58.5%
3960600 3812.1.1.0 ↗ alpha bundles › Type III secretion protein YscE › Type III secretion protein YscE › Type III secretion protein YscE 0.66 49.0 4.51e-01 78.0% 71.5%
4507133 3710.1.1.1 ↗ alpha bundles › Golgi to ER traffic protein 1 cytosolic domain › Golgi to ER traffic protein 1 cytosolic domain › Golgi to ER traffic protein 1 cytosolic domain › CHD5 0.66 51.0 5.49e-01 85.3% 93.7%
4521514 605.1.1.0 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.66 42.0 4.90e-01 92.7% 94.7%
3584061 604.1.1.136 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin_7 0.65 45.0 4.55e-01 92.7% 70.0%
3215082 4177.1.1.0 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like 0.65 46.0 4.32e-01 90.8% 59.3%
3988260 7516.1.1.2 ↗ a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glycos_transf_2 0.65 43.0 3.08e-01 88.1% 22.8%
5032963 5069.1.1.0 ↗ alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes 0.65 45.0 3.88e-01 70.6% 86.9%
4484997 3755.3.1.0 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.64 48.0 4.41e-01 93.6% 61.5%
4976497 4163.1.1.0 ↗ alpha bundles › GINS helical bundle-like › GINS helical bundle-like › PSF1 N-terminal domain-like 0.64 41.0 4.03e-01 77.1% 59.2%
4010416 1.1.7.0 ↗ beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C 0.62 46.0 4.41e-01 86.2% 68.0%
3999274 5086.1.1.102 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › PTHB1_hp 0.62 49.0 5.01e-01 99.1% 85.7%
60007 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.62 49.0 3.69e-01 95.4% 33.9%
3511563 192.29.1.143 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › CCDC28 0.62 41.0 4.22e-01 91.7% 70.5%
3200160 604.7.1.0 ↗ alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A 0.61 50.0 5.04e-01 97.2% 86.4%
4243427 3560.1.1.1 ↗ a+b complex topology › Mediator of RNA polymerase II transcription subunit 8 › Mediator of RNA polymerase II transcription subunit 8 › Mediator of RNA polymerase II transcription subunit 8 › Med8 0.61 38.0 3.40e-01 92.7% 42.5%
3486453 310.2.1.0 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF 0.61 39.0 3.98e-01 86.2% 65.7%
3651438 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.61 44.0 4.48e-01 91.7% 75.5%
3696658 3559.1.1.1 ↗ a+b complex topology › Mediator of RNA polymerase II transcription subunit 22 › Mediator of RNA polymerase II transcription subunit 22 › Mediator of RNA polymerase II transcription subunit 22 › Med22 0.60 44.0 4.15e-01 90.8% 64.6%
3367913 603.1.1.1 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin 0.60 45.0 4.18e-01 94.5% 62.9%
3944006 5086.1.1.0 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.59 48.0 4.56e-01 89.0% 75.2%
3904130 1203.1.2.1 ↗ alpha bundles › Shroom domain 2 › Shroom domain 2 › Human SD2 › ASD2 0.58 47.0 4.54e-01 95.4% 76.7%
3221299 310.2.1.0 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF 0.58 43.0 4.05e-01 83.5% 63.0%
3642682 603.1.1.5 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin-6_N 0.58 44.0 4.41e-01 96.3% 78.3%
3744077 4177.1.1.1 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH 0.58 50.0 3.89e-01 98.2% 75.3%
3363809 4177.1.1.8 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR_3 0.58 47.0 3.58e-01 88.1% 67.1%
4029042 3939.1.1.0 ↗ alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain 0.57 44.0 3.56e-01 97.2% 40.9%
5068463 3758.1.1.0 ↗ alpha bundles › Bacterial hemolysins-like › Bacterial hemolysins › Bacterial hemolysins 0.57 48.0 4.03e-01 91.7% 75.1%
5048272 5073.1.1.11 ↗ alpha bundles › Calcium ATPase transmembrane domain-related › Calcium ATPase transmembrane domain-related › Calcium ATPase transmembrane domain M › Cation_ATPase_C 0.55 50.0 3.35e-01 100.0% 59.3%
3839108 310.2.1.65 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF › MotA_ExbB 0.55 44.0 4.26e-01 90.8% 75.2%
3201935 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.55 43.0 3.19e-01 83.5% 32.6%
3883526 4177.1.1.1 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH 0.55 46.0 3.31e-01 89.9% 73.7%
3516367 174.1.1.1 ↗ few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin 0.55 46.0 4.27e-01 89.0% 96.3%
3882129 5001.1.1.126 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › PF25987 0.55 48.0 3.63e-01 96.3% 86.5%
3231243 4177.1.1.10 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › GMIP-like_FCH 0.55 47.0 3.53e-01 97.2% 70.7%
3261777 4177.1.1.8 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR_3 0.54 45.0 3.55e-01 89.0% 72.9%
3950765 3755.3.1.0 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.54 47.0 3.28e-01 93.6% 75.9%
3450053 3939.1.1.0 ↗ alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain 0.54 47.0 3.91e-01 95.4% 56.3%
None — 0.53 45.0 3.29e-01 89.9% 71.5%
3395623 174.1.1.0 ↗ few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.51 45.0 4.30e-01 92.7% 95.2%