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thymidine_kinase
Euk-VirAlcelaphine_gammaherpesvirus_1
thymidine_kinase__NP_065520__Alcelaphine_gammaherpesvirus_1__35252
Identity
- Accession:
- NP_065520 ↗
- Protein ID:
- thymidine_kinase
- Kingdom:
- euk
Quality
65.9
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Macavirus›
Alcelaphine_gammaherpesvirus_1
TaxID: 35252
Cluster
View cluster (22 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 234-268_391-517
D2
medium
residues 269-328
Domain cluster:
representative
CATH (30)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1s35A01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.72 | 55.0 | 4.71e-01 | 93.3% | 50.5% |
| 4q20A01 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.70 | 60.0 | 5.44e-01 | 98.3% | 75.6% |
| 2wmmA01 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.68 | 46.0 | 4.95e-01 | 85.0% | 85.7% |
| 3g3oA00 | 3.20.100.30 | Alpha Beta › Alpha-Beta Barrel › mRNA Triphosphatase Cet1; Chain A › VTC, catalytic tunnel domain | 0.67 | 48.0 | 3.05e-01 | 75.0% | 37.7% |
| 1m62A00 | 1.20.58.120 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain | 0.67 | 49.0 | 4.44e-01 | 88.3% | 55.2% |
| 3lszA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.67 | 52.0 | 4.07e-01 | 81.7% | 40.0% |
| 2mpkA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.67 | 52.0 | 4.93e-01 | 96.7% | 71.6% |
| 3fxdB00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.66 | 52.0 | 5.32e-01 | 88.3% | 91.4% |
| 1hqoA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.66 | 52.0 | 4.16e-01 | 91.7% | 43.5% |
| 8b6jF01 | 1.10.287.20 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Ubiquinol-cytochrome C reductase hinge domain | 0.66 | 53.0 | 5.23e-01 | 100.0% | 85.1% |
| 1nt2B02 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.65 | 54.0 | 5.28e-01 | 95.0% | 83.6% |
| 2rkhA02 | 1.20.1280.20 | Mainly Alpha › Up-down Bundle › Monooxygenase › HscB, C-terminal domain | 0.65 | 46.0 | 4.35e-01 | 85.0% | 60.5% |
| 5jrcA00 | 1.20.58.2140 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.64 | 46.0 | 3.34e-01 | 86.7% | 25.8% |
| 3fxdC00 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.62 | 45.0 | 4.83e-01 | 81.7% | 94.0% |
| 3d36B02 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.62 | 48.0 | 4.79e-01 | 86.7% | 85.2% |
| 1kxpD04 | 1.10.246.10 | Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › | 0.62 | 47.0 | 4.45e-01 | 93.3% | 67.5% |
| 4l0rB00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.62 | 49.0 | 4.68e-01 | 93.3% | 87.7% |
| 2gsvA00 | 6.10.140.40 | Special › Helix non-globular › Helix Hairpins › | 0.61 | 43.0 | 4.21e-01 | 81.7% | 67.2% |
| 1b5lA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.61 | 50.0 | 3.79e-01 | 93.3% | 99.3% |
| 7zxkC01 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.61 | 51.0 | 3.91e-01 | 98.3% | 97.3% |
| 3axjB02 | 1.20.58.200 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 | 0.60 | 46.0 | 4.21e-01 | 91.7% | 62.4% |
| 1iurA01 | 1.10.287.110 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › DnaJ domain | 0.60 | 43.0 | 4.26e-01 | 81.7% | 74.6% |
| 1j1jA02 | 1.20.58.200 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 | 0.59 | 42.0 | 3.88e-01 | 93.3% | 56.5% |
| 1ylmA00 | 1.20.120.580 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › bsu32300-like | 0.58 | 46.0 | 3.61e-01 | 90.0% | 42.3% |
| 3eabE00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.57 | 44.0 | 4.01e-01 | 90.0% | 61.6% |
| 3deoA02 | 1.25.40.20 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Ankyrin repeat-containing domain | 0.57 | 41.0 | 3.13e-01 | 78.3% | 54.8% |
| 7mwzD01 | 3.40.50.12100 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Stimulator of interferon genes protein | 0.56 | 47.0 | 3.44e-01 | 98.3% | 67.8% |
| 3terA00 | 1.10.287.3550 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.55 | 45.0 | 3.70e-01 | 96.7% | 47.1% |
| 1vibA00 | 1.10.287.120 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Neurotoxin B-IV-like | 0.54 | 42.0 | 4.39e-01 | 88.3% | 100.0% |
| 1d0cA03 | 3.90.1230.10 | Alpha Beta › Alpha-Beta Complex › Bovine Endothelial Nitric Oxide Synthase Heme Domain; Chain: A,domain 3 › Nitric Oxide Synthase; Chain A, domain 3 | 0.54 | 43.0 | 3.85e-01 | 90.0% | 94.4% |
ECOD (26)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3215911 | 4970.1.1.0 ↗ | alpha bundles › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I | 0.75 | 61.0 | 6.15e-01 | 95.0% | 88.3% |
| 3479953 | 604.3.1.1 ↗ | alpha bundles › Spectrin repeat-like › BAG domain › BAG domain › BAG | 0.72 | 60.0 | 5.32e-01 | 91.7% | 67.1% |
| 3967290 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.71 | 58.0 | 5.56e-01 | 90.0% | 78.6% |
| 4075864 | 192.6.1.0 ↗ | alpha bundles › Long alpha-hairpin › Epsilon subunit of F1F0-ATP synthase C-terminal domain › Epsilon subunit of F1F0-ATP synthase C-terminal domain | 0.68 | 53.0 | 5.47e-01 | 96.7% | 92.7% |
| 3581757 | 11.12.1.2 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Nicotinic receptor ligand binding domain-like › Nicotinic receptor ligand binding domain-like › Neur_chan_LBD,Neur_chan_memb | 0.67 | 57.0 | 3.88e-01 | 96.7% | 63.1% |
| 4185894 | 7022.1.1.1 ↗ | alpha bundles › central core domain of D-alanyl transfer protein › central core domain of D-alanyl transfer protein › central core domain of D-alanyl transfer protein › MBOAT | 0.67 | 53.0 | 3.85e-01 | 93.3% | 31.2% |
| 3676043 | 5076.2.1.10 ↗ | alpha complex topology › Mitochondrial ADP/ATP carrier-like › Putative sulfate permease CysZ › Putative sulfate permease CysZ › PF29520 | 0.66 | 56.0 | 3.60e-01 | 96.7% | 21.1% |
| 3676172 | 604.6.1.0 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain | 0.66 | 54.0 | 4.18e-01 | 91.7% | 40.7% |
| 3171363 | 605.8.1.2 ↗ | alpha duplicates or obligate multimers › ROP-like › BAS1536-like › BAS1536-like › PF27894 | 0.65 | 50.0 | 5.19e-01 | 91.7% | 90.9% |
| 3757869 | 4006.1.1.0 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain | 0.64 | 50.0 | 4.35e-01 | 90.0% | 54.7% |
| 3988700 | 5082.1.1.1 ↗ | alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation_efflux | 0.64 | 50.0 | 3.57e-01 | 93.3% | 27.2% |
| 3610706 | 3602.1.1.0 ↗ | alpha bundles › Kinase suppressor of Ras 1 helical hairpin domain › Kinase suppressor of Ras 1 helical hairpin domain › Kinase suppressor of Ras 1 helical hairpin domain | 0.64 | 50.0 | 4.67e-01 | 93.3% | 67.5% |
| 3792329 | 109.10.1.1 ↗ | alpha superhelices › Repetitive alpha hairpins › Translin › Translin › Translin | 0.63 | 53.0 | 3.51e-01 | 93.3% | 22.8% |
| 3757999 | 219.1.1.9 ↗ | a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C12 | 0.63 | 51.0 | 3.32e-01 | 93.3% | 19.0% |
| 3838120 | 1056.1.1.0 ↗ | a+b two layers › tRNA pseudouridine synthase TruD insertion domain › tRNA pseudouridine synthase TruD insertion domain › tRNA pseudouridine synthase TruD insertion domain | 0.63 | 50.0 | 3.60e-01 | 88.3% | 39.4% |
| 3251775 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.63 | 50.0 | 4.23e-01 | 90.0% | 95.2% |
| 3845883 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.63 | 50.0 | 4.26e-01 | 91.7% | 52.4% |
| 3346803 | 5076.2.1.10 ↗ | alpha complex topology › Mitochondrial ADP/ATP carrier-like › Putative sulfate permease CysZ › Putative sulfate permease CysZ › PF29520 | 0.62 | 52.0 | 3.36e-01 | 98.3% | 31.1% |
| 4237725 | 1056.1.1.1 ↗ | a+b two layers › tRNA pseudouridine synthase TruD insertion domain › tRNA pseudouridine synthase TruD insertion domain › tRNA pseudouridine synthase TruD insertion domain › TruD | 0.62 | 46.0 | 3.52e-01 | 80.0% | 35.0% |
| 4455667 | 192.7.1.3 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Phe_tRNA-synt_N | 0.61 | 48.0 | 4.52e-01 | 96.7% | 70.7% |
| 4098488 | 192.7.1.3 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Phe_tRNA-synt_N | 0.61 | 52.0 | 4.76e-01 | 98.3% | 72.5% |
| 3806609 | 540.1.1.1 ↗ | few secondary structure elements › Cytochrome c oxidase subunit h › Cytochrome c oxidase subunit h › Cytochrome c oxidase subunit h › COX6B | 0.58 | 42.0 | 3.95e-01 | 78.3% | 62.7% |
| 5051549 | 3080.1.1.0 ↗ | a+b complex topology › Necrosis and ethylene-inducing peptide 1-like proteins › Necrosis and ethylene-inducing peptide 1-like proteins › Necrosis and ethylene-inducing peptide 1-like proteins | 0.58 | 38.0 | 2.55e-01 | 73.3% | 15.2% |
| 3644831 | 101.1.1.3 ↗ | alpha arrays › HTH › HTH › Three-helical HTH › Myb_DNA-binding | 0.57 | 40.0 | 3.80e-01 | 75.0% | 70.7% |
| 5071044 | 7601.1.1.2 ↗ | a/b three-layered sandwiches › Lactate racemase N-terminal domain › Lactate racemase N-terminal domain › Lactate racemase N-terminal domain › DUF362 | 0.54 | 37.0 | 2.31e-01 | 78.3% | 12.1% |
| 4514735 | 1049.2.1.4 ↗ | alpha duplicates or obligate multimers › Baseplate wedge protein gp7 helical domain-like › Baseplate wedge protein gp6 helical domain › Baseplate wedge protein gp6 helical domain › Baseplate_J | 0.51 | 41.0 | 3.04e-01 | 98.3% | 32.6% |