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thymidine_kinase

Euk-Vir

Cercopithecine_alphaherpesvirus_9

thymidine_kinase__NP_077451__Cercopithecine_alphaherpesvirus_9__35246

Identity

Accession:
NP_077451 ↗
Protein ID:
thymidine_kinase
Kingdom:
euk

Quality

88.8 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Varicellovirus› Cercopithecine_alphaherpesvirus_9

TaxID: 35246

Cluster

View cluster (35 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 21-128_316-337
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00693.25 best Herpes_TK 91.0 1.20e-25 85.4% 31.1%
CATH (11)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1osnC00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.87 84.0 6.05e-01 100.0% 96.5%
1e2jA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.83 79.0 5.81e-01 100.0% 95.1%
1p72A00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.83 80.0 5.72e-01 100.0% 94.7%
3axjB02 1.20.58.200 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 0.72 31.0 3.80e-01 77.7% 61.2%
4kb2A01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.66 39.0 4.24e-01 77.7% 69.7%
4oydB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.65 39.0 4.15e-01 75.4% 66.7%
2c5iT00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.64 34.0 3.94e-01 78.5% 70.2%
7zmgL01 1.10.287.3510 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.60 36.0 4.39e-01 89.2% 96.2%
1qhxA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.55 42.0 3.77e-01 85.4% 58.4%
3t0yA01 1.10.1740.10 Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif 0.53 26.0 3.40e-01 84.6% 87.9%
1qsdA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.53 35.0 3.84e-01 80.8% 84.3%
ECOD (17)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
9545 2004.1.1.52 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK 0.91 87.0 6.20e-01 100.0% 94.9%
9546 2004.1.1.52 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK 0.90 86.0 6.18e-01 100.0% 96.3%
1322887 2004.1.1.52 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK 0.83 79.0 5.78e-01 100.0% 94.8%
4945691 192.15.1.0 ↗ alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains 0.80 32.0 4.12e-01 74.6% 62.5%
4971500 192.15.1.0 ↗ alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains 0.75 35.0 3.69e-01 76.2% 49.2%
5052036 605.1.1.0 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.72 39.0 5.05e-01 72.3% 92.0%
4946898 375.1.9.0 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Zinc-nucleated domain of serine integrase 0.72 34.0 4.39e-01 75.4% 77.3%
5043437 192.8.1.0 ↗ alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain 0.69 37.0 4.08e-01 79.2% 64.8%
5066143 5041.1.1.0 ↗ extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C 0.66 32.0 4.20e-01 81.5% 81.3%
4138504 310.2.1.1 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF › RRF 0.65 38.0 3.32e-01 76.2% 40.0%
5044912 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.62 37.0 3.46e-01 76.2% 47.5%
4138735 632.22.1.1 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › EzrA 0.59 39.0 4.33e-01 81.5% 87.0%
3742303 310.2.1.1 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF › RRF 0.59 40.0 3.56e-01 70.8% 91.8%
5049806 2004.1.1.163 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › KTI12 0.57 39.0 3.44e-01 86.9% 48.4%
3261852 174.1.1.83 ↗ few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › TRAM_LAG1_CLN8 0.55 43.0 3.51e-01 83.1% 43.6%
3200626 310.2.1.1 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF › RRF 0.55 38.0 3.31e-01 70.0% 87.5%
3691750 376.1.1.8 ↗ few secondary structure elements › RING/U-box-like › RING/U-box-like › RING/U-box › U-box 0.51 37.0 3.55e-01 74.6% 96.0%
D2 medium residues 129-315
PDB
Domain cluster: rep: thymidina_kinase__YP_009664657__Bubaline_alphaherpesvirus_1__202910__D121-329
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00693.25 best Herpes_TK 207.9 2.70e-61 90.4% 60.0%
CATH (4)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1osnC00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.98 93.0 7.48e-01 100.0% 57.5%
1p72A00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.95 93.0 7.40e-01 100.0% 57.9%
1e2jA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.94 83.0 6.80e-01 100.0% 55.2%
4ii2A01 3.50.50.80 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 0.51 23.0 2.77e-01 82.4% 61.7%
ECOD (3)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
9546 2004.1.1.52 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK 0.98 93.0 7.38e-01 100.0% 55.4%
9545 2004.1.1.52 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK 0.95 93.0 7.34e-01 100.0% 56.2%
1322887 2004.1.1.52 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK 0.94 83.0 6.81e-01 100.0% 55.2%