←Back to structures
thymidine_kinase
Euk-VirPsittacid_alphaherpesvirus_1
thymidine_kinase__NP_944395__Psittacid_alphaherpesvirus_1__50294
Identity
- Accession:
- NP_944395 ↗
- Protein ID:
- thymidine_kinase
- Kingdom:
- euk
Quality
84.8
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Iltovirus›
Psittacid_alphaherpesvirus_1
TaxID: 50294
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 1-31_164-313
Domain cluster:
rep: thymidina_kinase__YP_009664657__Bubaline_alphaherpesvirus_1__202910__D121-329
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00693.25 best | Herpes_TK | 166.7 | 9.80e-49 | 72.9% | 46.1% |
CATH (5)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1p72A00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.85 | 82.0 | 6.56e-01 | 100.0% | 91.3% |
| 1osnC00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.84 | 81.0 | 6.55e-01 | 100.0% | 93.0% |
| 1e2jA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.77 | 75.0 | 6.06e-01 | 100.0% | 91.2% |
| 4cvnA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.52 | 43.0 | 4.41e-01 | 98.3% | 87.7% |
| 4u7iA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.52 | 21.0 | 2.98e-01 | 95.0% | 74.2% |
ECOD (4)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 9545 | 2004.1.1.52 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK | 0.85 | 82.0 | 6.50e-01 | 100.0% | 91.6% |
| 1322887 | 2004.1.1.52 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK | 0.77 | 75.0 | 6.08e-01 | 100.0% | 90.8% |
| 5043508 | 2004.1.1.192 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_18 | 0.51 | 43.0 | 4.41e-01 | 97.8% | 90.3% |
| 4963297 | 3236.1.1.12 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Cons_hypoth698 | 0.51 | 40.0 | 3.41e-01 | 84.0% | 88.7% |
D2
medium
residues 32-163_314-339
Domain cluster:
rep: thymidine_kinase__YP_009230154__Leporid_alphaherpesvirus_4__481315__D1-149_256-295
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00693.25 best | Herpes_TK | 202.0 | 1.70e-59 | 88.6% | 46.4% |
CATH (11)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1e2jA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.89 | 86.0 | 6.62e-01 | 100.0% | 91.8% |
| 1p72A00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.86 | 83.0 | 6.30e-01 | 100.0% | 89.8% |
| 1osnC00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.85 | 80.0 | 6.18e-01 | 97.5% | 90.4% |
| 1zm7B00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.78 | 53.0 | 4.84e-01 | 83.5% | 54.5% |
| 1p5zB00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.69 | 56.0 | 4.88e-01 | 84.2% | 76.4% |
| 3rkgA02 | 1.20.58.340 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region | 0.56 | 44.0 | 4.42e-01 | 82.9% | 93.3% |
| 3kyiA00 | 1.20.120.160 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain | 0.56 | 36.0 | 4.00e-01 | 94.9% | 80.5% |
| 2v4iB01 | 3.30.2330.10 | Alpha Beta › 2-Layer Sandwich › arginine biosynthesis bifunctional protein fold › arginine biosynthesis bifunctional protein suprefamily | 0.53 | 23.0 | 3.03e-01 | 98.7% | 74.0% |
| 1xzpA02 | 1.20.120.430 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › tRNA modification GTPase MnmE domain 2 | 0.52 | 37.0 | 3.69e-01 | 72.8% | 72.3% |
| 6dewA01 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.52 | 37.0 | 3.53e-01 | 73.4% | 91.6% |
| 4mhlA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.50 | 37.0 | 3.71e-01 | 97.5% | 74.5% |
ECOD (18)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 9545 | 2004.1.1.52 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK | 0.91 | 88.0 | 6.60e-01 | 100.0% | 90.1% |
| 1322887 | 2004.1.1.52 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK | 0.87 | 84.0 | 6.51e-01 | 100.0% | 91.2% |
| 9546 | 2004.1.1.52 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK | 0.87 | 82.0 | 6.20e-01 | 97.5% | 90.5% |
| 3753842 | 2004.1.1.70 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › dNK | 0.68 | 55.0 | 4.82e-01 | 84.2% | 69.8% |
| 5060871 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.63 | 48.0 | 5.29e-01 | 82.3% | 99.2% |
| 3885340 | 109.4.1.906 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › N-HEAT_ATR | 0.59 | 46.0 | 3.78e-01 | 83.5% | 45.3% |
| 3827214 | 603.2.1.0 ↗ | alpha bundles › STAT-like › STAT › STAT | 0.58 | 43.0 | 4.55e-01 | 77.2% | 92.4% |
| 3909982 | 109.4.1.557 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TTC7_N | 0.58 | 45.0 | 3.78e-01 | 82.3% | 86.9% |
| 3911736 | 109.4.1.513 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › CCDC142 | 0.57 | 47.0 | 3.33e-01 | 89.2% | 38.0% |
| 3502594 | 603.1.1.98 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › SNARE, Syntaxin_2 | 0.57 | 45.0 | 4.05e-01 | 84.2% | 81.8% |
| 3324745 | 109.4.1.1154 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › INTS7_N | 0.56 | 43.0 | 2.89e-01 | 79.1% | 21.7% |
| 3975106 | 4121.1.1.1 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › CorA | 0.56 | 46.0 | 3.79e-01 | 86.1% | 55.7% |
| 3765228 | 109.4.1.1484 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_ZSWIM8 | 0.56 | 40.0 | 3.39e-01 | 73.4% | 87.5% |
| 3561537 | 109.4.1.898 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_leprecan | 0.55 | 45.0 | 3.38e-01 | 85.4% | 63.6% |
| 3188362 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.53 | 43.0 | 3.95e-01 | 86.1% | 88.0% |
| 3789674 | 109.3.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat | 0.53 | 40.0 | 3.54e-01 | 77.8% | 77.3% |
| 3862881 | 109.4.1.1484 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_ZSWIM8 | 0.52 | 41.0 | 3.97e-01 | 82.9% | 80.0% |
| 4959000 | 1075.1.1.3 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain › ABC2_membrane_2 | 0.50 | 43.0 | 3.77e-01 | 92.4% | 67.9% |