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thymidine_kinase

Euk-Vir

Gallid_alphaherpesvirus_2

thymidine_kinase__YP_001033951__Gallid_alphaherpesvirus_2__10390

Identity

Accession:
YP_001033951 ↗
Protein ID:
thymidine_kinase
Kingdom:
euk

Quality

85.6 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Mardivirus› Gallid_alphaherpesvirus_2

TaxID: 10390

Cluster

View cluster (35 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 24-52_134-322
PDB
Domain cluster: rep: thymidina_kinase__YP_009664657__Bubaline_alphaherpesvirus_1__202910__D121-329
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00693.25 best Herpes_TK 245.8 7.70e-73 80.7% 59.6%
D2 medium residues 53-133_323-352
PDB
Domain cluster: rep: ORF38_gene_product__YP_006273018__Equid_alphaherpesvirus_8__39637__D59-120_334-352
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00693.25 best Herpes_TK 113.6 1.50e-32 82.0% 32.1%
CATH (13)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1e2jA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.93 90.0 6.22e-01 100.0% 89.9%
1osnC00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.85 78.0 5.41e-01 96.4% 87.9%
3kd3A02 1.10.150.210 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Phosphoserine phosphatase; domain 2 0.77 32.0 4.32e-01 72.1% 73.3%
2ycdA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.60 38.0 3.73e-01 98.2% 58.1%
4mt4A00 1.20.1600.10 Mainly Alpha › Up-down Bundle › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) 0.60 42.0 2.76e-01 93.7% 16.9%
1hqoA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.56 43.0 4.08e-01 100.0% 68.7%
3p96A02 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.56 34.0 3.80e-01 99.1% 78.6%
5uh5D02 1.10.132.30 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › RNA polymerase Rpb1 funnel domain 0.55 39.0 3.63e-01 73.0% 72.5%
2o5iN07 1.10.132.30 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › RNA polymerase Rpb1 funnel domain 0.55 38.0 3.83e-01 73.0% 73.3%
4pxoA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.54 38.0 3.64e-01 73.0% 73.3%
3dzaA01 1.20.120.1940 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YfdX protein domain 0.53 33.0 3.24e-01 96.4% 59.0%
4c91A03 1.20.58.2150 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.52 37.0 3.17e-01 73.0% 67.0%
1jgsA00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.51 36.0 3.39e-01 73.9% 87.7%
ECOD (25)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1322887 2004.1.1.52 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK 0.92 89.0 6.15e-01 100.0% 89.2%
9545 2004.1.1.52 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK 0.91 87.0 5.94e-01 100.0% 88.3%
9546 2004.1.1.52 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK 0.85 78.0 5.39e-01 96.4% 88.0%
3555742 103.1.1.0 ↗ alpha arrays › RuvA-C › RuvA-C, UBA, CRAL/TRIO-N, HBS1 › UBA-like domain 0.76 40.0 4.61e-01 71.2% 68.2%
5046133 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.69 44.0 4.83e-01 73.0% 78.9%
5054079 192.4.1.0 ↗ alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) 0.69 39.0 4.61e-01 73.0% 78.8%
4015612 616.1.1.0 ↗ alpha arrays › S15/NS1 RNA-binding domain › S15/NS1 RNA-binding domain › S15/NS1 RNA-binding domain 0.67 36.0 4.03e-01 98.2% 67.1%
3988447 5043.1.1.0 ↗ extended segments › Sensor proteins transmembrane domains › Htr2 transmembrane domain-like › Htr2 transmembrane domain-like 0.64 31.0 4.21e-01 98.2% 92.7%
3488183 622.4.1.0 ↗ alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related 0.61 43.0 3.51e-01 72.1% 77.5%
3549652 109.26.1.1 ↗ alpha superhelices › Repetitive alpha hairpins › Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains › Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains › Nucleoporin_C 0.61 44.0 2.64e-01 74.8% 28.5%
3628378 192.15.1.0 ↗ alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains 0.60 42.0 3.69e-01 96.4% 48.5%
5043291 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.60 37.0 4.22e-01 71.2% 85.0%
3560925 604.1.1.20 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › AKNA 0.57 40.0 4.10e-01 73.0% 73.6%
3789674 109.3.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat 0.57 42.0 3.37e-01 95.5% 38.2%
3256821 603.1.1.99 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins › PF27021 0.56 38.0 3.72e-01 81.1% 63.3%
4419476 4958.1.1.1 ↗ a+b complex topology › second helical domain in RNA-polymerase beta-prime subunit › second helical domain in RNA-polymerase beta-prime subunit › second helical domain in RNA-polymerase beta-prime subunit › RNA_pol_Rpb1_5,RNA_pol_Rpb1_4 0.56 39.0 3.37e-01 73.0% 49.1%
4002640 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.55 39.0 2.74e-01 73.0% 71.7%
4642508 4958.1.1.1 ↗ a+b complex topology › second helical domain in RNA-polymerase beta-prime subunit › second helical domain in RNA-polymerase beta-prime subunit › second helical domain in RNA-polymerase beta-prime subunit › RNA_pol_Rpb1_5,RNA_pol_Rpb1_4 0.54 38.0 2.94e-01 73.0% 34.5%
5081920 304.160.1.1 ↗ a+b two layers › Alpha-beta plaits › Gas vesicle protein GvpF › Gas vesicle protein GvpF › GvpL_GvpF 0.54 47.0 4.49e-01 99.1% 81.5%
5032498 304.160.1.1 ↗ a+b two layers › Alpha-beta plaits › Gas vesicle protein GvpF › Gas vesicle protein GvpF › GvpL_GvpF 0.54 49.0 4.51e-01 100.0% 83.6%
3410594 4177.1.1.6 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR_3_WASP_bdg 0.53 44.0 3.52e-01 86.5% 83.4%
5083210 3291.1.1.0 ↗ alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related 0.52 41.0 4.20e-01 82.9% 87.3%
4647018 4958.1.1.2 ↗ a+b complex topology › second helical domain in RNA-polymerase beta-prime subunit › second helical domain in RNA-polymerase beta-prime subunit › second helical domain in RNA-polymerase beta-prime subunit › RNA_pol_Rpb1_4 0.52 36.0 3.08e-01 72.1% 60.1%
5032075 304.160.1.1 ↗ a+b two layers › Alpha-beta plaits › Gas vesicle protein GvpF › Gas vesicle protein GvpF › GvpL_GvpF 0.52 46.0 4.36e-01 99.1% 83.8%
4106626 2002.1.1.154 ↗ a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › Meth_synt_1 0.51 45.0 3.09e-01 96.4% 94.8%