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thymidine_kinase

Euk-Vir

Acanthamoeba_polyphaga_mimivirus

thymidine_kinase__YP_003986756__Acanthamoeba_polyphaga_mimivirus__212035

Identity

Accession:
YP_003986756 ↗
Protein ID:
thymidine_kinase
Kingdom:
euk

Quality

82.4 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Megaviricetes› Imitervirales› Mimiviridae› Mimivirus› Acanthamoeba_polyphaga_mimivirus

TaxID: 212035

Cluster

View cluster (85 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 3-142
PDB
Domain cluster: rep: NC_021330__YP_008059651.1__M202-gp129__00089__D21-171
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00265.25 best TK 105.4 4.50e-30 100.0% 75.6%
D2 high residues 145-203
PDB
Domain cluster: rep: Thymidine_kinase__YP_009703106__African_swine_fever_virus__10497__D144-190
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00265.25 best TK 40.3 4.20e-10 67.8% 22.2%
CATH (36)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1w4rA02 3.30.60.20 Alpha Beta › 2-Layer Sandwich › Wheat Germ Agglutinin (Isolectin 2); domain 1 › 0.93 63.0 7.38e-01 71.2% 97.6%
4e1pA00 3.30.60.230 Alpha Beta › 2-Layer Sandwich › Wheat Germ Agglutinin (Isolectin 2); domain 1 › Lsr2, dimerisation domain 0.80 60.0 6.23e-01 93.2% 85.5%
1e7lA01 3.40.1800.10 Alpha Beta › 3-Layer(aba) Sandwich › His-Me finger endonuclease fold › His-Me finger endonucleases 0.67 59.0 5.33e-01 98.3% 80.0%
7l9pK01 3.30.900.10 Alpha Beta › 2-Layer Sandwich › Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A › HORMA domain 0.63 42.0 3.35e-01 100.0% 33.6%
3eoqB02 3.30.830.10 Alpha Beta › 2-Layer Sandwich › Cytochrome Bc1 Complex; Chain A, domain 1 › Metalloenzyme, LuxS/M16 peptidase-like 0.63 46.0 3.24e-01 78.0% 52.5%
3gr5A02 3.30.1370.120 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › 0.62 45.0 4.30e-01 78.0% 100.0%
2dfkC02 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.61 52.0 3.91e-01 94.9% 77.3%
3kreA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.59 38.0 3.26e-01 81.4% 39.2%
3n5fA02 3.30.70.360 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.59 43.0 3.52e-01 79.7% 89.5%
3thxB04 1.10.1420.10 Mainly Alpha › Orthogonal Bundle › MutS, DNA mismatch repair protein; Chain A, domain 3 › 0.59 50.0 3.84e-01 93.2% 59.4%
1kwmA01 3.30.70.340 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Metallocarboxypeptidase-like 0.57 39.0 3.43e-01 71.2% 76.1%
1zc3B00 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.57 48.0 3.94e-01 94.9% 92.7%
1p4xA02 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.56 43.0 3.36e-01 81.4% 59.3%
1ewqA04 1.10.1420.10 Mainly Alpha › Orthogonal Bundle › MutS, DNA mismatch repair protein; Chain A, domain 3 › 0.56 43.0 3.24e-01 100.0% 35.3%
1lxjA00 3.30.70.930 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.56 42.0 3.54e-01 81.4% 68.0%
4wu3A02 3.30.70.1690 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.55 39.0 3.48e-01 74.6% 92.9%
2lg1A02 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.55 45.0 3.74e-01 96.6% 90.4%
1v89A00 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.55 46.0 3.66e-01 93.2% 91.5%
2qndA02 3.30.1370.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › K Homology domain, type 1 0.55 41.0 3.74e-01 81.4% 100.0%
2n8lA00 3.30.310.210 Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › 0.55 48.0 3.38e-01 100.0% 45.0%
2fwrA01 3.40.1170.30 Alpha Beta › 3-Layer(aba) Sandwich › MutS, DNA mismatch repair protein, domain I › 0.54 36.0 3.74e-01 71.2% 75.4%
5yk4A04 1.10.1420.10 Mainly Alpha › Orthogonal Bundle › MutS, DNA mismatch repair protein; Chain A, domain 3 › 0.53 48.0 3.62e-01 98.3% 50.7%
5wjpA01 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.53 43.0 3.33e-01 91.5% 42.3%
2o8bB04 1.10.1420.10 Mainly Alpha › Orthogonal Bundle › MutS, DNA mismatch repair protein; Chain A, domain 3 › 0.53 45.0 3.45e-01 93.2% 56.5%
3d68A01 3.30.70.340 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Metallocarboxypeptidase-like 0.52 40.0 3.50e-01 84.7% 71.7%
2yq1C00 3.30.70.390 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Epstein Barr virus nuclear antigen-1, DNA-binding domain 0.52 40.0 3.22e-01 88.1% 66.4%
2xzmZ00 3.30.1230.20 Alpha Beta › 2-Layer Sandwich › Hypothetical Cytosolic Protein; Chain: A; › Ribosomal protein S21 0.52 38.0 3.29e-01 79.7% 54.6%
3h14A00 3.40.640.10 Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) 0.52 43.0 2.64e-01 91.5% 89.7%
7txnA01 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.52 36.0 3.16e-01 74.6% 70.0%
1cqmA00 3.30.70.60 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S6/Translation elongation factor EF1B 0.51 36.0 3.13e-01 76.3% 86.7%
2rhqB05 3.30.930.10 Alpha Beta › 2-Layer Sandwich › BirA Bifunctional Protein; domain 2 › Bira Bifunctional Protein; Domain 2 0.51 36.0 2.53e-01 74.6% 90.7%
3dgpB00 3.30.70.1220 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › TFB5-like 0.51 43.0 4.23e-01 98.3% 96.8%
2jzxA02 3.30.1370.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › K Homology domain, type 1 0.51 42.0 3.83e-01 91.5% 94.9%
6gvdA02 3.20.20.70 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I 0.51 38.0 2.40e-01 94.9% 14.8%
1ve4A01 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.50 36.0 2.97e-01 78.0% 76.3%
3u2rA00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.50 44.0 3.29e-01 94.9% 85.9%
ECOD (40)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1868224 377.1.1.3 ↗ few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like › TK 0.97 75.0 7.40e-01 79.7% 77.0%
3717094 2004.1.1.28 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › TK 0.96 75.0 4.80e-01 81.4% 21.3%
4517886 377.1.1.3 ↗ few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like › TK 0.89 65.0 7.33e-01 78.0% 100.0%
1636870 377.1.1.3 ↗ few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like › TK 0.88 64.0 7.17e-01 76.3% 97.8%
3674153 2004.1.1.28 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › TK 0.84 76.0 5.04e-01 100.0% 26.8%
4007998 2004.1.1.28 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › TK 0.80 60.0 4.04e-01 79.7% 24.9%
4675823 377.1.1.3 ↗ few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like › TK 0.79 60.0 5.80e-01 79.7% 78.5%
3402915 376.1.3.0 ↗ few secondary structure elements › RING/U-box-like › RING/U-box-like › FYVE/PHD zinc finger 0.75 65.0 5.35e-01 93.2% 80.0%
3960493 1001.1.1.0 ↗ a+b two layers › Formate dehydrogenase/DMSO reductase, domain 1 › Formate dehydrogenase/DMSO reductase, domain 1 › Formate dehydrogenase/DMSO reductase, domain 1 0.71 42.0 3.29e-01 78.0% 28.0%
3755680 5001.1.1.43 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › V1R 0.69 47.0 2.93e-01 71.2% 48.2%
4022846 101.1.2.0 ↗ alpha arrays › HTH › HTH › winged helix domain 0.63 45.0 3.01e-01 74.6% 57.2%
3184642 327.11.2.0 ↗ a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) 0.61 44.0 3.74e-01 76.3% 97.9%
3998992 220.1.1.79 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like › TBC1D23_C 0.60 44.0 3.45e-01 81.4% 89.6%
4950064 327.16.1.22 ↗ a+b two layers › Alpha-lytic protease prodomain-like › Ring-building motif II in type III secretion system › Ring-building motif II in type III secretion system › PF27275 0.60 42.0 4.03e-01 76.3% 100.0%
3583067 109.4.1.182 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Sec7-like_HUS,DCB 0.59 45.0 2.56e-01 81.4% 18.0%
3843080 5001.1.1.43 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › V1R 0.59 45.0 2.88e-01 94.9% 15.9%
3255991 601.23.1.4 ↗ alpha bundles › Four-helical up-and-down bundle › DNA repair protein MutS, domain III › DNA repair protein MutS, domain III › MutS_IV, MutS_III 0.57 49.0 3.06e-01 93.2% 25.2%
3716480 331.18.1.0 ↗ a+b two layers › TBP-like › C-terminal TBP-like domain of Roc › C-terminal TBP-like domain of Roc 0.57 44.0 3.24e-01 96.6% 30.6%
3753304 5001.1.1.43 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › V1R 0.57 45.0 2.81e-01 94.9% 16.2%
3181789 601.23.1.4 ↗ alpha bundles › Four-helical up-and-down bundle › DNA repair protein MutS, domain III › DNA repair protein MutS, domain III › MutS_IV, MutS_III 0.57 49.0 3.07e-01 93.2% 25.1%
4124135 601.23.1.4 ↗ alpha bundles › Four-helical up-and-down bundle › DNA repair protein MutS, domain III › DNA repair protein MutS, domain III › MutS_IV, MutS_III 0.57 49.0 3.04e-01 93.2% 25.7%
4013601 601.23.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › DNA repair protein MutS, domain III › DNA repair protein MutS, domain III 0.57 49.0 3.06e-01 93.2% 24.7%
5049391 310.1.1.2 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain › Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain › Arg_tRNA_synt_N 0.56 28.0 2.32e-01 78.0% 21.9%
3769334 5001.1.1.43 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › V1R 0.56 43.0 2.74e-01 94.9% 16.2%
4539032 314.1.1.11 ↗ a+b three layers › Class II aaRS and biotin synthetases › Class II aaRS and biotin synthetases › Class II aaRS and biotin synthetases › tRNA_synthFbeta 0.55 39.0 2.84e-01 93.2% 25.7%
4969654 601.23.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › DNA repair protein MutS, domain III › DNA repair protein MutS, domain III 0.55 48.0 3.05e-01 94.9% 27.0%
3522222 5001.1.1.43 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › V1R 0.55 43.0 2.96e-01 94.9% 25.1%
3521199 220.1.1.26 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like › Vps36_ESCRT-II 0.55 42.0 3.27e-01 83.1% 85.4%
3564603 304.9.1.0 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.54 38.0 3.30e-01 74.6% 87.4%
3759939 5001.1.1.43 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › V1R 0.53 46.0 2.86e-01 94.9% 89.7%
3720761 2484.1.1.153 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DUF1744 0.53 41.0 2.56e-01 83.1% 28.3%
3600206 241.6.1.0 ↗ a+b two layers › Type III secretory system chaperone-like › Arp2/3 complex subunits › Arp2/3 complex subunits 0.53 46.0 3.32e-01 100.0% 83.4%
3739577 327.11.2.1 ↗ a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) › KH_1 0.53 43.0 3.87e-01 89.8% 100.0%
4208861 2004.1.1.224 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › P-loop_SecA 0.52 43.0 2.89e-01 94.9% 22.9%
4959707 304.120.1.0 ↗ a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI 0.52 38.0 3.73e-01 78.0% 86.2%
2320836 4340.1.1.1 ↗ a+b complex topology › TFB5-related › TFB5-related › TFB5-related › Tfb5 0.52 44.0 4.31e-01 100.0% 93.9%
4001087 371.1.1.1 ↗ few secondary structure elements › Phospholipase A2, PLA2 › Phospholipase A2, PLA2 › Phospholipase A2, PLA2 › Phospholip_A2_1 0.52 43.0 3.36e-01 93.2% 44.2%
3871063 383.1.1.9 ↗ few secondary structure elements › Defensin-like › Defensin-related › Defensin-related › Defensin_beta_2 0.51 38.0 3.87e-01 86.4% 79.3%
3176065 327.11.2.32 ↗ a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) › PF29529 0.50 43.0 3.80e-01 94.9% 100.0%
5083428 304.3.1.0 ↗ a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.50 34.0 3.32e-01 71.2% 86.2%